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Search Results: 1 - 10 of 6347 matches for " Amir Hossein Siadat and Elaheh HaftBaradaran "
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Treatment of Recalcitrant Electrical Burn Ulcer with Application of Topical Trichloroacetic Acid and Autologous Cultured Fibroblast
Mohammad Ali Nilforoushzadeh, Mohhamad Hossein Nasr Esfahani, Mehr Afarin Fesharaki, Amir Hossein Siadat and Elaheh HaftBaradaran
Cell & Tissue Transplantation & Therapy , 2012, DOI: 10.4137/CTTT.S3779
Abstract: In this case report, we present a case of deep, partial-thickness, recalcitrant electrical burn ulcer that was healed completely using tissue debridement with topical 50% TCA (Trichloroacetic acid) and application of autologous fibroblasts. To the best of our knowledge, this is the first time that the application of topical TCA along with autologous fibroblasts have been used for the treatment of an electrical burn ulcer with a satisfactory result.
Dermatology case diagnosis
Amir Hossein Siadat,Neda Adibi,Mohhamad Ali NilfroushZadeh,Parvin Rajabi
Journal of Research in Medical Sciences , 2007,
Abstract: A patient with multiple subcutaneous mobile lesions limited to forearms is presented. Pathologic review of the biopsy confirmed the diagnosis.
Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy
Elaheh Konoz,Amir Hossein Mohsen Sarrafi,Marjaneh Samadizadeh,Samaneh Boreiri
Journal of Chemistry , 2012, DOI: 10.1155/2012/914974
Abstract: A Fourier transform infrared (FTIR) spectrophotometric method was development for the rapid, direct measurement of lorazepam in different pharmaceutical products. The method involves the off-line extraction of lorazepam with sonication and direct determination in the extract through peak height measurement in the 1704 cm-1 using a baseline correction between 1850 and 1550 cm-1. For standardization an external calibration line established from standard solutions of lorazepam in chloroform were used. The method provides a limit of detection of 0.0030 mg per tablet (n=5), a relative standard deviation (RSD) of 2.65% for 5 independent measurement of standard solution at a concentration level of 1 mgg-1. Result obtained by FTIR agrees with those obtained by a reference methodology based on ultraviolet spectrometry and thus the developed procedure offers a good alternative for the determination of lorazepam in commercial products.
Quantitative Analysis of Lorazepam in Pharmaceutical Formulation Through FTIR Spectroscopy
Elaheh Konoz,Amir Hossein Mohsen Sarrafi,Marjaneh Samadizadeh,Samaneh Boreiri
Journal of Chemistry , 2012, DOI: 10.1155/2012/914974
Abstract: A Fourier transform infrared (FTIR) spectrophotometric method was development for the rapid, direct measurement of lorazepam in different pharmaceutical products. The method involves the off-line extraction of lorazepam with sonication and direct determination in the extract through peak height measurement in the 1704 cm-1 using a baseline correction between 1850 and 1550 cm-1. For standardization an external calibration line established from standard solutions of lorazepam in chloroform were used. The method provides a limit of detection of 0.0030 mg per tablet (n=5), a relative standard deviation (RSD) of 2.65% for 5 independent measurement of standard solution at a concentration level of 1 mgg-1. Result obtained by FTIR agrees with those obtained by a reference methodology based on ultraviolet spectrometry and thus the developed procedure offers a good alternative for the determination of lorazepam in commercial products.
Treatment of atrophic cutaneous leishmaniasis scar using autologous fibroblasts and keratinocytes (a case report and literature review):
Mohammad Ali Nilforoushzadeh,Mohhamad Hossein Nasr Esfahani,Mehr Afarin Fesharaki,Amir Hossein Siadat
Journal of Research in Medical Sciences , 2010,
Abstract: In this case report we present a case of wide, deep, atrophic cutaneous leishmaniasis scar that was improved significantly using injection of autologus fibroblasts, dermabrasion and dressing with autologus keratinocytes and fibroblasts. To our best knowledge, it is the first time that separate cultured fibroblasts and keratinocytes are used in conjunction with dermabrasion for treatment of cutaneous leishmaniasis scar. We have started this procedure as an extensive research on patients with leishmaniasis scar that will be reported in the future.
