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Search Results: 1 - 10 of 79337 matches for " Alfio José;Del Negro "
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Lingual thyroid causing dysphonia: case report
Tincani, Alfio José;Martins, Antonio Santos;Del Negro, André;Araújo, Priscila Pereira Costa;Barretto, Gilson;
Sao Paulo Medical Journal , 2004, DOI: 10.1590/S1516-31802004000200007
Abstract: context: lingual thyroid gland is a rare clinical entity that is caused by the failure of the thyroid gland to descend to a normal cervical location during embryogenesis. the occurrence of an ectopic thyroid gland located at the base of the tongue may cause problems for the patient, with symptoms of dysphagia, dysphonia, upper airway obstruction or even hemorrhage at any time from infancy through adulthood. case report: we report on a case of lingual thyroid gland in a 41-year-old female patient. the embryology and diagnosis of ectopic thyroid are discussed and its management is outlined. features of the diagnostic and therapeutic evaluation are described with attention to the clinical findings, laboratory tests, thyroid scan and computed tomography imaging studies employed in the confirmation of diagnosis and planning of appropriate treatment. the history of the condition is reviewed and a treatment strategy is outlined. surgical excision of the gland is reserved for cases of gland enlargement that result in compromised airways (dysphagia or dysphonia) or recurrent hemorrhage.
Laryngeal adenoid cystic carcinoma: case report
Del Negro, André;Ichihara, Edson;Tincani, Alfio José;Altemani, Albina;Martins, Ant?nio Santos;
Sao Paulo Medical Journal , 2007, DOI: 10.1590/S1516-31802007000500010
Abstract: context: adenoid cystic carcinomas are malignant tumors that occur in both the major and the minor salivary glands. a laryngeal location is rare because of the paucity of accessory salivary glands in this area. adenoid cystic carcinomas account for less than 1% of all malignant tumors in the larynx, and only about 120 cases have been reported in the literature. these tumors have a slight female predisposition, and their peak incidence is in the fifth and sixth decades of life. in this article, we describe a case of laryngeal adenoid cystic carcinoma and discuss its clinical characteristics and treatment. case report: we report on a case of laryngeal adenoid cystic carcinoma in a 55 year-old female patient who presented with dyspnea and hoarseness. features of the diagnostic and therapeutic evaluation are described and the clinical management of such cases is outlined. the clinical course, definitive treatment strategy and surgical procedure, and also adjuvant treatment with irradiation are discussed. although the tumor is radiosensitive, it is not radiocurable.
Experimental carcinogenesis on the oropharyngeal mucosa of rats with hydrochloric acid, sodium nitrate and pepsin
Del Negro, André;Araújo, Marina Raquel;Tincani, Alfio José;Meirelles, Luciana;Martins, Ant?nio Santos;Andreollo, Nelson Adami;
Acta Cirurgica Brasileira , 2008, DOI: 10.1590/S0102-86502008000400007
Abstract: purpose: to investigate the carcinogenic action of hydrochloric acid, pepsin and sodium nitrate on the oropharyngeal mucosa of rats, simulating the reflux of gastric contents. methods: eighty-two wistar rats were divided in seven groups and submitted to 2 or 3 weekly applications of hydrochloric acid, pepsin and sodium nitrate on the pharyngeal mucosa during six months. study groups comprised 12 animals each. rats in groups i and ii were submitted to 2 (gi) or 3 (gii) weekly applications of 0.1n hydrochloric acid. groups iii and iv were submitted to 2 (giii) or 3 (giv) weekly applications of 0.1n hydrochloric acid solution with pepsin. groups v and vi were submitted to 2 (gv) or 3 (gvi) weekly applications of 0.1n hydrochloric acid and treated with daily nitrate diluted in water. group vii consisted of 10 animals submitted to 2 weekly applications of filtered water. results: no dysplasia, intra-epithelial neoplasia or invasive carcinomas were detected. inflammatory changes were observed in varying degrees and mast cells were more common in groups v and vi (p=0.006). conclusion: the data of the current study could not corroborate the hypothesis that gastroesophageal and pharyngolaryngeal refluxes are carcinogenic factors to the laryngopharyngeal mucosa, and more studies are necessary in the future.
