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Search Results: 1 - 10 of 2944 matches for " Andre Chambers "
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Models, AmI-Creator and A-Methodology for Ambient Intelligence Environments  [PDF]
Anna Chambers
Journal of Software Engineering and Applications (JSEA) , 2014, DOI: 10.4236/jsea.2014.74030
Abstract:

The current paper introduces an approach to a development of Ambient Intelligence domain-based software systems from scratch. The presented approach is based on models. The paper also presents the domain-related models expressing different levels of abstractions and stages of the development. The approach refers to a Model-Driven Development of Ambient Intelligence which was suggested at AmI-07-Ambient Intelligence conference. The approach is presented as a standard with its feasible realization. It starts from modeling of a content of the future AmI-dedicated software system and concludes by mapping the graphical concepts into a final code. A process proving feasibility and correctness of the approach is provided through a dedicated research methodology. Its process comprises an identification of needs in a speedy development of the systems. It is followed by studying of the currently available techniques capable of supporting the development and an experimenting with them. It continues by finding a solution, verified by its validation and concludes by an identification of the further perspectives. The developed approach presents a common way of a communication amongst stakeholders participating in creating of AmI-based environments. Such communication involves the notations of AmI-Creator—a Domain-Specific Language of Ambient Intelligence domain. Every part of DSL corresponds to a demonstration of A-methodology expressing a step-by-step guidance for the development. The methodology comprises two parts dedicated to providing semantics for DSL through studying of Ambient Intelligence domain ontology; and development of actual environments. A validity of the working proposition is confirmed by three examples. The further challenges refer to an extension of the presented work by other frameworks and expansion to a development of different domains with complex organizations.

Mining the chicken genome
David Chambers
Genome Biology , 2002, DOI: 10.1186/gb-2002-3-5-reports2013
Abstract: Anyone familiar with the standard format of BLAST search engines (for example, at NCBI BLAST and ExPASy) will be immediately at home with the chick EST BLAST page. It is a simple search engine, constructed upon BLASTN, where query sequences are copied into the web page and then compared directly with the sequence databases. A few options exist for more advanced similarity searching, such as alteration of filtering and expectation values, but no explanation of these appears at this site. However, a comprehensive BLAST user guide can be found at the NCBI BLAST website. As a default, the whole EST database will be scanned against the submitted sequence, but there is an option to search each developmental stage or tissue singly for an EST match.The chick EST database server was first released on 14 December 2001 and is presently in a preliminary form.The comprehensive nature of the construction of the EST sequences is the foundation of this site. As the sequences have been generated from 21 different tissues across a range of developmental stages there is a strong probability that a large proportion of the chicken transcriptome is present. In addition, analysis of the sequence information has revealed a large amount of redundancy in ESTs between different stages and/or tissues. This allows a cDNA-walking strategy to be adopted for any given hit. For example, where a given EST match is detected for the query sequence, one can then use the most 5' sequence of that EST (approximately 50 bases or so) to re-screen the database and identify a different EST that is longer and contains further 5' sequence. Because of the number of cDNA libraries used and the 5' sequencing, this process can be reiterated several times to move progressively up into coding (and thus more informative) regions of transcripts. This effectively allows very rapid in silico cloning of chick cDNAs. Using this strategy and the chick EST database, it is possible to obtain more than 3 kb of contiguous seque
Signaling in development
David Chambers
Genome Biology , 2001, DOI: 10.1186/gb-2001-2-4-reports4010
Abstract: It is a common theme in developmental biology that the fates of cells are often determined by interactions at the cell surface, where an incoming ligand meets its complementary receptor. In order to construct a complex organism, several different signaling systems and pathways are employed by the embryo. Scientists at this Keystone Symposium discussed some of the latest progress in the study of some of the major signaling pathways used in construction of the embryo. Several key questions ran through the Symposium, notably the following. How do multiple signals co-operate and converge to produce the correct fate? What are the molecular events controlling propagation of the signal from the cell surface and how can we go about finding new players in signal transduction pathways? Microarray analysis, sophisticated screens, and more conventional genetic and cellular techniques have given exciting new insights into these areas.The limbs arise from small outgrowths (the limb buds) of the body wall of an embryo. It has long been known that the apical ectodermal ridge (AER), a specialized epithelial region located at the distal tip of a limb bud, is critical for normal limb outgrowth. This is best demonstrated by the surgical removal of the AER, which causes a complete failure of limb outgrowth. It has been established that fibroblast growth factors (FGFs), ligands which are expressed in the AER, can ectopically substitute for its outgrowth-induction characteristics. Juan Carlos Izpisua Belmonte (Salk Institute, La Jolla, USA) shed light on how signaling by ligands of the Wnt and bone morphogenetic protein (BMP) families may cooperate to control FGF-dependent limb initiation in the chick embryo. This work demonstrates that Wnts 2b and 8c, which are expressed in the mesenchymal tissues adjacent to the prospective AER of the forelimb and hindlimb, respectively, act upstream of the FGFs, via the adhesion-associated protein ?-catenin, to initiate the signaling cascade required t
