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Search Results: 1 - 10 of 321 matches for " Amnon Golan "
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The Minimal Deneddylase Core of the COP9 Signalosome Excludes the Csn6 MPN? Domain
Elah Pick, Amnon Golan, Jacob Z. Zimbler, Liquan Guo, Yehonatan Sharaby, Tomohiko Tsuge, Kay Hofmann, Ning Wei
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043980
Abstract: The COP9 signalosome (CSN) is a eukaryotic protein complex, which regulates a wide range of biological processes mainly through modulating the cullin ubiquitin E3 ligases in the ubiquitin-proteasome pathway. The CSN possesses a highly conserved deneddylase activity that centers at the JAMM motif of the Csn5 subunit but requires other subunits in a complex assembly. The classic CSN is composed of 8 subunits (Csn1–8), yet in several Ascomycota, the complex is smaller and lacks orthologs for a few CSN subunits, but nevertheless contains a conserved Csn5. This feature makes yeast a powerful model to determine the minimal assemblage required for deneddylation activity. Here we report, that Csi1, a diverged S. cerevisiae CSN subunit, displays significant homology with the carboxyl terminal domain of the canonical Csn6, but lacks the amino terminal MPN- domain. Through the comparative and experimental analyses of the budding yeast and the mammalian CSNs, we demonstrate that the MPN? domain of the canonical mouse Csn6 is not part of the CSN deneddylase core. We also show that the carboxyl domain of Csn6 has an indispensable role in maintaining the integrity of the CSN complex. The CSN complex assembled with the carboxyl fragment of Csn6, despite its lack of an MPN? domain, is fully active in deneddylation of cullins. We propose that the budding yeast Csi1 is a functional equivalent of the canonical Csn6, and thus the composition of the CSN across phyla is more conserved than hitherto appreciated.
Possible Role of Exogenous Melatonin and Melatonin-Receptor-Agonists in the Treatment of Menopause―Associated Sleep Disturbances  [PDF]
Amnon Brzezinski
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.46047

One of the core symptoms of the menopausal transition is sleep disturbance. Peri-menopausal women often complain of difficulties initiating and/or maintaining sleep with frequent nocturnal and early morning awakenings. Factors that may play a role in this type of insomnia include vasomotor symptoms and changing reproductive hormone levels, circadian rhythm abnormalities, primary insomnia, mood disorders, coexistent medical conditions, and lifestyle. Exogenous melatonin reportedly induces drowsiness and sleep, and may ameliorate sleep disturbances, including the nocturnal awakenings associated with old age and the menopausal transition. Recently, more potent melatonin analogs with prolonged effects and slow-release melatonin preparations have been developed. The melatonergic receptor ramelteon is a selective melatonin-1 (MT1) and melatonin-2 (MT2) receptor agonist with negligible affinity for other neuronal receptors, including gamma-aminobutyric acid and benzodiazepine receptors. It was found effective in increasing total sleep time and sleep efficiency, as well as in reducing sleep latency, in insomnia patients. The melatonergic antidepressant agomelatine, displaying potent MT1 and MT2 melatonergic agonism and relatively weak serotonin 5HT2C receptor antagonism, reportedly is effective in the treatment of depression associated insomnia. This article presents the currently available evidence regarding the effects of these compounds on sleep quality and their possible use in menopause associated sleep disturbances.

Peer-Pressure and Rational Underage Binge-Drinking  [PDF]
Amnon Levy
Theoretical Economics Letters (TEL) , 2014, DOI: 10.4236/tel.2014.41018

This paper provides a utility-based definition of binge-drinking and examines the compatibility of this phenomenon with a rational decision making. Prohibition of young people’s consumption of alcohol is frequently violated by binge-drinking in groups. The analysis considers the roles of peer-pressure, full price of alcohol and crowding in underage group-drinking sessions and identifies the conditions for binge-drinking by expected utility maximizing members. Rational binge-drinking occurs when the impact of the peer-pressure on the individual member’s utility exceeds the loss of utility from the forgone spending on all other goods associated with the expected full marginal cost of consuming alcohol.

Can a Carbon Tax Be Effective without a Grand Coalition?  [PDF]
Amnon Levy
Theoretical Economics Letters (TEL) , 2014, DOI: 10.4236/tel.2014.41003

This paper analyzes an interaction between a carbon-tax collecting and investing coalition of rich countries, abstaining rich countries and poor countries. The non-coalition countries may suffer from loss of reputation and guilt and may overstate the emission-moderating effect of the carbon tax. As long as these three types of countries react to their counterparts’ emissions, taxing carbon-dioxide emissions unilaterally does not necessarily reduce the global emissions. Nor does it necessarily moderate the emissions of the coalition.

