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Search Results: 1 - 10 of 417151 matches for " Amany M. Ali "
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Risk-Adapted, Combined-Modality Therapy for Unfavorable Pediatric Hodgkin Lymphom  [PDF]
Amany M. Ali, Amira M. Mohamed, Shimaa Ahmed, Mohamed Abdallah, Tarek M. Alsaba, Samar Mansour
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.97046
Abstract: Background and Objectives: Risk-adapted therapy for children with HL is directed toward high survival, minimal toxicity and optimal quality of life, with long term follow up. We assess the impact of prognostic factors associated with local treatment failure of pediatric HL patients with unfavorable criteria treated with combined modality: Alternating ABVD (Doxorubicin, Bleomycin, Vinblastine and Decarbazine) and COEP (Cyclophosphamide, Oncovin, Etoposide and Prednisone) chemotherapy and response-based, involved-field radiation for newly diagnosed unfavorable pediatric HL patients, also will detect toxicities and long-term complications observed in the patients. Methods: This prospective study was carried out from January 2010 to January 2018, with a median follow up of 74 months (range 8 - 103 months). 54 patients were eligible for this study stratified into two groups: intermediate risk (IR) and high-risk group (HR). Patients were treated with (4 - 6 cycles) and (6 - 8 cycles) respectively of alternating ABVD/COEP chemotherapy followed by involved-field radiation therapy (IFRT): 15 Gy for patients achieved complete response, and 25.5 Gy for those achieved a partial response. Results: 27 patients were IR and 27 patients were HR. There were 16 treatment failures; 5 patients had progressive disease; and 11 patients had a relapse. 9 patients died from their disease progression. The 5-year overall survival (OS) and event-free survival (EFS) rates (±SE) were 81.8% ± 5.7% and 71.8% ± 6.2% respectively. Multivariate analysis revealed that the only independent factor for inferior OS was radiotherapy. Conclusion: Treatment results of unfavourable HL patients in our study are satisfactory for with IR group but not for HR group who needs intensification of therapy. Radiotherapy is considered as a cornerstone in the treatment of the patients with unfavourable criteria with better assessment of early responders needed by PET-CT to identify patients at risk for
Risk Stratification Treatment of Pediatric Rhabdomyosarcoma: South Egypt Cancer Institute Experience  [PDF]
Hamza Abbas, Amany M. Ali, Heba Abdel Razik Sayed, Mohamed A. Salem, Mohammed Hamdy
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.35076
Abstract: Risk stratification allows tailoring of treatment protocol using, for selected patients, reduced total chemotherapy exposure, including decreases in alkylator therapy and avoidance of agents with recognized risk of late complications (anthracyclines), elimination of irradiation and reduction of radiotherapy dose. Patients and Methods: Twenty-nine newly diagnosed pediatric rhabdomyosarcoma patients attended the pediatric oncology department between January 2008 and May 2011. Patients were divided into 3 groups according to age, stage, group, pathology and site of the tumor. Treatment protocol tailored according to risk group. Results: Twenty-nine newly diagnosed pediatric rhabdomyosarcoma patients were evaluated. Seven patients had low risk, Intermediate risk included 12 patients, and 10 patients had high risk. After three years median follow up, event free survival was 51.7% for all patients however it was 86%, 67% and 10% for low, intermediate and high risk respectively (P = 0.0002). There was statistical difference for survival among different sites, histology, clinical group and stage as risk factors within each risk group, no statistically survival significance of any of these factors within the same risk group. Conclusion: Risk stratification is the best single predictor factor for pediatric rhabdomyosarcoma and allows tailoring of the treatment protocol. For selected patients, reductions in total chemotherapy exposure, elimination of irradiation in selected low risk patients and reduction of radiotherapy dose according to postoperative margin and nodal status is safe.
