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Search Results: 1 - 10 of 10 matches for " Andis Klegeris "
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The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ
Sadayuki Hashioka, Andis Klegeris, Patrick L McGeer
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-113
Abstract: We examined the effects of SAHA on interferon (IFN)-γ-induced neurotoxicity of human astrocytes and on IFN-γ-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 in human astrocytes. We also studied the effects of SAHA on the astrocytic production of two representative IFN-γ-inducible inflammatory molecules, namely IFN-γ-inducible T cell α chemoattractant (I-TAC) and intercellular adhesion molecule-1 (ICAM-1).SAHA significantly attenuated the toxicity of astrocytes activated by IFN-γ towards SH-SY5Y human neuronal cells. In the IFN-γ-activated astrocytes, SAHA reduced the STAT3 phosphorylation. SAHA also inhibited the IFN-γ-induced astrocytic production of I-TAC, but not ICAM-1. These results indicate that SAHA suppresses IFN-γ-induced neurotoxicity of human astrocytes through inhibition of the STAT3 signaling pathway.Due to its anti-neurotoxic and anti-inflammatory properties, SAHA appears to have the therapeutic or preventive potential for a wide range of neuroinflammatory disorders associated with activated astrocytes.
Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs
Masato Hosokawa, Andis Klegeris, Patrick L McGeer
Journal of Neuroinflammation , 2004, DOI: 10.1186/1742-2094-1-17
Abstract: This study compared the expression level of complement inhibitor mRNAs by human oligodendrocytes, astrocytes and microglia using semi-quantitative RT-PCR.Semi-quantitative RT-PCR analysis showed that C1 inhibitor (C1-inh) mRNA expression was dramatically lower in oligodendroglial cells compared with astrocytes and microglia. The mRNA expression level of membrane cofactor protein (MCP) by oligodendrocytes was also significantly lower than for other cell types.The lower mRNA expression of C1-inh and MCP by oligodendrocytes could contribute to their vulnerability in several neurodegenerative and inflammatory diseases of the central nervous system.Resident brain cells including oligodendrocytes [1,2], astrocytes, astrocytomas, microglia, glioblastomas [3-14], neurons [15,16], neuroblastomas [17,18] and endothelial cells [19,20] express mRNAs for complement proteins. Although the role of complement expression by these cells remains unclear, local complement activation in the central nervous system (CNS) might damage these cells and contribute to the pathology in several inflammatory and neurodegenerative diseases including multiple sclerosis, Alzheimer's disease and progressive supranuclear palsy.For self-protection, resident brain cells also express complement inhibitors, such as membrane cofactor protein (MCP), decay-accelerating factor (DAF), CD59, and C1-esterase inhibitor (C1-inh). The human HOG oligodendroglial cell line produces MCP, DAF, CD59, C1-inh and S-protein, but not complement receptor 1 (CR1) [1]. Human oligodendrocytes have been reported to express CD59 [21] and DAF, but not MCP, CR1, homologous restriction factor (HRF: C8 bp) or clusterin [22]. Astrocytes [23], neurons and Schwann cells have been reported to express CD59 [24] and neuroblastoma cell lines C1-inh [18]. Astrocytoma cell lines have been reported to express MCP, DAF, and CD59 [25,26].In this study, the expression level of mRNAs for various complement inhibitors by human oligodendrocytes, ast
An effect of abrupt current disruption
Andis Dembovskis
Physics , 2011,
Abstract: Every engine, let it internal combustion engine in car or turbine of airplane, needs a high quality fuel igniter. During last decades there have been some minor changes made in ignition systems, like invention of Capacitive Discharge Ignition, Multiple Discharge Ignition, Ignition with Direct Current Discharge, but all based on the same priciple of High Voltage spark path creation. This work contains description, schematics and photographs of a new spark creation approach, providing high robustness through high power, big volume, long duration plasma. The system uses less or the same amount of energy as would CDI ignition, jet providing many times more efficient energy output. The solution is a highly applicable innovation, being able to significantly improve spark robustnes in all current HV spark ignition systems. Despite a simplicity of setup, it is still unclear why the effect persists, thus calling for additional research input.
