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Search Results: 1 - 10 of 335636 matches for " András Treszl "
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Selection effects may account for better outcomes of the German Disease Management Program for type 2 diabetes
Ingmar Sch?fer, Claudia Küver, Benjamin Gedrose, Eike-Christin von Leitner, András Treszl, Karl Wegscheider, Hendrik van den Bussche, Hanna Kaduszkiewicz
BMC Health Services Research , 2010, DOI: 10.1186/1472-6963-10-351
Abstract: Case control study comparing DMP patients with usual-care patients at baseline and follow up; mean follow-up period of 36 ± 14 months. We used chart review data from 51 GP surgeries. Participants were 586 DMP and 250 usual-care patients with type 2 diabetes randomly selected by chart registry. Data were analysed by multivariate logistic and linear regression analyses. Significance levels were p ≤ 0.05.There was a better chance for enrolment if patients a) had a lower risk status for diabetes complications, i.e. non-smoking (odds ratio of 1.97, 95% confidence interval of 1.11 to 3.48) and lower systolic blood pressure (1.79 for 120 mmHg vs. 160 mmHg, 1.15 to 2.81); b) had higher activity rates, i.e. were practicing blood glucose self-monitoring (1.67, 1.03 to 2.76) and had been prescribed a diabetes patient education before enrolment (2.32, 1.29 to 4.19) c) were treated with oral medication (2.17, 1.35 to 3.49) and d) had a higher GP-rated motivation for diabetes education (4.55 for high motivation vs. low motivation, 2.21 to 9.36).At baseline, future DMP patients had a lower risk for diabetes complications, were treated more intensively and were more active and motivated in managing their disease than usual-care patients. This finding a) points to the problem that the German DMP may not reach the higher risk patients and b) selection bias may impair the assessment of differences in outcome quality between enrolled and usual-care patients. Suggestions for dealing with this bias in evaluation studies are being made.Sufficient evaluation is a precondition for deciding whether the implementation of any new health care policy was successful. Policy makers depend on this scientific evidence, but their decisions sometimes restrain researchers from generating evidence in a valid way. This is the case with the nationwide disease management program (DMP) for type 2 diabetes, which was introduced in Germany in 2003.The DMP was started in a rush with no preceding randomized con
Targeting Class IA PI3K Isoforms Selectively Impairs Cell Growth, Survival, and Migration in Glioblastoma
Katrin H?land, Danielle Boller, Christian Hagel, Silvia Dolski, András Treszl, Olivier E. Pardo, Paulina ?wiek, Fabiana Salm, Zaira Leni, Peter R. Shepherd, Beata Styp-Rekowska, Valentin Djonov, André O. von Bueren, Karl Frei, Alexandre Arcaro
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094132
Abstract: The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancer and plays a crucial role in glioblastoma biology. We were interested in gaining further insight into the potential of targeting PI3K isoforms as a novel anti-tumor approach in glioblastoma. Consistent expression of the PI3K catalytic isoform PI3K p110α was detected in a panel of glioblastoma patient samples. In contrast, PI3K p110β expression was only rarely detected in glioblastoma patient samples. The expression of a module comprising the epidermal growth factor receptor (EGFR)/PI3K p110α/phosphorylated ribosomal S6 protein (p-S6) was correlated with shorter patient survival. Inhibition of PI3K p110α activity impaired the anchorage-dependent growth of glioblastoma cells and induced tumor regression in vivo. Inhibition of PI3K p110α or PI3K p110β also led to impaired anchorage-independent growth, a decreased migratory capacity of glioblastoma cells, and reduced the activation of the Akt/mTOR pathway. These effects were selective, because targeting of PI3K p110δ did not result in a comparable impairment of glioblastoma tumorigenic properties. Together, our data reveal that drugs targeting PI3K p110α can reduce growth in a subset of glioblastoma tumors characterized by the expression of EGFR/PI3K p110α/p-S6.
