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Search Results: 1 - 10 of 226080 matches for " André L Montagnini "
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Pancreatectomia distal videolaparoscópica em pacientes com cistadenoma de pancreas
Machado, Marcel Autran C.;Canedo, Leonardo F.;Herman, Paulo;Montagnini, André L.;Sallum, Rubens A. A.;Machado, Marcel Cerqueira Cesar;
Arquivos de Gastroenterologia , 2005, DOI: 10.1590/S0004-28032005000300006
Abstract: background: cystic neoplasms are an uncommon group among pancreatic tumors. these lesions are seen more frequently in recent surgical practice, probably because of advances in diagnostic and surgical techniques. total tumor resection provides the best chance of cure and may remove the risk of malignant transformation of the cystadenomas, particularly of the mucinous type. minimally invasive techniques have been revolutionary and provide clinical evidence of decreased morbidity and comparable efficacy to traditional, open surgery. however, laparoscopic pancreatic resection is not an established treatment for tumors of the pancreas. aim: the authors present their initial experience with laparoscopic distal pancreatectomy for pancreatic cystadenomas. material and methods: three female patients (mean age, 55 years) underwent laparoscopic pancreatic resection between september 2001 and december 2003. results: laparoscopic pancreatic resection was successfully performed in all patients. operative time varied between 4 and 6 hours. intraoperative bleeding was minimal. due to a thick pancreas, the application of vascular endoscopic stapler was difficult in one patient. two patients presented postoperative pancreatic leakage with spontaneous resolution. conclusions: resection of the pancreas can be safely performed via the laparoscopic approach with all the potential benefits to the patients of minimally invasive surgery.
TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report
Edaise M da Silva, Maria W Achatz, Ghyslaine Martel-Planche, André L Montagnini, Magali Olivier, Patricia A Prolla, Pierre Hainaut, Fernando A Soares
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-449
Abstract: The patient, diagnosed with metastatic disease, died seven months after surgery. DNA from intra-surgical specimens revealed a TP53 mutation at codon 337 (p.R337H) in samples with neoplastic cells (dysplasia, tumor and metastasis) but not in non-transformed cells (incomplete intestinal metaplasia and non-involved celiac lymph node). In all mutation-positive tissues, p.R337H occurred on the same background, a founder allele identified by a specific haplotype previously described in Brazilian Li-Fraumeni syndrome patients. The same mutant haplotype, corresponding to a founder mutation present in 0.3% of the general population in Southern Brazil, was found in the genome of the father. Presence of this inherited haplotype in the tumor as well as in the father's germline, suggests a rare case of microchimerism in this patient, who may have harbored a small number of mutant cells originating in another individual, perhaps a dizygotic twin that died early in gestation.This case represents one of the earliest ages at diagnosis of gastric cancer ever reported. It shows that cancer inheritance can occur in the absence of an obvious germline mutation, calling for caution in assessing early cancers in populations with common founder mutations such as p.R337H in Southern Brazil.Gastric cancer is the 4th most common cancer in both genders in Brazil, as observed in population-based cancer registries across the country, with incidence rates varying from 22.4 to 53.6 per 100.000 individuals in the States of Goiania and S?o Paulo, respectively [1]. Despite recent reduction in incidence and mortality observed in the country, occurrence of gastric cancer remains amongst the highest worldwide, in contrast with the sharp decline observed in many countries over recent years [2,3]. The reasons for high incidence are still unclear and are likely to involve multiple etiological factors.In recent studies on cancer occurrence in Li-Fraumeni syndrome subjects who are carriers of germline TP53 mu
Reduced Variability of Ongoing and Evoked Cortical Activity Leads to Improved Behavioral Performance
Anders Ledberg, Anna Montagnini, Richard Coppola, Steven L. Bressler
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043166
Abstract: Sensory responses of the brain are known to be highly variable, but the origin and functional relevance of this variability have long remained enigmatic. Using the variable foreperiod of a visual discrimination task to assess variability in the primate cerebral cortex, we report that visual evoked response variability is not only tied to variability in ongoing cortical activity, but also predicts mean response time. We used cortical local field potentials, simultaneously recorded from widespread cortical areas, to gauge both ongoing and visually evoked activity. Trial-to-trial variability of sensory evoked responses was strongly modulated by foreperiod duration and correlated both with the cortical variability before stimulus onset as well as with response times. In a separate set of experiments we probed the relation between small saccadic eye movements, foreperiod duration and manual response times. The rate of eye movements was modulated by foreperiod duration and eye position variability was positively correlated with response times. Our results indicate that when the time of a sensory stimulus is predictable, reduction in cortical variability before the stimulus can improve normal behavioral function that depends on the stimulus.
