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Search Results: 1 - 10 of 451792 matches for " Alice S. S. Li "
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New Gene Therapy Strategies for the Deletion of Exon 44 of Dystrophin Gene Based on Gene Editing by TALENs  [PDF]
Ping Li, Yunzhi Pan, Alice S. S. Li, Aijuan Sun, Jia Zhang, H. L. Gao, Pierre Sirois, Kai Li
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.31001

Duchenne Muscular Dystrophy (DMD) is a severe childhood form of muscular dystrophy. Both the severe form and its milder form of Becker Muscular Dystrophy (BMD) are caused by the mutation of dystrophin gene. Different from some other genetic diseases such as hemophilia that can be treated by replacement therapy, there is no effective therapy for muscular dystrophy in conventional medication. Gene editing technology from the recently developed engineered nucleases such as TALENs has been successfully employed in genome modification of a variety of species, and will be applied in gene therapy of selected human diseases. The genetic basis of DMD and BMD indicates that DMD is a good target for gene therapy through returning the reading frame of dystrophin gene. Gene therapy strategies described here may apply to many other genetic diseases. Wider application of TALENs in gene therapy have the potential to dramatically prolong the lifespan of individuals with genetic diseases.

Age-Correlated Gene Expression in Normal and Neurodegenerative Human Brain Tissues
Kajia Cao,Alice S. Chen-Plotkin,Joshua B. Plotkin,Li-San Wang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013098
Abstract: Human brain aging has received special attention in part because of the elevated risks of neurodegenerative disorders such as Alzheimer's disease in seniors. Recent technological advances enable us to investigate whether similar mechanisms underlie aging and neurodegeneration, by quantifying the similarities and differences in their genome-wide gene expression profiles.
Breast cancer in Marin County
Alice S Whittemore
Breast Cancer Research , 2003, DOI: 10.1186/bcr633
Abstract: Two articles previously published in Breast Cancer Research provide another example of the political/social/ psychological/scientific quandary presented by regional cancer clusters [1,2]. A community is concerned by what it perceives to be its high incidence of cancer, and a group of activists collaborates with epidemiologists to investigate the reasons for the cluster. They launch a study that considers every conceivable cause, but cannot come up with an answer because of limitations in their study design.Marin County is a small urban county north of San Francisco. Its 250,000 predominantly white, non-Hispanic residents have breast cancer rates approximately 38% higher than those of the United States as a whole [1]. In response to concerns about these high rates, breast cancer activists teamed with cancer epidemiologists to conduct a case–control study within Marin County.The paper by Wrensch and colleagues reports the results of this comparison of personal and environmental risk factors among 285 breast cancer cases and 286 control women [1]. The authors found more frequent screening for breast cancer, and longer and heavier alcohol consumption, among cases compared with controls. They did not, however, find significant case–control differences with respect to several other established breast cancer risk factors, including a family history of the disease and low parity. Moreover, cases and controls were similar with respect to age at first residence and to total years of residence in Marin County. This similarity fails to support exposure to a regional environmental toxicant as an explanation for the cluster. A limitation of this study is its low power for detecting case–control differences in risk factors for the disease, given the homogeneity of the women in the county with respect to socioeconomic status and its concomitants. A more informative study would have compared the distribution of established risk factors in Marin County with those in other California
Museus e Museologia: desafios para a constru o de territórios colaborativos
Alice Semedo,Inês Ferreira
Revista da Faculdade de Letras : Sociologia , 2011,
Investigation of charm and beauty production via semileptonic decays of heavy-flavour hadrons in pp at 7 TeV and Pb--Pb at 2.76 TeV with ALICE
S. Masciocchi,for the ALICE Collaboration
Physics , 2011, DOI: 10.1088/0954-3899/38/12/124069
Abstract: Electron spectra measured with ALICE at mid-rapidity are used to study the production of hadrons carrying a charm or a beauty quark. The production cross section of electrons from heavy-flavour hadron decays is measured in pp collisions at $\sqrt{s}$=7 TeV. Electrons from the beauty decays are identified via the displacement from the interaction vertex. From the electron spectra measured in Pb--Pb collisions, we determine the nuclear modification factor, which is sensitive to the heavy-quark energy loss in a hot strongly interacting medium.
Heavy-flavour production in ALICE at the LHC
S. Masciocchi,for the ALICE Collaboration
Physics , 2012,
Abstract: ALICE at the LHC is the experiment dedicated to study the physics of nucleus-nucleus collisions. The apparatus is well suited for the measurement of heavy-quark hadron production, making use of the high spatial resolution provided by the tracking detectors and the excellent particle identification, which are distinctive of the ALICE apparatus. Results from proton-proton collisions at sqrt(s) = 2.76 and 7 TeV, and from Pb--Pb collisions at sqrt(s_NN) = 2.76 TeV are presented. The measurements in pp collisions provide an important test of perturbative QCD predictions. The precise vertex reconstruction together with the electron identification, allows the separation of the charm and the beauty components. Furthermore, the pp results are essential as a reference for the measurements in heavy-ion collisions. Nuclear modification factors were measured for D mesons, for electrons and for muons from heavy-flavour hadron decays. The elliptic flow of D mesons is also discussed. These measurements are important because they will provide information on the Quark-Gluon Plasma produced in heavy-ion collisions, via the energy loss of the heavy partons in the strongly interacting medium, and hints on the medium thermalization.