Schwannomas in the head and neck: retrospective analysis of 21 patients and review of the literature
Langner, Erwin;Del Negro, André;Akashi, Hugo Kenzo;Araújo, Priscila Pereira Costa;Tincani, Alfio José;Martins, Antonio Santos;
Sao Paulo Medical Journal , 2007, DOI: 10.1590/S1516-31802007000400005
Abstract: context and objective: schwannomas are benign neoplasms of the peripheral nerves originating in the schwann cells. according to their cellularity, they can be subdivided into antoni a or antoni b types. they are rare and usually solitary, with clearly delimited capsules. they occur in the head and neck region in only 25% of the cases, and may be associated with von recklinghausen's disease. the present study retrospectively analyzed some data on this disease in the head and neck region and reviewed the literature on the subject. design and setting: retrospective study at head and neck service, universidade estadual de campinas. methods: data on 21 patients between 1980 and 2003 were reviewed. the sites of cervical schwannomas and the intraoperative, histopathological and postoperative clinical status of these cases were studied. diagnostic methods, type of surgery and association with neurofibromatosis were evaluated. results: the patients' ages ranged from 16 to 72 years. four patients had a positive past history of type i neurofibromatosis or von recklinghausen's disease. the nerves affected included the brachial and cervical plexuses, vagus nerve, sympathetic chain and lingual or recurrent laryngeal nerve. the nerve of origin was not identified in six cases. tumor enucleation was performed in 16 patients; the other five required more extensive surgery. conclusion: schwannomas and neurofibromas both derive from schwann cells, but are different entities. they are solitary lesions, except in von recklinghausen's disease. they are generally benign, and rarely recur. the recommended surgical treatment is tumor enucleation.
Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series
Tincani, Alfio José;Del Negro, André;Araújo, Priscila Pereira Costa;Akashi, Hugo Kenzo;Martins, Antonio Santos;Altemani, Albina Milani;Barreto, Gilson;
Sao Paulo Medical Journal , 2006, DOI: 10.1590/S1516-31802006000100006
Abstract: context and objective: salivary gland tumor management requires long-term follow-up because of tumor indolence and possible late recurrence and distant metastasis. adenoid cystic carcinoma (acc) accounts for 10-15% of such tumors. the aim here was to evaluate surgical and clinical management, staging and follow-up of acc patients in one academic institution. design and setting: retrospective study at head and neck service, universidade estadual de campinas. methods: data on 21 patients treated between 1993 and 2003 were reviewed. management utilized clinical staging, histology and imaging. major salivary gland tumor extent was routinely assessed by preoperative ultrasonography. diagnosis, surgery type, margin type (negative/positive), postoperative radiotherapy and recurrence (presence/absence) were evaluated. results: there were eleven major salivary gland tumors (52.3%), seven submandibular and four parotid. ten patients (47.7%) had minor salivary gland acc (all in palate), while the submandibular was the most frequently affected major one. diagnoses were mostly via fine-needle aspiration (fna) and incision biopsy. frozen sections were used for six patients. there was good ultrasound/fna correlation. sixteen (76%) had postoperative radiotherapy. one (4.7%) died from acc and five now have recurrent disease: three (14.2%) locoregional and two (9.5%) distant metastases. conclusion: adenoid cystic carcinoma has locally aggressive behavior. in 21 cases, of acc, the facial nerve was preserved in all except in the few with gross tumor involvement. treatment was defined from physical examination, imaging, staging and histology.
