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Search Results: 1 - 10 of 130360 matches for " Anelia V. Balabanova "
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Contemporary Diagnostic and Therapeutic Abilities in Childhood Thyroid-Associated Ophthalmopathy with a Clinical Case Description
Nartzis N. Kaleva , Neli I. Pehlivanova , Zlatka P. Misheva , Tatyana D. Shabanova , Anelia V. Balabanova
Folia Medica , 2010, DOI: 10.2478/v10153-010-0048-4
Abstract: Introduction: Eye symptoms are comparatively frequent in the clinical evidence of Basedow's disease in childhood. Severe forms of thyroid-associated ophthalmopathy are casuistic in pediatric patients. Early diagnose and evaluation of the severity of thyroid orbitopathy and relevant specialist treatment are key prognostic factors according to the contemporary consensuses. Aim: The aim of the present study was to make a review of the contemporary diagnostic and therapeutic abilities in pediatric patients with Basedow's disease and thyroid-associated ophthalmopathy. We present a clinical case of severe TAO in an 11-year-old girl with Basedow's disease. The combined therapeutic scheme based on the EUGOGO (European Group on Graves' orbitopathy) consensus of 2008 includes not only thyrostatics but also local ophthalmic agents and pulse corticosteroid therapy, followed by an alternating dose regimen. The favourable outcome of the treatment is determined to a great extend by the close collaboration between the pediatric endocrinologist and the ophthalmologist. Conclusion: It is concluded that children with thyroid-associated ophthlmopathy should promptly be referred to a specialized centre for evaluation of the severity of orbitopathy and an adequate therapy. This is of crucial importance for the preservation of patient's sight.
Cross Skin Reactivity to Tyrosine Kinase Inhibitors in a Patient with Chronic Myelogenous Leukemia  [PDF]
V. Broshtilova, M. Balabanova
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.47130
Abstract:

Tyrosine kinase inhibitors (TKI) targeting the bcr-abl protein, c-kit and the platelet-derived growth factor receptors, are significant part of the pathogenic therapy of chronic myelogenous leukemia. A broad spectrum of cutaneous side effects has been described with the clinical use of imatinib mesylate, ranging from various acute rashes to toxic epidermal necrolysis. Herein, a case of cross skin toxicity to TKI in a patient with chronic myelogenous leukemia is presented. In the course of imatinib mesylate therapy the patient developed a grade 4 diffuse lichenoid drug eruption. Six months after switching to nilotinib, hyperpigmented macules and patches spread over his trunk and extremities. To date, few cases of cross skin reactivity to imatinib and nilotinib have been described, none of which showing different clinical phenotypes. Further understanding of the underlying mechanisms and leading to the development of skin rashes from different class of TKI is important to highlight new drug targets and modify the current therapies to a level of maximal efficacy.

The Distribution and Substrate Specificity of Extracellular Nuclease Activity in Marine Fungi  [PDF]
Larissa A. Balabanova, Michael V. Pivkin, Valery A. Rasskazov
Open Journal of Marine Science (OJMS) , 2012, DOI: 10.4236/ojms.2012.24022
Abstract: The distribution and specificity of extracellular nucleases produced by marine fungi belonging to eleven genera, namely: Alternaria, Aspergillus, Aureobasidium, Chaetomium, Fusarium, Gliomastix, Humicola, Penicillium, Scopulariopsis, Wardomyces, Periconia, have implied its important function in the organic phosphorus and nitrogen circle in the Ocean. The fungal nucleases of 64 isolates tested were more or less specific for single-stranded DNA with a high preferential specificity towards poly-U substrate with forming of 5’-phosphate mononucleotides. A couple of the nucleases were capable of RNA digesting. The highest level of extracellular nucleolytic ability was observed in Penicillium spp. isolates. The tight correlation found between extracellular nuclease activity and the rate of thymidine uptake by actively growing and sporulating marine fungus Penicillium melinii suggests that this nuclease is required for fulfilling the nucleotide pool of precursors of DNA biosynthesis during transformation of hyphae into the aerial mycelium and conidia in stressful environmental conditions.