Characteristics of frequent emergency department presenters to an Australian emergency medicine network
Donna Markham, Andis Graudins
BMC Emergency Medicine , 2011, DOI: 10.1186/1471-227x-11-21
Abstract: A retrospective chart review utilising an electronic emergency medicine patient medical record database was performed on patients presenting to Southern Health EDs from March 2009 to March 2010. Non-frequent presenters were defined as patients presenting less than 5 times and frequent presenters as presenting 8 or more times in the study period. Characteristics of both groups were described and compared.During the 12-month study period there were 540 FP patients with 4549 admissions and 73,089 NFP patients with 100,943 admissions. FP patients were slightly older with a significant increase in frequency of patients between the ages of 70 to 79 years and they were more likely to be divorced or separated than NFP patients. Frequent presenters to the emergency department were more likely to utilise the ambulance service to arrive at the hospital, or in the custody of police than NFP patients. FPs were more likely to be admitted to hospital, more likely to have an admission to a mental health bed than NFP patients and more likely to self-discharge from the emergency department while waiting for care.There are major implications for the utilisation of limited ED resources by frequent presenters. By further understanding the characteristics of FP we may be able to address the specific health care needs of this population in more efficient and cost effective ways. Further research analysing the effectiveness of targeted multidisciplinary interventions aiming to reduce the frequency of ED attendances may be warranted.The increasing demand placed on hospital Emergency departments (EDs) by patients who frequently present has been well documented in studies from North America and the United Kingdom [1-9]. However, there is a paucity of Australasian literature describing the characteristics of this patient group and further definition is required. The ED is often utilised by patients with complex health care needs including those with multiple medical co-morbidities, and long-st
A New Method for Synthesis of Poly(2,6-dimethyl-1,4-phenylene oxide) and Poly(2,6-diphenyl-1,4-phenyl oxide)
Naser M. Al Andis
Journal of Chemistry , 2013, DOI: 10.1155/2013/856928
Parameter Changes Which Characterize the Wear of the Cutting Tool in the Milling Process of Aspen Wood
Pro Ligno , 2012,
Abstract: The aim of the paper is to determine changesof parameters (cutting power, roughness of woodensurface and rounding of cutting edge) whichcharacterize the wear of the cutting tool in the millingprocess of aspen wood (Populus tremula),depending on the rake angle of the cutting tool.The milling process was performed by meansof a computer numerical control milling machine andtwo cutterheads with a rake angle of the fixed cutterknife adjusted at 100, 150, 200 and 300. The cuttersmade of high speed steel and highly alloyed toolsteel. After reaching the definite length of the cuttingtrajectory, the cutting power and the roughness ofthe processed wood surface were measured, as wellas replicates of the cutting edge, by pressing it inlead sheet.By milling aspen wood with highly alloyed toolsteel cutter knives at rake angle of cutter 10o, theroughness of the processed wooden surface beganincreasing after 44 000m length of cutting trajectory,which corresponds to a cutting time of 15 hours.
Two-dimensional apparent microfabric of the basal Late Weichselian till and associated shear zone: case study from western Latvia
Kalvāns, Andis,Saks, Tomas
Estonian Journal of Earth Sciences , 2008,
Abstract: The examination of glacial sediments in thin sections has become a common procedure in recent years. Apparent sand grain orientation (microfabric) in thin sections is one of the key elements marking certain microstructures. In an attempt to make till micromorphology studies less subjective and investigate the orientation of sand-sized particles in tills, we have developed an image analysis procedure to measure and analyse the spatial distribution of the till microfabric. We studied 13 thin sections of the Weichselian subglacial till and basal shear zone outcropping in the Baltic Sea bluffs at the Ziemupe site in western Latvia. The results were visualized as a two-dimensional grid of rose diagrams covering the area of the thin section and were compared to macrofabric. We found that in larger areas microfabric, although much weaker than macrofabric, coincides with macrofabric orientation. In the sub-centimetre scale till microfabric in short distances appears to be highly variable both in strength and preferred orientation, and a domain-like pattern appears.
Me a nobiru frakcijas un to īmiskais sastāvs prie u (Pinus sylvestris L.) audzē 2. līme a me a monitoringa parauglaukumā
Arta Bārdule , Andis Lazdi , Andis Bārdulis , Dagnija Lazdi a , Je ena Stola
Proceedings of the Latvia University of Agriculture , 2012, DOI: 10.2478/v10236-012-0003-4
Abstract: Forest monitoring is dated back to early 1980s, when a severe decline in tree crown condition and forest health occurred across large part of Europe. Foresters and scientists all over the Europe started to monitor indicators of forest health, including litterfall, in order to objectively describe changes in forest health. Since 1985, forest condition in Europe has been monitored within the scope of two-level system of ICP-Forests (International Co-operative Programme on Assessment and Monitoring of Air Pollution Effects on Forests). General information on forest health is annually recorded on Level I monitoring sites, but more intensive investigations, including quantitative and qualitative characteristics of litterfall, are carried out in Level II sites. In Latvia, one Level II monitoring plot was established in a Scots pine (Pinus sylvestris L.) stand in Valgunde parish of the Jelgava municipality in 2004. Canopy litterfall is a significant pathway for return of nutrients to soil in a forest ecosystem and may provide important information as a phenological indicator of climate change effects on forests. The main objective of this study was to determine preliminary characteristics of nutrient return with litterfall. The quality and quantity of litterfall fractions in a Level II forest monitoring plot were investigated in 2009. The chemical elements involved into the study were nitrogen (N), calcium (Ca), potassium (K), magnesium (Mg), phosphorus (P), sulphur (S), and carbon (C).
A Framework on Collaboration: an Interdisciplinary Project across Multiple Colleges
Andis Kwan,Lin Leung,Xiangdong Li,Michael Anshel
Journal of Systemics, Cybernetics and Informatics , 2007,
Abstract: The order of complexity in carrying out collaborative research at multiple campuses poses a challenge to standard knowledge management systems. In this paper, we present a collaboration framework in which computer science students work in partnership with computer scientists, mathematicians and physicists on an emerging field of research, quantum information science. We first develop a few heuristic criteria to determine the rationale that makes project a successful one. We then demonstrate that our knowledge management systems produce publishable results and grant proposals within our framework.
Post-Quantum Key Exchange Protocols
Xiangdong Li,Lin Leung,Andis Chi-Tung Kwan,Xiaowen Zhang,Dammika Kahanda,Michael Anshel
Physics , 2006, DOI: 10.1117/12.665685
Abstract: If an eavesdropper Eve is equipped with quantum computers, she can easily break the public key exchange protocols used today. In this paper we will discuss the post-quantum Diffie-Hellman key exchange and private key exchange protocols.
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