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Search Results: 1 - 10 of 231768 matches for " Ana Luísa Palhares de;Barreiro "
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Therapeutic approaches for tumor necrosis factor inhibition
Barbosa, Maria Letícia de Castro;Fumian, Milla Machado;Miranda, Ana Luísa Palhares de;Barreiro, Eliezer J.;Lima, Lídia Moreira;
Brazilian Journal of Pharmaceutical Sciences , 2011, DOI: 10.1590/S1984-82502011000300002
Abstract: tumor necrosis factor (tnf) consists of an inflammatory cytokine essential for homeostasis and organism defense. despite its physiological relevance, both increased biosynthesis and release of tnf lead to the exacerbation of inflammatory and oxidative responses, which are related to the pathogenesis of a host of diseases of an inflammatory, autoimmune and/or infectious nature. in this context, effective therapeutic approaches for the modulation of tnf have been the focus of research efforts. approximately one million individuals worldwide have been treated with biotechnological inhibitors of this cytokine, the so-called anti-tnf biopharmaceuticals. however, given the high risk of infection and the limitations related to cost and administration routes, new therapeutic approaches aimed at biological targets that directly or indirectly modulate the production and/or activation of tnf appear promising alternatives for the discovery of new anti-inflammatory and immunomodulatory orally active drugs and are therefore discussed in this paper.
OS MODELOS DE ESTADO E AS CARACTERíSTICAS DA JURISDI O A
Ana Luísa Zago de Moraes
Revista Eletr?nica do Curso de Direito da UFSM , 2008, DOI: 10.5902/198136946828
Abstract: O Estado Moderno, diferentemente das formas pré-modernas de organiza o, é caracterizado pela domina o burocrática. Apresentou-se inicialmente como Estado Absoluto, em face do qual se op s o Estado Liberal e, posteriormente o Estado Social. O Estado de Direito, produto de meados do século XIX, erigiu-se tendo como conteúdo tanto o social como o liberal, porém sua forma mais atual é a do Estado Democrático de Direito, um modelo ideal que exige a satisfa o de direitos e garantias fundamentais tanto individuais como coletivas. A organiza o judiciária, desde a institucionaliza o dos Estados absolutos, passou por várias etapas, dentre elas a de sua própria estrutura o mediante a influência dos ideais surgidos nas universidades entre os séculos XII XIII até a sua crise derivada da própria relativiza o do conceito de soberania e o surgimento dos Tribunais internacionais. Tem, como modelos ideais de juízes, “Júpiter”, o legalista baseado na piramide kelseneana, “Hércules”, o assistencialista, que utiliza a piramide invertida, e “Hermes”, comprometido com as “regras do jogo”, os direitos e garantias fundamentais e as responsabilidades de todos perante os problemas mundiais.
Endocrine Disruptors and Fetal Programming  [PDF]
Tatiane Andreazza Lucchese, Naiana Grunow, Ian Werner, Ana Luísa de Jesus, Alberto Krayyem Arbex
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2017, DOI: 10.4236/ojemd.2017.71007
Abstract: The concept “fetal programming” shows who still in the intrauterine life, can interfere in factors related to the genesis and development of diseases in childhood, adolescence and adult life. The literature shows that children born to mothers with gestational diabetes mellitus (GDM) are at increased risk for the development of obesity in adulthood, it becomes fundamental to study more about the subject. Obesity is a disease of multifactorial etiology, resulting from complex interactions between genetic and environmental factors. However, the marked increase in its incidence, precocity and severity are not yet fully understood. Several findings suggest that stressor stimuli (e.g. diabetes, nutritional changes) during intrauterine development may promote epigenetic changes, as well as affect mitochondrial metabolism, which may modulate fetal development and predispose to the late development of diseases. Despite the considerable amount of evidence accumulated about intrauterine programming for diseases of adult life, the determinant mechanisms of such programming are not yet clear.
Percursos alternativos - o Parkour enquanto fenómeno (sub)cultural
Carvalho,Rui Gon?alves de; Pereira,Ana Luísa;
Revista Portuguesa de Ciências do Desporto , 2008,
Abstract: through this work, we proposed to analyse a group of urban alternative sports participants to try to understand if they are, or not, a part of a subculture. our data was collected throughout participant observation as a means to obtain the information and was complemented with semi-structured interviews. these data were submitted to content analysis, from which resulted our categorical system. the categories for analysis were: i) ideology; ii) social resistance; iii) identity construction; iv) symbology and aesthetics; v) independency from global space and vi) relationship with space of practice. we concluded that parkour has a unique ideology; a group dynamics with it?s own rules and conducts; an aesthetic related to the way it explores the space of practice on one hand, and with functionality of the clothes worn, on the other hand, a sense of independence towards the evolution of the global scene; and a new way of relating to urban space.
