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Search Results: 1 - 10 of 32173 matches for " Ana Figueiras "
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Modular Hydrogels for Drug Delivery  [PDF]
Susana Sim?es, Ana Figueiras, Francisco Veiga
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.32025
Abstract: The development of novel drug delivery systems is an essential step toward controlled site-specific administration of therapeutics within the body. It is desirable for delivery vehicles to be introduced into the body through minimally invasive means and, these vehicles should be capable of releasing drug to their intended location at a controlled rate. Furthermore, it is desirable to develop drug delivery systems that are capable of in vivo to suffer degradation and to deliver the drug completely, avoiding the need to surgically remove the vehicle at the end of its useful lifetime. Hydrogels are of particular interest for drug delivery applications due to their ability to address these needs in addition to their good biocompatibility, tunable network structure to control the diffusion of drugs and, tunable affinity for drugs. However, hydrogels are also limited for drug delivery applications due to the often quick elution of drug from their highly swollen polymer matrices as well as the difficulty inherent in the injection of macroscopic hydrogels into the body. This paper presents an overview to the advances in hydrogels based drug delivery. Different types of hydrogels can be used for drug delivery to specific sites in the gastrointestinal tract ranging from the oral cavity to the colon. These novel systems exhibit a range of several peculiar properties which make them attractive as controlled drug release formulations. Moreover, such materials are biocompatible and can be formulated to give controlled, pulsed, and triggered drug release profiles in a variety of tissues.
Aggregation mediated by faeces and footprints in Triatoma pseudomaculata (Heteroptera: Reduviidae), a Chagas disease vector
Vitta Ana Cristina R,Figueiras Alicia N Lorenzo,Lazzari Claudio R,Diotaiuti Liléia
Memórias do Instituto Oswaldo Cruz , 2002,
Abstract: The behavioural response of Triatoma pseudomaculata to chemical substances present in their faeces or cuticle (footprints) was analyzed. Groups of larvae were simultaneously exposed to a clean filter paper and to another paper impregnated with a chemical stimulus in a circular arena. In these choice experiments, the insects aggregated significantly around papers impregnated with dry faeces. In addition, the bugs also showed a significant aggregation response to papers impregnated with compounds derived from their cuticle that were deposited by contact on the substrate. These results indicate that chemical compounds that affect the behaviour of T. pseudomaculata are present in the faeces and in the cuticle of this species. Results are discussed in relation to chemical communication in the Triatominae, as well as to the potential use of these substances in traps or sensors for the detection of this species.
Aggregation mediated by faeces and footprints in Triatoma pseudomaculata (Heteroptera: Reduviidae), a Chagas disease vector
Vitta, Ana Cristina R;Figueiras, Alicia N Lorenzo;Lazzari, Claudio R;Diotaiuti, Liléia;Lorenzo, Marcelo G;
Memórias do Instituto Oswaldo Cruz , 2002, DOI: 10.1590/S0074-02762002000600020
Abstract: the behavioural response of triatoma pseudomaculata to chemical substances present in their faeces or cuticle (footprints) was analyzed. groups of larvae were simultaneously exposed to a clean filter paper and to another paper impregnated with a chemical stimulus in a circular arena. in these choice experiments, the insects aggregated significantly around papers impregnated with dry faeces. in addition, the bugs also showed a significant aggregation response to papers impregnated with compounds derived from their cuticle that were deposited by contact on the substrate. these results indicate that chemical compounds that affect the behaviour of t. pseudomaculata are present in the faeces and in the cuticle of this species. results are discussed in relation to chemical communication in the triatominae, as well as to the potential use of these substances in traps or sensors for the detection of this species.
