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Search Results: 1 - 10 of 85607 matches for " Andy W Holley "
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Obesity promotes 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in female zucker rats
Reza Hakkak, Andy W Holley, Stewart L MacLeod, Pippa M Simpson, George J Fuchs, Chan Jo, Thomas Kieber-Emmons, Soheila Korourian
Breast Cancer Research , 2005, DOI: 10.1186/bcr1263
Abstract: Fifty-day-old female obese (n = 25) and lean (n = 28) Zucker rats were orally gavaged with 65 mg/kg DMBA. Rats were weighed and palpated twice weekly for detection of mammary tumors. Rats were killed 139 days after DMBA treatment.The first mammary tumor was detected in the obese group at 49 days after DMBA treatment, as compared with 86 days in the lean group (P < 0.001). The median tumor-free time was significantly lower in the obese group (P < 0.001). Using the days after DMBA treatment at which 25% of the rats had developed mammary tumors as the marker of tumor latency, the obese group had a significantly shorter latency period (66 days) than did the lean group (118 days). At the end of the study, obese rats had developed a significantly (P < 0.001) greater mammary tumor incidence (68% versus 32%) compared with the lean group. The tumor histology of the mammary tumors revealed that obesity was associated with a significant (P < 0.05) increase in the number of rats with at least one invasive ductal and lobular carcinoma compared with lean rats.Our results indicate that obesity increases the susceptibility of female Zucker rats to DMBA-induced mammary tumors, further supporting the hypothesis that obesity and some of its mediators play a significant role in carcinogenesis.Obesity has been identified as an epidemic in the USA for more than two decades, yet the proportion of overweight and obese adults in the population continues to grow. The most recent data from the 1999–2000 National Health and Nutrition Examination Survey (NHANES) [1] showed that almost 65% of adults in the USA are overweight, defined as having a body mass index (BMI) greater than 25 kg/m2. This is a significant increase from the 56% for adults reported as overweight in NHANES III, which was conducted between 1988 and 1994. The prevalence of obesity, defined as a BMI of 30 kg/m2 or greater, also increased dramatically from 23% to 31% during the same period. It is estimated that the prevalence of
Conceptualizing Transnational Community Formation: Migrants, Sojourners and Diasporas in a Globalized Era
Knight, W. Andy
Canadian Studies in Population , 2002,
Abstract: English Transnational communities have flourished in the globalized era, creating aDiaspora and sojourners that are unlike earlier waves of migrants. This paper first examines the maintheories currently used to describe and explain international migration and find them wanting. Throughan examination of two case studies of ethnic Japanese migrants (the Brazilian Nikkeijin and PeruvianNikkei) who return to their homeland after living abroad for one or two generations, the paper goes onto demonstrate that the concept of 'international migrant' needs further theorizing to account for theimpact of globalization and globalism. To this end, the author calls for the development of newtheoretical understandings of the evolution of transnational community formation that would be multi-variate and robust enough to guide future public policy and research. French A l'heure de la mondialisation, les communautés transnationales ont fleuri et donné naissance à une diaspora et à des personnes de passage qui différent des précédentes vagues de migrants. En premier lieu, cet article examine les principales theories selon lesquelles sont actuellement décrites et expliquées les migrations internationales et considère les failles de ces dernières. A travers deux études de cas de migrants japonais de deux ethnies (les Brésiliens Nikkeijin et les Péruviens Nikkei) qui retournent chez eux après avoir vécu à l'étranger pendant une ou deux générations, l'article démontre que le concept de " migrant international " demande une théorisation plus poussée qui tienne compte de l'impact de la mondialisation et du mondialisme. Pour aller dans ce sens, les auteurs appellent au développement de nouveaux moyens théoriques qui permettent de comprendre l'évolution de la formation des communautés transnationales. Des moyens qui devraient être multidiversifiés et suffisamment robustes pour guider la politique publique et la recherche à venir.