Head and neck reconstruction using infrahyoid myocutaneous flaps
Tincani, Alfio José;Del Negro, André;Araújo, Priscila Pereira Costa;Akashi, Hugo Kenzo;Neves, Flávia da Silva Pinto;Martins, Ant?nio Santos;
Sao Paulo Medical Journal , 2006, DOI: 10.1590/S1516-31802006000500007
Abstract: context and objective: the use of pedicled myocutaneous flaps in head and neck reconstruction is widely accepted. here we describe our experience with infrahyoid flaps (ihfs) employed to cover surgical defects in the oral cavity and oropharynx in patients with benign and malignant tumors. the aim was to evaluate the success rate for infrahyoid myocutaneous flap procedures performed at a single institution. design and setting: retrospective study, at the head and neck surgery service, unicamp. methods: fourteen ihfs were used to reconstruct surgical defects in eleven men (78.5%) and three women (21.5%) with a mean age of 66.4 years. the anterior floor of the mouth was reconstructed in nine patients (64.2%), the base of tongue in three (21.4%), the lateral floor in one (7.1%), and the retromolar area (7.1%) in one. thirteen patients (92.8%) had squamous cell carcinoma (scc) and one (7.2%) ameloblastoma. the disease stage was t3 in eight (61.5%) of the scc cases and t4 in five (38.5%). results: no patient presented total flap loss or fistula. the most common complication was epidermolysis, which delayed the beginning of oral ingestion. the patients with scc received postoperative radiotherapy without major consequences to the flap. conclusion: ihf is a safe and reliable procedure for reconstructing head and neck surgical defects. due to its thinness and malleability, its use for oral cavity and oropharynx defects provides favorable cosmetic and functional outcomes. complications, when present, are easy to manage.
Colorectal cancer in the elderly: characteristics and short term results Cáncer colorrectal en el anciano: Características y resultados a corto plazo
Juan José Arenal Vera,Claudia Tinoco Carrasco,Araceli del Villar Negro,Fernando Labarga Rodríguez
Revista Espa?ola de Enfermedades Digestivas , 2011,
Abstract: Objective: to analyse the characteristics of colorectal cancer in elderly patients and to assess the outcomes of treatment. Material and methods: the study included 1,924 patients diagnosed with colorectal cancer during a 22 year period (1985-2007). We analysed patient clinical and demographic characteristics as well as their treatment and its outcome. Results: there was an increase in emergency surgery with age, increasing from 13% among patients under 80 years of age to 47% in those over 90 years of age (p = 0.0001). On the other hand, the overall percentage of patients who underwent surgical treatment decreased from 96% in patients younger than 80 years of age, to 85% and 59% in octogenarians and nonagenarians, respectively (p = 0.0001), and there was a similar pattern in the rates of curative surgery among patients who underwent surgery. The overall mortality of patients who underwent surgery was 8% (141 out of 1,769), increasing from 4% in patients younger than 70 years of age to 25% in those over 90 (p = 0.0001). Multivariate analysis showed that the factors associated with mortality were the emergency nature of the surgery (p = 0.001), the ASA grade (p = 0.0001), and the presence of systemic complications (p = 0.0001), the weight of age decreasing significantly with respect to the univariate analysis (p = 0.013). Conclusions: there is an increase in the rate of complicated forms of colorectal cancer with increasing age of patients. In addition, there is a dramatic decrease in the rate of curative tumour resection with increasing age. Intraoperative mortality for colorectal cancer in octogenarians and nonagenarians is more closely related to the nature and intent of the surgery (elective or emergency; palliative or curative), the perioperative risk (ASA grade), and severe systemic complications, than to age. Objetivo: analizar las características del cáncer colorrectal en pacientes ancianos y evaluar los resultados de su tratamiento. Material y métodos: 1.924 pacientes diagnosticados por cáncer colorrectal un periodo de 22 a os (1985-2007). Se analizan parámetros del paciente, clínicos, tratamiento y resultados del mismo. Resultados: hay un incremento de la cirugía de urgencia con la edad, pasando del 13% en pacientes menores de 80 a os al 47% en pacientes mayores de 90 (p = 0,0001). El porcentaje de pacientes sometidos a tratamiento quirúrgico desciende del 96% en los pacientes menores de 80 a os, al 85% en los octogenarios y al 59% en los nonagenarios (p = 0,0001), así como de la tasas de cirugía curativa entre los pacientes sometidos a tratamien
