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Search Results: 1 - 10 of 239172 matches for " Ana Luisa P. Miranda "
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The synthesis of new isochromanylacetylarylhydrazones designed as probable non-addictive analgesic agents
Santos, Margareth R?se L.;Barreiro, Eliezer J.;Braz-Filho, Raimundo;Miranda, Ana Luisa P.;
Journal of the Brazilian Chemical Society , 1997, DOI: 10.1590/S0103-50531997000500007
Abstract: the synthesis and pharmacological profile as analgesic and anti-inflammatory agents of new isochromanylacetylarylhydrazone derivatives (3) are described in this paper. the synthetic route used in this work to construct the heterocyclic six member ring explored a lewis acid-catalyzed cyclization process as the key step, which represents a modified friedel-crafts reaction. these new derivatives (3) were obtained in ca. 85 % overall yields from the starting material safrole (4), an abundant natural product isolated from sassafras oil. the nmr spectral analysis of these new derivatives indicated, at the c=n double bond level, the diastereomeric nature in a 70:30 ratio, where the major compound is the (e)-isomer. the results obtained from the pharmacological evaluation of (3) using the carrageenan-induced rat paw edema test and the acetic acid solution-induced constrictions in mouse test, indicated the pharmacophoric nature of the acylarylhydrazone moiety to the analgesic activity observed in this series.the role of the aryl substituents in the bioactivity seems to indicate that the presence of hydrophobic groups may improve the analgesic profile. these new isochromanylacetylarylhydrazone derivatives (3) represent a new class of non-addictive analgesic agents.
Identification of impact aroma compounds in Eugenia uniflora L. (Brazilian Pitanga) leaf essential oil
Melo, Rosineia M.;Corrêa, Vivian F. S.;Amorim, Ana Carolina L.;Miranda, Ana Luisa P.;Rezende, Claudia M.;
Journal of the Brazilian Chemical Society , 2007, DOI: 10.1590/S0103-50532007000100020
Abstract: the leaf essential oil of eugenia uniflora l. (myrtaceae) was extracted by clevenger apparatus and analysed by gas chromatography-mass spectrometry (gc-ms). the leaves were collected and immediately extracted for five consecutive days at 9:00 am and 2:00 pm. no variance in the oil yields were observed in the period. furanodiene and its rearrangement product, furanoelemene (or curzerene, 50.2%), b-elemene (5.9%) and a-cadinol (4.7%) were identified as the most abundant compounds. gc-olfatometry (gc-o) associated to aroma extract dilution analysis (aeda) allowed the identification of nine active aroma compounds, where furanodiene (along with furanoelemene, fd 1024), b-elemene (fd 256) and (e,e)-germacrone (fd 256) were characterized as the main impact aroma compounds in the odor of this essential oil. those substances were collected through a sniffing port adapted on the gc allowing to obtain a typical essence of pitanga as indicated by comparative olfatometric analysis.
Screening of the odour-activity and bioactivity of the essential oils of leaves and flowers of Hyptis Passerina Mart. from the Brazilian Cerrado
Zellner, Barbara D.;Amorim, Ana Carolina L.;Miranda, Ana Luisa P. de;Alves, Ruy J. V.;Barbosa, Jussara P.;Costa, Gisela L. da;Rezende, Claudia M.;
Journal of the Brazilian Chemical Society , 2009, DOI: 10.1590/S0103-50532009000200018
Abstract: the chemical profile of the essential oils obtained from the leaves and flowers of hyptis passerina mart., a rare species of the brazilian cerrado, has been determined for the first time. analyses by gc-ms showed sesquiterpenes as major compounds. β-epi-acorenol (35.7% and 32.8%, respectively from leaf and flower essential oils), was isolated and identified by 1d and 2d nmr. the flower-derived oil presented a higher concentration of hydrocarbon and oxygenated monoterpenes, while the leaf-oil was richer in diterpenes. the global odour impressions of both oils were given by direct analysis and gc-ms-o and were characterized as herbaceous with tea notes, and green, cooked and woody impressions for leaf-oil; herbaceous, with spicy, woody and minty notes for flower-oil. β-epi-acorenol, spathulenol, β-caryophyllene, and caryophyllene oxide were relevant for the odour-activity of both oils, as well as minor constituents, such as linalool. the antimicrobial activity was investigated by means of agar diffusion disc method and contact bioautography, against gram-positive and negative bacteria and yeast. both oils presented to be bioactive against the tested microorganisms with significant inhibition level.
