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Search Results: 1 - 10 of 431 matches for " Amber Watters "
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Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer
Ruben Rene Gonzalez, Amber Watters, Yanbo Xu, Udai P Singh, David R Mann, Bo R Rueda, Manuel L Penichet
Breast Cancer Research , 2009, DOI: 10.1186/bcr2321
Abstract: To test the contribution of leptin signaling to BC growth and expression of leptin-targeted molecules, PEG-LPrA2 treatment was applied to severe immunodeficient mice hosting established ER+ (MCF-7 cells; ovariectomized/supplemented with estradiol) and ER- (MDA-MB231 cells) BC xenografts. To further assess leptin and PEG-LPrA2 effects on ER+ and ER- BC, the expression of VEGF and VEGFR2 (protein and mRNA) was investigated in cell cultures.PEG-LPrA2 more effectively reduced the growth of ER+ (>40-fold) than ER- BC (twofold) and expression of pro-angiogenic (VEGF/VEGFR2, leptin/leptin receptor OB-R, and IL-1 receptor type I) and pro-proliferative molecules (proliferating cell nuclear antigen and cyclin D1) in ER+ than in ER- BC. Mouse tumor stroma in ER+ BC expressed high levels of VEGF and leptin that was induced by leptin signaling. Leptin upregulated the transcriptional expression of VEGF/VEGFR2 in MCF-7 and MDA-MB231 cells.These results suggest that leptin signaling plays an important role in the growth of both ER+ and ER- BC that is associated with the leptin regulation of pro-angiogenic and pro-proliferative molecules. These data provide support for the potential use of leptin-signaling inhibition as a novel treatment for ER+ and ER- BC.Leptin is a small nonglycosylated protein (16 kDa) product of the ob gene. White adipose tissue is the primary source of leptin in benign tissue, but leptin is also expressed and secreted by cancer cells [1]. Leptin exclusively binds to its receptor, OB-R. Several isoforms of OB-R are found in diverse tissues and in cancer cells including the long isoform, OB-Rb [2,3]. Upon leptin activation, the OB-R isoforms can utilize a number of diverse signaling pathways relevant to cancer growth [4,5]. The well-documented biological actions of leptin at the hypothalamic level occur through OB-Rb signals that are linked to the control of appetite and energy balance [4].Evidence is mounting to support the idea that leptin is the link between
A americaniza o da doen a mental
Ethan Watters
Revista Latinoamericana de Psicopatologia Fundamental , 2010, DOI: 10.1590/s1415-47142010000100007
Abstract:
Climate Change Associated with Global Teleconnections, Volcanic Eruptions, and the Arctic’s Snow-Ice Albedo in Godthab, Greenland  [PDF]
Amber Penner, Jacqueline Binyamin
Atmospheric and Climate Sciences (ACS) , 2013, DOI: 10.4236/acs.2013.31005
Abstract:

To study the impact of climate change on Godthab(Greenland), temperature and precipitation gathered from the Global Historical Climatology Network (GHCN) were analyzed for patterns within 1866-2011. Both temperature and precipitation have experienced an overall increase throughout the past 146 years. Precipitation, however, has experienced a declining trend since 1985. North Atlantic Oscillation (NAO) and Arctic Oscillation (AO) indices showed strong correlations with average annual temperature (R = ?0.6) and smaller correlations with annual total precipitation (R = ?0.2). There are moderate correlations between temperature, precipitation, and Southern-Oscillation Index (SOI). The positive phases of Pacific-North American (PNA) led to increased winter and spring precipitation. The climate mode’s influential strength on Godthab’s temperature and precipitation, vary seasonally. In contrast with global average temperatures, Greenland has not experienced a continual warming trend since the 1950s; 30- and 10-year trends show a cooling period between 1965 and 1995. From 1866 to 2011, Godthab’s average annual temperature has increased by 1.9?C, and is anticipated to continue to warm in accordance with the global warming trend and the Arctic’s associated feedback mechanisms.

Efficient isolation of live microglia with preserved phenotypes from adult mouse brain
Maria Nikodemova, Jyoti J Watters
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-147
Abstract: After enzymatic digestion of brain tissues and myelin removal, CD11b+ cells were isolated using immunomagnetic separation, yielding highly purified microglia without astrocyte or neuronal contamination. We used three methods of myelin removal (30% Percoll, 0.9?mol/l sucrose and anti-myelin magnetic beads), and compared their effects on microglial viability and yield. To determine whether the isolation procedure itself activates microglia, we used flow cytometry to examine microglial properties in brain-tissue homogenates and isolated microglia from control and lipopolysaccharide (LPS) -treated mice.This method yielded a highly purified CD11b+ cell population with properties that reflected their in vivo phenotype. The viability and yield of isolated cells were significantly affected by the myelin removal method. Although the microglial phenotype was comparable in all methods used, the highest viability and number of CD11b+ cells was obtained with Percoll. Microglia isolated from LPS-treated mice displayed a pro-inflammatory phenotype as determined by upregulated levels of TNF-α, whereas microglia isolated from control mice did not.Immunomagnetic separation is an efficient method to isolate microglia from the CNS, and is equally suitable for isolating quiescent and activated microglia. This technique allows evaluation of microglial activities ex vivo, which accurately reflects their activities in vivo. Microglia obtained by this method can be used for multiple downstream applications including qRT-PCR, ELISA, Western blotting, and flow cytometry to analyze microglial activities in any number of CNS pathologies or injuries.
