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Search Results: 1 - 10 of 674110 matches for " Andréa F. P.;Vaisman "
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Tiroidite pós-parto: prevalência e evolu??o clínica
Barros, Andréa F. P.;Vaisman, Mário;
Arquivos Brasileiros de Endocrinologia & Metabologia , 1998, DOI: 10.1590/S0004-27301998000600007
Abstract: postpartum thyroiditis (ppt) is an autoimmune thyroid dysfunction that occurs in the first year after delivery. we evaluated the prevalence and clinical evolution of ppt in 115 pregnant women between the 16th and 20th weeks of gestation. we studied both thyroid function (t3, t4, t4l, tsh) and the presence of antithyroid antibodies (antithyroglobulin and antiperoxidase). reevaluation was done six months postpartum. in the first phase, 12 (10.4%) were tpo-ab positive: two (16.6%) had a miscarriage between the 5th and 6th month, three (25%) were euthyroid, three (25%) subclinic hypothyroidism and four (33,3%) ppt. the most frequent symptom was fatigue (4/4). all women showed risk factors for ppt. based on our data, we recommend that pregnant women with risk factor for ppt should be screened during pregnancy and the postpartum period for the development of thyroid dysfunction.
Follow-up of patients treated with retinoic acid for the control of radioiodine non-responsive advanced thyroid carcinoma
Coelho, S.M.;Vaisman, F.;Buescu, A.;Mello, R.C.R.;Carvalho, D.P.;Vaisman, M.;
Brazilian Journal of Medical and Biological Research , 2011, DOI: 10.1590/S0100-879X2010007500120
Abstract: during thyroid tumor progression, cellular de-differentiation may occur and it is commonly accompanied by metastatic spread and loss of iodine uptake. retinoic acid (ra) administration might increase iodine uptake in about 40% of patients, suggesting that ra could be a promising therapeutic option for radioiodine non-responsive thyroid carcinoma, although a prospective study with a long-term follow-up has not been reported. this was a clinical prospective study assessing the value of 13-cis-ra in patients with advanced thyroid carcinoma and its impact on major outcomes such as tumor regression and cancer-related death with a long-term follow-up of patients submitted to radioiodine (131i) therapy after ra administration. sixteen patients with inoperable disease and no significant radioiodine uptake on post-therapy scan were selected. patients were treated orally with 13-cis-ra at a dose of 1.0 to 1.5 mg·kg-1·day-1 for 5 weeks and then submitted to radioiodine therapy (150 mci) after thyroxine withdrawal. a whole body scan was obtained 5 to 7 days after the radioactive iodine therapy. recist criteria were used to evaluate the response. an objective partial response rate was observed in 18.8%, a stable disease rate in 25% and a progression disease rate in 56.2%. five patients died (62.5%) in the group classified as progression of disease. progression-free survival rate (pfs) ranged from 72 to 12 months, with a median pfs of 26.5 months. ra may be an option for advanced de-differentiated thyroid cancer, due to the low rate of side effects.
A High Power Density Electrostatic Vibration-to-Electric Energy Converter Based On An In-Plane Overlap Plate (IPOP) Mechanism
A. M. Paracha,Ph. Basset,F. Marty,A. Vaisman Chasin,P. Poulichet,T. Bourouina
Computer Science , 2008,
Abstract: In this paper, design, fabrication and characterization issues of a bulk silicon-based, vibration powered, electric energy generator are addressed. The converter is based on an In-Plane Overlap Plate (IPOP) configuration [1]. Measurements have shown that with a theoretically lossless electronics and a starting voltage of 5 V, power density of 58 $\mu$W/cm3 is achievable at the resonance frequency of 290 Hz. It can be further improved by reducing the parasitic capacitance, which can be achieved by silicon etching, but a considerable mass is lost. In [2], it is shown that 19% of mass reduction improves power density from 12.95 $\mu$W/cm3 to 59 $\mu$W/cm3. Hence an enhancement in fabrication process is proposed, which is termed as Backside DRIE. It helps in increasing power density without loosing an important quantity of mass. Simulations have shown that 2.5% of mass removal improves power density up to 76.71 $\mu$W/cm3. Initial simulation results and problems of associated electronics are also discussed.
