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Search Results: 1 - 10 of 5120 matches for " Angela Pizzolla "
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Mice Lacking NCF1 Exhibit Reduced Growth of Implanted Melanoma and Carcinoma Tumors
Tiina Kelkka, Angela Pizzolla, Juha Petteri Laurila, Tomas Friman, Renata Gustafsson, Eva K?llberg, Olof Olsson, Tomas Leanderson, Kristofer Rubin, Marko Salmi, Sirpa Jalkanen, Rikard Holmdahl
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084148
Abstract: The NADPH oxidase 2 (NOX2) complex is a professional producer of reactive oxygen species (ROS) and is mainly expressed in phagocytes. While the activity of the NOX2 complex is essential for immunity against pathogens and protection against autoimmunity, its role in the development of malignant tumors remains unclear. We compared wild type and Ncf1m1J mutated mice, which lack functional NOX2 complex, in four different tumor models. Ncf1m1J mutated mice developed significantly smaller tumors in two melanoma models in which B16 melanoma cells expressing a hematopoietic growth factor FLT3L or luciferase reporter were used. Ncf1m1J mutated mice developed significantly fewer Lewis Lung Carcinoma (LLC) tumors, but the tumors that did develop, grew at a pace that was similar to the wild type mice. In the spontaneously arising prostate carcinoma model (TRAMP), tumor growth was not affected. The lack of ROS-mediated protection against tumor growth was associated with increased production of immunity-associated cytokines. A significant increase in Th2 associated cytokines was observed in the LLC model. Our present data show that ROS regulate rejection of the antigenic B16-luc and LLC tumors, whereas the data do not support a role for ROS in growth of intrinsically generated tumors.
Women entrepreneurship in Romania
Angela ON
Revista Romana de Economie , 2011,
Abstract: Considering entrepreneurship the domain with the greatest potential for creativity and innovation, any investigation on this field is recommended, in order to reveal new aspects that can influence the small enterprises development. From this point of view, female entrepreneurship represents an important source of innovation, only partially exploited or even forgotten.
Impact of Simulated Airborne Soot on Maize Growth and Development  [PDF]
Angela Anda, Berndett Illes
Journal of Environmental Protection (JEP) , 2012, DOI: 10.4236/jep.2012.38092
Abstract: Various effects of the dry deposition of soot on maize were investigated in Keszthely (Hungary) in two consecutive years. In order to be able to study a wider range of weather conditions, some of the plants were placed in a Thornthwaite-Matter type evapotranspirometer and given ad libitum water supplies. Pollution with airborne black carbon was simulated throughout the season by distributing rates of 3 g?m–2 a week using a motorised dust sprayer. Among the plant growth parameters, the leaf area index was increased by 3% - 14%, depending on the year, suggesting that the plants were able to absorb the carbon settling on the leaves. The black carbon reduced the albedo of the canopy by 17.5% - 21.8%, depending on the year, forcing the polluted maize to absorb more energy. Part of this surplus energy was utilised for increased evapotranspiration (3.9% and 11% in the two years) and to raise the surface temperature of the canopy by 1℃ - 2℃ during the mid-day hours. The effect of the contamination on maize was more intense in the hot, dry year. The unfavourable effect of soot on maize fertilisation could be observed as a significant increase in the number of deformed ears, leading to a reduction in grain dry matter. The reduction in dry matter yield for polluted maize grown with irrigation in the evapotranspirometer was far less severe than that on non-irrigated plots, suggesting that irrigation was the most obvious solution for mitigating the negative effects of contamination with airborne soot.
Current Attitudes of Anesthesiologists towards Medically Futile Care  [PDF]
Angela Saettele,Joseph Kras
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.34048
Abstract: Purpose: To explore anesthesiologists’ perceptions of the reasons underlying why physicians continue to provide care that they consider futile. Methods: A qualitative study was conducted utilizing a grounded theory approach. Four separate focus groups (2 resident physician groups and 2 attending physician groups) were conducted over a three week span. An interview guide was used consisting of a proposed definition of futility and five open-ended questions. Responses to the five open-ended questions were used to guide follow up questions. Transcribed audio recordings were then analyzed. Results: With data reduction, we were able to separate responses into definitions of futility, stories of cases where futile care was provided, and opinions as to the underlying causes of continuing to provide futile care. A variety of opinions was obtained, suggesting the possibility that different groups (surgeons, anesthesiologists, family members) view questions of futility differently. Conclusions: Complete agreement on a definition of futility does not exist. Even when some agreement exists, there is great difficulty in predicting outcomes in individual cases. Future quantitative studies may provide more evidence of trends in underlying reasons for providing futile care. Focused education efforts may then lead to more agreement between all involved.