Discovery of Novel Orally Active Anti-Inflammatory N-Phenylpyrazolyl-N-Glycinyl-Hydrazone Derivatives That Inhibit TNF-α Production
Renata B. Lacerda, Leandro L. da Silva, Cleverton K. F. de Lima, Eduardo Miguez, Ana Luisa P. Miranda, Stefan A. Laufer, Eliezer J. Barreiro, Carlos A. M. Fraga
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046925
Abstract: Herein, we describe the synthesis and pharmacological evaluation of novel N-phenylpyrazolyl-N-glycinyl-hydrazone derivatives that were designed as novel prototypes of p38 mitogen-activated protein kinase (MAPK) inhibitors. All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit tumor necrosis factor α (TNF-α production in cultured macrophages) and in vitro MAPK p38α inhibition. The two most active anti-TNF-α derivatives, (E)-2-(3-tert-butyl-1-phenyl-1H-pyrazol-5-ylamino)-N’-((4-(2-morpholinoethoxy)naphthalen-1-y?l)methylene)acetohydrazide(4a) and (E)-2-(3-tert-butyl-1-phenyl-1H-pyrazol-5-ylamino)-N’-(4-chlorobenzylid?ene)acetohydrazide(4f), were evaluated to determine their in vivo anti-hyperalgesic profiles in carrageenan-induced thermal hypernociception model in rats. Both compounds showed anti-inflammatory and antinociceptive properties comparable to SB-203580 used as a standard drug, by oral route at a dose of 100 μmol/kg. This bioprofile is correlated with the ability of NAH derivatives (4a) and (4f) suppressing TNF-α levels in vivo by 57.3 and 55.8%, respectively.
Novel Potent Imidazo[1,2-a]pyridine-N-Glycinyl-Hydrazone Inhibitors of TNF-α Production: In Vitro and In Vivo Studies
Renata B. Lacerda, Natália M. Sales, Leandro L. da Silva, Roberta Tesch, Ana Luisa P. Miranda, Eliezer J. Barreiro, Patricia D. Fernandes, Carlos A. M. Fraga
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091660
Abstract: In this work, we describe the design, synthesis and pharmacological evaluation of novel imidazo[1,2-a]pyridine-N-glycinyl-hydraz?onederivatives (1a–k) intended for use as inhibitors of tumor necrosis factor alpha (TNF-α) production. The compounds were designed based on the orally active anti-inflammatory prototype LASSBio-1504 (2), which decreases the levels of the pro-inflammatory cytokine TNF-α in vitro and in vivo. The in vitro pharmacological evaluation of the imidazo[1,2-a]pyridine compounds (1) showed that substitution of the N-phenylpyrazole core present in prototype 2 by a bioisosteric imidazo[1,2-a]pyridine scaffold generated anti-TNF-α compounds that were more potent than the previously described N-phenylpyrazole derivative 2 and as potent as SB-203580, a p38 MAPK inhibitor. The most active derivative (E)-2-(2-tert-butylimidazo[1,2-a]pyridin?-3-ylamino)-N’-(4-chlorobenzylidene)acetohydrazide, or LASSBio-1749 (1i) was orally active as an anti-inflammatory agent in a subcutaneous air pouch model, reducing expressively the levels in vivo of TNF-α and other pro-inflammatory cytokines at all of the tested doses.
Arjunolic acid in the ethanolic extract of Combretum leprosum root and its use as a potential multi-functional phytomedicine and drug for neurodegenerative disorders: anti-inflammatory and anticholinesterasic activities
Facundo, Valdir A.;Rios, Katiúscia A.;Medeiros, Ciléia M.;Milit?o, Júlio S. L. T.;Miranda, Ana Luisa P.;Epifanio, Rosangela de A.;Carvalho, Meriane P.;Andrade, Aline T.;Pinto, Angelo C.;Rezende, Claudia M.;
Journal of the Brazilian Chemical Society , 2005, DOI: 10.1590/S0103-50532005000800002
Abstract: combretum leprosum mart. & eicher (combretaceae) leaves and roots ethanolic extracts were investigated by hrgc-ms and showed mono- and oligosaccharides, fatty acids and triterpenes as major compounds after derivatization with bstfa/ tmcs. arjunolic acid (1) was quantified on dried roots ethanolic extract (65%) by external standard. anti-inflammatory, antinociceptive and anticholinesterasic (ache and buche) activities were observed for roots ethanolic extract of c. leprosum and arjunolic acid, suggesting both as promising targets for the development of innovative multi-functional medicines for alzheimer desease treatment.