Leadership to Creativity and Management of Innovation? The Case of the “Innovation Club” in a Production Company  [PDF]
Vered Holzmann, Joseph Golan
American Journal of Industrial and Business Management (AJIBM) , 2016, DOI: 10.4236/ajibm.2016.61005
Abstract: In the current era of ongoing dynamic business developments and advancements, any company that wishes to succeed needs to sustain an innovative culture in order to keep its position in the front line of competition. However, being creative and innovative in a production and manufacturing environment is challenging due to the organizational characteristics derive from a hierarchical structure in which systematic procedures are strictly followed. In this paper, we present a model for creating a sustainable culture of creativity and innovation in a manufacturing organization and we demonstrate the use of this model in a leading production company in the defense industry. The model explains the initiation phase that motivates employees to explore new opportunities and the maintenance phase that forms a sustainable infrastructure, which are integrated into a coherent foundation for continuous improvement and excellence. The case study describes how the model was implemented in the production company and reviews the major barriers the management faced in the process of implementing a culture of innovation. We discuss the actions taken to create a supportable infrastructure to promote innovative behavior by employees and managers and analyze different aspects of innovation strategy. We conclude with reporting the results of implementing this model in the case company and with recommendations for other manufacturing and production companies aspire to be innovative.
Empiric anti-Candida therapy for patients with sepsis in the ICU: how little is too little?
Yoav Golan
Critical Care , 2009, DOI: 10.1186/cc7977
Abstract: In their article in Critical Care, Zilberberg and colleagues examine the cost-effectiveness of empiric anti-Candida treatment for ICU patients with sepsis [1]. Over the past decade, Candida has emerged as an invasive pathogen in many ICUs [2-4]. The case-fatality rate for Candida blood-stream infections is substantially higher than that for bacterial blood-stream infections [5]. Exploring the reasons for such a trend, Kumar and colleagues [6] compared a large number of severe sepsis episodes caused by bacteria or Candida. Despite their high severity of illness and in contrast to patients with bacterial sepsis, most of those with Candida sepsis did not receive effective treatment within 24 hours of hypotension. Although the overall case-fatality rate was higher among those with Candida sepsis, the case-fatality rate among those who received early anti-Candida therapy was substantially lower and comparable to that seen in bacterial sepsis [6]. These data suggest that the early initiation of empiric anti-Candida treatment is life saving.The initiation of empiric anti-Candida therapy to patients with sepsis represents a tradeoff. On one hand, it can increase the survival rate among those infected with Candida. On the other hand, it increases costs and, possibly, the risk of drug-related toxicity, drug-drug interactions, and emergence of antifungal resistance [7]. Clinicians caring for ICU patients with sepsis frequently wonder in which circumstances is the administration of an empiric anti-Candida agent advisable? Which agent is most attractive? Similar to other clinical questions, the best experimental design to evaluate treatment strategies is the clinical trial. But like any trial that evaluates an empiric strategy, the required sample size, and, therefore, the cost and ability to enroll enough patients, are often prohibitive. When data from clinical trials are not available, an alternative research design needs to be utilized.Decision analysis is used to compare the
Ready, Willing and Able
Moria Golan
Motivational Interviewing : Training, Research, Implementation, Practice , 2012, DOI: 10.5195/mitrip.2012.16
A comparison of Monte Carlo generators
Tomasz Golan
Physics , 2014, DOI: 10.1063/1.4919467
Abstract: A comparison of GENIE, NEUT, NUANCE, and NuWro Monte Carlo neutrino event generators is presented using a set of four observables: protons multiplicity, total visible energy, most energetic proton momentum, and $\pi^+$ two-dimensional energy vs cosine distribution.
Groups with Tarski number 5
Gili Golan
Mathematics , 2014,
Abstract: The Tarski number of a non-amenable group G is the minimal number of pieces in a paradoxical decomposition of G. Until now the only numbers which were known to be Tarski numbers of some groups were 4 and 6. We construct a group with Tarski number 5 and mention a related result for Tarski numbers of group actions.
Tarski numbers of group actions
Gili Golan
Mathematics , 2014,
Abstract: The Tarski number of an action of a group G on a set X is the minimal number of pieces in a paradoxical decomposition of it. For any k>3 we construct a faithful transitive action of a free group of rank k-1 with Tarski number k. Using similar techniques we construct a group action of a free group F with Tarski number 6 such that the Tarski numbers of restrictions of this action to finite index subgroups of F are arbitrarily large.
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