Charge Transport Phenomena in Peptide Molecular Junctions
Alessandra Luchini,David P. Long,Iosif I. Vaisman,Emanuel F. Petricoin,David H. Geho,Lance A. Liotta
Journal of Nanotechnology , 2008, DOI: 10.1155/2008/853253
Abstract: Inelastic electron tunneling spectroscopy (IETS) is a valuable in situ spectroscopic analysis technique that provides a direct portrait of the electron transport properties of a molecular species. In the past, IETS has been applied to small molecules. Using self-assembled nanoelectronic junctions, IETS was performed for the first time on a large polypeptide protein peptide in the phosphorylated and native form, yielding interpretable spectra. A reproducible 10-fold shift of the I/V characteristics of the peptide was observed upon phosphorylation. Phosphorylation can be utilized as a site-specific modification to alter peptide structure and thereby influence electron transport in peptide molecular junctions. It is envisioned that kinases and phosphatases may be used to create tunable systems for molecular electronics applications, such as biosensors and memory devices.
Ein narrativ-entwicklungspsychologischer Ansatz zur Untersuchung früher Emotionen A Narrative-Developmental Approach to Early Emotions Un enfoque narrativo-evolutivo para las emociones tempranas
Andréa P.F. Pantoja
Forum : Qualitative Social Research , 2001,
Abstract: Innerhalb der letzten Jahrzehnte wurde dem Begriff der Narration eine gro e Aufmerksamkeit zuteil, gefolgt von der Entwicklung unterschiedlicher narrationsanalytischer Modelle, so dass teilweise bereits von einer "narratological renaissance" (e.g., CURRIE, 1998; HERMAN, 1999) die Rede ist. Versuche, diese Modelle im Feld der frühen Kindheitsentwicklung anzuwenden, scheinen allerdings bisher beschwerlich. Dies gilt insbesondere für die Nutzung des Konzeptes der Narration (als theoretischer Rahmen und als methodische Strategie) im Rahmen von Untersuchungen zu psychologischen Prozessen, die dem Spracherwerb vorausgehen. Mit dem vorliegenden Beitrag soll ein systematischer Ansatz zur frühen Emotionsgenese vorgestellt werden, der narrationsanalytischen Konzepten verpflichtet ist. Hierzu wird zun chst kurz die relevante Literatur diskutiert und dann mit dem hier vertretenen narrativ-entwicklungspsychologischen Ansatz in Verbindung gesetzt. Dieser Ansatz geht davon aus, dass Narrationen und Pers nlichkeitsentwicklung unaufl sbar miteinander verbunden sind, und dass Narrationen im Lebenslauf sukzessive aus dem Kommunikationsgeschehen gebildet werden. Anschlie end werden narrationsanalytische Verfahrensschritte vorgestellt, die von der Autorin im Rahmen einer Untersuchung zur Emotionsgenese in Eltern-Baby-Beziehungen entwickelt wurden. Es wird gezeigt, dass der beschriebene narrativ-entwicklungspsychologische Ansatz eine konzeptuell fundierte qualitative Forschungsstrategie bereith lt, um auf einer mikroanalytischen Ebene Prozesse der Emotionsentwicklung und die diesen inh rente Genese von Narrationen zu untersuchen. URN: urn:nbn:de:0114-fqs0103147 Over the past decades a great deal of attention has been dedicated to the broadening and diversification of the notion of narratives, which lead to a variety of models for narrative analysis and encouraged some to speak of a "narratological renaissance" (e.g., CURRIE, 1998; HERMAN, 1999). However, the application of these concepts to early development has faced a major challenge—the use of narratives (as both a theoretical framework and a methodological tool) to examine psychological processes prior to the acquisition of language. The present contribution offers a systematic approach to examine early emotional development grounded on narrative traditions. I begin by briefly presenting the relevant literature and linking it with the narrative-developmental approach proposed herein. This approach, I contend, implies that narratives and development are inextricably anchored to one another as narratives evolve over time th
Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old
A. B. W. Tavares,E. Micmacher,S. Biesek,R. Assump??o,R. Redorat,U. Veloso,M. Vaisman,P. T. V. Farinatti,F. Concei??o
International Journal of Endocrinology , 2013, DOI: 10.1155/2013/942030
Abstract: Growth hormone (GH) use has been speculated to improve physical capacity in subjects without GH deficiency (GHD) through stimulation of collagen synthesis in the tendon and skeletal muscle, which leads to better exercise training and increased muscle strength. In this context, the use of GH in healthy elderly should be an option for increasing muscle strength. Our aim was to evaluate the effect of GH therapy on muscle strength in healthy men over 50 years old. Fourteen healthy men aged 50–70 years were evaluated at baseline for body composition and muscle strength (evaluated by leg press and bench press exercises, which focus primarily on quadriceps—lower body part and pectoralis major—upper body part—muscles, resp.). Subjects were randomised into 2 groups: GH therapy (7 subjects) and placebo (7 subjects) and reevaluated after 6 months of therapy. Thirteen subjects completed the study (6 subjects in the placebo group and 7 subjects in the GH group). Subjects of both groups were not different at baseline. After 6 months of therapy, muscle strength in the bench press responsive muscles did not increase in both groups and showed a statistically significant increase in the leg press responsive muscles in the GH group. Our study demonstrated an increase in muscle strength in the lower body part after GH therapy in healthy men. This finding must be considered and tested in frail older populations, whose physical incapacity is primarily caused by proximal muscle weakness. The trial was registered with NCT01853566. 1. Introduction The ageing process is accompanied by an increased prevalence of the signs and symptoms of physical fragility, including sarcopenia, a decrease in exercise tolerance, osteopenia, an increase in visceral adiposity and a worsening of quality of life. Adults with growth hormone deficiency (GHD) exhibit similar clinical signs, but it is possible to treat them with GH to ameliorate these signs and symptoms [1]. The GH secretion declines gradually with age, whereby studies demonstrate a progressive reduction of 14% secretion per decade of life beginning in the second decade [2, 3]. These findings suggest a possible association between GHD and the ageing process [4, 5]. The association between the physiological alterations of the ageing process and the reduction of GH secretion is called somatopause. GH replacement is well known to improve body composition, leading to a decrease in total body fat and an increase in lean body mass [1]. However, GH replacement has only shown an effect on muscle strength in GH-deficient adults subjected to
Desenvolvimento da vida emocional durante o segundo ano de vida: narrativas e sistemas dinamicos
Pantoja, Andréa P. F.;Nelson-Goens, G. Christina;
Psicologia: Reflex?o e Crítica , 2000, DOI: 10.1590/S0102-79722000000200007
Abstract: emotions have been investigated traditionally as internal and pre-existing states manifested in the face. this paper proposes an alternative perspective by illustrating the theoretical and methodological utility of the concepts of narratives and dynamic systems to the study of emotions. emotions are conceived as emerging from the interaction between the individual and the environment. we consider the body, vocal, and facial actions of both partners simultaneously, as well as the communicative contexts created during their interaction. we use the method of narrative analysis to capture the emergent and social nature of emotions in one mother-infant dyad during the second year of life. we aim to elucidate how the development of emotions emerge from the subtle transformations in the daily relationship of the mother-infant dyad.
