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Search Results: 1 - 10 of 10878 matches for " Alfredo Rodriguez-Tebar "
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Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity
Pedro J Chacon, Rosa Garcia-Mejias, Alfredo Rodriguez-Tebar
Molecular Neurodegeneration , 2011, DOI: 10.1186/1750-1326-6-14
Abstract: We show here that Aβ activates the RhoA GTPase by binding to p75NTR, thereby preventing the NGF-induced activation of protein tyrosine phosphatase 1B (PTP1B) that is required for neuron survival. We also show that the inactivation of RhoA GTPase and the activation of PTP1B protect cultured hippocampal neurons against the noxious effects of Aβ. Indeed, either pharmacological inhibition of RhoA with C3 ADP ribosyl transferase or the transfection of cultured neurons with a dominant negative form of RhoA protects cultured hippocampal neurons from the effects of Aβ. In addition, over-expression of PTP1B also prevents the deleterious effects of Aβ on cultured hippocampal neurons.Our findings indicate that potentiating the activity of NGF at the level of RhoA inactivation and PTP1B activation may represent a new means to combat the noxious effects of Aβ in Alzheimer's disease.According to the amyloid hypothesis, amyloid beta (Aβ) aggregates form deposits in the brain, the process that precipitates the different manifestations of Alzheimer's disease (AD) [1]. Consequently, most therapeutic approaches to treat AD centre on this peptide: on the one hand attempting to limit the production of Aβ or the formation of fibrils and aggregates [2,3], while on the other hand, favouring its clearance. Therapeutic approaches aimed at clearing Aβ plaques have received special attention, and methods for active or passive immunisation have proven effective in reducing Aβ content in the brain. Nevertheless, these strategies have failed to conclusively ameliorate or retard cognitive deterioration in AD patients [4,5].Another approach that could be considered involves blocking the signals induced by Aβ that provoke neuronal death. However, despite extensive studies into the effects of Aβ on neurons, our understanding of Aβ signalling remains fragmented, and a consistent framework for such processes has yet to be defined. Still, recent publications have reinforced the notion that Aβ interferes
Formin1 Mediates the Induction of Dendritogenesis and Synaptogenesis by Neurogenin3 in Mouse Hippocampal Neurons
Julia Simon-Areces, Ana Dopazo, Markus Dettenhofer, Alfredo Rodriguez-Tebar, Luis Miguel Garcia-Segura, Maria-Angeles Arevalo
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021825
Abstract: Neurogenin3, a proneural transcription factor controlled by Notch receptor, has been recently shown to regulate dendritogenesis and synaptogenesis in mouse hippocampal neurons. However, little is known about the molecular mechanisms involved in these actions of Ngn3. We have used a microarray analysis to identify Ngn3 regulated genes related with cytoskeleton dynamics. One of such genes is Fmn1, whose protein, Formin1, is associated with actin and microtubule cytoskeleton. Overexpression of the Fmn1 isoform-Ib in cultured mouse hippocampal neurons induced an increase in the number of primary dendrites and in the number of glutamatergic synaptic inputs at 4 days in vitro. The same changes were provoked by overexpression of Ngn3. In addition downregulation of Fmn1 by the use of Fmn1-siRNAs impaired such morphological and synaptic changes induced by Ngn3 overexpression in neurons. These results reveal a previously unknown involvement of Formin1 in dendritogenesis and synaptogenesis and indicate that this protein is a key component of the Ngn3 signaling pathway that controls neuronal differentiation.
Creating Scenarios and Guiding Learning in a Medical Simulation Center  [PDF]
Gregorio Ma?eru Zunzarren, Alfredo Rodriguez-Sedano
Creative Education (CE) , 2011, DOI: 10.4236/ce.2011.23044
Abstract: In this article we propose to address the importance of learning scenarios in a simulation center in graduate studies in Medicine. We will describe in detail the context in which this learning is developed. To do this, we need to reflect briefly on the contents that permit the configuration of these scenarios as teaching units, the objectives which should be commensurate with the level of training and experience of the students, the activities to develop and the means by which these are arranged, and, finally, the evaluation of the process. The development of this learning would not be possible without an activity guide, as a well as an evolution and debriefing stage.
A Simple Numerical Method to Compute the Signal-to-Noise Ratio of a Magnetic Resonance Imaging Surface Coil
Rafael Rojas_Rodriguez;Alfredo O. Rodriguez Gonzalez
PIER M , 2009, DOI: 10.2528/PIERM09040604
Abstract: The quality of a magnetic resonance image can be reliably measured by the signal-to-noise ratio. This widely accepted parameter is a function of the magnetic field generated by the coil and the electric field produced by the sample to be imaged. A simple numerical method is proposed to calculate the coil signal-to-noise ratio of a circular-shaped coil and a spherical phantom. The phantom is composed of two-concentric sphere simulating a brain-skull model. The electromagnetic fields produced were then numerically computed by solving Maxwell's equations with the finite element method implemented in a commercial software tool. The electric and magnetic fields were used to numerically determine the signal-to-noise ratio using the quasi-static approach. The numerical results demonstrated that this simple method is able to calcualte the signal-to-noise ratio of surface coils with simple coil geometries involving a simulated phantom.
