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Search Results: 1 - 10 of 149848 matches for " Amen H. Zaky "
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Self-Expandable Metal Stents in Palliation of Inoperable Esophageal & Gastro-Oesophageal Carcinoma
Ahmed A. S. Salem,Ashraf Al-yamany,Esam Abd-el Mohsen,Amen H. Zaky
Cancer and Clinical Oncology , 2012, DOI: 10.5539/cco.v1n1p159
Abstract: Background: Most of patients with carcinoma of the esophagus are inoperable at the time of presentation. The aim of this study was to evaluate the results of self expandable metal stents for the treatment of malignant dysphagia. Material & Methods: This study was conducted at Assiut University, Egypt from July 2009 to Dec 2011. Twenty Enrolled patients with grade 3 or 4 dysphagia due to inoperable carcinoma of the esophagus and gastro-oesophageal junction underwent Self Expandable Metal Stenting under endoscopic guidance. They were followed during all the study period. Dysphagia score will be calculated at baseline and at follow up according to Atkinson’s scale. Data were analyzed using SPSS version 16. Results: Mean age of patients was 55.5±15 years with male to female ratio of 3:2. Mean dysphagia score improved from 3.4 (pre-stent) to 1.07 (post-stent) (p <0.05). Improvement in dysphagia (conversion of grade 3 or 4 dysphagia into grade 1 or 0) was seen in 90% of patients. Eight patients required re-intervention after initial improvement for their stent blockage (40%) and two patients followed conservatively for stent migration (10%). Other minor complications like cough and regurgitation occurred in 10% and 40% patients respectively. Most patients experienced severe chest pain necessitating narcotic analgesics. One patient with pulmonary metastasis died within one week, three patients died within 3months, ten patients died within 1.5 years and six patients under flow-up until now. Conclusion: Self expandable metal stents are an effective method for palliation of dysphagia but not without complications.
The Prognostic Significance of Pre and Post Treatment Neutrophil to Lymphocyte Ratio in Breast Cancer Patients  [PDF]
Nehal A. Rayan, Amen H. Zaky, Hanan A. Eltyb, Ashraf Zeidan, Asmaa M. Zahran
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.107044
Abstract: Background: The neutrophil/lymphocyte ratio (NLR) has been reported to reflect systemic inflammation and independent prognostic significance in different types of cancer. In present study, we analyzed the association between NLR and clinicopathologic features and verified the significance of NLR as a prognostic factor for patients with breast cancer. Patients and Methods: A total of 388 patients with stage I - III breast cancer were retrospectively recruited into this study. Associations with clinicopathologic factors and NLR were assessed; disease-free survival and overall survival were estimated. Results: There was no significant association between NLR and clinicopathologic factors. Patients with low pre/post-treatment NLR had longer OS. Conclusion: A high pre/postoperative NLR may be considered an important factor for predicting poor prognosis in non-metastatic breast cancer patients.
Efficacy of Nilotinib versus Imatinib in Philadelphia Positive Patients with Chronic Myeloid Leukemia in Early Chronic Phase Who Have a Warning Molecular Response to Imatinib  [PDF]
Amen Hamdy Zaky Aly, Ahmed EL Sayed Mohammed Khalifa, Esraa Abdallah Abdelkariem Gadallah
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.911073
Abstract: Background and Objectives: Chronic myeloid leukemia (CML) accounts for approximately 15% of newly diagnosed cases of leukemia in adults. In this study, the efficacy of nilotinib at 400 mg BID is compared with imatinib at 400 mg BID in CML patients with suboptimal molecular response after at least 12 months of daily dose 400 mg of imatinib therapy. Patients and Methods: This study included a total number of 50 patients, divided into two groups (25 patients each). The first group (Group I): Patients received imatinib at 400 mg BID, second group (Group II): Patients had a suboptimal molecular response to imatinib and received nilotinib at 400 mg BID in early chronic phase. During the two years period of data collection, the primary end included median survival. The secondary end included response rate, type of response, duration of response and progression free survival. Also side effects were recorded. Patients were followed up every month by complete and differential blood counts, liver function test, renal function test and (PCR) every three months for two year. Results: Nilotinib group had significantly higher frequency of major molecular response (MMR) where 23 (92%) patients achieved it while only 16 (64%) patients in Imatinib group achieved MMR (P = 0.01). Nilotinib had better toxicities profile than Imatinib. Conclusion: Both Nilotinib and high dose Imatinib achieved response in CML patients with suboptimal response with rapid and deeper molecular response, better survival outcomes and less side effects in nilotinib.