The Higher Education System in Argentina. Networks, Genealogies and Conflicts  [PDF]
Santos Sharpe Andrés
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.618200
Abstract: The present manuscript aims to identify the genealogies, understood in a Foucaultian perspective, which leads to the actual Higher Education System in Argentina, by distinguishing how series of events are organized, distributed, organized in terms of institutional relations, signifying chains in the social amalgam and educational networks. This analysis will allow understanding the hierarchical relationships between higher education institutions and how the differences on cultural and curricular traditions and history also motivate (though not impose) the differences on the students and on policies. Finally, it is as well an accurate description of the Higher Education System in Argentina with a strong emphasis on universities.
On the Origin of the Common Bean (Phaseolus vulgaris L.)  [PDF]
Andrés J. Cortés
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.410248
Abstract:

Phylogeographic methods provide the tools to accurately access the geographic origin and diversification of crop species. In the present commentary, I urge the common bean community to face those methods and a tree-thinking mentality with regards to the long standing debate of the origin of common bean. Such efforts will ultimately bring back interest into wild bean studies and reinforce the uniqueness of this species as a system to study diversification, domestication and adaptive processes across the two most diverse hotspots in the world.

The Role of R&D in Shaping Public Sector Typologies: An European Perspective  [PDF]
Andrés Maroto, Luis Rubalcaba
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.37110
Abstract: One of functions of the modern public states for improving dynamism in the economic system is the use of their support to cope with the market and systemic failures created in the innovation area: the R&D promoted by public administrations can be considered a dimension, among others, of their performance in society. This paper explores the relationships between the R&D promoted by public administrations and the different typologies of states from a European perspective. The results show some similarities between the public sectors in terms of general characteristics such as performance or stability and the most R&D-oriented promoters. However, differences are found depending on indicators and types analyzed. The existence of large differences within each type of public sector is also confirmed. Results suggest the influence that pro-innovation profiles of public sectors might exert on general innovation system and performance patterns in EU countries.
A Global Public Good: The Linkage between Veterinary Medicine and the Sanitary Management of Food Hygiene  [PDF]
Andrés Cartín Rojas
American Journal of Industrial and Business Management (AJIBM) , 2013, DOI: 10.4236/ajibm.2013.35058
Abstract:

Ensuring food safety is a key and crucial factor for those agro-exporting nations seeking to improve their competitiveness, opening new options for global markets and positioning their products at a better price. A number of international guidelines serve a reference framework for defining national public policies aimed to provide safe food to the population. Veterinary services act as guarantors in this process along all the manufacture and value chain. The public and private veterinary services are nurtured and amalgamate together to ensure the attainment of common goals; strengthen and foment a robust and efficient alimentary legislation by using the World Animal Health Organization’s normative as a standard reference. In this conceptual paper, an appraisal about the interrelationship and the interconnection between veterinary professionals and the sanitary management of food hygiene is widely developed by reviewing relevant literature, and discussing current trends. The author adopts an inductive approach, designed to generate understanding and propositions about this relevant topic.

Theoretical Deduction of the Hubble Law Beginning with a MoND Theory in Context of the ΛFRW-Cosmology  [PDF]
Nelson Falcon, Andrés Aguirre
International Journal of Astronomy and Astrophysics (IJAA) , 2014, DOI: 10.4236/ijaa.2014.44051
Abstract: We deduced the Hubble law and the age of the Universe, through the introduction of the Inverse Yukawa Field (IYF), as a non-local additive complement of the Newtonian gravitation (Modified Newtonian Dynamics). As a result, we connected the dynamics of astronomical objects at great scale with the Friedmann-Robertson-Walker ΛFRW) model. From the corresponding formalism, the Hubble law can be expressed as = (4π[G]/c)r, which was derived by evaluating the IYF force at distances much greater than 50 Mpc, giving a maximum value for the expansion rate of the universe of H0(max≈ 86.31 km·s-1Mpc-1, consistent with the observational data of 392 astronomical objects from NASA/IPAC Extragalactic Database (NED). This additional field (IYF) provides a simple interpretation of dark energy as the action of baryonic matter at large scales. Additionally, we calculated the age of the universe as 11 Gyr, in agreement with recent measurements of the age of the white dwarfs in the solar neighborhood.