Dietary Patterns and Their Association with Depression among Type 2 Diabetes Patients in Gaza Strip, Palestine  [PDF]
Abdel Hamid el Bilbeisi, Mohammed Srour, Amany el Afifi, Halgord Ali M. Farag, Kurosh Djafarian
Food and Nutrition Sciences (FNS) , 2019, DOI: 10.4236/fns.2019.105039
Abstract: Background: Depression is a common mental disorder. Globally, more than 340 million people of all ages suffer from depression. The aim of our study was to determine the association between major dietary patterns and depression among type 2 diabetes patients. Methods: This cross-sectional study was conducted among 480 type 2 diabetes patients attending primary healthcare centers in Gaza Strip, Palestine. The depression, anxiety, stress scales (DASS, 21-items) questionnaire was used to measure the score of depression. The participants’ demographic, socioeconomic and medical history data was collected and the 98-items semi-quantitative food frequency questionnaire was used for evaluating the dietary patterns. Statistical analysis was performed using SPSS version 20. Results: Based on depression scale, 29.0% of type 2 diabetes patients had depression, (58.3% females, and 41.7% males). The prevalence of mild, moderate, severe, and very severe depression was 11.7%, 8.5%, 6.7%, and 2.1%, respectively. Furthermore, two major dietary patterns were identified by factor analysis: The Western, and the grains-vegetables, and fruits patterns. After adjusting for the potential confounders, patients in the lowest tertile (T1) of the grains-vegetables, and fruits dietary pattern had a lower odds for depression (OR 0.763 95% CI (0.667 - 0.871), P value = 0.001); where as a higher odds for healthy (OR 1.443 95% CI (1.131 - 1.839), P value = 0.004), compared to those in the highest tertile (T3). Conclusion: The grains-vegetables, and fruits dietary pattern may be associated with a lower prevalence of depression, and has been shown to be the healthiest dietary pattern among type 2 diabetes patients.
Influence of Reaction Conditions on Sol-Gel Process Producing SiO2 and SiO2-P2O5 Gel and Glass  [PDF]
Amany Mohamed Elnahrawy, Ahmed Ibrahim Ali
New Journal of Glass and Ceramics (NJGC) , 2014, DOI: 10.4236/njgc.2014.42006
Abstract: The effect of H2O and the slow thermal annealing on the properties of pure silica (SiO2) and phosphosilicate (SiO2-P2O5) gel-glasses are presented. The monolithic samples have been prepared via sol-gel process using tetraethorthosilicate (TEOS), Si(C2H5O)4 and Triethylphosphate (TEP) (C2H5O)3P(O) as SiO2 and P2O5 precursors. Phosphate incorporates into the silicate network by substituting Si atoms and consequently, we observed changes in structural and spectroscopic properties for these systems. The structures of prepared samples were examined by observed weight loss, XRD and FTIR. It has been found that in the structure of pure silica and phosphosilicate glasses there are formed domains characterized by certain degree of ordering of the units present in their composition, while the structure of pure silica is still amorphous of these glasses. The changing character of domains structure may be the reason of different chemical activities of phosphosilicate glass.