Emergence of Haemophilus influenzae Strains in the Nasopharynx of Children with Tuberculosis
Alina V. Martynova,Larisa A. Balabanova,Alexei Pruschinskyi
Pulmonary Medicine , 2011, DOI: 10.1155/2011/420284
Abstract: Being rigorously studied, epidemiology aspects of Haemophilus influenzae carriage are still remaining unclear. Especially it concerns such a group as children with low immune status and also such group as children with tuberculosis infection. We examined nasopharyngeal tract of children with tuberculosis infection in remission and checked how often these children are carriers of Haemophilus influenzae strains. Also we gained microbiology characteristics of the isolates and defined the clinical significance of H. influenzae carriage in development of opportunistic infections in children with the tuberculosis infection. 1. Introduction Despite improvements in diagnosis, treatment,and preventive measures, tuberculosis remains an important cause of morbidity globally. In the Primorye Region of far east Russia (population 2000.000), the incidence of tuberculosis in 2008 was 105.7 per 100.000 and with a prevalence of 222 per 100.000. For children under 17 years, the incidence of tuberculosis was 36.6 per 100.000. In 2008, there were 108 cases of tuberculosis in??children under 11 years, and 83 cases in children from 11 to 17 years (Federal Morbidity Report, 2009). Mortality increased by 20.7% compared to 2000. In the pediatric population, pulmonary tuberculosis accounted for 90.9% of all tuberculosis in 2008, up from 72.7% in 1999. It was recognized that children treated for tuberculosis were more often ill with other bacterial respiratory tract infections than children without such comorbidity. There are several possible contributing factors to this, for example, impaired immune status, malnutrition, and low??socioeconomical status of their family. However, other important factors could be the regular antimicrobial (antituberculosis) chemotherapy they receive or attendance at the Pediatric Tuberculosis Center for anything between 20 and 180 days, according to the current tuberculosis treatment protocol. As the main focus for such patients is the treatment of tuberculosis, the problem of other bacterial respiratory tract infections could be underestimated. There are some data on the carriage of bacterial respiratory tract pathogens in children with various comorbidities [1–5], but little information on the carriage of H.influenzae in children with tuberculosis or children from closed communities [5, 6]. Aim We aim to study the prevalance of H. influenzae in the??nasopharynx of children with tuberculosis and to assess antimicrobial susceptibility of these bacteria. 2. Materials and Methods We examined 85 children from the Pediatric Tuberculosis Center (Group
Study of Acute Alcohol Poisoning in Children Admitted to a Emergency Hospital Pirogov in Sofia, Bulgaria
Anelia Loukova
Macedonian Journal of Medical Sciences , 2011, DOI: 10.3889/MJMS.1857-5773.2011.0182
Abstract: Aim. The aim of the current study is to analyze the medical and social dimensions of acute alcohol poisoning in children with regard of improving prevention of addictive habitis and develop effective preventative strategies for reducing underage alcohol consumption. Methods. We have studied the patients at the age up to 18 years with acute alcohol poisoning hospitalized in the Children Toxicology Department of Emergency Hospital Pirogov, Sofia, Bulgaria, from January 1, 2007 to June 31, 2008. All of them were at teen years - between 12 and 17 years old. Data on children were retrived from hospital medical records (age, sex, level of consciousness, blood ethanol level). The initial blood ethanol level was measured on admission by thin-layer chromatography for each patient. We have used the inquiry method - specially created for the purpose of the survey questionnaire comprising 39 questions (location and the reason for drinking, type of alcoholic beverage, age at first drink, combination alcohol-illicit drug, type of family, education and employment of parents, frequency of alcohol consumption by parents, consecutiveness of the children in family, presence of siblings, presence of children in a single room, interests etc.). Psychiatric interview was used. Results. We have studied 137 children with acute alcohol poisoning. Average age of children intoxicated by alcohol was 14.91±1.45 years. 