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Search Results: 1 - 10 of 223638 matches for " Amatur R. Amarah "
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Hypoglycemic myocardial stunning as cause of cardiogenic shock in a patient with ischemic cardiomyopathy: A case report and review of literature  [PDF]
Khawar Maqsood, Ghazi Mirrani, Nosheen Sarwar, Amatur R. Amarah, Muhammad Rizwan Sardar, Timothy A. Shapiro
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.21024
Abstract:

Hypoglycemia is a common complication seen in patients with diabetes mellitus and has been proven to have adverse effects on cardiovascular mortality. Hypoglycemia can potentially lead to worsening of cardiac function in patients with ischemic heart disease. We present a case of cardiogenic shock in a patient with hypoglycemia secondary to insulin accumulation due to worsening renal function with dramatic recovery of shock once his sugars normalized.

Liraglutide in the management of type 2 diabetes
Estela Wajcberg, Amatur Amarah
Drug Design, Development and Therapy , 2010, DOI: http://dx.doi.org/10.2147/DDDT.S10180
Abstract: aglutide in the management of type 2 diabetes Review (7574) Total Article Views Authors: Estela Wajcberg, Amatur Amarah Published Date October 2010 Volume 2010:4 Pages 279 - 290 DOI: http://dx.doi.org/10.2147/DDDT.S10180 Estela Wajcberg, Amatur Amarah Premier Nephrology and Hypertension, Internal Medicine Department, Trinitas Regional Medical Center, Elizabeth, New Jersey, USA Abstract: The pathophysiology of type 2 diabetes has been attributed to the classic triad of decreased insulin secretion, increased insulin resistance, and elevated hepatic glucose production. Research has shown additional mechanisms, including incretin deficiency or resistance in the gastrointestinal tract. Liraglutide is a modified form of human glucagon-like peptide-1. Liraglutide was obtained by substitution of lysine 34 for arginine near the NH2 terminus, and by addition of a C16 fatty acid at the e-amino group of lysine (at position 26) using a γ-glutamic acid spacer. Liraglutide has demonstrated glucose-dependent insulin secretion, improvements in β-cell function, deceleration of gastric emptying, and promotion of early satiety leading to weight loss. Liraglutide has the potential to acquire an important role, not only in the treatment of type 2 diabetes, but also in preservation of β-cell function, weight loss, and prevention of chronic diabetic complications.
Liraglutide in the management of type 2 diabetes
Estela Wajcberg,Amatur Amarah
Drug Design, Development and Therapy , 2010,
Abstract: Estela Wajcberg, Amatur AmarahPremier Nephrology and Hypertension, Internal Medicine Department, Trinitas Regional Medical Center, Elizabeth, New Jersey, USAAbstract: The pathophysiology of type 2 diabetes has been attributed to the classic triad of decreased insulin secretion, increased insulin resistance, and elevated hepatic glucose production. Research has shown additional mechanisms, including incretin deficiency or resistance in the gastrointestinal tract. Liraglutide is a modified form of human glucagon-like peptide-1. Liraglutide was obtained by substitution of lysine 34 for arginine near the NH2 terminus, and by addition of a C16 fatty acid at the e-amino group of lysine (at position 26) using a γ-glutamic acid spacer. Liraglutide has demonstrated glucose-dependent insulin secretion, improvements in β-cell function, deceleration of gastric emptying, and promotion of early satiety leading to weight loss. Liraglutide has the potential to acquire an important role, not only in the treatment of type 2 diabetes, but also in preservation of β-cell function, weight loss, and prevention of chronic diabetic complications.Keywords: diabetes mellitus, incretin, glucagon-like peptide, insulin resistance
Water Stress Tolerance, Its Relationship to Stem Reserve Mobilization and Potence Ratio in Spring Wheat  [PDF]
Ijaz Rasool Noorka, Amarah Batool, Sultan AlSultan, Saba Tabasum, Amjed Ali
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.42030
Abstract: Twelve wheat (Triticum aestivum L.) cultivars and their sixteen direct and reciprocal crosses were evaluated for heterosis, heterobeltiosis and potence ratio to determine the potential of wheat genotypes under contrasting water regimes. The highest positive heterosis and heterobeltiosis was observed in cross combination Sehr-06 × Pasban-90 under both water regimes for the trait stem reserve mobilization (SRM). While in trait 1000-grain weight the cross-combination Pari-73 × C-273 (Normal irrigation) and Fsd-08 × SA-42 (water stress) showed highest heterosis and Pari-73 × C-273(Normal irrigation) and Fsd-08 × Chenab-70(water stress) showed highest value of heterobeltiosis. The potence ratio in both traits expressed overdominance estimates exhibiting the presence of transgressive segregants, may be exploited for on-ward selection in the bread wheat improvement. The genotypes showing better SRM based 1000-grain weight in the absence of photosynthesis indicates relative water stress tolerance. This procedure paved an indirect way to screen the wheat genotypes to withhold water stress situation and sustain wheat production.
Power Aware Routing Protocol (PARP) for Wireless Sensor Networks  [PDF]
R. Prema, R. Rangarajan
Wireless Sensor Network (WSN) , 2012, DOI: 10.4236/wsn.2012.45019
Abstract: Several wireless sensor network applications ought to decide the intrinsic variance between energy efficient communication and the requirement to attain preferred quality of service (QoS) such as packet delivery ratio, delay and to reduce the power consumption of wireless sensor nodes. In order to address this challenge, we propose the Power Aware Routing Protocol (PARP), which attains application-specified communication delays at low energy cost by dynamically adapting transmission power and routing decisions. Extensive simulation results prove that the proposed PARP attains better QoS and reduced power consumption.
Studies on Dissolution Behaviour of Nanoparticulate Curcumin Formulation  [PDF]
R. Ravichandran
Advances in Nanoparticles (ANP) , 2013, DOI: 10.4236/anp.2013.21010
Abstract:

Curcumin is the main biologically active phytochemical compound of turmeric that has been widely used by ancient cultures throughout Asia. However the dissolution rate limited absorption and pre-absorption degradation limits its use as a potential therapeutic. In this study an attempt has been made to overcome the above limitations by curcumin delivery through nanotechnology. Nanocurcumin solid dosage formulations were prepared and studied for its dissolution behaviour. Considerable improvement in the dissolution behavior was observed in the drug nanocrystal-loaded solid dosage forms. This is expected to enhance the bioavailability of poorly soluble medicinal herbs such as turmeric in the body.