An exploratory mixed methods study of the acceptability and effectiveness of mindfulness -based cognitive therapy for patients with active depression and anxiety in primary care
Andy Finucane, Stewart W Mercer
BMC Psychiatry , 2006, DOI: 10.1186/1471-244x-6-14
Abstract: 13 patients with recurrent depression or recurrent depression and anxiety were recruited to take part in the study. Semi-structured qualitative interviews were conducted three months after completing the MBCT programme. A framework approach was used to analyse the data. Beck depression inventories (BDI-II) and Beck anxiety inventories (BAI) provided quantitative data and were administered before and three months after the intervention.The qualitative data indicated that mindfulness training was both acceptable and beneficial to the majority of patients. For many of the participants, being in a group was an important normalising and validating experience. However most of the group believed the course was too short and thought that some form of follow up was essential. More than half the patients continued to apply mindfulness techniques three months after the course had ended. A minority of patients continued to experience significant levels of psychological distress, particularly anxiety.Statistically significant reductions in mean depression and anxiety scores were observed; the mean pre-course depression score was 35.7 and post-course score was 17.8 (p = 0.001). A similar reduction was noted for anxiety with a mean pre-course anxiety score of 32.0 and mean post course score of 20.5 (p = 0.039). Overall 8/11 (72%) patients showed improvements in BDI and 7/11 (63%) patients showed improvements in BAI. In general the results of the qualitative analysis agreed well with the quantitative changes in depression and anxiety reported.The results of this exploratory mixed methods study suggest that mindfulness based cognitive therapy may have a role to play in treating active depression and anxiety in primary care.Mindfulness Based Cognitive Therapy (MBCT) is an innovative, empirically validated treatment program designed to prevent relapse in people who have recovered from depression [1]. Two randomised controlled trials have found that MBCT, when taught to patients in the
On the p-parts of Weyl group multiple Dirichlet series
Holley Friedlander
Mathematics , 2015,
Abstract: We study the structure of $p$-parts of Weyl group multiple Dirichlet series. In particular, we extend results of Chinta, Friedberg, and Gunnells and show, in the stable case, that the $p$-parts of Chinta and Gunnells agree with those constructed using the crystal graph technique of Brubaker, Bump, and Friedberg. In this vein, we give an explicit recurrence relation on the coefficients of the $p$-parts, which allows us to describe the support of the $p$-parts and address the extent to which they are uniquely determined.
Gender Differences in Social Relationships, Social Integration and Substance Use  [PDF]
Gloria Jones-Johnson, Matt DeLisi, Andy Hochstetler, W. Roy Johnson, Natalia Frishman
Sociology Mind (SM) , 2013, DOI: 10.4236/sm.2013.31016

Although numerous studies have examined the relationship between family and religion on delinquency, there have not been studies of the relationship between parents, friends, and religion on substance use among adults. The analysis for this study was based on two waves of data (Wave 1, 1986 and Wave 2, 1989) of the Americans’ Changing Lives Survey. The results revealed that social relationships, social integration and attendance at religious services influence the number of drinks and cigarettes smoked per day among adults. Parental influence varies by gender. The implications for social control, social networks and gender perspectives are discussed.

Symplectic integrator for $s$-dependent static magnetic fields based on mixed-variable generating functions
Andy Wolski,Jonathan Gratus,Robin W. Tucker
Physics , 2012, DOI: 10.1088/1748-0221/7/04/P04013
Abstract: We describe a technique for constructing a symplectic transfer map for a charged particle moving through an accelerator component with arbitrary three-dimensional static magnetic field. The transfer map is constructed by symplectic integration; by representing the map at each step of the integration by a mixed-variable generating function, exact symplecticity is ensured. By using an appropriate integration algorithm, there is no necessity to make the paraxial approximation. The technique is illustrated by application (in one degree of freedom) to a quadrupole magnet with strong octupole component and fringe field.
Fully implicit time-stepping schemes and non-linear solvers for systems of reaction-diffusion equations
Anotida Madzvamuse,Andy H. W. Chung
Mathematics , 2015, DOI: 10.1016/j.amc.2014.07.004
Abstract: In this article we present robust, efficient and accurate fully implicit time-stepping schemes and nonlinear solvers for systems of reaction-diffusion equations. The applications of reaction-diffusion systems is abundant in the literature, from modelling pattern formation in developmental biology to cancer research, wound healing, tissue and bone regeneration and cell motility. Therefore, it is crucial that modellers, analysts and biologists are able to solve accurately and efficiently systems of highly nonlinear parabolic partial differential equations on complex stationary and sometimes continuously evolving domains and surfaces. The main contribution of our paper is the study of fully implicit schemes by use of the Newton method and the Picard iteration applied to the backward Euler, the Crank-Nicolson (and its modifications) and the fractional-step theta methods. Our results conclude that the fractional-step theta method coupled with a single Newton iteration at each timestep is as accurate as the fully adaptive Newton method; and both outperform the Picard iteration. In particular, the results strongly support the observation that a single Newton iteration is sufficient to yield as accurate results as those obtained by use of an adaptive Newton method. This is particularly advantageous when solving highly complex nonlinear partial differential equations on evolving domains and surfaces. To validate our theoretical results, various appropriate numerical experiments are exhibited on stationary planary domains and in the bulk of stationary surfaces.
