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Search Results: 1 - 10 of 2248 matches for " Alexei Oulanov "
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Music Education, Aesthetics, and the Measure of Academic Achievement  [PDF]
Karl Madden, David Orenstein, David Orenstein, Alexei Oulanov, Yelena Novitskaya, Ida Bazan, Thomas Ostrowski, Min Hyung Ahn
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.519194
Abstract: Grades and test scores are the traditional measurement of academic achievement. Quantitative improvements on standardized scores in Math/Science/Language are highly-coveted outcomes for meeting accreditation standards required for institutional program funding. Music and the Fine Arts, difficult to assess by traditional academic achievement measurement, and often devalued as so-called “luxury” subjects, struggle for necessary funding. Showing measureable collateral value to other academic subjects—such as math—in order to justify music program funding is dubious. To objectify the purpose of music education in terms of its influence on other subjects is to overlook aesthetic value. The scholarly literature recognizes an historical tendency to correlate music activities and aptitude to other subjects (and to intelligence in general), but quantitative cause-effect claims are not supported scientifically. Music participation from childhood helps build productive, well-socialized, excellent people, but to quantitatively trace the cause to music itself remains unproven. To recognize the benefits of music and the arts by aesthetic merit involves practical, holistic views of education not based on quantifiable test scoring.
Intracellular Notch1 May Induce a Conformational Change in CSL/DNA, without Forming ICN1/CSL/DNA Molecular Complex, in Vitro  [PDF]
Alexei A. Stortchevoi
CellBio (CellBio) , 2013, DOI: 10.4236/cellbio.2013.22010
Abstract: Intracellular Notch (ICN) initiates DNA transcription in cooperation with CSL that acts as repressor in the absence of ICN. The ICN mediates recruitment of MAML protein, leading to the formation of minimal transcriptional complex, MAML/ICN/CSL/DNA. Crystal structure reveals that different conformations exist between the free (CSL/DNA) and bound (ICN/MAML/CSL/DNA) forms. The significance of this modulation of the CSL/DNA molecular complex can be better understood by experimental approaches that aim to elucidate the cause and timing of these events. There are four orthologues of human ICN (ICN1-4). We studied interactions between human full-length ICN1 and CSL/DNA without involvement of MAML, in vitro, and found that 1) the EMSA profile of CSL/DNA is altered in the presence of ICN1 as a consequence of an intrinsic change(s) in CSL/DNA, and not due to the formation of an ICN/CSL/DNA molecular complex; 2) ICN1 destabilizes CSL/DNA. These findings indicate that human ICN1 functions to modulate the CSL/DNA molecular complex for subsequent recruitment of MAML, and that modulated CSL/DNA cannot accommodate ICN1 in the absence of MAML. The latter in turn, implies that the formation of the MAML/ICN1/CSL/DNA is likely to be a collective event, wherein preassembly of MAML and ICN1 as a binary complex co-localizes at the CSL/DNA promoter site, or the MAML/ICN1/CSL complex is pre-assembled prior to binding to the promoter, rather than ICN1 arriving at CSL/DNA ahead of MAML and/or other associated transcription factors. The novel finding that ICN1 destabilizes the CSL/DNA complex opens new possibilities of transcriptional regulation by Notch.

New Theoretical Aspects of Software Engineering for Development Applications and E-Learning  [PDF]
Ekaterina Lavrischeva, Alexei Ostrovski
Journal of Software Engineering and Applications (JSEA) , 2013, DOI: 10.4236/jsea.2013.69A004
Abstract:

This paper presents new theoretical aspects of software engineering which oriented on product lines for building applied systems and software product families from readymade reusable components in conditions of program factories. These aspects are the new disciplines such as the theory of component programming; models variability and interoperability of system; theory for building systems and product families from components. Principles and methods of implementing these theories were realized in the instrumental and technological complex by lines of component development: assembling program factories using lines, e-learning to new theories and technologies in textbook of “Software Engineering” by the universities students.

On a conjecture of Widom
Alexei Borodin,Alexei Novikov
Mathematics , 2005, DOI: 10.1088/0305-4470/39/28/S07
Abstract: We prove a conjecture of H.Widom stated in [W] (math/0108008) about the reality of eigenvalues of certain infinite matrices arising in asymptotic analysis of large Toeplitz determinants. As a byproduct we obtain a new proof of A.Okounkov's formula for the (determinantal) correlation functions of the Schur measures on partitions.
