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Search Results: 1 - 10 of 29641 matches for " Alfredo Rodríguez-Antigüedad "
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Increased expression of cystine/glutamate antiporter in multiple sclerosis
Olatz Pampliega, María Domercq, Federico N Soria, Pablo Villoslada, Alfredo Rodríguez-Antigüedad, Carlos Matute
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-63
Abstract: Primary cultures of human monocytes and the cell line U-937 were used to investigate the mechanism of glutamate release. Expression of cystine glutamate exchanger (xCT) was quantified by quantitative PCR, Western blot, flow cytometry and immunohistochemistry in monocytes in vitro, in animals with experimental autoimmune encephalomyelitis (EAE), the animal model of MS, and in samples of MS patients.We show here that human activated monocytes release glutamate through cystine/glutamate antiporter xc- and that the expression of the catalytic subunit xCT is upregulated as a consequence of monocyte activation. In addition, xCT expression is also increased in EAE and in the disease proper. In the later, high expression of xCT occurs both in the central nervous system (CNS) and in peripheral blood cells. In particular, cells from monocyte-macrophage-microglia lineage have higher xCT expression in MS and in EAE, indicating that immune activation upregulates xCT levels, which may result in higher glutamate release and contribution to excitotoxic damage to oligodendrocytes.Together, these results reveal that increased expression of the cystine/glutamate antiporter system xc- in MS provides a link between inflammation and excitotoxicity in demyelinating diseases.Multiple sclerosis (MS) is a chronic, degenerative disease of the CNS, which is characterized by focal lesions with inflammation, demyelination, infiltration of immune cells, oligodendroglial death and axonal degeneration [1-3]. MS is typically considered as a primary inflammatory disease in the early, relapsing phase which progresses to a secondary, progressive stage that is characterized by a diminished inflammatory activity and global brain atrophy [4].Oligodendroglial death and demyelination can occur through glutamate excitotoxicity [5,6], a phenomenon that takes place when an excessive amount of glutamate overactivates ionotropic glutamate receptors (iGluRs). Several observations have linked glutamate excitotoxic
Existe una personalidad jaquecosa?.
C Ramo,E García Albea,I Posada,A Rodríguez-Antigüedad
Revista de la Asociación Espa?ola de Neuropsiquiatría , 1985,
Abstract: Se revisa brevemente el concepto actual de jaqueca y se analiza detalladamente la literatura existente sobre la personalidad jaquecosa. El concepto de personalidad jaquecosa fue mantenido por clínicos y autores de orientación psicoanalítica en las décadas de 1930-1950. los estudios recientes efectuados con criterios epidemiológicos (no basados en estudios hospitalarios) y realizados, empleando tests psicológicos estandarizados no son concordantes con la existencia de una personalidad jaquecosa.
Streamflow response of a small forested catchment on different timescales
A. Zabaleta ,I. Antigüedad
Hydrology and Earth System Sciences (HESS) & Discussions (HESSD) , 2013,
Abstract: The hydrological response of a catchment to rainfall on different timescales is result of a complex system involving a range of physical processes which may operate simultaneously and have different spatial and temporal influences. This paper presents the analysis of streamflow response of a small humid-temperate catchment (Aixola, 4.8 km2) in the Basque Country on different timescales and discusses the role of the controlling factors. Firstly, daily time series analysis was used to establish a hypothesis on the general functioning of the catchment through the relationship between precipitation and discharge on an annual and multiannual scale (2003–2008). Second, rainfall-runoff relationships and relationships among several hydrological variables, including catchment antecedent conditions, were explored at the event scale (222 events) to check and improve the hypothesis. Finally, the evolution of electrical conductivity (EC) during some of the monitored storm events (28 events) was examined to identify the time origin of waters. Quick response of the catchment to almost all the rainfall events as well as a considerable regulation capacity was deduced from the correlation and spectral analyses. These results agree with runoff event scale data analysis; however, the event analysis revealed the non-linearity of the system, as antecedent conditions play a significant role in this catchment. Further, analysis at the event scale made possible to clarify factors controlling (precipitation, precipitation intensity and initial discharge) the different aspects of the runoff response (runoff coefficient and discharge increase) for this catchment. Finally, the evolution of EC of the waters enabled the time origin (event or pre-event waters) of the quickflow to be established; specifically, the conductivity showed that pre-event waters usually represent a high percentage of the total discharge during runoff peaks. The importance of soil waters in the catchment is being studied more deeply.
Respuesta de una cuenca de cabecera durante eventos de crecida (Aixola, País Vasco)
Zabaleta, A.,Antigüedad, I.