Strategies for the recovery of degraded ecosystems: experiences from latin america
Interciencia , 2001,
Abstract: physical and biological barriers can delay natural regeneration in degraded ecosystems. tropical tree plantations can contribute to restore soils and accelerate forest regeneration. in a program on ecosystem rehabilitation in three regions of latin america, about 50% of a total of 29 tree species tested had positive effects on soils and good growth, making them attractive to farmers for reforestation. in plantations with indigenous tree species in the humid lowlands of costa rica, tree regeneration was higher under plantations than in abandoned pastures. tree regeneration was high under mixed-species plantations. open pastures had the highest proportion of wind-dispersed seeds, while bird and bat seed dispersal was predominant in the plantations. high litter accumulation on the plantation floor diminished grass growth and encouraged woody invasion. in regions with larger agricultural fields and farther from sources of propagules, windbreaks and remnant trees in pastures may be important reservoirs of native tree species. windbreaks are more attractive to birds if they include native, fruit-producing trees, if they have high species and structural complexity, and if positioned between forest patches, facilitating bird movement. strategies for recovery of degraded ecosystems need to consider factors influencing tree regeneration, other potential effects on the ecosystem, and economic, social and environmental constraints.
Análise imuno-histoquímica das sintases do óxido nítrico em adenocarcinomas gástricos
Begnami, Maria Dirlei F. S.;Cunha, Isabela Werneck da;Montagnini, André;Nonogaki, Sueli;Soares, Fernando;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2004, DOI: 10.1590/S1676-24442004000500011
Abstract: introduction: nitric oxide is an important bioactive and signaling molecule that mediates a diverse array of actions such as vasodilatation, neurotransmission, and iron metabolism. also, it can act as a carcinogen. recent studies have examined the expression and activity of the nos isoforms in several human cancers. objectives: to investigate the expression of nitric oxide synthases in gastric carcinomas and correlate the results. material and methods: the immunohistochemistry expression of constitutive and inducible nitric oxide synthases (nos-1, nos-2 e nos-3) were evaluated in 128 cases of gastric cancer classified according to lauren system. results: the rate of expression of nos-1 was 92 (70%) of the 12 cases, nos-2 was 36 (30%) and nos-3 was 54 (42%) of the cases. the expression of nos-3 was associated with the intestinal type of carcinoma and deeply invasive tumors showed high rate of expression of nos-2. conclusion: there is high expression of all the isoforms of nitric oxide synthases in gastric cancer; the constitutive isoforms show higher expression than the inducible forms. the high expression of the inducible form in deeply invasive tumors is related with tumoral progression and dissemination in the gastric mucosa.
Carcinoid tumor of the gallbladder
Machado, Marcel Cerqueira Cesar;Penteado, S?nia;Montagnini, André Luís;Machado, Marcel Autran Cesar;
Sao Paulo Medical Journal , 1998, DOI: 10.1590/S1516-31801998000300010
Abstract: the carcinoid tumor is a relatively rare type of endocrine tumor, which arises mainly in the gastrointestinal tract. primary gallbladder and biliary duct system carcinoids comprise less than 1% of all carcinoid tumors arising from any tissue or organ in the body. we describe a case of carcinoid tumor of the gallbladder in a 39-year-old man. there have been only 32 cases described in the literature.
Tratamento laparoscópico de coledocolitíase
MACHADO Marcel Autran C.,ROCHA Julio Rafael Mariano da,HERMAN Paulo,MONTAGNINI André Luís
Arquivos de Gastroenterologia , 2000,
Abstract: Paciente com história de 18 meses de emagrecimento e icterícia foi encaminhado ao Servi o de Cirurgia Abdominal do Hospital do Cancer, S o Paulo, SP., com hipótese diagnóstica de cancer de cabe a de pancreas. Exames laboratoriais mostraram eleva o de bilirrubinas e de enzimas canaliculares. Ultra-sonografia abdominal revelou dilata o de via biliar intra e extra-hepática. Tomografia computadorizada mostrou árvore biliar dilatada com presen a de cálculo de cerca de 3 cm em colédoco distal. O paciente foi submetido a colecistectomia com coledocotomia, retirada do cálculo e anastomose colédoco-duodenal por laparoscopia. Evoluiu sem intercorrências, recebendo alta no sexto dia de pós-operatório. Conclui-se que o tratamento laparoscópico da coledocolitíase é factível em alguns pacientes, especialmente naqueles com dilata o de via biliar. A retirada de cálculos deve ser seguida de procedimento de drenagem da via biliar com dreno de Kehr. Em alguns pacientes com colédoco cronicamente dilatado, como o do presente caso, a anastomose colédoco-duodenal é o procedimento de escolha.
