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Search Results: 1 - 10 of 32088 matches for " Ana Anbinder "
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Peripheral calcifying cystic odontogenic tumour of the maxillary gingiva
Ana Lima, Dárcio Kitakawa, Janete Almeida, Adriana Aigotti Brand?o, Ana Anbinder
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-455
Abstract: Authors report a rare case of a peripheral calcifying cystic odontogenic tumor of the maxillary gingiva. A 39-year-old male patient presented with a fibrous mass on the attached buccal gingiva of the upper left cuspid teeth. It was 0.7-cm-diameter, painless and it was clinically diagnosed as a peripheral ossifying fibroma. After an excisional biopsy, the diagnosis was peripheric calcifying cystic odontogenic tumor. The patient was monitored for five years following the excision, and no recurrence was detected.All biopsy material must be sent for histological examination. If the histological examination of gingival lesions with innocuous appearance is not performed, the frequency of peripheral calcifying cystic odontogenic tumor and other peripheral odontogenic tumors may be underestimated.A calcifying cystic odontogenic tumor (CCOT) is an extremely rare benign cystic neoplasm that is characterized by an ameloblastoma-like epithelium and ghost cells that have the potential to undergo calcification [1]. Originally, CCOTs were referred to as calcifying odontogenic cysts (COC). The structure was first described by Gorlin in 1962 as a distinct entity and was therefore called Gorlin cyst [2]. COC was considered as a developmental odontogenic cyst in the jaw. In their first report, Gorlin et al. [2] considered this lesion to be a possible analogue of the cutaneous calcifying epithelioma of Malherbe (the pilomatrixoma). COC accounted for approximately 1% of jaw cysts. In 1981, Praetorius et al. [3] studied and reevaluated 16 cases of COC and proposed that the group actually contained two entities, a cyst and a neoplasm. Since then, neoplastic potential has been investigated.In 2005, the World Health Organization (WHO) designated Gorlin’s cyst as a tumor and described it as belonging to a group of related neoplasms, including the benign cystic-type (CCOT), the benign solid-type dentinogenic ghost cell tumor, and the malignant ghost cell odontogenic carcinoma [1]. The dentino
Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats
Lima, Carlos Eugênio Villaboim de Castro;Calixto, Jimmy Cavalcanti;Anbinder, Ana Lia;
Brazilian Oral Research , 2011, DOI: 10.1590/S1806-83242011000100008
Abstract: simvastatin, a drug used to lower blood cholesterol, has been reported to have an anabolic effect on bone. the purpose of this study was to evaluate the influence of simvastatin and demineralized bovine bone matrix (dbbm) on the repair of rat calvarial defects. defects of 5 mm were created in 64 rats, divided into four groups: no local treatment (control); treatment with dbbm (dbbm); treatment with a combination of simvastatin solution (2.2 mg/50 μl) and dbbm (dbbmsim-1); and treatment with simvastatin solution (0.5 mg/50 μl) and dbbm (dbbmsim-2). animals were sacrificed on postoperative day 30 or 60, after which the calvariae were x-rayed and prepared for histomorphometric evaluation. the data were submitted to statistical analysis (p < 0.05). x-rays revealed that, on postoperative day 30, animals treated with a lower dose of simvastatin presented the lowest bone density, whereas on postoperative day 60 the use of simvastatin, regardless of the dose, resulted in lower density than that observed in control and dbbm group samples. histomorphometric analysis revealed that, on postoperative day 30, both dbbm and dbbmsim-1 had a negative impact on bone formation. on postoperative day 60, none of the combinations tested impaired bone repair. these results showed that the association between dbbm and simvastatin had a negative impact on bone repair.
Cimentos endod nticos: análise morfológica imediata e após seis meses utilizando microscopia de for a at mica
VALERA Marcia Carneiro,ANBINDER Ana Lia,LEONARDO Mário Roberto,PARIZOTO Nivaldo Ant?nio
Pesquisa Odontológica Brasileira , 2000,
Abstract: O objetivo deste trabalho foi analisar a morfologia dos cimentos Sealapex, Apexit, Sealer 26 (cimentos a base de hidróxido de cálcio) e Ketac Endo (cimento de ion mero de vidro), através da microscopia de for a at mica, verificando-se as características de suas partículas após a obtura o dos canais radiculares e após um período de seis meses de contato com o plasma sanguíneo humano. Utilizaram-se 16 dentes unirradiculares humanos extraídos e incluídos em blocos de resina após o preparo biomecanico. As raízes foram divididas em quatro grupos de quatro raízes cada e os canais radiculares obturados pela técnica de condensa o lateral passiva com os cimentos em estudo. Verificou-se que o cimento Apexit foi o que mais sofreu desintegra o após seis meses de imers o em plasma sanguíneo humano, seguido pelo Ketac Endo e Sealapex. Dentre todos os cimentos estudados, o Sealer 26 mostrou-se o mais uniforme e com a menor desintegra o.
Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats
Anbinder, Ana Lia;Junqueira, Juliana Campos;Mancini, Maria Nadir G.;Balducci, Ivan;Rocha, Rosilene Fernandes da;Carvalho, Yasmin Rodarte;
Brazilian Dental Journal , 2006, DOI: 10.1590/S0103-64402006000400001
Abstract: the purpose of this study was to evaluate the effects of simvastatin, by oral or subcutaneous administration, on tibial defects regeneration and blood cholesterol level in rats. a surgical defect was made on the right tibia of 40 male animals assigned to 4 groups (n=10), based on two routes of administration and on the use or not of simvastatin: subcutaneous injection of simvastatin (7 mg/kg) (group at) or only the vehicle of drug suspension (group ac), above the defect area, for 5 days; and 20 mg/kg of simvastatin macerated on water (group bt) or only water (group bc), orally, daily, during the whole observation period. the animals were sacrificed after 15 or 30 days, when blood samples were analyzed to check plasma cholesterol levels. tibiae were removed and, after decalcification and routine laboratorial processing, histological and histomorphometrical analyses were carried out. anova was used for statistical analysis at 5% signficance level. the histological and histomorphometrical analyses showed significant differences only between the experimental periods (p<0.05). animals sacrificed after 30 days showed better bone repair (p<0.05). there was no statistically significant difference (p>0.05) for blood cholesterol levels between the groups. in conclusion, simvastatin administration either orally or subcutaneously did not improve bone repair of experimental tibial defects and did not alter blood cholesterol levels in rats.
Estrogen deficiency and periodontal condition in rats: a radiographic and macroscopic study
Anbinder, Ana Lia;Prado, Marcela de Almeida;Spalding, Marianne;Balducci, Ivan;Carvalho, Yasmin Rodarte;Rocha, Rosilene Fernandes da;
Brazilian Dental Journal , 2006, DOI: 10.1590/S0103-64402006000300005
Abstract: the purpose of this study was to evaluate the impact of ovariectomy-induced estrogen deficiency as a risk factor of periodontal disease in rats. forty 90-day old female rats were either ovariectomized (ovx; n=20) or sham operated (sham; n=20). after 30 days, periodontitis was induced by placement of a cotton ligature around the upper second molars of 10 ovx and 10 sham animals. all animals were sacrificed 5 weeks later. body weight was assessed before all surgical procedures. the left hemimaxillas were removed and the percentage of periodontal bone support was determined radiographically and buccal alveolar bone loss was determined macroscopically using an image-analysis software. furcation involvement was also evaluated. data were analyzed statistically by anova at 5% significance level. within the evaluated period, the ovariectomized rats gained more weight than the sham-operated animals (p<0.001). the animals in which periodontitis was induced had less bone support, greater alveolar bone loss and furcation involvement than those without ligature (p<0.001). however, there was no difference between ovariectomized and sham-operated animals (p>0.05). based on the findings of this study, estrogen deficiency could not be considered as a risk factor for periodontal disease.
The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats
Anbinder, Ana Lia;Prado, Fernanda de Almeida;Prado, Marcela de Almeida;Balducci, Ivan;Rocha, Rosilene Fernandes da;
Brazilian Oral Research , 2007, DOI: 10.1590/S1806-83242007000300010
Abstract: bisphosphonates are currently used in the treatment of many diseases involving increased bone resorption such as osteoporosis. statins have been widely used for the treatment of hypercholesterolemia and recent studies have shown that these drugs are also capable of stimulating bone formation. the purpose of this study was to evaluate the influence of an estrogen deficient state and the effects of simvastatin and sodium alendronate therapies on alveolar bone in female rats. fifty-four rats were either ovariectomized (ovx) or sham operated. a month later, the animals began to receive a daily dose of simvastatin (sin - 25 mg/kg), sodium alendronate (aln - 2 mg/kg) or water (control) orally. thirty-five days after the beginning of the treatment, the rats were sacrificed and their left hemimandibles were removed and radiographed using digital x-ray equipment. the alveolar radiographic density under the first molar was determined with gray-level scaling and the values were submitted to analysis of variance (a = 5%). ovariectomized rats gained more weight (mean ± standard deviation: 20.06 ± 6.68%) than did the sham operated animals (12.13 ± 5.63%). alveolar radiographic density values, expressed as gray levels, were lowest in the ovx-water group (183.49 ± 6.47), and differed significantly from those observed for the groups receiving alendronate (sham-aln: 193.85 ± 3.81; ovx-aln: 196.06 ± 5.11) and from those of the sham-water group (193.66 ± 4.36). other comparisons between groups did not show significant differences. it was concluded that the ovariectomy reduced alveolar bone density and that alendronate was efficient for the treatment of this condition.