Pirineos : Revista de Ecología de Monta?a , 2010,
Abstract: Turbidity (T, FNU), discharge (Q, l/s) and precipitation (P, mm) are being continuously monitored in the gauging station located at the outlet of Aixola catchment (Gipuzkoa, 5 km2) since October 2003. Several data sets recorded during flood events occurred between 2003 and 2005 were used to estimate continuous suspended sediment concentration (SSC). Electrical conductivity was also measured in samples taken during runoff events. Several event (discharge, precipitation and suspended sediment concentration) and pre-event (discharge and precipitation) factors are calculated for all the events registered. With them a correlation matrix was developed. Good correlation between precipitation (P), discharge (Q) and suspended sediment (SS) variables is found in general but pre-event conditions don’t show correlation with event parameters. Analysis of SSC-discharge evolutions through the events showed that four different kinds of hysteretic loops can be observed in Aixola. Hysteretic loops have also been related to event and pre-event factors. Evolution of electrical conductivity of waters during events shows that the catchment has a considerable regulation capacity. La turbidez (T, FNU), el caudal (Q, l/s) y la precipitación (P, mm) se están midiendo en continuo en la estación de aforo situada en la salida de la cuenca de Aixola (Gipuzkoa, 5 km2) desde octubre 2003. Se han utilizado los datos recogidos en los eventos ocurridos entre octubre 2003 y octubre 2005 para establecer la relación turbidez-concentración de sedimentos en suspensión (CSS), y así, estimar las series continuas de CSS. Además, también se ha medido la conductividad eléctrica en muestras tomadas durante las crecidas. Por otro lado, se cuantificaron varios parámetros del evento (P, Q y CSS) y anteriores al mismo (Q y P) para todos los eventos registrados. Se observa un nivel significativo de correlación entre las variables de precipitación, caudal y sedimentos en suspensión. Sin embargo, las condiciones anteriores al evento no se correlacionan bien con los parámetros calculados para el mismo. En el análisis de la relación entre la concentración de sedimentos en suspensión y el caudal durante los eventos se han observado cuatro tipos diferentes de bucles de histéresis relacionados con diferentes condiciones antecedentes al evento y del propio evento. La evolución de la conductividad eléctrica durante los eventos de crecida indica que la cuenca posee una capacidad de regulación considerable.
Streamflow response of a small forested catchment on different time scales
A. Zabaleta,I. Antigüedad
Hydrology and Earth System Sciences Discussions , 2012, DOI: 10.5194/hessd-9-9257-2012
Abstract: The hydrological response of a catchment to rainfall on different time scales is result of a complex system involving a range of physical processes which may operate simultaneously and have different spatial and temporal influences. This paper presents the analysis of streamflow response of a small humid-temperate catchment (Aixola, 4.8 km2) in the Basque Country on different time scales and discusses the role of the controlling factors. Firstly, daily time series analysis was used to establish a hypothesis on the general functioning of the catchment through the relationship between precipitation and discharge on an annual and multi-annual scale (2003–2008). Second, rainfall-runoff relationships and relationships among several hydrological variables, including catchment antecedent conditions, were explored at the event scale (222 events) to check and improve the hypothesis. Finally, the evolution of electrical conductivity (EC) during some of the monitored storm events (28 events) was examined to identify the time-origin of waters. Quick response of the catchment to almost all the rainfall events as well as a considerable regulation capacity was deduced from the correlation and spectral analyses. These results agree with runoff event scale data analysis; however the event analysis revealed the non-linearity of the system, as antecedent conditions play a significant role in this catchment. Further, analysis at the event scale made possible to clarify factors controlling (precipitation, precipitation intensity and initial discharge) the different aspects of the runoff response (runoff coefficient and discharge increase) for this catchment. Finally, the evolution of EC of the waters enabled the time origin (event or pre-event waters) of the quickflow to be established; specifically, the conductivity showed that pre-event waters usually represent a high percentage of the total discharge during runoff peaks. The importance of soil waters in the catchment is being studied more deeply.
La cuestión del método en la pedagogía social
Rodríguez Sedano,Alfredo;
Educación y Educadores , 2007,
Abstract: desde sus inicios, en la segunda mitad del siglo xix, la pedagogía social no ha sido ajena a los diversos debates y perspectivas metodológicas que se han propuesto para un mejor conocimiento de lo que es objeto de esta ciencia. trataré de se?alar cuál es, a mi modo de ver, el método más apropiado. a continuación, expondré los diversos paradigmas existentes en la investigación en educación. posteriormente, se ofrecerá un análisis comparativo de esos paradigmas. la propuesta que aquí se presenta, se centra en que, junto al método analítico -propio de los paradigmas que se expondrán- el método sintético arroja luz sobre los datos obtenidos por el análisis.
Hacia una fundamentación epistemológica de la pedagogía social
Rodríguez Sedano,Alfredo;
Educación y Educadores , 2006,
Abstract: theoretical and epistemological foundation of social pedagogy requires getting back to its origins and historical background, in order to clarify the objective of studying social pedagogy. the different specialized authors' points of view will help us to see the panorama of what people understand by social pedagogy. from this panorama we will be able to take out the sociological referents that constitute the noetic foundation of this science. at the end, we will propose a new definition (according to those referents) that will give a more precise and real dimension to social pedagogy.