Current Attitudes of Anesthesiologists towards Medically Futile Care  [PDF]
Angela Saettele, Joseph Kras
Open Journal of Anesthesiology (OJAnes) , 2013, DOI: 10.4236/ojanes.2013.34048
Abstract:

Purpose: To explore anesthesiologists’ perceptions of the reasons underlying why physicians continue to provide care that they consider futile. Methods: A qualitative study was conducted utilizing a grounded theory approach. Four separate focus groups (2 resident physician groups and 2 attending physician groups) were conducted over a three week span. An interview guide was used consisting of a proposed definition of futility and five open-ended questions. Responses to the five open-ended questions were used to guide follow up questions. Transcribed audio recordings were then analyzed. Results: With data reduction, we were able to separate responses into definitions of futility, stories of cases where futile care was provided, and opinions as to the underlying causes of continuing to provide futile care. A variety of opinions was obtained, suggesting the possibility that different groups (surgeons, anesthesiologists, family members) view questions of futility differently. Conclusions: Complete agreement on a definition of futility does not exist. Even when some agreement exists, there is great difficulty in predicting outcomes in individual cases. Future quantitative studies may provide more evidence of trends in underlying reasons for providing futile care. Focused education efforts may then lead to more agreement between all

Keeping the White Family Together: Racial Disparities in the Out-of-Home Placements of Maltreated Children  [PDF]
Angela M. Kaufman
Advances in Applied Sociology (AASoci) , 2013, DOI: 10.4236/aasoci.2013.38041
Abstract: The likelihood of being removed from the home following a case of maltreatment is much higher for black youth than for whites. Two explanations exist in the literature. The first, black children experience more serious forms of maltreatment and have fewer resources to remedy the maltreatment situation than do whites. The second, there is an underlying racial bias within the child welfare system. The present study examines 789 dependency cases from child welfare services in a large urban county in the Northwest United States. Using multiple logistic regression models, it examines whether race has an effect on child placement within the child welfare system, and whether the factors influencing placement are the same for white and black youth. Findings illustrate a racial disparity in out-of-home placements supporting both of the competing explanations in the current literature. Overall, the present study finds that two separate processes seem to be at play in the placement decisions of maltreated youth, and concludes with possible explanations for this differential treatment.
Analysing a Pricing Policy for a Home Centre: A Case Study  [PDF]
Dora Maglione, Angela Diblasi
Journal of Financial Risk Management (JFRM) , 2014, DOI: 10.4236/jfrm.2014.31002
Abstract:

One critical aspect of retailer category management is pricing the items in order to maximize total profits. To define an appropriate pricing policy, a retailer should evaluate how changes in prices of a set of items may impact their shelves or inter demands. In this setting, elasticities play a major role. In addition, a proper policy can be defined from different points of view. In this paper, estimation of a profit function and its maximization under different scenarios is used as a tool to analyze such policy. Estimation of this function is performed through a previous selection of items within a home center category. Then, an adequate AIDS model allowing calculation of elasticities is fitted. Moreover, a profit function is defined in terms of prices and demands. This functionis linearized for the following two purposes, to express it in terms of elasticities, and to maximize it more easily under the consideration of different sets of item prices defined in a convex set. Then, confidence intervals for the total and marginal profits were built to gather the randomness of demands. The results are applied to the selected items in a home center that behaves as a monopoly in the area.