Feedforward control strategies of subjects with transradial amputation in planar reaching
Anthony J. Metzger, MBE,Alexander W. Dromerick, MD,Christopher N. Schabowsky, MS,Rahsaan J. Holley, MS
Journal of Rehabilitation Research and Development , 2010,
Abstract: The rate of upper-limb amputations is increasing, and the rejection rate of prosthetic devices remains high. People with upper-limb amputation do not fully incorporate prosthetic devices into their activities of daily living. By understanding the reaching behaviors of prosthesis users, researchers can alter prosthetic devices and develop training protocols to improve the acceptance of prosthetic limbs. By observing the reaching characteristics of the nondisabled arms of people with amputation, we can begin to understand how the brain alters its motor commands after amputation. We asked subjects to perform rapid reaching movements to two targets with and without visual feedback. Subjects performed the tasks with both their prosthetic and nondisabled arms. We calculated endpoint error, trajectory error, and variability and compared them with those of nondisabled control subjects. We found no significant abnormalities in the prosthetic limb. However, we found an abnormal leftward trajectory error (in right arms) in the nondisabled arm of prosthetic users in the vision condition. In the no-vision condition, the nondisabled arm displayed abnormal leftward endpoint errors and abnormally higher endpoint variability. In the vision condition, peak velocity was lower and movement duration was longer in both arms of subjects with amputation. These abnormalities may reflect the cortical reorganization associated with limb loss.
The Ethics of Direct Primary Care  [PDF]
Andy Wible
Open Journal of Philosophy (OJPP) , 2019, DOI: 10.4236/ojpp.2019.91003
Abstract: Direct primary care (DPC) is a market based approach to providing medical care. Patients avoid insurance and directly pay a monthly membership type of fee to physicians for unlimited access. DPC practices have been growing throughout the United States by claiming to be better for patients and primary care physicians. This paper looks into the ethical implications of such practices and explores future moral concerns if DPC continues to expand. Finally, from a societal perspective, regulated universal coverage, as provided in countries such as Japan, is examined as a way to achieve most of the benefits of DPC while avoiding many of the problems.
A Role for SPARC in the Moderation of Human Insulin Secretion
Lorna W. Harries, Laura J. McCulloch, Janet E. Holley, Thomas J. Rawling, Hannah J. Welters, Katarina Kos
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068253
Abstract: Aims/Hypothesis We have previously shown the implication of the multifunctional protein SPARC (Secreted protein acidic and rich in cysteine)/osteonectin in insulin resistance but potential effects on beta-cell function have not been assessed. We therefore aimed to characterise the effect of SPARC on beta-cell function and features of diabetes. Methods We measured SPARC expression by qRT-PCR in human primary pancreatic islets, adipose tissue, liver and muscle. We then examined the relation of SPARC with glucose stimulated insulin secretion (GSIS) in primary human islets and the effect of SPARC overexpression on GSIS in beta cell lines. Results SPARC was expressed at measurable levels in human islets, adipose tissue, liver and skeletal muscle, and demonstrated reduced expression in primary islets from subjects with diabetes compared with controls (p< = 0.05). SPARC levels were positively correlated with GSIS in islets from control donors (p< = 0.01). Overexpression of SPARC in cultured beta-cells resulted in a 2.4-fold increase in insulin secretion in high glucose conditions (p< = 0.01). Conclusions Our data suggest that levels of SPARC are reduced in islets from donors with diabetes and that it has a role in insulin secretion, an effect which appears independent of SPARC’s modulation of obesity-induced insulin resistance in adipose tissue.
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