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Search Results: 1 - 10 of 2772 matches for " Alvaro Mayor-Olea "
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Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder
Angel Aneiros-Guerrero, Ana M Lendinez, Arturo R Palomares, Beatriz Perez-Nevot, Lidia Aguado, Alvaro Mayor-Olea, Maximiliano Ruiz-Galdon, Armando Reyes-Engel
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-75
Abstract: A case-control study was designed to evaluate the impact of genetic polymorphisms above described on TMD. A total of 229 individuals (69% women) were included at the study; 86 were patients with TMD and 143 were healthy control subjects. Subjects underwent to a clinical examination following the guidelines by the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Genotyping of 20 Single Nucleotide Polymorphisms (SNPs), divided in two groups, was performed by multiplex minisequencing preceded by multiplex PCR. Other seven genetic polymorphisms different from SNPs (deletions, insertions, tandem repeat, null genotype) were achieved by a multiplex-PCR. A chi-square test was performed to determine the differences in genotype and allelic frequencies between TMD patients and healthy subjects. To estimate TMD risk, in those polymorphisms that shown significant differences, odds ratio (OR) with a 95% of confidence interval were calculated.Six of the polymorphisms showed statistical associations with TMD. Four of them are related to enzymes of folates metabolism: Allele G of Serine Hydoxymethyltransferase 1 (SHMT1) rs1979277 (OR = 3.99; 95%CI 1.72, 9.25; p = 0.002), allele G of SHMT1 rs638416 (OR = 2.80; 95%CI 1.51, 5.21; p = 0.013), allele T of Methylentetrahydrofolate Dehydrogenase (MTHFD) rs2236225 (OR = 3.09; 95%CI 1.27, 7.50; p = 0.016) and allele A of Methionine Synthase Reductase (MTRR) rs1801394 (OR = 2.35; 95CI 1.10, 5.00; p = 0.037). An inflammatory oxidative stress enzyme, Gluthatione S-Tranferase Mu-1(GSTM1), null allele (OR = 2.21; 95%CI 1.24, 4.36; p = 0.030) and a neurotransmission receptor, Dopamine Receptor D4 (DRD4), long allele of 48 bp-repeat (OR = 3.62; 95%CI 0.76, 17.26; p = 0.161).Some genetic polymorphisms related to folates metabolism, inflammatory oxidative stress, and neurotransmission responses to pain, has been significantly associated to TMD syndromeTemporomandibular joint disorder (TMD) is characterized by a set of symptoms
Human genetic selection on the MTHFR 677C>T polymorphism
álvaro Mayor-Olea, Gonzalo Callejón, Arturo R Palomares, Ana J Jiménez, María Gaitán, Alfonso Rodríguez, Maximiliano Ruiz, Armando Reyes-Engel
BMC Medical Genetics , 2008, DOI: 10.1186/1471-2350-9-104
Abstract: A total of 1305 subjects born in the 20th century were genotyped for the 677C>T polymorphism using allele specific real-time PCR with Taqman? probes. A section of our population (n = 276) born in 1980–1989 was compared with fetal samples (n = 344) from SA of unknown etiology from the same period.An increase in the frequency of the T allele (0.38 vs 0.47; p < 0.001) and of the TT genotype (0.14 vs 0.24; p < 0.001) in subjects born in the last quarter of the century was observed. In the 1980–1989 period, the results show that the frequency of the wild type genotype (CC) is about tenfold lower in the SA samples than in the controls (0.03 vs 0.33; p < 0.001) and that the frequency of the TT genotype increases in the controls (0.19 to 0.27) and in the SA samples (0.20 to 0.33 (p < 0.01)); r = 0.98.Selection in favor of the T allele has been detected. This selection could be due to the increased fetal viability in early stages of embryonic development, as is deduced by the increase of mutants in both living and SA populations.The methylenetetrahydrofolate reductase enzyme (MTHFR) catalyzes a reaction that produces 5-methyltetrahydrofolate (5-methylTHF), the methyl donor for homocysteine in the synthesis of methionine. The 677C>T mutation of the MTHFR gene has been associated with a thermolabile enzyme with decreased activity that may cause an increase in plasma homocysteine concentrations [1] when folate status is poor. This polymorphism is one of the most widely studied clinically relevant polymorphisms in humans, as it is related to cardiovascular disease [2] and neural tube defects (NTD; 601634) [3].A large number of studies have provided a broad overview of the prevalence of the 677C>T polymorphism in different human populations, showing that the distribution of frequencies is diverse [4]. These differences have been also observed between groups of different ages in the same Spanish population (older and younger than 24 years) [5] and in a Swiss population (older and
Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
AYBAR,MANUEL J.; GLAVIC,ALVARO; MAYOR,ROBERTO;
Biological Research , 2002, DOI: 10.4067/S0716-97602002000200018