Strategies, Performances and Profiling of a Sample of U.S. Universities in 2012  [PDF]
Angela Besana, Annamaria Esposito
Open Journal of Applied Sciences (OJAppS) , 2015, DOI: 10.4236/ojapps.2015.53008
Abstract: The global economic crisis is affecting performances of not-for-profits. At the same time donors are targeted by a pressing good-cause related marketing, so that the competition for philanthropy is particularly keen. U.S. universities can be public, not-for-profit and for-profit. U.S. not-for-profit universities are confronted with different marketing, fundraising and revenue diversification. Above all, marketing concerns customers and their segmentation and their purchasing-power exploitation; fundraising aims to gain the trustworthiness of donors, instead. The aim of this paper is the analysis of the revenue diversification of a sample of 100 U.S. not-for-profit universities according to IRS (Internal Revenue Service) Forms. These 100 U.S. universities had the highest 2012’s revenues for the Guidestar ranking (www.guidestar.org). The cluster analysis gives evidence that the highest gain and the highest solvency are both connected with the implementation of revenue diversification for one profile. The most crowded cluster is the Marketing Expert with the second highest gain.
Polyhexamethylene Biguanide in Vaginal Solution Is Effective in the Treatment of Vulvovaginal Candidiasis: A Pilot Study  [PDF]
Alberto Biamonti, Angela Saracino
Open Journal of Obstetrics and Gynecology (OJOG) , 2017, DOI: 10.4236/ojog.2017.71002
Abstract: Vaginitis is one of the most recurrent conditions that afflict women and require medical care. Vulvovaginal candidiasis (VVC) is frequently related to vaginal carriage of Candida albicans, an opportunistic polymorphic fungus, which colonizes the human skin, the mucosa and the reproductive tract. Actually, standard treatments to counteract vaginitis include several topical and oral treatments. The aim of this study was to evaluate the efficacy of a new biguanide compound, polyhexamethylene biguanide (PHMB) in avaginal solution, in women affected by vaginal candidiasis. For this reason, 40 women showing the symptoms previously ascribed to vaginal candidiasis were recruited and treated with a single PHMB dose of vaginal solution. After a single dose of treatment, 80% of them had a complete resolution of the fungal infection; furthermore, all of them reported clinical benefits, statistically significant reduction in both clinical signs and symptoms of candidiasis and a score’s reduction of 50%.
Selected Bibliography from the Special Collections Department of The College of The Bahamas Library
Gottardi, Angela,Gottardi, Angela
College Forum , 1997,
Abstract: In the Special Collections Department of The College of The Bahamas Library resides a little treasure trove of resources pertaining to The Bahamas, the West Indies and Africa. These collections hold a variety of printed materials: books, dissertations, research studies, government documents, journals, newspaper clippings and ephemera. The Bahamian Collection is the most extensive. Established in 1984, it serves the purpose of a research depository for The Bahamas, as the National Library is yet to be built. Officially, the National Archives is the depository for the historical records of the country. The Bahamas is fortunate in having a very fine archival institution, located on Mackey Street. Titles included in the Bahamian Collection Selected Bibliography are books chosen for their representational appeal. The intention was to represent a cross-section of publications highlighting all aspects of The Bahamas. That was the primary criterion. The other consideration was motivational value. By this is meant the ability to tantalize the reader into discovering more about whom, why and what has been printed to preserve, inform, entertain and contemplate the fascinating evolution of The Bahamas. Owing to the strong oral tradition of the country, the printed record of the people began somewhat later than in many other cultures. This too is of significance to the interested reader. In August 1996 when I came to work at The College of The Bahamas as the Special Collections Librarian, I knew nothing of the colors, textures and vitality of this country. A Fodor's travel guide provided factual information and description and some enticing photographs. The context of Bahamian life was a mystery to me. As the authors of the books selected for this bibliography, I have grown more and more intrigued by this island archipelago. Thanks to the encoded voice of natives and, like myself, windblown curious wanderers who have had the good fortune to arrive, if only for a short while, and partake, a cache of Bahamian wealth has been shared. This is a reader's bibliography and a work unto itself. It is not meant to support a work of research or any other work. The format used for this bibliography is presented in the following manner: title (in bold italics), author, publication information. This style is a deliberate departure from that of APA to which other articles in this publication of College Forum are required to conform.
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