All you need for proteomics
David Chambers
Genome Biology , 2001, DOI: 10.1186/gb-2001-2-7-reports2004
Abstract: The web interface is well laid out, with each set of tools represented by a single hyperlink. Services available are grouped according to their general function, such as protein similarity searching or secondary structure prediction. Initially, it is assumed that the user is familiar with what these services have to offer, but, the true depth of the site is revealed by following one of these links, whereupon a great deal more explanatory information is provided in conjunction with a comprehensive listing of the tools available to perform the specified task. For example, entry to the 'Transmembrane Region Detection' tool provides eight further hyperlinks, each with a brief description of the manner in which the tool serves its purpose. This hierarchy is further reinforced after arrival at a particular tool, where specific instructions can be retrieved about the application. In this way, users can select the appropriate way to investigate their protein without in-depth prior knowledge. The whole server is well coordinated with other dedicated proteomics sites, so that any given tool can readily be located.The ExPASy sever was last updated on 18 January 2001. Additions and improvements can be viewed at the 'What's new on ExPASy' hyperlink, which also provides information on the applicability of new software.ExPASy's coverage of the world of proteomic analysis is its greatest strength. Many sites aim to achieve this but few are so accomplished and well ordered. For each tool there are several available programs. Although this may appear redundant, combinatorial use of related packages compensates for any given weakness in a single program. The user can very rapidly navigate the ExPASy server and be relatively well informed as to the nature of the enquiry. In addition, all of the software provided is in the public domain. So, one could obtain staggering amounts of information about a query sequence from the free services provided here. Further detailed analysis, for exam
Exploring protein family relationships
David Chambers
Genome Biology , 2001, DOI: 10.1186/gb-2001-2-5-reports2003
Abstract: The home page is a straightforward, hyperlinked, entry point to the tools available. This is fine if you already have an idea of what you are doing or how you would like to do it, but it is somewhat sparse for the first-time user. Help is at hand, however - every analysis tool has an associated 'Help' or 'About' link. The background information on each of the Blocks-orientated tools is minimal but explanatory. It is assumed that the user already has basic experience of the mechanics of investigating molecular relationships. The Blocks server is also particularly well set up to provide an entry point from which other similar bioinformatics servers can be accessed. The facilities of the Blocks tools are already coordinated with those of other specialized protein analysis programs to ensure maximum coverage of databases and blocks. Thus the user can move very rapidly between sites dedicated to proteomics.The present release is Blocks Database Version 12.0, June 2000, consisting of 4,071 blocks representing 998 groups documented in InterPro 1.0 keyed to SWISS-PROT 38 and TrEMBL.The Block Searcher compares a sequence of a newly identified DNA or protein against the current database of protein blocks. The advantage of searching a database of blocks is that information from multiply aligned sequences is present in a concentrated unbiased form, reducing background 'noise' and increasing sensitivity to distant relationships. Such a tool can give an indication of the evolutionary origins of a protein, and hence an indication of its function, without the query protein containing well-characterized functional motifs per se. In general, a group of related proteins have more than one region in common and their relationship is represented as a series of blocks separated by unaligned regions. If other blocks from a group also score highly in the search against the query sequence, this further reinforces the relationship of the query sequence to the proteins used to compile the bloc
Supporting Teaching and Research in an Online Environment: Developing the University of London Library Model
Sally Chambers
Liber Quarterly : The Journal of European Research Libraries , 2002,
Abstract: Founded in 1837, the University of London Library (ULL) is the central research library of the University of London with particular research strengths across the broader arts, humanities and social sciences. With the development of information and communications technology, it has become a hybrid library, offering access to electronic collections but also extending access to services and its physical collections through its website and online catalogue. Research libraries now face the challenge of supporting distance learning. The ULL has risen to this challenge by being a partner in the development of webenhanced distance learning by the University of London External Programme’s Virtual Campus Project. To do this, the ULL has initiated the Virtual Library Service (VLS) Project. Within the research-focussed University of London, the ULL has anticipated the potential research-support needs of its students. It is also leading a separately funded Virtual Research Environment (VRE) Project on behalf of the University Libraries Committee to address these needs and inform the University of London’s activities in the virtual sphere. The University of London has created the Electronic Library Projects Team (ELPT) to undertake the VLS and VRE projects and ensure that they develop along complementary lines. This paper outlines how the ULL is supporting teaching and research in an online environment through the development of its VLS and VRE models.
