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Search Results: 1 - 10 of 106135 matches for " Angèle I. Masewu "
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Prognostic Signification of Admission Hyperglycemia among Acute Stroke Patients in Intensive Care Units in Kinshasa, the Democratic Republic of the Congo  [PDF]
Josée K. Tshituta, Fran?ois B. Lepira, Fran?ois P. Kajingulu, Jean Robert R. Makulo, Ernest K. Sumaili, Pierre Z. Akilimali, Aliocha N. Nkodila, Freddy M. Mbuyi, Angèle I. Masewu, Stéphane Mutombo, Eric B. Amisi, Jean Pierre M. Ilunga, Wilfrid B. Mbombo, Patrick M. Mukuna, Adolphe M. Kilembe
World Journal of Cardiovascular Diseases (WJCD) , 2019, DOI: 10.4236/wjcd.2019.99060
Abstract:
BACKGROUND AND AIM: Although admission hyperglycemia has been reported to be associated with unfavorable outcomes in acute stroke, little is known about this association in sub-Saharan Africa. Therefore, the aim of the present study was to assess the prognostic significance of admission hyperglycemia in the acute phase of stroke in Congolese patients. METHODS: In a multicenter prospective cohort study, consecutive patients with acute stroke were examined in 5 Emergency Rooms or Intensive Care Units of Kinshasa between July 15th, 2017 and March 15th, 2018. The severity of stroke was assessed at admission using the Glasgow Coma Scale. Stress hyperglycemia was defined as random blood glucose levels at admission > 140 mg/dL in patients without known type 2 diabetes mellitus (T2DM). The endpoint was 10-day all-cause in-hospital mortality. Survival (time-to-death) curves were built using the Kaplan Meier methods. Cox proportional analysis was used to identify predictors of 10-day all-cause in-hospital mortality. The predictive performance of blood glucose level
Effect of the Various Processed Food of the Far North Cameroon on the Glycemic Index  [PDF]
Beno?t B. Koubala, Germain Kansci, Abdoulaye N. P. Fifen, Angèle I. Ngoufack, Yvette C. M. Dadjeu
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.59088
Abstract:


Metabolic Syndrome (MS) has reached a pandemic proportion and has an impact on the incidence and severity of cardiovascular pathologies. This study was conducted to evaluate the effect of different processed food commonly consumed in Maroua (Far North Region, Cameroon) on the Glycemic Index (GI). To ameliorate the follow up of MS and population’s nutrition education, a survey was conducted among 200 families. The ten most consumed meals were selected after a food survey among 200 families. The meals were mostly made of a vegetable soup associated to a high carbohydrate staple. Vegetables and cereals were processed according to the food survey results. Then, a food tolerance test was performed on 30 male volunteers living in the same region. Among them, 12 were selected with an average age of 28.25 and a mean BMI of 19.63. They were studied on separate occasions in the morning after an overnight fast. After fasting, blood glucose was taken before and (15, 30, 45, 60, 90 and 120 minutes) after eating a test meal compared to sucrose and glucose solution (33.33%) used as reference. Glycemic response curves were used to calculate the gi of each meal. Results show that GI of the tested meals varied significantly (p < 0.05) between 20 and 79. Red millet porridge with kelenkelen-beans (Cochorus oletorius-Vigna unguiculata) sauce and red millet porridge with kelenkelen-peanut (Cochorus oletorius-Arachis hypogea) sauce exhibited the lowest GI. The highest GI was observed in corn porridge associated with fresh okra (Hibuscus esculentus) or with tasba (Cassia tora)-okra-beans sauce.

Enfrentamiento terapéutico del trastorno por déficit atencional en una población infantil escolar perteneciente a la Región Metropolitana de Chile
Sandoval I,Angélica; Acosta G,Natalia; Crovetto G,Francesca; León A,Mónica;
Revista chilena de neuro-psiquiatría , 2009, DOI: 10.4067/S0717-92272009000100005
Abstract: an evaluation was made of a retrospective evolution presented by the patients from to 14 years and 11 month old (average 9,2 years old), with a diagnostic of attentional hyperactive disorder (ahd), treated with metilfenidate in huechuraba during the year 2007. a revision of every clinic history showed the principal results: a high positive response (higher than the 76% of the measured parameters). the evaluated parameters were, academic response, self report of subjective opinion from the patient, opinion from the tutor of the child in relationships with his/her conduct at home and teacher's evaluations of the child conduct at school. no differences were found between the evolution of the clinic parameters, in children with and without comorbilities. it was found a 52, 7% of comorbility. specific learning disease, adaptative disorder, anxious disorder, and depression were more frequent diagnoses. this study concludes that the high percent of success in the treatment of the student group is similar to the one found in literature. the presence of comorbility won't cause to down of the treatment efficiency. this is conditioned by the presence of psychosocial factors like maternal psychopathology and familiar violence.