Desenvolvimento da vida emocional durante o segundo ano de vida: narrativas e sistemas dinamicos
Pantoja Andréa P. F.,Nelson-Goens G. Christina
Psicologia: Reflex?o e Crítica , 2000,
Abstract: Tradicionalmente, a emo o tem sido concebida como um estado interno e preexistente manifestado na face. Assim, a emo o tem sido analisada através do estudo detalhado da face. O presente trabalho prop e uma perspectiva alternativa, defendendo a utilidade teórica e metodológica dos conceitos de narrativas e sistemas dinamicos para o estudo da emo o. Partindo desta perspectiva, a emo o é concebida enquanto emergente da intera o do indivíduo com seu meio. Em nossas investiga es, enfatizamos, simultaneamente, as a es corporais, vocais, e faciais de ambos parceiros bem como os contextos comunicativos construídos durante a intera o. Utilizamos o método de análise de narrativas aplicado a dados longitudinais de uma díade m e-bebê durante o segundo ano de vida. Procuramos ilustrar como o desenvolvimento das emo es emerge das sutis transforma es que ocorrem no relacionamento social entre o bebê e sua m e.
Normal flow-mediated vasodilatation of the brachial artery and carotid artery intima-media thickness in subclinical hypothyroidism
Cabral, M.D.;Teixeira, P.F.S.;Silva, N.A.O.;Morais, F.F.C.;Soares, D.V.;Salles, E.;Henriques, J.M.;Leite, S.P.;Montenegro, C.A.B.;Vaisman, M.;
Brazilian Journal of Medical and Biological Research , 2009, DOI: 10.1590/S0100-879X2009000500005
Abstract: subclinical hypothyroidism (sht) is a disease for which exact therapeutic approaches have not yet been established. previous studies have suggested an association between sht and coronary heart disease. whether this association is related to sht-induced changes in serum lipid levels or to endothelial dysfunction is unclear. the aim of this study was to determine endothelial function measured by the flow-mediated vasodilatation of the brachial artery and the carotid artery intima-media thickness (imt) in a group of women with sht compared with euthyroid subjects. triglycerides, total cholesterol, hdl-c, ldl-c, apoprotein a (apo a), apo b, and lipoprotein(a) were also determined. twenty-one patients with sht (mean age: 42.4 ± 10.8 years and mean thyroid-stimulating hormone (tsh) levels: 8.2 ± 2.7 μiu/ml) and 21 euthyroid controls matched for body mass index, age and atherosclerotic risk factors (mean age: 44.2 ± 8.5 years and mean tsh levels: 1.4 ± 0.6 μiu/ml) participated in the study. lipid parameters (except hdl-c and apo a, which were lower) and imt values were higher in the common carotid and carotid bifurcation of sht patients with positive serum thyroid peroxidase antibodies (tpo-ab) (0.62 ± 0.2 and 0.62 ± 0.16 mm for the common carotid and carotid bifurcation, respectively) when compared with the negative tpo-ab group (0.55 ± 0.24 and 0.58 ± 0.13 mm, for common carotid and carotid bifurcation, respectively). the difference was not statistically significant. we conclude that minimal thyroid dysfunction had no adverse effects on endothelial function in the population studied. further investigation is warranted to assess whether subclinical hypothyroidism, with and without tpo-ab-positive serology, has any effect on endothelial function.
Aplica??o de algoritmos genéticos na determina??o da opera??o ótima de sistemas hidrotérmicos de potência
Leite, Patricia Teixeira;Carneiro, Adriano A. F. M.;Carvalho, André C. P. L. F.;
Sba: Controle & Automa??o Sociedade Brasileira de Automatica , 2006, DOI: 10.1590/S0103-17592006000100008
Abstract: this paper investigates the application of genetic algorithms in the optimization of the operation planning of hydrothermal power systems. the aim of this work to analyze the application of this technique in a complex problem of high dimension, composed by several plants, belonging to different cascades. the authors believe that, due to their simplicity, parallelism and generality, the genetic algorithms present a great potential for the resolution of the pointed problem. the tests were applied in two groups with plants belonging to the brazilian southeast system. the first considers only reservoir hydroelectric, in the total of 19 plants, and the second uses reservoir hydroelectric the and run-of-river capacity hydroelectric plants, composed by 35 plants.
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