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Search Results: 1 - 10 of 363 matches for " Amelie Bouchard "
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Comparative vascular responses three months after paclitaxel and everolimus-eluting stent implantation in streptozotocin-induced diabetic porcine coronary arteries
Alexander Sheehy, Steven Hsu, Amelie Bouchard, Pablo Lema, Claudine Savard, Louis-Georges Guy, Julie Tai, Igor Polyakov
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-75
Abstract: Twelve Yucatan swine were induced hyperglycemic with a single STZ dose intravenously to ablate pancreatic β-cells. After two months, each animal received one XIENCE V? (EES) and one Taxus Liberte (PES) stent, respectively, in each coronary artery. After three months, vascular healing was assessed by angiography and histomorphometry. Comparative in vitro effects of everolimus and paclitaxel (10-5?M–10-12?M) after 24 hours on carotid endothelial (EC) and smooth muscle (SMC) cell viability under hyperglycemic (42?mM) conditions were assayed by ELISA. Caspase-3 fluorescent assay was used to quantify caspase-3 activity of EC treated with everolimus or paclitaxel (10-5?M, 10-7?M) for 24 hours.After 3?months, EES reduced neointimal area (1.60?±?0.41?mm, p?<?0.001) with trends toward reduced % diameter stenosis (11.2?±?9.8%, p?=?0.12) and angiographic late-loss (0.28?±?0.30?mm, p?=?0.058) compared to PES (neointimal area: 2.74?±?0.58?mm, % diameter stenosis: 19.3?±?14.7%, late loss: 0.55?±?0.53?mm). Histopathology revealed increased inflammation scores (0.54?±?0.21 vs. 0.08?±?0.05), greater medial necrosis grade (0.52?±?0.26 vs. 0.0?±?0.0), and persistently elevated fibrin scores (1.60?±?0.60 vs. 0.63?±?0.41) with PES compared to EES (p?<?0.05). In vitro, paclitaxel significantly increased (p?<?0.05) EC/SMC apoptosis/necrosis at high concentrations (≥10-7?M), while everolimus did not affect EC/SMC apoptosis/necrosis within the dose range tested. In ECs, paclitaxel (10-5?M) significantly increased caspase-3 activity (p?<?0.05) while everolimus had no effect.After 3?months, both DES exhibited signs of delayed healing in a STZ-induced diabetic swine model. PES exhibited greater neointimal area, increased inflammation, greater medial necrosis, and persistent fibrin compared to EES. Differential effects of everolimus and paclitaxel on vascular cell viability may potentially be a factor in regulating delayed healing observed with PES. Further investigation of molecular mechanisms
Development and Preliminary Validation of the Shared Professional Leadership Inventory for Teams (SPLIT)  [PDF]
Amelie Grille, Simone Kauffeld
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.61008
Abstract: Shared leadership is viewed as an effective management form to encounter increased complexity in modern work life. However, the lack of reliable and valid instruments to assess shared leadership behaviors has limited empirical research. Based on literature in leadership and team work research a questionnaire was developed to assess four different aspects of shared leadership behavior—task-, relation-, change- and micropolitic-oriented leadership. The final version consisted of 20 items. Confirmatory factor analyses confirmed the theoretically hypothesized model in two independent German samples. Significant correlations with related scales support convergent and criterion validity. This study therefore provides researchers with a valid and reliable instrument to assess different aspects of shared leadership behavior and its advantages for research and human resource development are discussed.
L'aube des Lumières dans les pays roumains
Jacques Bouchard
Historical Review , 2008,
Abstract: En y introduisant le concept de l'aube des Lumières, l'auteur propose une périodisation des Lumières dans les pays roumains qui remet en question la périodisation des Lumières chez les Grecs. La Frühaufkl rung (1680-1780) s'avère une conjoncture de forces progressistes qui pr nent la modernisation de l'appareil étatique, des institutions, de la langue et de l'éducation. L'auteur y distingue quatre périodes: 1. l'église triomphante (1680-1710); 2. l'Absolutisme raisonné (1710-1730); 3. le Despotisme éclairé (1730-1780) et 4. l'église militante (1695-1780). L'Aufkl rung proprement dite ne commence qu'en 1780: elle aspire à réaliser en plus l'émancipation nationale et l'indépendance politique.
Butler, Judith. _Ces corps qui comptent_.
Sylvie Bouchard
Voix Plurielles , 2011,
Abstract: Compte rendu
Trevor Bennett and Katy Holloway, Drug-Crime Connections. Cambridge Studies in Criminology. New York: Cambridge University Press, 2007, 362 pp. $US 32.99 paper (978- 0-521-68714-0), $US 85.00 hardcover (978-0-521-86757-3)
Martin Bouchard
The Canadian Journal of Sociology , 2008,
Abstract:
No-arbitrage in discrete-time markets with proportional transaction costs and general information structure
Bruno Bouchard
Mathematics , 2005,
Abstract: We discuss the no-arbitrage conditions in a general framework for discrete-time models of financial markets with proportional transaction costs and general information structure. We extend the results of Kabanov and al. (2002), Kabanov and al. (2003) and Schachermayer (2004) to the case where bid-ask spreads are not known with certainty. In the "no-friction" case, we retrieve the result of Kabanov and Stricker (2003).