Surgical treatment of pressure ulcers: a two-year experience
Figueiras, Ricardo Goes;
Revista Brasileira de Cirurgia Plástica , 2011, DOI: 10.1590/S1983-51752011000300010
Abstract: background: pressure ulcers are defined as lesions of ischemic etiology in the skin or soft tissue. these lesions are secondary to increased external pressure and usually occur over bony prominences. classification of various stages of pressure ulcers is important for the development of therapeutic strategies. the fundamental surgical treatments are debridement and excision of underlying bursa and involved bone tissue, followed by tissue coverage. this study reports our experience in repairing pressure ulcers and analyzes patient characteristics, outcomes, and complications. methods: a total of 33 pressure ulcers were treated in 17 patients, the most prevalent of which was sacral ulcer. the development of pressure ulcers in hospitals accounted for 82% of the cases. treatment options included debridement, primary synthesis, random skin flaps, rhomboid skin flap, myocutaneous flaps of the gluteus maximus in v-y, classic fasciocutaneous flaps of fascia lata, fasciocutaneous flap of fascia lata in v-y, and posterior fasciocutaneous flaps of the thigh in v-y. results: complications occurred in 39% of cases. preoperative anemia was associated with complications. conclusions: pressure ulcers can be avoided in most cases, given sufficient knowledge of their pathogenesis and correct management of patients at risk. multi-professional and family participation is essential for the treatment of patients with pressure ulcers since complications, recurrence, and the incidence of new ulcers are common. complication risk factors such as anemia should be avoided in order to provide a better prognosis and proper closure of the ulcer.
Competencias del recién egresado de la licenciatura en psicología
Sandra Casta?eda Figueiras
Psicología desde el Caribe , 2004,
Abstract: Aun cuando se asume que la formación del licenciado en Psicología se fundamenta en principios académico - profesionales, altamente apreciados y comúnmente compartidos por académicos distinguidos de las instituciones formadoras, a la fecha se cuenta con evidencias insuficientes que permitan un análisis crítico acerca de su uso. Brechas importantes entre lo establecido y la realidad de la oferta educativa generada en este sentido plantean problemas serios que deben ser superados. Este trabajo aborda evidencias curriculares, un marco de trabajo y resultados derivados de una línea de investigación, desarrollada en México, cuyo interés ha sido aportar conocimiento acerca de mecanismos responsables del desarrollo de la pericia profesional en la formación académica del licenciado en Psicología. Asimismo, aborda avances y limitaciones de lo realizado hasta hoy
Evaluando y fomentando el desarrollo cognitivo y el aprendizaje complejo
Sandra Casta?eda Figueiras
Psicología desde el Caribe , 2004,
Abstract: Se abordan los desarrollos investigativos originales que han traducido premisas teóricas acerca de la cognición humana a marcos de trabajo y herramientas tecnológicas aplicables al campo educativo. Los artefactos han sido dise ados para abrir la caja negra del qué, del cómo y del hasta dónde de la oferta generada en los niveles educativos medio superior y superior en México. Marcos y herramientas se fundan en la actividad cognitiva constructiva autorregulada, apoyan la medición y el fomento de resultados del aprendizaje complejo y de sus habilidades asociadas. La asunción subyacente considera que la aplicación de premisas cognitivas al dise o de herramientas educativas es central y que, en este contexto, es fundamental asegurar la estrecha relación entre la investigación y la práctica educativa ordinaria, a fin de apoyar los cambios deseados. En este trabajo se argumentan fundamentos teóricos, se aportan evidencias en apoyo a los desarrollos generados y se enfatiza la necesidad de extender investigación que identifique mecanismos responsables del aprendizaje efectivo en escenarios reales, con el fin de lograr su comprensión cabal y generar alternativas ecológicamente válidas y útiles.
Synergism between Prior Anisakis simplex Infections and Intake of NSAIDs, on the Risk of Upper Digestive Bleeding: A Case-Control Study
Florencio M. Ubeira,Ana M. Anadón,Angel Salgado,Alfonso Carvajal,Sara Ortega,Carmelo Aguirre,María José López-Goikoetxea,Luisa Ibanez,Adolfo Figueiras
PLOS Neglected Tropical Diseases , 2011, DOI: 10.1371/journal.pntd.0001214
Abstract: Background The aim of this study was to investigate the relationship between prior Anisakis infections and upper gastrointestinal bleeding (UGIB), and its interaction with non-steroidal anti-inflammatory drug (NSAID) intake. Methods/Principal Findings We conducted a hospital-based case-control study covering 215 UGIB cases and 650 controls. Odds ratios (ORs) with their confidence intervals (95% CIs) were calculated, as well as the ratio of the combined effects to the sum of the separate effects of Anisakis allergic sensitization and NSAIDs intake. Prior Anisakis infections were revealed by the presence of anti-Anisakis IgE antibodies specific to the recombinant Ani s 1 and Ani s 7 allergens used as the targets in indirect ELISA. Prior Anisakis infections (OR 1.74 [95% CI: 1.10 to 2.75]) and the intake of NSAIDs (OR 6.63 [95% CI: 4.21 to 10.43]) increased the risk of bleeding. Simultaneous NSAIDs intake and Anisakis allergic sensitization increased the risk of UGIB 14-fold (OR = 14.46 [95% CI: 6.08 to 34.40]). This interaction was additive, with a synergistic index of 3.01 (95% CI: 1.18–7.71). Conclusions Prior Anisakis infection is an independent risk factor for UGIB, and the joint effect with NSAIDs is 3 times higher than the sum of their individual effects.
