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Increased Mortality Risk among Early Stage Hormone Receptor Positive Breast Cancer Patients Who Did Not Receive Adjuvant or Neoadjuvant Therapy  [PDF]
Sacha Satram-Hoang, Alisha Stein, Patricia Cortazar, Faiyaz Momin, Carolina Reyes
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.101001
Abstract: Background: Hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) is the most common biologic subtype of breast cancer. Although adjuvant therapy has demonstrated a survival benefit in clinical trials, its use is poorly understood in the real-world among elderly breast cancer patients since age is a barrier to receiving adjuvant therapy. An examination of treatment patterns and outcomes associated with receipt of adjuvant/neoadjuvant therapy among elderly HR + HER2-breast cancer patients was undertaken. Methods: There were 18,470 HR + HER2-breast cancer patients from the linked SEER-Medicare database. Patients were diagnosed with stage I-III disease between 1/1/2007-12/31/2011, ≥66 years, enrolled in Medicare Parts A, B and D, and underwent breast cancer surgery after diagnosis. Time-varying Cox proportional hazards regression assessed overall survival. Results: There were 13,670 (74%) patients treated with adjuvant/neoadjuvant therapy and 4800 (26%) untreated. Compared to treated patients, untreated patients were older, had earlier stage, lower grade, smaller tumors, poorer performance, higher comorbidity score, and less use of a 21-gene recurrence score (RS) assay (p < 0.0001). In the survival model, increasing age, stage, tumor size, tumor grade, comorbidity score and poor performance were significantly associated with higher mortality risks, while use of a
Treatment Patterns and Mortality Risk among Elderly Patients with Metastatic Triple Negative Breast Cancer in the United States: An Observational Cohort Study Using SEER-Medicare Data  [PDF]
Sacha Satram-Hoang, Preeti Bajaj, Alisha Stein, Patricia Cortazar, Faiyaz Momin, Carolina Reyes
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.102009
Abstract: Purpose: Triple negative breast cancer is more aggressive than other breast cancer subtypes and accounts for up to 20% of all breast cancers. Despite the poorer prognosis, there are no approved targeted treatments available and chemotherapy remains the only choice. We examined treatment patterns and outcomes among elderly metastatic triple-negative breast cancer (mTNBC) patients in routine clinical practice. Methods: Patients were identified from the linked SEER-Medicare database between 1/1/2001 and 12/31/2013 and included de novo Stage IV (n = 776) and patients with distant metastasis followed an initial diagnosis of Stage I - III disease (n = 1851). Kaplan-Meier analyses and time-varying Cox proportional hazards regression were used to assess overall survival (OS). Results: The mean age at metastatic diagnosis was 77.6 years and 1259 (48%) patients received chemotherapy. Compared to <70 year olds, ≥70 year olds had worse
The Effects of Age on Short-Term Memory Loss due to Proactive Interference
Alisha Berkauzer
Undergraduate Journal of Mathematical Modeling : One + Two , 2011, DOI: 10.5038/2326-3652.4.1.2
Abstract: This project focused on how proactive interference affects the short-term memory of people based on their age. The goal was to find the prime age for learning information and storing it in one's memory. Seven people from ages fifteen to forty were tested individually, using a set color pattern, in order to see how well each individual could remember the different color patterns as difficulty of the pattern increased. The obtained data was fitted by the polynomial regression. The “fitted” curve shows that as age increases, the individual's performance in memorizing the more difficult patterns decreases. Also, the peaked level of memory performance was found to be 24 for our experimental data.
F-theory and M-theory perspectives on N=2 supersymmetric gauge theories in four dimensions
Alisha Wissanji
Physics , 2012,
Abstract: Deformations of the original F-theory background are proposed. These lead to multiple new dualities and physical phenomena. We concentrate on one model where we let seven-branes wrap a multi-centered Taub-NUT space instead of R4. This configuration provides a successful F-theory embedding of a class of recently proposed four-dimensional N = 2 superconformal (SCFT) \`a la Gaiotto. Aspects of Argyres- Seiberg duality, of the new Gaiotto duality, as well as of the branes network of Benini- Benvenuti and Tachikawa are captured by our construction. The supergravity theory for the conformal case is also briefly discussed. Extending our construction to the non-conformal case, we find interesting cascading behavior in four-dimensional gauge theories with N = 2 supersymmetry. Since the analysis of this unexpected phenomenon is quite difficult in the language of type IIB/F-theory, we turn to the type IIA/M-theory description where the origin of the N = 2 cascade is clarified. Using the T-dual type IIA brane language, we first start by studying the N = 1 supersymmetric cascading gauge theory found in type IIB string theory on p regular and M fractional D3-branes at the tip of the conifold. We reproduce the supersymmetric vacuum structure of this theory. We also show that the IIA analog of the non-supersymmetric state found by Kachru, Pearson and Verlinde in the IIB description is metastable in string theory, but the barrier for tunneling to the supersymmetric vacuum goes to infinity in the field theory limit. We then use the techniques we have developed to analyze the N = 2 supersymmetric gauge theory corresponding to regular and fractional D3-branes on a near-singular K3, and clarify the origin of the cascade in this theory.