Optimal drug combinations and minimal hitting sets
Alexei Vazquez
BMC Systems Biology , 2009, DOI: 10.1186/1752-0509-3-81
Abstract: In this work we introduce a method to uncover drug combinations with a putative effective response when presented to a heterogeneous population of malignant agents (strains), such as cancer cell lines or viruses. Using data quantifying the effect of single drugs over several individual strains, we search for minimal drug combinations that successfully target all strains. We show that the latter problem can be mapped to a minimal hitting set problem in mathematics. We illustrate this approach using data for the NCI60 panel of tumor derived cell lines, uncovering 14 anticancer drug combinations.The drug-response graph and the associated minimal hitting set method can be used to uncover effective drug combinations in anticancer drug screens and drug development programs targeting heterogeneous populations of infectious agents such as HIV.The main stream in drug discovery has focused on identifying compounds targeting specific malignant agents, such as cancer subtypes or virus strains. In many cases, however, the target of drug therapy is a heterogeneous population of malignant agents, each characterized by a different degree of aggressiveness and response to therapy. Drug resistance is a clear example, whereby an induced or preexisting subpopulation of malignant agents is not responsive to a drug, escaping treatment.Drug combinations can improve over single therapeuthic agents in two ways. Synergy between two drugs may result in a better response than the two drugs independently. A drug combination may also be more effective when targeting heterogeneous populations of malignant agents. In the latter case, although each single drug may be only effective for a subset of the malignant agents, the drug set as a whole may cover all malignant agents.Uncovering drug combinations by direct screening is quite challenging due to the large number of potential combinations. A recent high-throughput screen was able to systematically test about 120,000 different two-drugs combinatio
Order without design
Alexei Kurakin
Theoretical Biology and Medical Modelling , 2010, DOI: 10.1186/1742-4682-7-12
Abstract: I suggest that the very idea of biological design (whether evolutionary or intelligent) is a misconception rooted in the time-honored and thus understandably precious error of interpreting living systems/organizations in terms of classical mechanics and equilibrium thermodynamics. This error, introduced by the founders and perpetuated due to institutionalization of science, is responsible for the majority of inconsistencies, contradictions, and absurdities plaguing modern sciences, including one of the most startling paradoxes - although almost everyone agrees that any living organization is an open nonequilibrium system of continuous energy/matter flow, almost everyone interprets and models living systems/organizations in terms of classical mechanics, equilibrium thermodynamics, and engineering, i.e., in terms and concepts that are fundamentally incompatible with the physics of life.The reinterpretation of biomolecules, cells, organisms, ecosystems, and societies in terms of open nonequilibrium organizations of energy/matter flow suggests that, in the domain of life, order and reproducibility do not come from design. Instead, they are natural and inevitable outcomes of self-organizing activities of evolutionary successful, and thus persistent, organizations co-evolving on multiple spatiotemporal scales as biomolecules, cells, organisms, ecosystems, and societies. The process of self-organization on all scales is driven by economic competition, obeys empirical laws of nonequilibrium thermodynamics, and is facilitated and, thus, accelerated by memories of living experience persisting in the form of evolutionary successful living organizations and their constituents.The cell is a fundamental building block of all living organisms. A typical cell represents a highly concentrated (300-400 mg/ml of proteins and RNA alone [1]) aqueous solution of macromolecules, small molecules, and ions enveloped in a semi-permeable lipid membrane. Due to their physicochemical and struct
The self-organizing fractal theory as a universal discovery method: the phenomenon of life
Alexei Kurakin
Theoretical Biology and Medical Modelling , 2011, DOI: 10.1186/1742-4682-8-4
Abstract: An application of the new discovery method to life sciences reveals that moving electrons represent a keystone physical force (flux) that powers, animates, informs, and binds all living structures-processes into a planetary-wide, multiscale system of electron flow/circulation, and that all living organisms and their larger-scale organizations emerge to function as electron transport networks that are supported by and, at the same time, support the flow of electrons down the Earth's redox gradient maintained along the core-mantle-crust-ocean-atmosphere axis of the planet. The presented findings lead to a radically new perspective on the nature and origin of life, suggesting that living matter is an organizational state/phase of nonliving matter and a natural consequence of the evolution and self-organization of nonliving matter.The presented paradigm opens doors for explosive advances in many disciplines, by uniting them within a single conceptual framework and providing a discovery method that allows for the systematic generation of knowledge