Enfrentamiento terapéutico del trastorno por déficit atencional en una población infantil escolar perteneciente a la Región Metropolitana de Chile Attentional deficit disorder treatment at a school children population in Region Metropolitana of Chile
Angélica Sandoval I,Natalia Acosta G,Francesca Crovetto G,Mónica León A
Revista Chilena de Neuro-Psiquiatría , 2009,
Abstract: Se realizó una evaluación restrospectiva de la evolución presentada por los pacientes desde 6 a 14 a os 11 meses de edad (edad media de 9,2 a os) con diagnóstico de Trastorno por déficit atencional (TDA) bajo tratamiento con metilfenidato en la comuna de Huechuraba durante el a o 2007. Se hizo la revisión y el análisis de cada ficha clínica, encontrándose como principales resultados el alto porcentaje de mejoría, igual o mayor al 76% de los parámetros medidos, consistentes en evolución del rendimiento académico; autoreporte de sensación subjetiva del ni o; reporte del cuidador principal en relación a la conducta del ni o (a) en el hogar y evaluación del profesor en cuanto su conducta en el colegio. No se encontraron diferencias entre la evolución de los parámetros clínicos entre los ni os con comorbilidad y sin comorbilidad, se encontró un 52,7% de esta, siendo los diagnósticos más frecuentes Trastorno específico del aprendizaje, trastorno adaptativo, trastorno ansioso y del ánimo. Se concluye que el alto porcentaje de éxito del tratamiento en el grupo estudiado es similar al encontrado en la literatura; que la presencia de comorbilidad no condiciona la disminución de la eficiencia del tratamiento y que esta es condicionada por presencia de factores psicosociales como psicopatología materna y violencia intrafamiliar. An evaluation was made of a retrospective evolution presented by the patients from to 14 years and 11 month old (average 9,2 years old), with a diagnostic of attentional hyperactive disorder (AHD), treated with metilfenidate in Huechuraba during the year 2007. A revision of every clinic history showed the principal results: a high positive response (higher than the 76% of the measured parameters). The evaluated parameters were, academic response, self report of subjective opinion from the patient, opinion from the tutor of the child in relationships with his/her conduct at home and teacher's evaluations of the child conduct at school. No differences were found between the evolution of the clinic parameters, in children with and without comorbilities. It was found a 52, 7% of comorbility. Specific learning disease, adaptative disorder, anxious disorder, and depression were more frequent diagnoses. This study concludes that the high percent of success in the treatment of the student group is similar to the one found in literature. The presence of comorbility won't cause to down of the treatment efficiency. This is conditioned by the presence of psychosocial factors like maternal psychopathology and familiar violence.
Oportunidades e desafios para o Jornalismo na internet
Angèle Murad
Ciberlegenda , 2011,
Abstract: As possibilidades abertas para o jornalismo na Internet colocam em pauta a necessidade de construir novo modelo. Os desafios específicos ao campo da comunica o referem-se ao processo de produ o e difus o da notícia e à forma o profissional.
O hipertexto eletr nico como base para reconfigurar a atividade jornalística
Angèle Murad
Ciberlegenda , 2001,
Abstract: Trabalho exploratório objetiva analisar como a ferramenta do hipertexto cria as bases para reconfigurar a atividade jornalística, ao proporcionar novas práticas de leitura e escrita, com o favorecimento à intertextualidade e à nova rela o entre autor-obra-leitor. As potencialidades e os questionamentos que advêm da aplica o do hipertexto eletr nico para o jornalismo, bem como experiências em curso na rede, revelam a urgência de se realizar pesquisas aplicadas para analisar as práticas.
Cibercultura
Angèle Murad
Ciberlegenda , 2011,
Abstract: Resenha do livro: LéVY, Pierre. Cibercultura (trad. Irineu da Costa). S o Paulo: Editora 34, 1999, 264p.