Aproxima es entre Pensamento Complexo e Estratégia Organizacional
Pedrozo, Eugenio Avila,Rodriguez, Ivan Alfredo Calderon
Teoria e Prática em Administra??o (TPA) , 2013,
Abstract: Organizations are social systems from joint activities of people, which operation and interaction among those people require a comprehension based on systemic principles. The study of business strategy provides reductive and disjunctive guidance as the product of its positivist treatment based on the precepts of classical science. However, the context of organizations and their own internal operation have been complexified over time, leading to questions about the relevance of the use of more classic orientations in the strategy of organizations. In this paper, we try to associate the development of an organizational strategy to the principles of Morinian complexity theory. Through the analysis of systemic principles, we found associations with various approaches used in studies of organizational strategy. The contribution of this paper is to show that complexity theory has applicability in various fields of science and, in particular, In the applied social sciences, because It provides new foundations that contribute to a better understanding of natural and social phenomena.
Advantages and disadvantages of biodegradable platforms in drug eluting stents
Agustina Rodriguez-Granillo, Bibiana Rubilar, Gaston Rodriguez-Granillo, Alfredo E Rodriguez
World Journal of Cardiology , 2011,
Abstract: Coronary angioplasty with drug-eluting stent (DES) implantation is currently the most common stent procedure worldwide. Since the introduction of DES, coronary restenosis as well as the incidence of target vessel and target lesion revascularization have been significantly reduced. However, the incidence of very late stent thrombosis beyond the first year after stent deployment has more commonly been linked to DES than to bare-metal stent (BMS) implantation. Several factors have been associated with very late stent thrombosis after DES implantation, such as delayed healing, inflammation, stent mal-apposition and endothelial dysfunction. Some of these adverse events were associated with the presence of durable polymers, which were essential to allow the elution of the immunosuppressive drug in the first DES designs. The introduction of erodable polymers in DES technology has provided the potential to complete the degradation of the polymer simultaneously or immediately after the release of the immunosuppressive drug, after which a BMS remains in place. Several DES designs with biodegradable (BIO) polymers have been introduced in preclinical and clinical studies, including randomized trials. In this review, we analyze the clinical results from 6 observational and randomized studies with BIO polymers and discuss advantages and disadvantages of this new technology.
Normalización del cemento. Resistencias mecánicas: Algunos comentarios sobre el método de ensayo
Gaspar Tebar, Demetrio
Materiales de Construccion , 1980,
Abstract: Not avaible Como es sabido la categoría de los distintos tipos y clases de los cementos del Pliego de Prescripciones Técnicas Generales para la Recepción de Cementos (RC-75) (1) viene fijada por la resistencia mecánica a compresión, en kp/cm2, que como valor mínimo se exige a los 28 días al mortero normal, sin tener un límite máximo; criterio que se sigue en las normas de numerosos países.
Normalización del cemento. Características químicas: Algunos comentarios sobre los métodos de ensayo
Gaspar-Tebar, Demetrio
Materiales de Construccion , 1978,
Abstract: El Pliego de Prescripciones Técnicas Generales para la Recepción de Cementos (RC-75), Decreto 1.064/1975 de 23 de mayo de 1975, publicado en los B.O.E. núms. 206 y 207, de fechas 28 y 29 de agosto, respectivamente, del mismo a o, incluye la clasificación de los cementos, las prescripciones relativas a las características químicas y físicas, así como los métodos de ensayo que se deben utilizar para determinar dichas características.
Nota Necrológica: Don Pablo
Gaspar-Tebar, Demetrio
Materiales de Construccion , 1986,
Abstract:
Aditivos para hormigones, morteros y pastas
Gaspar Tebar, Demetrio
Materiales de Construccion , 1984,
Abstract: This article comments on the increasing importance of the use of admixtures for concrete, mortars and grouts as well as the specific effects they produce, thus requiring a suitable Spanish Normative, whose performance was taken in charge by a Working Group of the Technical Commission n.° 83 from the IRANOR, created for this purpose. This article is first of a series which intends to give an account of the works, on the Normative of those additives, the Working Group is carrying out. En el presente artículo se comenta la importancia que ha adquirido el empleo de los aditivos para hormigones, morteros y pastas, así como las modificaciones y efectos específicos que producen, lo que ha motivado la necesidad de contar con una normativa espa ola apropiada, cuya realización se encomendó a un Grupo de Trabajo, creado al efecto, de la Comisión Técnica n.o 83 del IRANOR. Este artículo es el primero de una serie en la que se pretende dar cuenta de los trabajos que sobre normativa de los mencionados aditivos se viene realizando por dicho Grupo de Trabajo.
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