Understanding Requirement Engineering for Context-Aware Service-Based Applications  [PDF]
Seyed Hossein Siadat, Minseok Song
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.58062
Abstract: Requirements of software systems tend to change over time. The speed of this tendency depends on the application domain the software system under consideration belongs to. If we consider novel contexts such as pervasive systems and systems supporting dynamic B2B interaction, requirements change so fast that the research community is studying how to build systems that are able to self-adapt on the fly to some of these changes. When this happens, the system does not need to undergo through a new development cycle thus increasing its availability and, to a certain extent, its robustness. So far, the research in the area of self-adaptive systems has been focusing on the definition of the mechanisms for supporting self-adaptation. We argue that what is missing now is a structured and robust design process associated to these mechanisms. This design process should include a Requirement Engineering (RE) phase that somewhat differs from the traditional one. However, the identification of requirements for adaptation requires a good knowledge of the context in which the system will be executed. In this work, we consider the modeling of such context as part of the RE phase and we particularly focus on Service-Based Applications (SBAs). We argue that RE activities should be supported at run-time to handle context changes and to support adaptation for SBAs. We survey the state of the art for what concerns the elicitation, modeling, and analysis of requirements and will highlight some issues and challenges in order to support adaptation for SBAs.
The Efficacy of 5% Trichloroacetic Acid Cream in the Treatment of Cutaneous Leishmaniasis Lesions
elaheh haftbaradaran,mohammad ali nilforoushzadeh,Fariba Jaffary
Knowledge & Health Journal , 2010,
Abstract: Introduction: Cutaneous Leishmaniasis (CL) is an endemic parasitic disease in Iran. The residual unpleasant scar of this disease could be a potentially serious psychological threat to the patients. Based on the results of our previous study on the efficacy of trichloroacetic acid (TCA) in the treatment of CL, this study was designed to evaluate the effect of topical 5% TCA cream in the treatment of papulonodular leishmaniasis lesions. Methods: In this case series study, among the patients who were referred to skin disease and leishmaniasis research center(SDLRC), 16 patients with positive direct smear for leishmaniasis were randomly selected for treatment with 5% TCA cream or, twice a day for 8 weeks or up to complete healing(epithelization)of the lesions. At the end of the treatment period, the response rate was assessed as complete cure, partial cure or treatment failure. The size of the scar was measured 6 months after complete epithelization of the lesions. The data were analyzed using SPSS version 12. Results: The mean area of the lesions was 38.81± 81.9 mm2 before the treatment, and 3.6± 9.1 mm2 at 6 month follow up period. Complete cure was achieved in 1 patient (6.3%) at week 2, in 13 patients (86.7%) at week 7, and in all patients at week 8. There was no serious reaction in none of the patients. Only one patient had mild erythema at week 2 and edema at the application site at week 5 which completely was resolved within 2 weeks. Conclusion: Our results showed complete cure in all cases at week 8 without any serious side effects. Considering the efficacy of TCA in decreasing the size of the residual scar and its low cost compared to other treatments, 5% TCA cream could be considered as an alternative modality for intralesional glucantime in the treatment of CL. Further assessment as a double blind randomized clinical trial is warranted
Prevalence of cutaneous lesions , route of infection and distribution of lesions in HIV positive patients in Isfahan province in 1385
Mohammad Ali Nilforoushzadeh,Elaheh Haftbaradaran,Katayoon Tayeri
Dermatology and Cosmetic , 2010,
Abstract: "nBackground and aim: it has been estimated that 70000-100000 cases of HIV infection exist in Iran. The main route of transmission is intravenous drug (IV) injection. Rapid spread of this disease necessitates its prompt diagnosis. About 90% of HIV infected patients express cutaneous manifestations; therefore, recognition of these symptoms may be of help in early diagnosis."n"nMethods: HIV infected patients with suspected skin lesion were referred to Skin Disease and Leishmaniasis Research Center and were examined by an intern contributed in the study. All the information were gathered in data code sheets. Then, all of the patients were visited by the dermatologist for complementary examinations and the results including lesion type, location and duration were recorded in the check list."n"nResults: fifty persons were examined and 42 patients were selected. Prevalence of dermatologic manifestations was as follows: herpes zoster in 23.8%, seborrheic dermatitis in 14.3%, hyperpigmentation in 19%, oropharyngeal candidiasis in 14.3%, folliculitis in 14.3% dermatophytosis in 4.7%, wart in 4.7%, Kaposi’s sarcoma in 2.3%, and drug eruption in 2.3% , 75% of patient who had hyperpigmentation were infected by their sexual partner and 25% via IV injection. 33% of patient who had folliculitis were infected via IV injection, 33% through blood transfusion and 33% by sexual relationship."n"nConclusion: According to the results of this study, paying attention to cutaneous signs HIV/AIDS patients, their early detection and diagnostic and therapeutic measures for them are advocated.
Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis
Mohammad Nilforoushzadeh, Fariba Jaffary, Shahram Moradi, Roya Derakhshan, Elaheh Haftbaradaran
BMC Complementary and Alternative Medicine , 2007, DOI: 10.1186/1472-6882-7-13
Abstract: In a prospective clinical trial, 100 patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too. The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan – Mayer tests.In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime . Ten patients left out the study. In the glucantime alone treated group, 32 patients (71.1%) had complete cure whereas in the group treated with both glucantime & topical honey, 23 patients (51.1%) achieved complete cure. This difference was significant statistically (p = 0.04).Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed. We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis.Cutaneous leishmaniasis is still a large world problem [1]. Iran is one of the 7 important foci of leishmaniasis and Esfahan is one of the most important hyperendemic foci as annually 10–20 thousands of new cases of leishmaniasis are reported [2,3]. Many investigations are performed to find an effective, safe treatment for leishmaniasis. Pentavalent antimonials are still the mainstay of treating all forms of leishmaniasis. The most commonly used organic compounds of antimony are sodium antimony gluconate (SAG) and meglumine antimoniate (MA).Although the precise mechanism of action is not fully known, the antimonials are known to inhibit glycotic enzymes and fatty acid oxidation
Topical effectiveness of different concentrations of nanosilver solution on Leishmania major lesions in Balb/c mice
Mohammad Ali Nilforoushzadeh , Leila Shirani-Bidabadi , Azadeh Zolfaghari-Baghbaderani , Reza Jafari , Motahar Heidari-Beni , Amir Hossein Siadat & Mehdi Ghahraman-Tabrizi
Journal of Vector Borne Diseases , 2012,
Abstract: Background & objectives: Cutaneous leishmaniasis is an infection caused by protozoan genus Leishmania. Althoughglucantime is commonly used for the treatment of leishmaniasis, it has some side effects including increased liverenzymes and electrocardiogram changes. In addition, the drug is expensive, the injection is painful, and researchshows that resistance of parasite to glucantime is growing in different parts of the world. Therefore, scientists arepaying more attention to develop new drugs such as nanosilver solution. The present study is an attempt toevaluate the in vivo topical effects of different concentrations of nanosilver solution in the treatment of leishmaniasislesions.Methods: In all, 90 female Balb/c mice aged 6–8 wk were infected with 2×106 viable stationary-phase promastigotesin the base of tail. Different concentrations (60, 80, 120, 130 and 2000 ppm) nanosilver solution were used in thepresent study to test the efficacy in the treatment of lesions. Clinical control of the infection trends was conductedweekly for 5 wk by measuring lesion diameter with standard Kulis-Vernieh. Data were analyzed by paired t-test,analysis of variance (ANOVA), and Tukey test.Results: Mean lesion diameter pre- and post-treatment did not significantly differ between different treatmentgroups (p >0.05). Likewise, a significant difference in splenic parasite load was also not observed between differenttreatment groups.Interpretation & conclusion: Based on our results, different concentrations of nanosilver are ineffective in reducingmean sizes of lesions.
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