SHIFTING ALLIANCES: RECIPROCAL RELATIONSHIPS DURING TIMES OF ECONOMIC HARDSHIP IN URBAN BOLIVIA
Wutich,Amber;
Chungará (Arica) , 2011, DOI: 10.4067/S0717-73562011000100012
Abstract: recent research indicates that urban reciprocity, a survival strategy used by the urban poor to self-insure against economic risks, has been eroded by deepening poverty and economic insecurity. this paper examines how the urban poor maintain reciprocal relationships in villa israel, a periurban settlement located on the outskirts of the city of cochabamba, bolivia. the results indicate that, while some reciprocal relationships do appear to be in decline, others have been transformed in ways that enhance security for participants. in particular, there appears to have been a shift away from reciprocal relationships formed on the basis of compadrazgo (ritual godparenthood) and "paisanidad" (shared origin) and toward those formed around commerce and evangélico (protestant or evangelical) churches.
“AZTECS”, Royal Academy of Arts, London, 16th November 2002 - 11th April 2003. A Comment on Communicative Shortcomings
Amber Standifer
Papers from the Institute of Archaeology , 2003, DOI: 10.5334/pia.195
Abstract:
Personality at Work: A Study of Type A-B
Amber Raza
Market Forces , 2007,
Abstract: The objective of this study was to measure the impact of stressors on personality types in Call Centers. Based on literature survey five potential workplace stressors were identified, namely (1) Task Demands, (2) Role Demands, (3) Interpersonal Demands, (4) Organizational Structure and (5) Organizational Leadership. Based on the literature survey, a relationship model was developed that was inclusive of the above stressors, and three personality types, which were Type A, Type AB and Type B.The sample size for the study was 100. The subjects were supervisors and agents drawn non-randomly from various Call Centers of Karachi. All the subjects completed a questionnaire comprised of 27 questions based on occupational stress index (Srivasta and Singh 1981) and AB Personality Continuum (National Institute of Safety and Health 1975). The three personality types A, B & AB all go through stress, however it is the Type A, which thrives on stress. The sources of stress measured in the study were Task Demand, Role Demand, Interpersonal Demands, Organizational Structure and Organizational Leadership.The stressor that most contributed to the Personality type A’s stress in the study was Interpersonal Demand (0.38), which is justified by the literature review as Personality type A are not team players and prefer to work alone.Whereas Personality type B was stressed because of Role Demand (0.38) which is also proved by the literature review as personality type B are laid back and do not take there roles seriously. Hence it can be concluded that it type A tends to cope well with stress as compared to type AB and type B. The performance of the respondents can be made better if the supervisors are aware of the personality types and thereby motivate them according.
Monsivais Writes the (Bi)centennial
Amber Workman
Rupkatha Journal on Interdisciplinary Studies in Humanities , 2010,
Abstract: Despite his participation in many of the festivities and events related to the (Bi)centennial, CarlosMonsiváis was one of the most direct critics of the commemorations of the initiation of MexicanIndependence and the Mexican Revolution. However, in his literary chronicles to date, many ofthe author’s disagreements do not appear; instead, these writings show two general tendencies:1) the tendency to postpone the (Bi)centennial to another year or transform the festivities intocelebrations of something else; and 2) the tendency to mask the author’s own preferences, thatis, to not take sides in his chronicles on the commemorations. The article inserts Monsiváis’schronicles into a “tradition” of “commemoratory chronicling” and suggests some possible reasonsfor their somewhat unusual treatment of Mexico’s (bi)centennial celebrations.
Indigenous plants: a golden opportunity for discovery
Amber Farooqui
Journal of Infection in Developing Countries , 2007,
Abstract: Microbiologists and infectious disease experts are alarmed by the fact that effective antibiotics will not be available to treat severely ill patients in the near future because of the increasing emergence of antibiotic resistance. This threat is especially worrisome with regard to our lack of ability to combat multidrug resistant bacterial infections. This situation necessitates the development of new antimicrobial agents and their synergistic combinations. From conception of the idea to rational drug design, drug development is a decade-long process which requires the tireless efforts of scientists.
Margot Young, Susan B. Boyd, Gwen Brodsky, and Shelagh Day, eds., Poverty: Rights, Social Citizenship, and Legal Activism. Law and Society Series. Vancouver: University of British Columbia Press, 2007, 389 pp. $29.95 paper (978-0-77481-288-7), $85.00 hardcover (978-0-7748-1287- 0)
Amber Gazso
The Canadian Journal of Sociology , 2008,
Abstract:
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