Feasibility of Upfront Debulking Surgery versus Neoadjuvant Chemotherapy Followed by Interval Debulking Surgery for Advanced Ovarian Cancer  [PDF]
Amen Hamdy Zaky, Adel Gabr, Doaa Wadie Maximous, Ahmed A. S. Salem, Amr Farouk Mourad, Haisam Atta, Marwa Ismail
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.92015
Abstract: Background: Inappropriately ovarian cancer cannot be detected until an advanced stage. Radical debulking surgery is considered the cornerstone in the management of advanced ovarian cancer pointing to complete tumor resolution. Unless optimal debulking cannot be achieved, these patients gain little benefit from surgery. Neoadjuvant chemotherapy (NACT) has been recommended as a novel therapeutic modality to a diversity of malignant tumors when the disease is not willing to optimal surgical resection at the time of diagnosis or the patient who unfit for aggressive debulking surgery. The purpose of this study is to compare survival in the patient with advanced ovarian cancer (stage III/IV) underwent primary debulking surgery followed by adjuvant chemotherapy (PDS-ACTR) to those who received neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS). Results: Neoadjuvant chemotherapy (NACT-IDS) showed significant complete cytoreduction and decreased in surgical morbidity in comparison to primary debulking surgery (PDS-ACTR). NACT-IDS showed significant improvement in progression-free survival (P-value 0.002) and overall survival (P-value 0.03) in comparison to PDS-ACTR. Response to NACT and residual volume were the two independent prognostic factors for overall survival. Conclusion: NACT-IDS for advanced ovarian cancer (III/IV) resulted in higher frequency of
Late rising right ventricular pacing lead threshold four yearsafter implantation of a dual chamber pacemaker  [PDF]
H. Zaky, H. El Zein, A. Al-Mulla
Open Journal of Internal Medicine (OJIM) , 2011, DOI: 10.4236/ojim.2011.11001
Abstract: Late rising in pacing threshold is an uncommon complication of permanent pacing. Treatment with high dose systemic steroid could spare the patient another procedure. We report a case of late rising pacing threshold that responded to high dose sys-temic steroid which lowered the pacing threshold to one volt, then rose again to around 2 volts.
Impact of the Changes in Women’s Characteristics over Time on Antenatal Health Care Utilization in Egypt (2000-2008)  [PDF]
Hassan H. M. Zaky, Dina M. Armanious, Mohamed Ali Hussein
Open Journal of Obstetrics and Gynecology (OJOG) , 2015, DOI: 10.4236/ojog.2015.510078
Abstract: Objectives: This study empirically assesses the impact of the changes in women’s characteristics, empowerment, availability and quality of health services on woman’s decision to use antenatal care (ANC) and the frequency of that use during the period 2000-2008. Study Design: The study is a cross-sectional analytical study using 2000 and 2008 Egypt Demographic and Health Surveys. Methods: The assessment of the studied impact is conducted using the Zero-inflated Negative Binomial Regression. In addition, Factor Analysis technique is used to construct some of the explanatory variables such as women’s empowerment, the availability and quality of health services indicators. Results: Utilization of antenatal health care services is greatly improved from 2000 to 2008. Availability of health services is one of the main determinants that affect the number of antenatal care visits in 2008. Wealth index and quality of health services play an important role in raising the level of antenatal care utilization in 2000 and 2008. However, the impact of the terminated pregnancy on receiving ANC increased over time. Conclusions: Further research of the determinants of antenatal health care utilization is needed, using more updated measures of women’s empowerment, availability and quality of health services. In order to improve the provision of antenatal health care services, it is important to understand barriers to antenatal health care utilization. Therefore, it is advisable to collect information from women about the reasons for not receiving antenatal care.
Determinants of Antenatal Health Care Utilization in Egypt (2000-2014) Using Binary and Count Outcomes  [PDF]
Hassan H. M. Zaky, Dina M. Armanious, Mohamed Ali Hussein
Health (Health) , 2019, DOI: 10.4236/health.2019.111004
Abstract: Aim: This study seeks to investigate the factors determining the utilization of antenatal care services, the frequency of that use, and the timing of receiving antenatal care among Egyptian women utilizing a national representative data from Egypt Demographic and Health Surveys (EDHS) in 2000 and 2014. Methods: The paper estimates the logistic regression model, zero-inflated negative binomial model (ZINB), and negative binomial regression model (NB) to identify the most important determinants of antenatal health care utilization. Results: The findings indicate that the period 2000-2014 has experienced a significant increase in the use of antenatal health care services. The use of the public sector antenatal care services relative to that of the private sector has been decreasing over time. Moreover, wealth index, women’s education and quality of health services play significant roles in increasing accessibility of antenatal health care services. On the other hand, women’s empowerment has shown a positive effect in 2000 only. Conclusion: The study highlights the most vulnerable groups that are less likely to have access to antenatal health care services, mainly women who are less educated, poor and living in rural areas especially Upper Egypt. This certainly requires a more targeted health strategy with an equity lens.