Simulación numérica de la interconexión de corte de vigas mixtas de acero de alta resistencia y hormigón UHPC
Panés,Andrés;
Obras y proyectos , 2011, DOI: 10.4067/S0718-28132011000200002
Abstract: this article presents numerical analyses on composite beams made of high strength steel and ultra high performance concrete (uhpc). due to the high compressive strength of uhpc very slender structures with thin concrete elements are feasible. however, local stresses in the composite joints increase significantly due to the higher load capacity. for that, continuous shear connectors have been developed. numerical simulations are explained to the study of composite beams related to the shear connection (springs). details of uhpc are also presented. a composite beam with non-linear material properties was modelled. beam-bending tests were simulated with abaqus to calibrate the numerical model. the numerical results agree relatively well with the test results, even after first crack initiation. in addition, a three dimensional model with volume elements for the steel and the concrete parts and non-linear spring elements for the shear connection were implemented. the results from performed push-out tests were used in the nonlinear model of the springs elements. the punctual application of the forces in the model due to the springs were the reason for tension peaks and on this account there was an earlier loss of stiffness compared to the beam test result. the ultimate load and the occurring slip were satisfactorily calculated.
Bar Restaurant Barlovento
Andrés Garcés
ARQ , 2001,
Abstract:
Simulación numérica de la interconexión de corte de vigas mixtas de acero de alta resistencia y hormigón UHPC Numerical simulation of the interconnection of high strength steel composite beams and UHPC concrete
Andrés Panés
Obras y Proyectos , 2011,
Abstract: Este artículo presenta análisis numéricos de vigas mixtas de acero de alta resistencia y hormigón de ultra alto desempe o UHPC. Debido a la alta resistencia a la compresión del hormigón UHPC, son posibles estructuras muy esbeltas con elementos de hormigón delgados. Sin embargo, tensiones locales aumentan considerablemente en las uniones entre estos dos materiales debido a la mayor capacidad de carga. Para ello, han sido desarrollados conectores de corte continuos. Simulaciones numéricas son explicadas para estudiar vigas mixtas con conectores de corte (resortes). También se presentan detalles de los hormigones UHPC. Se modela una viga mixta con propiedades no lineales de los materiales. Ensayos de flexión de vigas son simulados con ABAQUS para calibrar el modelo numérico. Los resultados numéricos concuerdan relativamente bien con los resultados experimentales incluso después de iniciada la primera grieta. Además se implementó un modelo tridimensional con elementos de volumen para las partes de acero y hormigón y elementos de resorte no lineales para la conexión de corte. Los resultados de ensayos push-out fueron usados en el modelo no lineal de los elementos de resorte. La aplicación de cargas puntuales en el modelo debido a los resortes explican las tensiones máximas y debido a esto la pérdida de rigidez más temprana comparada con los ensayos de la viga. La carga última y la ocurrencia de deslizamiento fueron estimadas satisfactoriamente. This article presents numerical analyses on composite beams made of high strength steel and Ultra High Performance Concrete (UHPC). Due to the high compressive strength of UHPC very slender structures with thin concrete elements are feasible. However, local stresses in the composite joints increase significantly due to the higher load capacity. For that, continuous shear connectors have been developed. Numerical simulations are explained to the study of composite beams related to the shear connection (springs). Details of UHPC are also presented. A composite beam with non-linear material properties was modelled. Beam-bending tests were simulated with ABAQUS to calibrate the numerical model. The numerical results agree relatively well with the test results, even after first crack initiation. In addition, a three dimensional model with volume elements for the steel and the concrete parts and non-linear spring elements for the shear connection were implemented. The results from performed push-out tests were used in the nonlinear model of the springs elements. The punctual application of the forces in the model due to the
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