Northern Alberta Health Libraries Association News
Thane Chambers
Partnership : the Canadian Journal of Library and Information Practice and Research , 2011,
Abstract:
INTEGRATING CORPUS CONSULTATION IN LANGUAGE STUDIES
Angela Chambers
Language Learning and Technology , 2005,
Abstract: Alongside developments in language research, the potential of corpora as a resource in language learning and teaching has been evident to researchers and teachers since the late 1960s. Despite publications which emphasise the benefits of corpus consultation for language learners (Bernardini, 2002; Kennedy & Miceli, 2001), there is little evidence to suggest that direct corpus consultation is coming to be seen as a complement or alternative to consultation of a dictionary, course book, or grammar by the majority of learners. There is thus a need for research to underpin the integration of corpora and concordancing in the language-learning environment.This study begins with an account of published research relating to course design and structure in the area of corpus consultation by language learners. The focus then narrows to the initial training of learners in corpus consultation, using as an example a course involving undergraduate students on several language degree programmes. The results of the students' consultation of the corpora are examined, including choice of search word(s), analytical skills, the problems encountered, and their evaluation of the activity. The results reveal how corpus consultation can complement traditional language-learning resources, while also raising questions concerning its integration in the language-learning environment.
Review: Funston, John (ed.) (2009), Divided Over Thaksin: Thailand’s Coup and Problematic Transition
Paul Chambers
Journal of Current Southeast Asian Affairs , 2010,
Abstract: Review of the edited volume: Funston, John (ed.) (2009), Divided Over Thaksin: Thailand’s Coup and Problematic Transition, Chiangmai: Silkworm Books, Singapore: ISEAS. ISBN 978-981-230-961-7, 203 pages.
Superfluous, Mischievous or Emancipating? Thailand’s Evolving Senate Today Thailands Oberhaus: überflüssig, sch dlich oder unabh ngig?
Paul Chambers
Journal of Current Southeast Asian Affairs , 2009,
Abstract: In Thailand’s emerging democracy, the Senate has played an often underestimated role. This study analyzes Thailand’s Upper House, examining its historical evolution until 2009. In particular, it focuses on the following questions. What innovations did the 1997 Constitution bring to the Senate? How and why was the Senate adjusted under the 2007 constitution? The study further reviews the Senate elections of 2000 and 2006 as well as the election/selection of 2008. Finally, it postulates as to the continued significance of an Upper House in Thailand and offers recommendations for the future course of Thailand’s developing Senate. In Thailands junger Demokratie spielte der Senat eine h ufig untersch tzte Rolle. Die Studie analysiert die Entstehung des Oberhauses bis zum Jahr 2009. Der Artikel konzentriert sich auf folgende Fragen: Welche Neuerungen brachte die Verfassung von 1997 für den Senat? Wie und warum wurde der Senat im Jahr 2007 angepasst? Die Studie kommentiert ebenfalls die Senatswahlen der Jahre 2000 und 2006 sowie die Wahl/Ernennung 2008. Au erdem bewertet sie die Bedeutung des Oberhauses in Thailand und bietet Empfehlungen für die zukünftige Entwicklung des Senats.
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