Cutaneous Metastases from DifferentInternal Malignancies in Egypt
Amen Hamdy Zaky,Mostafa Elsayed Abd El-Wanis,Hisham Hamza,Hisham Zayan Abdel-Hafez
Middle East Journal of Cancer , 2010,
Abstract: Background:Cutaneous metastasis is defined as the spread of malignant cells froma primary malignancy to the skin. Generally, cutaneous involvement from internal malignancies is uncommon. No reports have focused on the cutaneous metastasis profiles in Egypt or the Middle Eastern population. In this study, we seek to determine the rates at which different internal malignancies give rise to cutaneous metastases upon first diagnosis of the primary tumor.Methods:Patients with internal malignancies who attended the South Egypt Cancer Institute from January 2004 through May 2010 were examined and followed to identify cutaneous metastases, which were confirmed by biopsy and histological evaluation.Results:Among 2208 cases of internal malignancies, 48 cases of cutaneous metastases were detected. The clinical profiles were similar to those from western and Asian countries, although the frequencies of primary tumors differed. Most commonly in Egypt breast cancer and urinary bladder cancers were seen.Conclusion:The risk of skin metastases depends largely on the characteristics of tumor cells, which are similar among different groups.
Preoperative Versus Postoperative Radiation Therapy in Patients with Soft Tissue Sarcomas
Mohamed Ibrahim El-sayed,Doaa Wadie Maximos,Mostafa El-sayed Abdel-wanis,Amen Hamdy Zaky
Cancer and Clinical Oncology , 2012, DOI: 10.5539/cco.v1n2p36
Abstract: Purpose: To evaluate treatment outcome and to determine whether or not the timing of radiotherapy (RT) was associated with any difference in disease relapse, survival, or incidence of complications in patients with soft tissue sarcomas (STS). Methods: The medical files of 63 patients with a primary, nonmetastatic, STS, treated with surgery and irradiation were evaluated. Data regarding tumor stage, grade, site, dosage and timing of radiotherapy, treatment complications, disease relapse, and disease-free (DFS) and overall survival (OAS) rates were analyzed. Results: The median follow up was 47 months (range; 5-66 months). Four-year OAS and DFS rates were 82.6% and 78.8% respectively. There were significant higher 4-year OAS (p = 0.024) and DFS (p = 0.011) rates in patients with stage I and II diseases than those in patients with stage III disease. On the other hand, there were no significant differences in 4-year OAS (p = 0.83, HR: 0.743, 95% CI: 0.165 to 3.345) and DFS (p = 0.64, HR: 0.74, 95% CI: 0.21 to 2.61) rates between preoperative and postoperative RT patients. Disease relapse for preoperative versus postoperative RT patients was not statistically different (p = 0.41). Wound complications were more frequent in preoperative RT patients (25%) compared to postoperative RT patients (8%) (p = 0.0566 chi-square). Conclusions: Preoperative irradiation has not a positive impact on survival or disease relapse rates, but is associated with high wound complication rate.
Characteristics of Antioxidant Isolated from Some Plant Sources  [PDF]
A. A. El Bedawey, E. H. Mansour, M. S. Zaky, Amal A. Hassan
Food and Nutrition Sciences (FNS) , 2010, DOI: 10.4236/fns.2010.11002
Abstract: Antioxidant characteristics of ginger roots, guava leaves, guava seeds, orange peel, sesame coat, rice bran and wheat germ as affected by ethanol, ethyl acetate, chloroform, hexane and petroleum ether were evaluated. Petroleum ether extract of ginger roots, ethanol extracts of guava leaves, guava seeds, orange peel and sesame coat and ethyl acetate extracts of rice bran and wheat germ appeared to possess higher antioxidant activity than those from other solvents. Ginger roots, orange peel and guava leaves exhibited higher antioxidant activity than that of α-tocopherol, while guava seeds, sesame coat, rice bran and wheat germ had lower antioxidant activity than that of α-tocopherol. Guava leaves extract had the highest total phenolics content among the other plant material extracts followed by ginger roots, sesame coat and orange peel extracts. However, total flavonoids content was the highest in ginger roots extract followed by guava leaves extract. Ferulic was the highest phenolic compounds in guava leaves and sesame coat extracts. However, chlorogenic acid was the highest phenolic compounds in ginger roots extract. Antioxidants in ginger roots, guava leaves and sesame coat extracts as well as α-tocopherol were heat stable with 73.1, 73.8, 66.7 and 71.6% activity, respectively, after heating at 100°C for 180 min. Induction periods of sunflower oil containing 2% guava leaves and 2% ginger roots extracts were increased by 230.6% and 226.7%, respectively. However, induction period of sunflower oil containing sesame coat was increased by 174.1%, at 0.5% concentration. Similar increment was found for the protection factor. Ginger roots, guava leaves and sesame coat might be promising sources of natural antioxidant to be used in food products.
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