Grazia Del Negro
Prisma Social , 2012,
Abstract: Actualmente se han producido en Europa cambios sociales, económicos y políticos que han conducido a un incremento en la precarización de las condiciones de vida; al tiempo que, las instituciones públicas tienden a delegar en la sociedad civil parte de su responsabilidad en el acceso a los derechos sociales. Los actores institucionales tradicionales como Estado, mercado y familia, parece que hayan fallado en responder satisfactoriamente a las nuevas necesidades sociales, por lo que la sociedad civil ha procurado reorganizarse en la búsqueda de una solución. En los actuales sistemas económicos, frente a “externalización de las funciones domésticas” y la “privatización de las funciones públicas”, han ido emergiendo las llamadas empresas sociales, entre ellas las de inserción. En las siguientes páginas se analizarán el fenómeno de la exclusión social a la vez que las características de las empresas sociales de inserción.
Application of the Wiener filter to magnetic profiling in the volcanic environment of Mt. Etna (Italy)
C. Del Negro
Annals of Geophysics , 1996, DOI: 10.4401/ag-3951
Abstract: The frequency-domain Wiener filtering was applied to magnetic anomalies in the volcanic area of Mt. Etna. This filter, under suitable conditions (additive noise, linear processing and mean-square error criterion), can furnish an effective tool for discriminating the geologic feature of interest (the signal) from the noise. The filter was first tested with synthetic data. Afterwards it was applied to a magnetic profile carried out across the principal fault system of the Mt. Etna volcano, that hosted the dykes feeding both the 1989 and the 1991-93 eruptions. The magnetic anomalies linked to the volcanic section and those linked to the contact between the clay basement and the lava coverage show significant spectral overlap. Thus by estimating the power spectrum of the signal, obtained resolving the forward problem, a least-squares Wiener filter has been designed. In such context, it was possible to verify the effectiveness of Wiener filters, whereas traditional band-pass filtering proved inadequate. In fact, analysis of the noise showed that all the meaningful components of the observed magnetic field were resolved. The results put further constraints on location and geometry of the shallow plumbing system of Mt. Etna.
Experimental model of smoking and simulation of reflux with acid and pepsin in rats
Zen Junior, José Hélio;Negro, André Del;Colli Neto, José Alexandre;Araujo, Marina Rachel;Altemani, Albina Maria;Andreollo, Nelson Adami;
Acta Cirurgica Brasileira , 2012, DOI: 10.1590/S0102-86502012000100004
Abstract: purpose: to develop experimental models to evaluate the effects of hydrochloric acid associated with the pepsin instilled in the mucosa of the upper esophagus and the esophagogastric junction of young male rats wistar, simulating injury caused by gastroesophageal reflux on the mucosa of aero-digestive tract in humans as well as the action of the risk exposure of mucosa to cigarette smoke. methods: fifty young male wistar rats divided in 5 groups with 10 animals each one, respectively simulating pharyngo-laryngeal reflux and gastroesophageal reflux, pharyngo-laryngeal reflux and smoking, smoking only, gastroesophageal reflux and control group. results: the histopathologic studies no recorded neoplasias, only mild changes and no significant alterations. the hemo-oximetry (carboxyhemoglobin and methemoglobim) and co2 concentration confirm that the animals were submitted to high intensity of exposure to carcinogens in tobacco and its derivatives. conclusion: the experimental models were highly efficient, practical, easy to use and economical and can be employed in other similar studies to determine the harmful effects by smoking and reflux.
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