Evaluating Health Risk Models
Alice S. Whittemore
Statistics , 2009,
Abstract: Interest in targeted disease prevention has stimulated development of models that assign risks to individuals, using their personal covariates. We need to evaluate these models, and to quantify the gains achieved by expanding a model with additional covariates. We describe several performance measures for risk models, and show how they are related. Application of the measures to risk models for hypothetical populations and for postmenopausal US women illustrate several points. First, model performance is constrained by the distribution of true risks in the population. This complicates the comparison of two models if they are applied to populations with different covariate distributions. Second, the Brier Score and the Integrated Discrimination Improvement (IDI) are more useful than the concordance statistic for quantifying precision gains obtained from model expansion. Finally, these precision gains are apt to be small, although they may be large for some individuals. We propose a new way to identify these individuals, and show how to quantify how much they gain by measuring the additional covariates. Those with largest gains could be targeted for cost-efficient covariate assessment.
Relationship between body mass index and serum 25-hydroxyvitamin D stronger among Caucasians than African Americans in NHANES adults 2001-2006  [PDF]
Lenore Arab, John S. Adams, Heeyoung Kim, Alice Kohlmeier
Open Journal of Epidemiology (OJEpi) , 2012, DOI: 10.4236/ojepi.2012.21002
Abstract: The rapid decline in circulating levels of serum 25-hydroxyvitamin D in both African Americans and Caucasians in the US population remains unexplained, and appears to parallel the obesity epidemic. The cross sectional data on 7349 Caucasian and African American adults between 21 and 69 years of age from the continuous National Health and Nutrition Examination Study (NHANES) 2001 to 2006 were used to model by race, with smoothing functions, the true relationship between body mass index (BMI), waist circumference and serum 25-hydroxyvitamin D in men and women. Weighted regressions of determinants of serum 25-hydroxyvitamin D levels were analyzed. Serum 25-hydroxyvitamin D is negatively associated with BMI linearly above an inflection point at 20 kg/m2 and positively associated below a BMI of 20 kg/m2. The gender- and age-adjusted regression coefficients of BMI on 25-hydroxyvitamin D levels demonstrate a 50% lower coefficient (r = –0.18 ng/ml/ BMI unit) among African Americans than among Caucasians (r = –0.36 ng/ml/BMI unit). These relationships were as great in men as in women and were replicated when waist circumference was used as a surrogate for visceral fat levels. The extent to which BMI is a strong predictor of serum 25-hydroxyvitamin D levels depends upon BMI being greater than 20 kg/m2. The hockey stick shape of the BMI 25-hydroxyvitamin D relationship needs to be taken into account when adjusting serum values for BMI. Both this inflection and reduction in serum levels of 25-hydroxyvitamin D in the population may be due to sequestration in an increasing adipose tissue reservoir. The interpretation of serum 25-hydroxyvitamin D levels as a biomarker of vitamin D adequacy requires appropriate adjustment of body fat mass.
Event-by-event mean p_T fluctuations in pp and Pb-Pb collisions measured by the ALICE experiment at the LHC
S. T. Heckel,for the ALICE collaboration
Physics , 2011, DOI: 10.1088/0954-3899/38/12/124095
Abstract: Non-statistical event-by-event fluctuations of the mean transverse momentum of charged particles in pp and Pb-Pb collisions are studied using the ALICE experiment at the LHC. Little collision energy dependence is observed in pp. The data indicate a common scaling behaviour with event multiplicity from pp to semi-central Pb-Pb collisions. In central Pb-Pb, the results deviate from this trend, exhibiting a significant reduction of the fluctuation strength. The results are compared with measurements in Au-Au collisions at lower energies and with Monte Carlo simulations.
Event-by-event mean p_T fluctuations in pp and Pb-Pb collisions at the LHC
S. T. Heckel,for the ALICE Collaboration
Physics , 2015, DOI: 10.1051/epjconf/20159008006
Abstract: The ALICE detector at the LHC is used to study the properties of the Quark-Gluon Plasma produced in heavy-ion collisions. As a reference measurement, also the analysis of proton-proton (pp) collisions is very important. In the study presented here, event-by-event fluctuations of the mean transverse momentum are analysed in pp collisions at sqrt(s) = 0.9, 2.76 and 7 TeV, and Pb-Pb collisions at sqrt(s_NN) = 2.76 TeV as a function of the charged-particle multiplicity. In both systems, dynamical fluctuations beyond the statistical expectation are observed. In pp collisions, no significant dependence on collision energy is found, even in comparison to inclusive results at much lower collision energies. Likewise, central A-A collisions show only little dependence on collision energy. The multiplicity dependence observed in peripheral Pb-Pb data is in agreement with that in pp collisions. Going to more central Pb-Pb collisions, a clear deviation from this trend is found, reaching a significant reduction of the fluctuations in most central collisions. Comparisons to Monte Carlo event generators show good agreement in pp, but rather large differences in Pb-Pb collisions.
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