Pharmacokinetic Study of Nanoparticulate Curcumin: Oral Formulation for Enhanced Bioavailability  [PDF]
R. Ravichandran
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.43037
Abstract:

Curcumin, a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of Curcumin in inflammatory disorders, cardiovascular disease, cancer, Alzheimer’s disease and neurological disorders have been shown. However, the clinical application of Curcumin is severely limited by its main drawbacks such as instability, low solubility, poor bioavailability and rapid metabolism. Multifarious nanotechnology-based drug delivery systems for Curcumin including liposomes, polymeric nanoparticles, solid lipid nanoparticles, micelles, nanogels, nanoemulsions, complexes and dendrimer/dimer, have been attempted to enhance the oral bioavailability, biological activity or tissue-targeting ability of Curcumin. We attempted the nanosuspensions based delivery of curcumin. Nanonisation renders curcumin completely dispersible in aqueous media. To enhance the curcumin absorption by oral administration, nanoparticulate solid oral formulation of curcumin was prepared by us and the resulting capsule was then examined for its efficiency on bioavailability in Male Wistar rats at a dose of 100 mg curcumin/kg body weight and the pharmacokinetic parameters were compared to those of normal curcumin powder and a commercial curcumin capsule CUR-500. The bio-distribution of curcumin in organs of rat was also studied. Nanoparticulation significantly raised the curcumin concentration in selective organs in the body. The results obtained provide promising results for nanoparticulate Curcumin to improve its biological activities. Enhanced bioavailability of curcumin in the form of nanoparticle is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease. The available information also strongly suggests that nano-formulation of ingredients such as curcumin may be used as a novel nutrient delivery system too.

The Arithmetic Mean Standard Deviation Distribution: A Geometrical Framework  [PDF]
R. Caimmi
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.411A4001
Abstract:

The current attempt is aimed to outline the geometrical framework of a well known statistical problem, concerning the explicit expression of the arithmetic mean standard deviation distribution. To this respect, after a short exposition, three steps are performed as 1) formulation of the arithmetic mean standard deviation, \"\", as a function of the errors, \"\", which, by themselves, are statistically independent; 2) formulation of the arithmetic mean standard deviation distribution, \"\", as a function of the errors, \"\"; 3) formulation of the arithmetic mean standard deviation distribution, \"\", as a function of the arithmetic mean standard deviation, \"\", and the arithmetic mean rms error, \"\". The integration domain can be expressed in canonical form after a change of reference frame in the n-space, which is recognized as an infinitely thin n-cylindrical corona where the symmetry axis coincides with a coordinate axis. Finally, the solution is presented and a number of (well known) related parameters are inferred for sake of completeness.

Optimized Parameter Combinations of Hydraulic Damper Modules  [PDF]
R. Sonnenburg
Journal of Transportation Technologies (JTTs) , 2014, DOI: 10.4236/jtts.2014.43025
Abstract:

This paper is devoted to the problem of finding optimized parameter combinations of automotive damper modules. Different cost functions using the amplitude spectrum of the excitation and the frequency response function of the car model will be investigated and it is shown that for three different arbitrary road excitations there exists a parameter combination of top mount stiffness, piston rod mass and damping constant that provides an optimum for the dynamic wheel load fluctuation. The achieved advantage of the optimized damper module regarding the dynamic wheel load fluctuation compared to a simple damper in a two mass vibration system can reach up to 20 percent.

CSA Discounting: Impacts on Pricing and Risk of Commodity Derivatives  [PDF]
R. Abbate
Journal of Financial Risk Management (JFRM) , 2014, DOI: 10.4236/jfrm.2014.33011
Abstract: The global financial crisis of 2007-2008 caused market practitioners to reassess the way in which financial derivative contracts had been priced during the preceding thirty years. The purpose of this paper is to examine the evolving practice of pricing and hedging commodity derivative contracts according to the terms of the Credit Support Annex (CSA). Using a series of case studies, we price crude oil swaps and Asian options in the pre-crisis, peak-crisis, post-crisis and recent market environments under two different frameworks: LIBOR discounting and CSA discounting (also referred to in a less general form as “OIS discounting”, which incorporates nearly risk-free interest rates). We also compute the widely used first-order and second-order Greek sensitivities. In each market environment, we shift the forward prices and implied volatilities crude oil and re-compute the trades’ valuation and Greek sensitivities at each incremental increase or decrease in price or implied volatility. Under each discounting framework, we quantify the change in trade valuation and Greek sensitivities that results from switching from LIBOR discounting to CSA discounting. The impact on the valuation and Greek sensitivities of a swap and an Asian option as the result of adopting CSA discounting can be significant under certain market conditions. There is likely to be larger impact on directional portfolios containing transactions that hedge either consumption or production (e.g. end users). Ceteris paribus, the impact on portfolio valuation and risk is likely to be limited for market participants (e.g. banks) with hedged portfolios that contain a large number of offsetting positions. Even though we focus our analysis on crude oil derivative contracts, the results easily extend to other asset classes such as natural gas, refined products, agriculture, metals, etc.
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