77 (56.2%) are boys and 60 (43.8%) girls. The results demonstrate tendency of increase of the poisonings in weekends and in late afternoon and evening. On admission to hospital most of them had different levels of depressed consciousness: 61.3% were somnolent, 28.5% were soporous and 5.1% were comatose. Blood ethanol level was over 2.00 mg/ml in 40.2%. In the 21 (15.3%) cases children have been poisoned at the first alcohol consumption. No repeated hospitalization for acute alcohol poisoning in the study group for that period has been registered. Combination alcohol-illicit drug was observed in 13 children (9.5%). Children most often used one type of alcoholic beverage. The most frequent alcoholic beverage leading to intoxication is the vodka (63.1%). 64% of the children come from complete families. Both parents have secondary education in 79.7% and in 53.3% both parents are employed. 60% were the first born child in the family. First alcohol consuption was at the 12 years and 10 months for boys, and at 13 years for girls. The most frequent reason for alcohol consumption was meeting and communicing with friends. The students have approximately 1.20 euro daily. Conclusion. Influence of "the group" is the main cause of alcohol consumption in adolescence. There is no increasing tendency for combining alcohol with other psychoactive drugs. We consider the brief intervention prior to hospital discharge as a preventive factor for repeated poisonings.
Study of Acute Alcohol Poisoning in Children Admitted to a Emergency Hospital Pirogov in Sofia, Bulgaria
Anelia Loukova
Macedonian Journal of Medical Sciences , 2011,
Abstract: Aim. The aim of the current study is to analyze the medical and social dimensions of acute alcohol poisoning in children with regard of improving prevention of addictive habitis and develop effective preventative strategies for reducing underage alcohol consumption.Methods. We have studied the patients at the age up to 18 years with acute alcohol poisoning hospitalized in the Children Toxicology Department of Emergency Hospital Pirogov, Sofia, Bulgaria, from January 1, 2007 to June 31, 2008. All of them were at teen years – between 12 and 17 years old. Data on children were retrived from hospital medical records (age, sex, level of consciousness, blood ethanol level). The initial blood ethanol level was measured on admission by thin-layer chromatography for each patient. We have used the inquiry method - specially created for the purpose of the survey questionnaire comprising 39 questions (location and the reason for drinking, type of alcoholic beverage, age at first drink, combination alcohol-illicit drug, type of family, education and employment of parents, frequency of alcohol consumption by parents, consecutiveness of the children in family, presence of siblings, presence of children in a single room, interests etc.). Psychiatric interview was used. Results. We have studied 137 children with acute alcohol poisoning. Average age of children intoxicated by alcohol was 14.91±1.45 years. 77 (56.2%) are boys and 60 (43.8%) girls. The results demonstrate tendency of increase of the poisonings in weekends and in late afternoon and evening. On admission to hospital most of them had different levels of depressed consciousness: 61.3% were somnolent, 28.5% were soporous and 5.1% were comatose. Blood ethanol level was over 2.00 mg/ml in 40.2%. In the 21 (15.3%) cases children have been poisoned at the first alcohol consumption. No repeated hospitalization for acute alcohol poisoning in the study group for that period has been registered. Combination alcohol-illicit drug was observed in 13 children (9.5%). Children most often used one type of alcoholic beverage. The most frequent alcoholic beverage leading to intoxication is the vodka (63.1%). 64% of the children come from complete families. Both parents have secondary education in 79.7% and in 53.3% both parents are employed. 60% were the first born child in the family. First alcohol consuption was at the12 years and 10 months for boys, and at 13 years for girls. The most frequent reason for alcohol consumption was meeting and communicing with friends. The students have approximately 1.20 euro daily.Conclusion.