Biliary tract schwannoma: A rare cause of obstructive jaundice in a young patient
Gilton Marques Fonseca,André Luis Montagnini,Manoel de Souza Rocha,Rosely Antunes Patzina
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i37.5305
Abstract: Schwannoma is a tumor derived from Schwann cells which usually arises in the upper extremities, trunk, head and neck, retroperitoneum, mediastinum, pelvis, and peritoneum. However, it can arise in the gastrointestinal tract, including biliary tract. We present a 24-year-old male patient with obstructive jaundice, whose investigation with computed tomography abdomen showed focal wall thickening in the common hepatic duct, difficult to differentiate with hilar adenocarcinoma. He was diagnosed intraoperatively schwannoma of common bile duct and treated with local resection. The patient recovered well without signs of recurrence of the lesion after 12 mo. We also reviewed the common bile duct schwannoma related in the literature and evaluated the difficulty in pre and intraoperative differential diagnosis with adenocarcinoma hilar. Resection is the treatment of choice for such cases and the tumor did not recur in any of the resected cases.
Tratamento laparoscópico de coledocolitíase
MACHADO, Marcel Autran C.;ROCHA, Julio Rafael Mariano da;HERMAN, Paulo;MONTAGNINI, André Luís;MACHADO, Marcel Cerqueira Cesar;
Arquivos de Gastroenterologia , 2000, DOI: 10.1590/S0004-28032000000300009
Abstract: with the advances of videolaparoscopic surgery, this approach had become the treatment of choice for cholelithiasis. however, about 5% to 10% may present common bile duct lithiasis. most surgeons have still difficulties to deal with this situation and do prefer resolve with open surgery or with further endoscopic approach. we present a case of a 60-year-old man, with 18 months history of right upper quadrant pain, weight loss and jaundice. he was referred with diagnostic of pancreatic cancer. laboratory investigation showed increased bilirrubin (10 mg/dl), alkaline phosphatase and ggt. abdominal ultrasound showed atrophic gallbladder with dilated intra and extrahepatic biliary tree. computerized tomography scan disclosed enlarged biliary tree with 3 cm stone in the distal common bile duct. the patient underwent a laparoscopic cholecystectomy followed by choledochotomy and retrieval of the large stone. a latero-lateral choledochoduodenum anastomosis was then performed to decompress the biliary tree. the patient had an uneventful recovery being discharged at the 6th postoperative day. laparoscopic management of choledocholithiasis is feasible in many patients, specially those with dilated biliary tree. the retrieval of stones may be followed by biliary drainage with t-tube. in some elderly patients with chronically dilated common bile duct, as in the present case, a choledochoduodenal anastomosis is the procedure of choice.
Express?o imuno-histoquímica de c-erb-B2 e p53 em carcinomas gástricos
Begnami, Maria Dirlei F. S.;Campos, Ant?nio Hugo J. F. M.;Silva, Edaíse;Montagnini, André;Nascimento, Carlos F.;Nonogaki, Sueli;Soares, Fernando;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2005, DOI: 10.1590/S1676-24442005000400010
Abstract: introduction: gastric cancer is one of the commonest cancers in our country being responsible for a high mortality rate. recently, the expression of p53 and amplification of c-erb-b2 gene have been described in gastric carcinoma. the relevance and biological significance of these findings are not established yet. objective: the authors investigated p53, c-erb-b2 immunohistochemical expression in 482 cases of gastric carcinomas. material and methods: tissue microarray (tma) blocks were designed using replicate samples of paraffin-embedded tissue from 482 gastric carcinomas. sections were stained with he, and antibodies to p53 and c-erb-b2. cases were considered p53 positive if nuclear staining was detected in > 10% of the tumor cells. cases were assessed c-erb-b2 positive if the entire circunference of the cell membrane was stained in > 10% of the tumor cells. results: overall expression of p53 and c-erb-b2 was observed in 30% and 12% of gastric carcinomas cases, respectively. relationship with intestinal type of gastric carcinomas and expression of c-erb-b2 was shown (p < 0.001), and expression of p53 was observed in tumors larger than 5cm (p = 0.003). there was not significant difference in survival curves of patients with gastric cancer in relation to the expression of these markers. conclusion: intestinal type of gastric carcinomas in our country are more frequently positive for c-erb-b2 than diffuse type. the expression of p53 is associated with tumor size. the tma is a valid and efficient way to study immunohistochemical markers, having a high correlation with the full section.
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