Abstract: the neural crest is induced at the border between the neural plate and the epidermis. a complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. here we discuss evidence supporting a model for neural crest induction in which different signals contribute in a sequential order. first, a gradient of bone morphogenic proteins (bmps) is established in the ectoderm that results in segreggation into neural plate, neural folds and epidermis at increasing levels of bmp activity. thus, the neural folds are induced at a precise threshold concentration of bmp, but this neural fold has an anterior character. in a second step, these anterior neural folds are transformed into prospective neural crest by posteriorizing signals due to fibroblast growth factor, wnts and retinoic acid. finally, the induced cells interact to complete neural crest induction by a process that requires notch/delta signaling. once neural crest formation has been induced by this combination of extracellular and intracellular signals, a cascade of transcription factors is activated in these cells that culminates in the ultimate steps of neural crest differentiation
Extracellular signals, cell interactions and transcription factors involved in the induction of the neural crest cells
MANUEL J. AYBAR,ALVARO GLAVIC,ROBERTO MAYOR
Biological Research , 2002,
Abstract: The neural crest is induced at the border between the neural plate and the epidermis. A complex set of signals is required for the specification of the crest cells between the epidermis and the neural plate. Here we discuss evidence supporting a model for neural crest induction in which different signals contribute in a sequential order. First, a gradient of bone morphogenic proteins (BMPs) is established in the ectoderm that results in segreggation into neural plate, neural folds and epidermis at increasing levels of BMP activity. Thus, the neural folds are induced at a precise threshold concentration of BMP, but this neural fold has an anterior character. In a second step, these anterior neural folds are transformed into prospective neural crest by posteriorizing signals due to fibroblast growth factor, Wnts and retinoic acid. Finally, the induced cells interact to complete neural crest induction by a process that requires Notch/Delta signaling. Once neural crest formation has been induced by this combination of extracellular and intracellular signals, a cascade of transcription factors is activated in these cells that culminates in the ultimate steps of neural crest differentiation
DIETA DE LA NUTRIA NEOTROPICAL Lontra longicaudis (CARNíVORA, MUSTELIDAE) EN EL RíO ROBLE, ALTO CAUCA, COLOMBIA
Mayor-Victoria,Rosemary; Botero-Botero,Alvaro;
Acta Biológica Colombiana , 2010,
Abstract: the diet of neotropical otters was studied at roble river, a tributary of la vieja river, upper cauca basin, colombia . from august 2006 to march 2007 otter scats were collected twice per month using plastic bags, from the lower stretch of the roble river. in the laboratory, the scats were washed, sieved and items were identified by comparing them with a reference collection. fourteen food categories were recognized. ranked by frequency of occurrence, benthic sucker-mouthed catfish were the favored food items, especially chaetostoma sp (22,6 %) followed by hypostomus sp. (9,55%) and ancistrus sp. (8,54%). other species of fish eaten by the otters are: apteronotus sp. (11,6 %), brycon henni (9,86 %), lebiasina sp. (0,70%), y rhamdia sp. (9,15 %); (family loricariidae)., followed by insects corydalus sp (9%) (family corydalidae). the lowest frequency observed was for lizards, basiliscus sp. (family corytophanidae). significant diet differences were found between the wet and dry seasons of the year (rs= 0.429; n= 11 p=0.00001)
DIETA DE LA NUTRIA NEOTROPICAL Lontra longicaudis (CARNíVORA, MUSTELIDAE) EN EL RíO ROBLE, ALTO CAUCA, COLOMBIA
Mayor-Victoria Rosemary,Botero-Botero Alvaro
Acta Biológica Colombiana , 2010,
Abstract: Se estudio la dieta de la nutria neotropical en el río Roble, sistema del río La Vieja, alto Cauca, Colombia. Desde agosto de 2006 hasta marzo de 2007 dos veces por mes fueron colectadas heces de la nutria en bolsas plásticas en la zona baja del río Roble, en laboratorio las muestras fueron lavadas, tamizadas y comparadas con una colección de referencia.Se reconocieron 14 categorías alimenticias, dentro los cuales los peces de la Familia Loricariidae, presentaron el mayor porcentaje de frecuencia, particularmente la especie Chetostoma sp. (22,6%), seguida de Hypostomus sp. (9,55%) y Ancistrus sp. (8,54%); otras especies de peces aprovechadas por la nutria en menor proporción son: Apteronotus sp. (11,6%), Brycon henni (9,86%), Lebiasina sp. (0,70%), y Rhamdia sp. (9,15%). Los insectos fueron el siguiente grupo en importancia, con la especie Corydalus sp. (9%) (Familia Corydalidae), y en menor presencia los reptiles de la Familia Corytophanidae, especie Basiliscus sp. Se encontró diferencias significativa, entre los ítems consumidos por temporada climática (Rs = 0,429; n= 11 p= 0.00001).