Cimentos endod?nticos: análise morfológica imediata e após seis meses utilizando microscopia de for?a at?mica
VALERA, Marcia Carneiro;ANBINDER, Ana Lia;LEONARDO, Mário Roberto;PARIZOTO, Nivaldo Ant?nio;KLEINKE, Maurício Urban;
Pesquisa Odontológica Brasileira , 2000, DOI: 10.1590/S1517-74912000000300002
Abstract: the aim of this study was to analyze the high resolution morphological characteristics of sealapex, apexit, sealer 26 (calcium hydroxide cements) and ketac endo (glass ionomer cement), using atomic force microscopy (afm), immediately after root canal obturation and six months after it, keeping the roots stored in human blood plasma. the afm evaluation used 16 single-rooted human teeth embedded in resin blocks after biomechanical preparation. the samples were divided into four groups (four roots each) and the passive lateral condensation filling technique was used in the obturation of the canals with the mentioned sealers. apexit suffered the highest degree of disintegration after the six-month storage in human blood plasma, followed by ketac endo and sealapex. sealer 26 was the most uniform cement and suffered the least disintegration.
Yerba Mate Extract Encapsulation with Alginate and Chitosan Systems: Interactions between Active Compound Encapsulation Polymers  [PDF]
Pablo S. Anbinder, Lorena Deladino, Alba S. Navarro, Javier I. Amalvy, Miriam N. Martino
Journal of Encapsulation and Adsorption Sciences (JEAS) , 2011, DOI: 10.4236/jeas.2011.14011
Abstract: Yerba mate (Ilex paraguariensis) contains a high amount of polyphenols associated with antiradical activity and possible benefits for preventing degenerative diseases. Natural extracts from this South American herb were encapsulated in calcium alginate and calcium alginate-chitosan beads to be incorporated as an additive in food products. The interactions between the active compound and the polymers were evaluated by Scanning Electron Microscopy (SEM), thermal analysis (Thermo Gravimetric Assays, TGA, and Differential Scanning Calorimetry, DSC) and Fourier Transform Infrared Spectrometry (FT-IR) studies. Also, the effect of these interactions on extract release in a gastrointestinal model system was evaluated. Results showed the interactions between the calcium alginate matrix and the chitosan external layer. Also, interactions between the natural extract and each polymer were observed. In both encapsulation systems the highest polyphenol content was released in simulated gastric fluid. However, capsules coated with chitosan allowed releasing a higher amount of polyphenols into the simulated intestinal fluid. This fact was attributed to both the protection of the chitosan barrier and the strong interaction between yerba mate extract and chitosan.
Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes
Melissa Simpson, Janet K Snell-Bergeon, Gregory L Kinney, Orit Lache, Rachel Miller-Lotan, Yefim Anbinder, Marian J Rewers, Andrew P Levy
Cardiovascular Diabetology , 2011, DOI: 10.1186/1475-2840-10-99
Abstract: CAC was measured three times in six years among 436 subjects with type 1 diabetes and 526 control subjects participating in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study. Hp typing was performed on plasma samples by polyacrylamide gel electrophoresis.The Hp 2-2 genotype predicted development of significant CAC only in subjects with diabetes who were free of CAC at baseline (OR: 1.95, 95% CI: 1.07-3.56, p = 0.03), compared to those without the Hp 2-2 genotype, controlling for age, sex, blood pressure and HDL-cholesterol. Hp 2 appeared to have an allele-dose effect on development of CAC. Hp genotype did not predict CAC progression in individuals without diabetes.Hp genotype may aid prediction of accelerated coronary atherosclerosis in subjects with type 1 diabetes.Coronary artery disease (CAD) is the leading cause of death in patients with type 1 diabetes and CAD mortality is 2-4 higher among type 1 diabetes patients than in subjects without diabetes [1,2]. While hyperglycemia and conventional cardiovascular risk factors contribute to this increased risk, they do not account for all of the excess risk. Therefore additional markers are needed to predict which individuals with type 1 diabetes are at greatest risk for developing CAD [3]. Coronary artery calcium (CAC) is a powerful marker of the coronary artery plaque burden [4]. Both the presence and progression of CAC have been shown to predict CAD events [5]and mortality [6].Haptoglobin (Hp) is a protein whose primary function is to modulate the fate and toxicity of extracorpuscular hemoglobin [7]. The Hp protein is polymorphic with two classes of alleles, designated 1 and 2. In most populations of European ancestry, the prevalence of the Hp 1-1 genotype is < 20%; Hp 2-1 and Hp 2-2 have approximately equal frequencies [8]. The protein products of the Hp 1 and Hp 2 alleles are structurally and functionally distinct. The Hp 1 protein mediates more rapid clearance of free hemoglobin and provides super
Research of Logistics and Regional Economic Growth  [PDF]
Ana Wang
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.24052
Abstract: This paper used Granger causality test method to analyze regional GDP growth in the domestic and regional freight turnover. And this paper used logistic model to analyze the reasons that regional logistics promote Anhui economic growth. Through the analysis that find Anhui economic growth on the leading role of regional logistics is not obvious. This showed that the role of regional logistics in promoting economic growth in Anhui Province has not been fully played out, which was not showing a good momentum of development co-ordination. So logistics will play an active role in the economy of Anhui province in the future.
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