Productividad científica de la Cardiología y de las Sociedades de Cardiología: diferencias y similitudes de la Argentina con la región y los países centrales
Rodríguez,Alfredo E;
Revista argentina de cardiolog?-a , 2012,
Abstract: scientific production by cardiologists and scientific societies of cardiology: differences and similarities between argentina and regional and central countries the present study analyzes the scientific production by cardiologists in general and by societies of cardiology in particular in argentina and other regions of the world, including latin america, usa, europe, asia, oceania and south africa. we used the h-index created by professor jorge e. hirsch, an argentinean physicist who is currently working in the university of california, usa. despite its limitations, the h-index is nowadays used in most of the universities of the developed countries to measure the scientific quality of an investigator, a group of investigators or a scientific society. this index considers all the publications performed by the author and the amount of citation the work has received. the limitations of this index are discussed in this paper. we have tried to quantify the scientific production in cardiology measured by the h-index in different countries. the h-index of the presidents of the scientific societies of cardiology in the last 20 years is also analyzed. the possible explanations for these findings are discussed. despite its shortcomings, the h-index is used in most of the universities in the usa and europe for the award of tenure, promotion and advancement in the career of an investigator, which i consider of undoubted value at the moment of measuring scientific and academic production.
El aprendizaje histológico inicial de Santiago Ramón y Cajal: notas acerca de sus investigaciones sobre la inflamación
Rodríguez Quiroga, Alfredo
Asclepio : Revista de Historia de la Medicina y de la Ciencia , 2002,
Abstract: Cajal attained the histological training which was the starting point for his brilliant work on the structure of the nervous system during the decade from the middle of 1877 to the end of 1887. More exactly, his initial histological training began to develop blossom once he did his Ph. D. with Aureliano Maestre de San Juan and he graduated with his thesis on the Pathogenesis of inflamation, which would be the subject of his first publication three years later. This first stage of Cajal's scientific career has been, on the whole, forgotten, as his full time work on histology did not take place till the Autumn of 1885, when he was Professor of Anatomy at Valencia. Therefore, the bibliography of a more or less panegyrical nature on this figure has led largely to the underrating, in most cases, of this decisive period in his scientific career. In study we aim, therefore, to attempt to fill this gap in Cajalian historiography, by firstly looking at the above mentioned Doctorate thesis of 1877, and subsequently the first micrographical essays wich he worked on for the following three years, as a resultt of the writing of his thesis and which became his first published monograph. Cajal adquirió la formación histológica que sirvió de punto de partida a su genial obra sobre la estructura del sistema nervioso durante la década comprendida entre mediados de 1877 y finales de 1887. De modo más exacto, su aprendizaje histológico inicial comenzó a fraguarse precisamente desde que cursó el doctorado con Aureliano Maestre de San Juan y se graduó con su discurso sobre la Patogenia de la inflamación, tema al que dedicaría tres a os más tarde su primera publicación. Esta primera etapa de la trayectoria científica de Cajal ha sido, generalmente, obviada, toda vez que su dedicación de modo continuado a la histología no se produjo hasta el oto o de 1885, siendo catedrático de anatomía en Valencia. En este sentido, la bibliografía de carácter más o menos panegírico que se ha ocupado de su figura ha contribuido en gran medida a minimizar en la mayoría de los casos este decisivo período de su carrera científica. En este trabajo pretendemos, pues, contribuir a paliar esta laguna de la historiografía cajaliana, recuperando en primera instancia el mencionado ejercicio con el cual Cajal se graduó como doctor en 1877 y, subsiguientemente, los primeros ensayos micrográficos que, a raíz de la redacción de su memoria emprendió a lo largo de los tres a os siguientes y que se tradujeron en su primera monografía publicada.
La exclusión social en Panamá ( sistema penitenciario o guetos?)
Alfredo Graham Rodríguez
Araucaria , 2007,
Abstract: Son los menores de edad en situación de marginalidad quienes principalmente sufren las consecuencias del clima de descomposición social que hoy afecta a un sector muy considerable de la ciudadanía paname a. En un contexto vital muy difícil y, lo que es peor, sin expectativas, hombres y mujeres jóvenes, algunos todavía ni os o ni as, caen con facilidad en la narcodependencia, el narcotráfico o la prostitución. El principal remedio aplicado hasta ahora, la represión penal, no hace en realidad sino trasladar y agravar el problema: el sistema penitenciario paname o puede considerarse al borde del colapso, sin que en el interior de los centros penitenciarios existan las condiciones para garantizar un mínimo respeto a los derechos humanos básicos. En tales circunstancias, cualquier perspectiva de rehabilitación de los internos resulta inviable.
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