Espa os paralelos : produ es e apropria es através dos desportos urbanos alternativos
Rui Gon?alves de Carvalho,Ana Luísa Pereira
Revista da Faculdade de Letras : Sociologia , 2010,
Abstract: Several studies conducted on the problems associated with sedentary lifestyle are focused on the need for moderate physical exercise, but do not appeal to younger populations because they are aimed at physical activity devoid of the most valued aspects by this population. The purpose of this study is to analyze the city of Oporto by direct observation of informal sports practitioners, through the use of interviews, mapping of the city's places used, and the use of photography as a complementary means of data collection. Thus, it is possible to understand what are the characteristics that make an urban space suitable for informal sporting activities, as well as examine how these spaces are distributed throughout the city, describing the areas of highest concentration in order to understand the production and appropriation space through alternative urban sports
Zika Virus Controversies: Epidemics as a Legacy of Mega Events?  [PDF]
Alberto Krayyem Arbex, Vagner Rosa Bizarro, Mikele Torino Paletti, Odirlei Joanir Brandt, Ana Luísa Concei??o de Jesus, Ian Werner, Luiggi Miguez Dantas, Mirella Hansen de Almeida
Health (Health) , 2016, DOI: 10.4236/health.2016.87074
Abstract: The current knowledge of the Zika Virus epidemic clearly lacks a comprehensive understanding of its determinants and clinical outcomes. Until recently regarded as a “simple” dengue-like infection, it nowadays turned into a real challenge to Public Health around the world. The Zika Epidemic shows a quick spread, affects unprepared health systems, and presents with severe neurological complications of newborns—a concrete threat to pregnancies. This re-emerging infectious disease is a source of deep doubts and harsh debates regarding Public Health and even bioethical issues. Several doubts still remain on how to deal with the various possible transmission ways of the disease, the surge of a generation of thousands of microcephalic newborns (and questions on how to handle them within limited health systems), and severe malformations concentrated so far in Northeastern Brazil. Finally, a debate is raised about how the “Endemic State” of Brazil, deeply merged in a health care crisis for almost 40 years now, currently confronts 3 current epidemics of the arboviruses Dengue, Chikungunya and now Zika, all associated with a lack of basic sanitation. Brazil must deal with these biological threats in the context of the Rio 2016 Olympic Games, since Chikungunya has probably been brought to Brazil during the FIFA Soccer World Cup (2014) and Zika Virus spread is associated with the Soccer Confederations Cup (2013).
Aspectos químicos, biológicos e etnofarmacológicos do gênero Cassia
Viegas Junior, Cláudio;Rezende, Amanda de;Silva, Dulce Helena Siqueira;Castro-Gamb?a, Ian;Bolzani, Vanderlan da Silva;Barreiro, Eliezer J.;Miranda, Ana Luisa Palhares de;Alexandre-Moreira, Magna Suzana;Young, Maria Cláudia Marx;
Química Nova , 2006, DOI: 10.1590/S0100-40422006000600025
Abstract: species of cassia are widely distributed in tropical and subtropical regions throughout the world, and have been extensively investigated chemically and pharmacologically.they are known to be a rich source of phenolic derivatives, most of them with important biological and pharmacological properties. some asian, african and indian tribes use these species as a laxative, purgative, antimicrobial, antipyretic, antiviral and anti-inflammatory agent. among a number of other classes of secondary metabolites, such as anthracene derivatives, antraquinones, steroids and stilbenoids, biologically active piperidine alkaloids are an especially important bioactive class of compounds that showed to be restricted to a small group of cassia species. in this paper we present an overview of the chemical, biological and ethnopharmacological data on cassia piblished in the literature.
Nursing Diagnoses of the Domain Safety/Protection and Socioeconomic and Clinical Aspects of Critical Patients  [PDF]
Anna Lívia de Medeiros Dantas, Ana Beatriz de Almeida Medeiros, Jéssica de Araújo Olímpio, Jéssica Dantas de Sá Tin?co, Maria Isabel da Concei??o Dias Fernandes, Ana Luísa Brand?o de Carvalho Lira
Open Journal of Nursing (OJN) , 2016, DOI: 10.4236/ojn.2016.64033
Abstract: Objective: The objective is to correlate the nursing diagnoses of the domain Safety/Protection of NANDA-I in critically ill patients with sociodemographic and clinical data. Method: A cross-sectional study with 86 individuals was conducted, from October 2013 to May 2014 in the Intensive Care Unit of a university hospital in northeastern Brazil, through a formal interview and physical examination. Results: It was possible to identify a total of 20 significant statistical associations, and 15 were clinically justified by the literature, namely: risk for aspiration and reason for admission; impaired dentition and age; risk for peripheral neurovascular dysfunction and sex and comorbidity; skin integrity and comorbidity; risk for impaired skin integrity and gender and reason for admission; impaired tissue integrity and gender and reason for admission; risk for perioperative positioning injury and reason for admission; risk for thermal injury and age and comorbidity; delayed surgical recovery and reason for admission; risk for poisoning and years of schooling; and risk for imbalanced body temperature and age. Conclusions: By understanding the relationship between customers’ answers and the sociodemographic and clinical profile, positive health outcomes can be achieved in particular in the prevention of risks facing vulnerability characteristics, providing greater safety and protection for the critical customer.