DNA damage levels in systemic lupus erythematosus patients with low disease activity: An evaluation by comet assay  [PDF]
Thaís Muniz Montalv?o, Ana Luisa Miranda-Vilela, Mariana Matos Roll, Cesar Koppe Grisolia, Leopoldo Santos-Neto
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.327121
Abstract: Oxidative stress has been implicated in the inflammatory process of Systemic Lupus Erythematosus (SLE), particularly by the formation of anti-DNA autoantibodies, which can lead to DNA damage. The aim of this study was to investigate, through comet assay, whether the level of DNA damage in SLE patients is different from that of healthy subjects. Twenty-five adult SLE patients with SLEDAI up to ten, and 25 healthy subjects were paired according to age, gender and Body Mass Index (BMI). Other anthropometric variables were also assessed. Comet assay was assessed as the marker of oxidative stress described as DNA Damage (DD) percentage. Waist Circumference (WC), Hip Circumference (HC) and BMI were also performed. Exclusion criteria for patients and controls comprised smoking and other chronic disorders. Level of damage index was remarkably higher in SLE patients than in controls, and no significant differences between the groups were found for age, BMI, WC and HC. No stratification concerning gender was performed, since there were just two males per group. No correlation was observed between BMI and DD (%). DD increased in SLE, which reflects the oxidant/antioxidant imbalance in these patients. These findings support an association between oxidative stress and SLE. This stronger correlation observed in patients with low disease activity may be useful in elucidating the mechanisms of disease pathogenesis.
Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida
Martins, Marina V.;Estevam, Charles dos S.;Santos, André L. L. M.;Dias, Antonio S.;Cupertino-da-Silva, Yolanda K.;Araújo-Júnior, Jo?o X.;Miranda, Ana Luisa P.;Barreiro, Eliezer J.;Pizza, Cosimo;Piacente, Sonia;Montoro, Paola;Quintans-Júnior, Lucindo J.;Araujo, Brancilene S.;Alexandre-Moreira, Magna S.;Sant'Ana, Ant?nio E.G.;
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/S0102-695X2012005000007
Abstract: the antinociceptive activity of the maytenus rigida mart. (celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4'-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ed50 for 1 in the writhing test was 14.14 mg/kg. the acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. in the hot plate test, mice pretreated with 1 showed significantly increased reaction times (60-89%). oral administration of 1 significantly inhibited first and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). ethanol extract and its fraction showed effects on inflammatory pain, while neurogenic and inflammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-inflammatory potential.
Estudio comparativo de la susceptibilidad de cuatro especies del genero Rhodnius a la infección experimental con Trypanosoma cruzi
Pérez R,Ana Gisela; Moreno,Jorge E; Colina,Luisa;
Boletín de Malariología y Salud Ambiental , 2009,
Abstract: in order to compare their susceptibility to trypanosoma cruzi specimens of rhodnius prolixus, r. robustus, r. neivai and r. neglectus were experimentally infected with this parasite. statistically significant differences among the species in the volume of blood ingested, volume of urine produced and number of parasites in urine and grounds developed in each stage, were detected with a non parametric kruskall-wallis analysis of variance, with the data grouped in species and instars. the low significative difference posteriori test, shows that r. prolixus ingested the highest blood volume while r. neivai produced the highest urine volume, followed by r. robustus, r. prolixus and r. neglectus. likewise, r. neivai showed the highest average of parasites in urine and feces, while r. robustus and r. neglectus showed significantly less parasites in urine and feces respectively. the four studied species are able to infect, to multiply and to excrete the parasite in their infective form in all instars stages.
Centro de aten??o psicossocial: panorama das publica??es de 1997 a 2008
Ballarin, Maria Luisa Gazabim Sim?es;Miranda, Iara Monteiro Smeke de;Fuentes, Ana Carolina de Ramos Castelhano;
Psicologia: Ciência e Profiss?o , 2010, DOI: 10.1590/S1414-98932010000400005
Abstract: the psychosocial care centers (caps) are characterized as strategic services in the articulation of mental health care and attention network services and have been gradually introduced due to the changes that occurred in the psychiatric care in brazil, considering the deinstitutionalization of the mentally ill people, the psychosocial rehabilitation and the psychiatric reform movements. considered as services that determine a recent history of attention to mental health, they deserve to be systematically studied. this paper aims to examine the scientific publications related to the caps produced between 1997 and 2008. it is characterized as a descriptive and quantitative-qualitative study. the bibliographical research was carried out using lilacs and scielo databases. the results showed a predominance of papers published in scientific journals, and the themes related to the services offered by the mental health network, the organization, the evaluation and the projects developed at the caps, the theoretical analyses of the psychiatric reform and the clinical, epidemiological and socio-anthropological studies prevailed. the research showed the relevance of identifying the key aspects of the scientific production on caps, considering the psychiatric reform context and the new ways of giving assistance in mental health, thus allowing the apprehension of a panoramic view of this field of study.
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