Implicación Afectiva y Evolución de Estrategias de Resolución de Problemas de Conteo en la Transición desde Primaria a Secundaria (Affective Involvement and Evolution of Solving Strategies on Counting Problems in the Transition from Primary to Secondary Education)
Sainza Fernández,Lourdes Figueiras
PNA , 2011,
Abstract: En este artículo se analizan comparativamente las estrategias empleadas por alumnos de sexto de primaria y de primero de bachillerato en la resolución de un mismo problema de combinatoria. Se compara también en ambos niveles la evolución de su grado de implicación afectiva en relación con la dificultad y el tipo de tarea propuesta. Las conclusiones apuntan a una mayor libertad al proponer estrategias de solución en los alumnos de primaria que en los de Bachillerato y una variabilidad extrema de la implicación afectiva de los estudiantes de primaria que no se da en los estudiantes de bachillerato. This article discusses the strategies used by 6th and 7th grade students in solving the same combinatorics problem. Also, it shows a comparison between both levels in terms of the evolution of students’ degree of involvement during the process of solving the problem, relating this evolution to the type of task and its difficulty. The conclusions point to a greater freedom in the resolution strategies within the primary group as well as extreme and highly variable emotions in the primary students who are not found in the older ones.
A Multi-species Bait for Chagas Disease Vectors
Theo Mota,Ana C. R. Vitta,Alicia N. Lorenzo-Figueiras,Carla P. Barezani,Carlos L. Zani,Claudio R. Lazzari,Liléia Diotaiuti,Lynne Jeffares,Bj?rn Bohman,Marcelo G. Lorenzo
PLOS Neglected Tropical Diseases , 2014, DOI: 10.1371/journal.pntd.0002677
Abstract: Background Triatomine bugs are the insect vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. These insects are known to aggregate inside shelters during daylight hours and it has been demonstrated that within shelters, the aggregation is induced by volatiles emitted from bug feces. These signals promote inter-species aggregation among most species studied, but the chemical composition is unknown. Methodology/Principal Findings In the present work, feces from larvae of the three species were obtained and volatile compounds were identified by solid phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS). We identified five compounds, all present in feces of all of the three species: Triatoma infestans, Panstrongylus megistus and Triatoma brasiliensis. These substances were tested for attractivity and ability to recruit insects into shelters. Behaviorally active doses of the five substances were obtained for all three triatomine species. The bugs were significantly attracted to shelters baited with blends of 160 ng or 1.6 μg of each substance. Conclusions/Significance Common compounds were found in the feces of vectors of Chagas disease that actively recruited insects into shelters, which suggests that this blend of compounds could be used for the development of baits for early detection of reinfestation with triatomine bugs.
Influências ambientais na saúde mental da crian?a
Halpern, Ricardo;Figueiras, Amira C. M.;
Jornal de Pediatria , 2004, DOI: 10.1590/S0021-75572004000300013
Abstract: objective: to present an up-to-date review about environmental influences on child mental health, describing major risk factors and discussing recommendations for intervention by pediatricians. sources of data: medline, psyclit and lilacs, technical books and publications about child development and child and adolescent mental health problems and health promotion. summary of the findings: children are exposed to multiple risk factors, among them high prevalence of disease, premature birth, being born from a problematic pregnancy, and living in poverty. this negative chain of events increases the risk for emotional problems. the negative effects on development and behavior result from the complex interaction between genetic, biological, psychological and environmental risk factors. the main factors influencing the mental health of children are the social and psychological environment. the cumulative risk effect is more important in determining emotional problems in children than the presence of one single stressor, regardless of its magnitude. conclusion: environmental factors play an important role in the etiology of emotional problems in childhood. an adequate clinical investigation allows pediatricians to identify risk factors for the development of mental health problems and to ensure early intervention for children at risk.
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