Efficacy evaluation of functional motor regulation method with mathematical analysis of EEG
Balabanova V.A.,Kiselev D.A.,Laisheva О.А.,Gubanov V.V.
Saratov Journal of Medical Scientific Research , 2011,
Abstract: Effects of functional motor regulation method have been measured using the spectral and coherent EEG. Obtained results have fully confirmed the hypothesis that the clinical effectiveness of the method is associated with the formation of new regulatory links in the CNS with inclusion of such deep structures as the limbic and diencephalic systems
The Directly Observed Therapy Short-Course (DOTS) strategy in Samara Oblast, Russian Federation
Y Balabanova, F Drobniewski, I Fedorin, S Zakharova, V Nikolayevskyy, R Atun, R Coker
Respiratory Research , 2006, DOI: 10.1186/1465-9921-7-44
Abstract: The purpose of this study was to implement a DOTS programme in the civilian and prison sectors of Samara Region of Russia, describe the clinical features and outcomes of recruited patients, determine the proportion of individuals in the cohorts who were infected with drug resistant TB, the degree to which resistance was attributed to the Beijing TB strain family and establish risk factors for drug resistance.prospective study2,099 patients were recruited overall. Treatment outcomes were analysed for patients recruited up to the third quarter of 2003 (n = 920). 75.3% of patients were successfully treated. Unsuccessful outcomes occurred in 7.3% of cases; 3.6% of patients died during treatment, with a significantly higher proportion of smear-positive cases dying compared to smear-negative cases. 14.0% were lost and transferred out. A high proportion of new cases (948 sequential culture-proven TB cases) had tuberculosis that was resistant to first-line drugs; (24.9% isoniazid resistant; 20.3% rifampicin resistant; 17.3% multidrug resistant tuberculosis). Molecular epidemiological analysis demonstrated that half of all isolated strains (50.7%; 375/740) belonged to the Beijing family. Drug resistance including MDR TB was strongly associated with infection with the Beijing strain (for MDR TB, 35.2% in Beijing strains versus 9.5% in non-Beijing strains, OR-5.2. Risk factors for multidrug resistant tuberculosis were: being a prisoner (OR 4.4), having a relapse of tuberculosis (OR 3.5), being infected with a Beijing family TB strain (OR 6.5) and having an unsuccessful outcome from treatment (OR 5.0).The implementation of DOTS in Samara, Russia, was feasible and successful. Drug resistant tuberculosis rates in new cases were high and challenge successful outcomes from a conventional DOTS programme alone.Since the 1990s the World Health Organization Directly Observed Therapy Short Course (DOTS) management strategy has become the internationally recommended approach for tubercul
Basic features of agrotourism in Germany
Anna O. Balabanova
European Researcher , 2011,
Abstract: The article concerns basic questions of rural tourism development in Europe and Germany, history of its formation and the form of realization
Primary pigmented nodular adrenocortical disease and Cushing's syndrome
Horvath, Anelia;Stratakis, Constantine;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2007, DOI: 10.1590/S0004-27302007000800009
Abstract: primary pigmented nodular adrenocortical disease (ppnad) is a form of bilateral adrenocortical hyperplasia that is often associated with corticotrophin (acth)-independent cushing's syndrome (cs) and is characterized by small to normal-sized adrenal glands containing multiple small cortical pigmented nodules (1,2). ppnad may occur in an isolated form or associated with a multiple neoplasia syndrome, the complex of spotty skin pigmentation, myxomas, and endocrine overactivity, or carney complex, in which cushing's syndrome is the most common endocrine manifestation (3). molecular studies have led to the identification of several genes, defects in which may predispose ppnad formation; all of these molecules play important role for the camp signaling pathway. this review intends to present the most recent knowledge of the pathology and molecular genetics of the benign bilateral adrenocortical lesions, as well as to discuss the modern tools for diagnostics and treatment of this condition.
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