Dunnigan-Type Familial Partial Lipodystrophy: Understanding and Treating the Syndrome  [PDF]
Ana Raisa Jatahy Santos, Sabrina Pinto Ferreira, Moacir Benazzi, Mara Capra, Helen Paula Apparicio Medeiros, Ana Luísa de Jesus, Mirella Hansen de Almeida, Larissa Bianca Paiva Cunha de, Alberto Krayyem Arbex
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2017, DOI: 10.4236/ojemd.2017.71003
Abstract: Dunnigan-type partial lipodystrophy, which is characterized by a number of metabolic alterations, change in body fat distribution, and autosomal dominant inheritance pattern, is rare in the general population. Objective: To report the case of an adolescent with clinical and laboratory findings suggestive of Dunnigan-type partial lipodystrophy. Methods: Case report and literature review. Results: A 15-year-old adolescent presented at the clinic complaining of darkening of skin folds on her trunk and back. During physical examination, the presence of serious acanthosis nigricans in her cervical region, axillae, and intergluteal space was noted. Hirsutism in androgen-dependent areas was also observed, as well as relevant reduction of subcutaneous adipose tissue in the limbs, gluteal region, abdomen, and trunk and fat accumulation in the face and chin. Discussion. Dunnigan-type familial partial lipodystrophy is a rare dominant autosomal disease resulting from a heterozygous missense mutation in the LMNA gene, known as LPF type 2 (Dunnigan variant), which encodes the nuclear protein A/C-type lamin. It is characterized by the progressive disappearance of the subcutaneous adipose tissue in the limbs, gluteal region, abdomen, and trunk, with onset in puberty, followed by fat accumulation in other areas such as the face, chin, labia majora, and intra-abdominal region, leading to hypertrophy that may mimic the Cushing’s syndrome phenotype. Affected patients display marked insulin resistance and may consequently develop diabetes mellitus, acanthosis nigricans, hirsutism, and polycystic ovary syndrome. Conclusion: This case report highlights the importance of suspecting Dunnigan-type familial partial lipodystrophy in clinical practice. Early clinical diagnosis allows for measures that minimize the severe metabolic disorders associated with this disease and, consequently, these adolescents’ self-esteem issues.
Biomicroscopia ultra-s?nica na avalia??o da posi??o das lentes intra-oculares em uma técnica de fixa??o escleral
Vianna Filho, Raul de Camargo;Freitas, Lincoln de;Allemann, Norma;Lima, Ana Luísa Hofling de;
Arquivos Brasileiros de Oftalmologia , 2000, DOI: 10.1590/S0004-27492000000500004
Abstract: purpose: to assess, through ultrasound biomicroscopy (ubm), the positioning of the intraocular lenses (iol) haptics as related to the ciliary sulcus by using a scleral fixation technique; and to evaluate, as well, if two fixation points are sufficient to avoid tilting of the lenses. methods: sixteen aphakic eyes underwent an iol implan-tation by means of the same scleral fixation technique, performed by the same surgeon. one month following surgery, both the positioning of the iol haptics and the distances between the iols and the cornea were assessed by ubm. results were statistically studied. results: of the 32 intraocular lenses haptics fixed to the sclera, eight were placed in the ciliary sulcus and 24 were placed out of the ciliary sulcus. there was no statistical difference in the distances measured between the intraocular lenses and the cornea for the haptics placed out of the ciliary sulcus as compared to the haptics placed in the ciliary sulcus, suggesting that other factors, besides the distance to the limbus, may be relevant in the positioning of haptics in the ciliary sulcus. the same measurements performed at 3, 6, 9, and 12 hours, on the periphery of the lenses, were also similar, suggesting that 2-point fixation is sufficient to avoid tilting of the lenses in the eye. conclusions: further factors (e.g. the ciliary sulcus opening angle), other than the distance of the limbus where the sclera is transfixed, are important for the placement of the lenses in the ciliary sulcus. two fixation points are sufficient to avoid tilting of the iol in the eye.
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