Portfolio management under risk contraints - Lectures given at MITACS-PIMS-UBC Summer School in Risk Management and Risk Sharing
Bruno Bouchard
Mathematics , 2013,
Abstract: The aim of these lectures at MITACS-PIMS-UBC Summer School in Risk Man- agement and Risk Sharing is to discuss risk controlled approaches for the pricing and hedging of financial risks. We will start with the classical dual approach for financial markets, which al- lows to rewrite super-hedging problems in terms of optimal control problems in standard form. Based on this, we shall then consider hedging and pricing prob- lems under utility or risk minimization criteria. This approach will turn out to be powerful whenever linear (or essentially linear) problems are considered, but not adapted to more general settings with non-linear dynamics (e.g. large investor models, high frequency trading with market impact features, mixed finance/insurance issues). In the second part of this lecture, we will develop on a new approach for risk control problems based on a stochastic target formulation. We will see how flexible this approach is and how it allows to characterize very easily super- hedging prices in term of suitable Hamilton-Jacobi-Bellman type partial differ- ential equations (PDEs). We will then see how quantile hedging and expected loss pricing problems can be embeded into this framework, for a very large class of financial models. We shall finally consider a simple example of optimal book liquidation in which the control is a continuous non-decreasing process, as an illustration of possible practical developments in optimal trading under risk constraint.These lectures are organized in small chapters, each of them being focused on a particular aspect.
Novel Peptide-Mediated Interactions Derived from High-Resolution 3-Dimensional Structures
Amelie Stein,Patrick Aloy
PLOS Computational Biology , 2010, DOI: 10.1371/journal.pcbi.1000789
Abstract: Many biological responses to intra- and extracellular stimuli are regulated through complex networks of transient protein interactions where a globular domain in one protein recognizes a linear peptide from another, creating a relatively small contact interface. These peptide stretches are often found in unstructured regions of proteins, and contain a consensus motif complementary to the interaction surface displayed by their binding partners. While most current methods for the de novo discovery of such motifs exploit their tendency to occur in disordered regions, our work here focuses on another observation: upon binding to their partner domain, motifs adopt a well-defined structure. Indeed, through the analysis of all peptide-mediated interactions of known high-resolution three-dimensional (3D) structure, we found that the structure of the peptide may be as characteristic as the consensus motif, and help identify target peptides even though they do not match the established patterns. Our analyses of the structural features of known motifs reveal that they tend to have a particular stretched and elongated structure, unlike most other peptides of the same length. Accordingly, we have implemented a strategy based on a Support Vector Machine that uses this features, along with other structure-encoded information about binding interfaces, to search the set of protein interactions of known 3D structure and to identify unnoticed peptide-mediated interactions among them. We have also derived consensus patterns for these interactions, whenever enough information was available, and compared our results with established linear motif patterns and their binding domains. Finally, to cross-validate our identification strategy, we scanned interactome networks from four model organisms with our newly derived patterns to see if any of them occurred more often than expected. Indeed, we found significant over-representations for 64 domain-motif interactions, 46 of which had not been described before, involving over 6,000 interactions in total for which we could suggest the molecular details determining the binding.
Contextual Specificity in Peptide-Mediated Protein Interactions
Amelie Stein, Patrick Aloy
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002524
Abstract: Most biological processes are regulated through complex networks of transient protein interactions where a globular domain in one protein recognizes a linear peptide from another, creating a relatively small contact interface. Although sufficient to ensure binding, these linear motifs alone are usually too short to achieve the high specificity observed, and additional contacts are often encoded in the residues surrounding the motif (i.e. the context). Here, we systematically identified all instances of peptide-mediated protein interactions of known three-dimensional structure and used them to investigate the individual contribution of motif and context to the global binding energy. We found that, on average, the context is responsible for roughly 20% of the binding and plays a crucial role in determining interaction specificity, by either improving the affinity with the native partner or impeding non-native interactions. We also studied and quantified the topological and energetic variability of interaction interfaces, finding a much higher heterogeneity in the context residues than in the consensus binding motifs. Our analysis partially reveals the molecular mechanisms responsible for the dynamic nature of peptide-mediated interactions, and suggests a global evolutionary mechanism to maximise the binding specificity. Finally, we investigated the viability of non-native interactions and highlight cases of potential cross-reaction that might compensate for individual protein failure and establish backup circuits to increase the robustness of cell networks.
Disk Galaxy Scaling Relations in the SFI++: Intrinsic Scatter and Applications
Amelie Saintonge,Kristine Spekkens
Physics , 2010, DOI: 10.1088/0004-637X/726/2/77
Abstract: We study the scaling relations between the luminosities, sizes, and rotation velocities of disk galaxies in the SFI++, with a focus on the size-luminosity (RL) and size-rotation velocity (RV) relations. Using isophotal radii instead of disk scale-lengths as a size indicator, we find relations that are significantly tighter than previously reported: the correlation coefficients of the template RL and RV relations are r=0.97 and r=0.85, which rival that of the more widely studied LV (Tully-Fisher) relation. The scatter in the SFI++ RL relation is 2.5-4 times smaller than previously reported for various samples, which we attribute to the reliability of isophotal radii relative to disk scale-lengths. After carefully accounting for all measurement errors, our scaling relation error budgets are consistent with a constant intrinsic scatter in the LV and RV relations for velocity widths logW>2.4, with evidence for increasing intrinsic scatter below this threshold. The scatter in the RL relation is consistent with constant intrinsic scatter that is biased by incompleteness at the low-luminosity end. Possible applications of the unprecedentedly tight SFI++ RV and RL relations are investigated. Just like the Tully-Fisher relation, the RV relation can be used as a distance indicator: we derive distances to galaxies with primary Cepheid distances that are accurate to 25%, and reverse the problem to measure a Hubble constant H_0=72+/-7 km/s/Mpc. Combining the small intrinsic scatter of our RL relation (0.034+/-0.001 log(kpc/h)) with a simple model for disk galaxy formation, we find an upper limit on the range of disk spin parameters that is a factor of ~7 smaller than that of the halo spin parameters predicted by cosmological simulations. This likely implies that the halos hosting Sc galaxies have a much narrower distribution of spin parameters than previously thought.
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