Role of Surgery in Stages II and III Pediatric Abdominal Non-Hodgkin Lymphoma: A 5-Years Experience
Amany M. Ali,Heba A. Sayd,Hesham M. Hamza,Mohamed A. Salem
Cancers , 2011, DOI: 10.3390/cancers3021593
Abstract: Abdominal Non-Hodgkin lymphomas (NHL) are the most common extra nodal presentation of pediatric NHL. Our aim is to assess the role of surgery as a risk factor and to evaluate the impact of risk-adjusted systemic chemotherapy on survival of patients with stages II and III disease. This study included 35 pediatric patients with abdominal NHL treated over five years at South Egypt Cancer Institute (SECI), Assiut University, between January 2005 and January 2010. The data of every patient included: Age, sex, and presentation, staging work up to determine extent of the disease and the type of resection performed, histopathological examination, details of chemotherapy, disease free survival and overall survival. The study included 25 boys and 10 girls with a median age of six years (range: 2.5:15). Thirty patients (86%) presented with abdominal pain, 23 patients (66%) presented with abdominal mass and distention, 13 patients (34%) presented with weight loss, and intestinal obstruction occurred in six patients (17%). The ileo-cecal region and abdominal lymph nodes were the commonest sites (48.5%, 21% respectively). Burkitt's lymphoma was the most common histological type in 29 patients (83%). Ten (28.5%) stage II (group A) and 25 (71.5%) stage III (group B). Complete resections were performed in 10 (28.5%), debulking in 6 (17%) and imaging guided biopsy in 19 (54%). A11 patients received systemic chemotherapy. The median follow up duration was 63 months (range 51-78 months). The parameters that significantly affect the overall survival were stage at presentation complete resection for localized disease. In conclusion, the extent of disease at presentation is the most important prognostic factor in pediatric abdominal NHL. Surgery is restricted to defined situations such as; abdominal emergencies, diagnostic biopsy and total tumor extirpation in localized disease. Chemotherapy is the cornerstone in the management of pediatric abdominal NHL.
Treatment results and prognostic factors of pediatric neuroblastoma: a retrospective study
Mohamed I El-Sayed, Amany M Ali, Heba A Sayed, Eman M Zaky
International Archives of Medicine , 2010, DOI: 10.1186/1755-7682-3-37
Abstract: This retrospective study was carried out analyzing the medical records of patients with the pathological diagnosis of neuroblastoma seen at South Egypt Cancer Institute, Assiut University during the period from January 2001 and January 2010. After induction chemotherapy, response according to international neuoblastoma response criteria was assessed. Radiotherapy to patients with residual primary tumor was applied. Overall and event free survival (OAS and EFS) rates were estimated using Graphed prism program. The Log-rank test was used to examine differences in OAS and EFS rates. Cox-regression multivariate analysis was done to determine the independent prognostic factors affecting survival rates.Fifty three cases were analyzed. The median follow-up duration was 32 months and ranged from 2 to 84 months. The 3-year OAS and EFS rates were 39.4% and 29.3% respectively. Poor prognostic factors included age >1 year of age, N-MYC amplification, and high risk group. The majority of patients (68%) presented in high risk group, where treatment outcome was poor, as only 21% of patients survived for 3 year.Multivariate analysis confirmed only the association between survival and risk group. However, in univariate analysis, local radiation therapy resulted in significant survival improvement. Therefore, radiotherapy should be given to patients with residual tumor evident after induction chemotherapy and surgery. Future attempts to improve OAS in high risk group patients with aggressive chemotherapy and bone marrow transplantation should be considered.Neuroblastoma is the third most common malignancy in childhood and accounts for at least 15 percent of cancer-related deaths in children [1]. Despite concerted clinical and scientific efforts, prognoses of patients with high-risk neuroblastoma remain poor. About 30 to 35% of patients with high-risk disease who are older than 1 year survive more than 5 years [2,3].Children with neuroblastoma exhibit marked variability in outcome whe
Optimal Placement of Multi DG Units Including Different Load Models Using PSO  [PDF]
Amany M. El-Zonkol
Smart Grid and Renewable Energy (SGRE) , 2010, DOI: 10.4236/sgre.2010.13021
Abstract: This paper proposes a multi-objective index-based approach to optimally determine the size and location of multi-distributed generators (DG) units in distribution system with different load models. It is shown that load models can significantly affect the optimal location and sizing of DG resources in distribution systems. The proposed multi-objective function to be optimized includes a short circuit level parameter to represent the protective device requirements. The proposed function also considers a wide range of technical issues such as active and reactive power losses of the system, the voltage profile, the line loading and the MVA intake by the grid. The optimization technique based on particle swarm optimization (PSO) is introduced. The analysis of continuation power flow to determine the effect of DG units on the most sensitive buses to voltage collapse is carried out. The proposed algorithm is tested using the 38-bus radial system and the IEEE 30-bus meshed system. The results show the effectiveness of the proposed algorithm.