Golden Research Thoughts , 2012, DOI: 10.9780/22315063
Abstract: International and national conventions, legislations and frameworks have endorsed the need for educating all children under one roof. The Article 3 of the Salamanca Framework for Action (1994) documented that schools should accommodate all children regardless of their physical intellectual, emotional, social, linguistic or other conditions. In order to attract and retain all children including children with hearing impairment (CWHI), Indian education system should respond flexibly. The flagship programmes of Sarva Shiksha Abhiyan (SSA) and Rashtriya Madyamik Shiksha Abhiyan (RMSA) launched by the Ministry of HRD promote inclusive education of all including CWHI in mainstream schools. In order to achieve the goals of SSA and RMSA, the barriers in inclusive education of CWHI need to be identified and fixed. The present paper lists the ways and means of creating a barrier free environment for children with hearing impairment in secondary schools.
Visitor profiling for, and promotion of the biological and earth sciences museums, Macquarie University
Alisha Halliwell,Andrew Simpson
University Museums and Collections Journal , 2010,
Abstract: In 2007 Macquarie University undertook a significant restructure. It was anticipated that this would impact on the viability of the programs and resources of campus museums. The changes to university management practices involved possible cessation of centralized funding contributions to museum management. The biological and earth sciences museums, along with the other museums on campus, felt compelled to demonstrate a capacity for independent operation in case justifying their financial position became a key criteria for survival. A research project was designed and undertaken to identify and highlight the services of the biological and earth sciences museums at Macquarie University in order to increase their audience base. The results of this research have lead to the identification of distinct potential audiences and the formation of new promotional strategies within the Faculty of Science.
On the Importance of Relative Salience: Comparing Overt Selection Behavior of Single versus Simultaneously Presented Stimuli
Alisha Siebold, Mieke Donk
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099707
Abstract: The goal of the current study was to investigate time-dependent effects of the number of targets presented and its interaction with stimulus salience on oculomotor selection performance. To this end, observers were asked to make a speeded eye movement to a target orientation singleton embedded in a homogeneous background of vertically oriented lines. In Experiment 1, either one or two physically identical targets were presented, whereas in Experiment 2 an additional orientation-based salience manipulation was performed. The results showed that the probability of a singleton being available for selection is reduced in the presence of an identical singleton (Experiment 1) and that this effect is modulated by the salience of the other singleton (Experiment 2). While the absolute orientation contrast of a target relative to the background contributed to the probability that it is available for selection, the crucial factor affecting selection was the relative salience between singletons. These findings are incompatible with a processing speed account, which highlights the importance of visibility and claims that a certain singleton identity has a unique speed with which it can be processed. In contrast, the finding that the number of targets presented affected a target's availability suggests an important role of the broader display context in determining oculomotor selection performance.
Reliable Testing of Capacitors
Anoosha Movva,,Singavarapu Navya,,Alisha
International Journal of Innovative Technology and Exploring Engineering , 2013,
Abstract: A capacitor is an electronic device that consists of two conducting plates bearing opposite electronic charges, having dielectric (insulator) medium as their separator. Different capacitors may make use of different dielectric. Mostly include air, paper, and plastic, polyester and polystyrene. A potential difference across the conducting plates causes the formation of a static electric field in the dielectric. Capacitor stores energy between the two conductors where the electric field is present. Charging is the process allows the capacitor to store energy. The capacitor has a wide range of application in electronic circuits with the purpose of restricting direct current (DC) and allowing alternating current (AC) to pass through. The device is basically built for storing energy and for releasing all the energy at once. The capacity of this device to hold an electrical charge is termed as 'capacitance' and it is measured by Farads. For the measurement of electric charge between the two conducting plates is measured in the reliable methodology is described below.
Mindfulness and the aging brain: A proposed paradigm shift
Ruchika S. Prakash,Alisha Janssen
Frontiers in Aging Neuroscience , 2014, DOI: 10.3389/fnagi.2014.00120
Abstract: There has been a proliferation of cognitive training studies investigating the efficacy of various cognitive training paradigms as well as strategies for improving cognitive control in the elderly. While some have found support for the transfer of training, the majority of training studies show modest to no transfer effects. When transfer effects have been observed, the mechanisms contributing to enhanced functioning have been difficult to dissociate. In this review, we provide a theoretical rationale for the study of mindfulness in older adults as a particular type of training program designed to improve cognitive control by capitalizing on older adults’ acquired behavioral orientation toward higher socioemotional goals. Given the synergistic relationship between emotional and cognitive control processes, the paradoxical divergence in older adults’ functional trajectory in these respective domains, and the harmonious interplay of cognitive and emotional control embedded in the practice of mindfulness, we propose mindfulness training as an opportunistic approach to cultivating cognitive benefits in older adults. The study of mindfulness within aging, we argue, capitalizes on a fundamental finding of the socioemotional aging literature, namely the preferential change in motivational goals of older adults from ones involving future-oriented wants and desires to present-focused emotion regulation and gratification.
A Quantitative Analysis of Integrated Reporting via CAGR on Publicly Traded U.S. Corporations Listed in the S & P 500  [PDF]
Sean Stein Smith
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.88093

The business environment continues to change and evolve at a rapid pace, and the reporting process by which organizations communicate performance to external stakeholder must also change and adapt. As both financial and non-financial stakeholder become increasingly interested in not only the financial results of the organization, but how these results are achieved, management teams must take appropriate steps. Incorporating both the operational and financial results of the organization into data communicated to internal and external users remains a fiduciary responsibility of management professionals across industry lines. Integrated reporting, although not a panacea for short-termism and other pressures on organizations, does provide a vehicle for more comprehensive financial reporting. This research examines both the literature and academic support for integrated reporting, and, as of the date of this research, implications that adopting such a framework has a financial performance.

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