through comparison and complementation of empirical data across different sciences and disciplines.It is a self-evident fact that life, as we know it, has a natural tendency to expand in space and time and to evolve from simplicity to complexity. Periodic but transient setbacks in the form of mass extinctions notwithstanding, living matter on our planet has been continuously expanding in terms of its size, diversity, complexity, order, and influence on nonliving matter. In other words, living matter as a whole appears to evolve spontaneously from states of relative simplicity and disorder (i.e., high entropy states) to states of relative complexity and order (i.e., low entropy states). Moreover, when considered over macroevolutionary timescales, the expansion and ordering of living matter appears to proceed at an accelerating pace [1,2]. Yet this empirical trend stands in stark contrast with one of the fundamental laws of physi
Scale-free flow of life: on the biology, economics, and physics of the cell
Alexei Kurakin
Theoretical Biology and Medical Modelling , 2009, DOI: 10.1186/1742-4682-6-6
Abstract: The introduction of proteomics technologies has opened unprecedented opportunities to compile comprehensive "parts lists" for various macromolecular complexes, organelles, and whole cells. In a typical proteomics experiment, an organelle or a macromolecular complex of interest, such as mitochondria [1,2], lysosomes [3], synaptosomes [4], postsynaptic densities [5,6], phagosomes [7], or lipid rafts [8-10], is purified from cultured cells or a tissue, using one of the available fractionation/isolation techniques. The protein components present in a given isolate are further dissociated and spatially resolved, typically by gel electrophoresis or chromatography. Finally, the identities of individual proteins are determined with the aid of mass spectrometry. A review of the multiple "parts lists" obtained for various organelles and complexes clearly shows that they share one noticeable pattern-they invariably feature proteins that are not expected to be present in the studied complex/organelle/location. Given the nature of sample preparation, potential cross-contamination during isolation procedures is always an issue in proteomics experiments. It is natural, therefore, that the surprises of apparent "mislocalization" revealed in proteomics experiments are commonly disregarded and ignored. Yet a number of investigators have pointed out that, at least in some cases, apparently "mislocalized" proteins cannot be easily explained away as cross-contaminants [7,9]. In addition, as proteomics data accumulate, certain recurring patterns in protein "mislocalization" begin to emerge. For example, various metabolic enzymes, particularly proteins involved in energy metabolism, such as F1 F0 ATP synthase components and glycolytic enzymes, have been found in diverse and seemingly unrelated cellular locations, complexes, and organelles [3,4,7-9,11]. Taken together, proteomics studies appear to suggest that protein localization in the cell may be inherently uncertain or, at least, signi
Endoplasmic reticulum calcium signaling in nerve cells
VERKHRATSKY,ALEXEI;
Biological Research , 2004, DOI: 10.4067/S0716-97602004000400027
Abstract: the endoplasmic reticulum (er) is an important organelle involved in various types of signaling in nerve cells. the er serves as a dynamic ca2+ pool being thus involved in rapid signaling events associated with cell stimulation by either electrical (action potential) or chemical (neurotransmitters) signals. this function is supported by ca2+ release channels (insp3 and ryanodine receptors) and serca ca2+ pumps residing in the endomembrane. in addition the er provides a specific environment for the posttranslational protein processing and transport of various molecules towards their final destination. in parallel, the er acts as a "calcium tunnel," which facilitates ca2+ movements within the cell by avoiding cytoplasmic routes. finally the er appears as a source of numerous signals aimed at the nucleus and involved in long-lasting adaptive cellular responses. all these important functions are controlled by intra-er free ca2+ which integrates various signaling events and establishes a link between fast signaling, associated with er ca2+ release/uptake, and long-lasting adaptive responses relying primarily on the regulation of protein synthesis. disruption of er ca2+ homeostasis triggers several forms of cellular stress response and is intimately involved in neurodegeneration and neuronal cell death
Inverse problems for differential equations on the half-line having a singularity in an interior point
Alexei Fedoseev
Tamkang Journal of Mathematics , 2011, DOI: 10.5556/j.tkjm.42.2011.343-354
Abstract: Arbitrary order ordinary dierential equations on the half-line having a nonintegrable singularity inside are studied under additional matching conditions for solutions at the singular point. We construct special fundamental systems of solutions for this class of dierential equations, study their asymptotical, analytical and structural properties and the behavior of the corresponding Stokes multipliers. These fundamental systems of solutions are used in spectral analysis of dierential operators with singularities. We study the inverse problem of recovering dierential equation from the given Weyl-Yurko matrix and prove the corresponding uniqueness theorem.
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