Gamaencefalografía con Tc - 99m DTPA en el Diagnostico de la Ventriculitis Gammaencephalography with Tc 99m in the Diagnosis of Ventriculitis
Enrique Olea G,Alvaro Palma F,Gilda Guzmán M,Maria I Robinson O
Revista chilena de pediatría , 1983,
Abstract:
ESCRITORAS DE LA GENERACIóN DEL CINCUENTA: CLAVES PARA UNA LECTURA POLíTICA
Olea,Raquel;
Universum (Talca) , 2010, DOI: 10.4067/S0718-23762010000200007
Abstract: in the production of denaturalization of women’s submission, historically inscribed in the religious-patriarchal society, bourgeoise and landowning, which evidences its own fall and decadence, women’s writing of the generation of 1950, proposes reading clues that play in the relationships that texts establish with: contemporary writing policies, the historical and social context (global and local), with the relationship with power and politics, and existentialism as a philosophical system. facing the hegemony of the marxist discourse that dominates the interpretation of the period, the feminist dictum private sphere is political as well offers a discursive clue to make intelligible the political discourses that these texts support.
Es hora de aplicar el principio de precaución
Olea N.
Gaceta Sanitaria , 2003,
Abstract:
Leishmaniosis visceral en un paciente con infección por VIH Visceral leishmaniasis in patient with HIV infection
Pilar Olea
Revista chilena de infectología , 2013,
Abstract: La leishmaniosis es una infección producida por parásitos del género Leishmania, transmitida por mosquitos hematófagos. Puede ocasionar infecciones subclínicas o manifestarse con compromiso cutáneo, mucoso o visceral. Esta última forma de presentación, que constituye la leishmaniosis visceral, es la más grave pudiendo llegar a ser fatal y en los pacientes con infección por VIH se presenta como una infección oportunista de difícil diagnóstico y tratamiento. Se reporta el caso de un paciente con infección por VIH con leishmaniosis visceral cuyo cuadro clínico se presentó como un síndrome febril prolongado con hepato-esplenomegalia, linfadenopatías y pancitopenia. Se plantearon los diagnósticos diferenciales de linfoma y otras infecciones oportunistas, como mico-bacteriosis. La demostración de amastigotes del parásito en el aspirado de médula ósea confirmó el diagnóstico. El paciente se trató con anfotericina B deoxicolato por 14 días y a los 2 meses presentó una recaída por lo cual recibió un segundo curso con el mismo medicamento por 21 días y se mantuvo posteriormente con profilaxis secundaria. Además se realizó cambio de la TAlRV por fracaso virológico e inmunológico. Ha continuado controlándose en forma ambulatoria por 29 meses presentando evolución satisfactoria, sin nuevas recaídas. Leishmaniasis is a parasitic disease caused by the protozoa of the genus Leishmania transmitted by sandfly bites. It causes subclinical infection and diverse clinical manifestations with cutaneous, mucosal or visceral involvement. The last one, called visceral leishmaniasis, is usually fatal without treatment and in VIH patients with deep immunosuppression, has been recognized as an opportunistic infection with a high degree of difficulty in diagnosis and treatment. We present the case of a patient with HIV infection and visceral leishmaniasis. The clinical presentation was a prolonged febril syndrome with hepatosplenomegaly, lymphadenopathy and pancytopenia. The diferential diagnosis was made with lymphoma and other opportunistic infections, as mycobacteriosis. The bone marrow aspirate reveled parasite amastigotes. The patient received treatment with amphotericin B deoxycholate for 14 days and 2 months after he relapsed. Then he was treated with the same drug for 21 days and after that he has been in prophylaxis for 29 months with good outcome, without any other relapse.
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