Exclusive $ρ^{0}$ Production in Polarized DIS at SMC
Angèle Tripet
Physics , 1999, DOI: 10.1016/S0920-5632(99)00773-2
Abstract: Preliminary spin cross section asymmetries for exclusive $\rho^{0}$ lepto-production, $\vec{\mu} + \vec{N} \to \mu' + N + \rho^{0} (\rho^{0} \to \pi^{+} \pi^{-})$, are reported. These asymmetries have been determined for the first time by the Spin Muon Collaboration (SMC) at low Q^2 (photoproduction) and at large Q^2 (DIS) for different $p_T^2$ intervals in the kinematic range $0.01 \simeq 15 GeV) for the full SMC data set. About 100 K $\rho^{0}$'s have been selected for $0.62 < m (\pi^{+} \pi^{-}) < 1.07 GeV/c^2$ and $|I|< 0.05$. Within the statistical precision, no significant asymmetries have been observed at low $Q^{2}$ in the preliminary results.
Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function
Angèle T. Parent,Gopal Thinakaran
International Journal of Alzheimer's Disease , 2010, DOI: 10.4061/2010/825918
Abstract: Mutations in PSEN genes, which encode presenilin proteins, cause familial early-onset Alzheimer's disease (AD). Transgenic mouse models based on coexpression of familial AD-associated presenilin and amyloid precursor protein variants successfully mimic characteristic pathological features of AD, including plaque formation, synaptic dysfunction, and loss of memory. Presenilins function as the catalytic subunit of -secretase, the enzyme that catalyzes intramembraneous proteolysis of amyloid precursor protein to release -amyloid peptides. Familial AD-associated mutations in presenilins alter the site of -secretase cleavage in a manner that increases the generation of longer and highly fibrillogenic -amyloid peptides. In addition to amyloid precursor protein, -secretase catalyzes intramembrane proteolysis of many other substrates known to be important for synaptic function. This paper focuses on how various animal models have enabled us to elucidate the physiological importance of diverse -secretase substrates, including amyloid precursor protein and discusses their roles in the context of cellular signaling and synaptic function. 1. Introduction Mutations in PSEN1 and PSEN2 genes, which encode polytopic proteins termed presenilin 1 (PS1) and presenilin 2 (PS2), respectively, cause autosomal dominant early-onset familial Alzheimer’s disease (FAD) [1]. Both PS1 and PS2 proteins (PS) share about 63% homology with the highest similarity in the transmembrane domains where most of the FAD-linked mutations are found [2, 3]. Since the first report of mutation in the PSEN1 on chromosome 14, about 170 mutations have been identified, making mutations in PSEN1 the most common cause of autosomal dominant early-onset AD [4]. In the case of PSEN2, 18 mutations have been reported so far, although not all have been confirmed to be pathogenic [2, 5]. As a probable explanation for the disparity between the two genes, defects in PSEN2 function may be offset by the normal function of its homolog PSEN1. In support of this view, PSEN2 null mice do not exhibit the phenotypic and functional defects seen in mice lacking PSEN1 gene. PSEN1 knockout (KO) mice are lethal, and disruption of PSEN2 and PSEN1 genes causes earlier embryonic lethality compared to PSEN1 KO [6–10]. As supported by mouse model studies, it appears that PS1 contributes largely to total -amyloid (A ) production in the brain [11, 12]. PS is the catalytic subunit of -secretase, the enzyme responsible for intramembraneous cleavage of amyloid precursor protein (APP) to generate peptides. FAD-linked PS variants enhance
Echinococcus multilocularis and Its Intermediate Host: A Model of Parasite-Host Interplay
Dominique Angèle Vuitton,Bruno Gottstein
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/923193
Abstract: Host-parasite interactions in the E. multilocularis-intermediate host model depend on a subtle balance between cellular immunity, which is responsible for host's resistance towards the metacestode, the larval stage of the parasite, and tolerance induction and maintenance. The pathological features of alveolar echinococcosis. the disease caused by E. multilocularis, are related both to parasitic growth and to host's immune response, leading to fibrosis and necrosis, The disease spectrum is clearly dependent on the genetic background of the host as well as on acquired disturbances of Th1-related immunity. The laminated layer of the metacestode, and especially its carbohydrate components, plays a major role in tolerance induction. Th2-type and anti-inflammatory cytokines, IL-10 and TGF-, as well as nitric oxide, are involved in the maintenance of tolerance and partial inhibition of cytotoxic mechanisms. Results of studies in the experimental mouse model and in patients suggest that immune modulation with cytokines, such as interferon-, or with specific antigens could be used in the future to treat patients with alveolar echinococcosis and/or to prevent this very severe parasitic disease.
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