Fault Diagnosis in Distribution Networks with Distributed Generation  [PDF]
Amany M. El-Zonkoly
Smart Grid and Renewable Energy (SGRE) , 2011, DOI: 10.4236/sgre.2011.21001
Abstract: The penetration of distributed generation (DG) in distribution power system would affect the traditional fault current level and characteristics. Consequently, the traditional protection arrangements developed in distribution utilities are difficult in coordination. Also, the reclosing scheme would be affected. With the rapid developments in distribution system automation and communication technology, the protection coordination and reclosing scheme based on information exchange for distribution power system can be realized flexibly. This paper proposes a multi-agent based scheme for fault diagnosis in power distribution networks with distributed generators. The relay agents are located such that the distribution network is divided into several sections. The relay agents measure the bus currents at which they are located such that it can detect and classify the fault, and determine the fault location. The proposed technique uses the entropy of wavelet coefficients of the measured bus currents. The performance of the proposed protection scheme is tested through simulation of two systems. The first system is a benchmark medium voltage (MV) distribution system and the second system is practical 66 kV system of the city of Alexandria.
Production of Mayonnaise from Date Pit Oil  [PDF]
Amany Mohamed Mohamed Basuny, Maliha Ali AL-Marzooq
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.29128
Abstract: Chemical compositionof the residual pits from processing of date (Phoenix dactylifera L.) variety khalas from AL-Hasa region–Saudi Arabia was investigated. The extracted oil from residual pits was analyzed for its physico-chemical properties, (refractive index, colour, acid value, peroxide value, iodine number, saponification number and unsaponifiable matter), total phenols, tocopherol content, fatty acid composition, hydrocarbons, and sterol compounds by gas liquid chromatography, and oxidative stability by Rancimat method at 100℃ ± 2℃. Mineral content of date pits was analyzed by atomic absorption spectrophotometry. Date pit oil was used to replace conventional oil in producing mayonnaise, and sensory qualities were evaluated in comparison with commercial mayonnaise prepared from corn oil. The data demonstrated that mayonnaise containing date pit oil was superior in sensory characteristics as compared with control manufactured from corn oil. Results showed that the date pit oil could be used as nontraditional oil in some food processing such as mayonnaise products.
New Route for Novel Polycarboxylic Starch Hybrid  [PDF]
Ali Hebeish, Abdul Rhman Mousa, Mohamed A. Ramadan, Amany Saleh
Materials Sciences and Applications (MSA) , 2013, DOI: 10.4236/msa.2013.411087
Abstract:

Starch was polymerized with methacrylic acid (MAA) to different magnitudes of poly (MAA) using potassium persulphate/sodium thiosulphate redox initiation system. The polymerization products are referred to as composite. The latter consists of poly (MAA)-starch graft copolymer, poly (MAA) in the form of homopolymer, oxidized starch brought about under the influence of the initiator and intact starch. At this end, the composite, the copolymer, and the untreated (native) starch were subjected to carboxymethylation under different conditions and the rheological properties of these starchbased on products before and after carboxymethylation examined. Results obtained disclosed that the susceptibility of these products toward carboxymethylation follows the order: native starch > Copolymer > composite. Meanwhile, these products exhibit non-Newtonian thixotropic behavior before carboxymethylation; and their rheology signifies the order: Composite > copolymer > native starch whereas after carboxymethylation these products are characterized by non-Newtonian Pseudoplastic behavior. For a given rate of shear, the apparent viscosity follows the order: native starch > composite > copolymer > carboxymethyl composite > carboxymethyl starch > carboxymethyl copolymer, in contrast with pseudoplasticity which reveals an opposite order. It was also shown that the apparent viscosity increases by increasing poly (MAA) in the copolymer and composite and that redrying of the copolymer and the composite after normal precipitation and drying causes a considerable enhancement in the apparent viscosity of these products.

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