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Search Results: 1 - 10 of 214398 matches for " Alexandre Wagner Silva de;Cruvinel "
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Sistema imunitário - parte II: fundamentos da resposta imunológica mediada por linfócitos T e B
Mesquita Júnior, Danilo;Araújo, Júlio Ant?nio Pereira;Catelan, Tania Tieko Takao;Souza, Alexandre Wagner Silva de;Cruvinel, Wilson de Melo;Andrade, Luís Eduardo Coelho;Silva, Neusa Pereira da;
Revista Brasileira de Reumatologia , 2010, DOI: 10.1590/S0482-50042010000500008
Abstract: the immune system consists of an intricate network of organs, cells, and molecules responsible for maintaining the body's homeostasis and responding to aggression in general. innate immunity operates in conjunction with adaptive immunity and is characterized by rapid response to aggression, regardless of previous stimulus, being the organism first line of defense. its mechanisms include physical, chemical and biological barriers, cellular components, as well as soluble molecules. the organism first line of defense against tissue damage involves several steps closely integrated and constituted by different components of this system. the aim of this review is to restore the foundations of this response, which has high complexity and consists of several components that converge to articulate the development of adaptive immune response. we selected some of the following steps to review: perception and molecular recognition of aggressive agents; activation of intracellular pathways, which result in vascular and tissue changes; production of a myriad of mediators with local and systemic effects on cell activation and proliferation, synthesis of new products involved in the chemoattraction and migration of cells specialized in destruction and removal of offending agent; and finally, tissue recovery with restoration of functional tissue or organ.
Sistema imunitário: Parte I. Fundamentos da imunidade inata com ênfase nos mecanismos moleculares e celulares da resposta inflamatória
Cruvinel, Wilson de Melo;Mesquita Júnior, Danilo;Araújo, Júlio Ant?nio Pereira;Catelan, Tania Tieko Takao;Souza, Alexandre Wagner Silva de;Silva, Neusa Pereira da;Andrade, Luís Eduardo Coelho;
Revista Brasileira de Reumatologia , 2010, DOI: 10.1590/S0482-50042010000400008
Abstract: the immune system consists of an intricate network of organs, cells, and molecules responsible for maintaining the body's homeostasis and responding to aggression in general. innate immunity operates in conjunction with adaptive immunity and is characterized by rapid response to aggression, regardless of previous stimulus, being the organism first line of defense. its mechanisms include physical, chemical and biological barriers, cellular components, as well as soluble molecules. the organism first line of defense against tissue damage involves several steps closely integrated and constituted by different components of this system. the aim of this review is to restore the foundations of this response, which has high complexity and consists of several components that converge to articulate the development of adaptive immune response. we selected some of the following steps to review: perception and molecular recognition of aggressive agents; activation of intracellular pathways, which result in vascular and tissue changes; production of a myriad of mediators with local and systemic effects on cell activation and proliferation, synthesis of new products involved in the chemoattraction and migration of cells specialized in destruction and removal of offending agent; and finally, tissue recovery with restoration of functional tissue or organ.
Sistema imunitário: parte III. O delicado equilíbrio do sistema imunológico entre os pólos de tolerancia e autoimunidade
Souza, Alexandre Wagner Silva de;Mesquita Júnior, Danilo;Araújo, Júlio Ant?nio Pereira;Catelan, Tania Tieko Takao;Cruvinel, Wilson de Melo;Andrade, Luís Eduardo Coelho;Silva, Neusa Pereira da;
Revista Brasileira de Reumatologia , 2010, DOI: 10.1590/S0482-50042010000600007
Abstract: the immune system consists of an intricate network of organs, cells, and molecules responsible for maintaining the body's homeostasis and responding to aggression in general. innate immunity operates in conjunction with adaptive immunity and is characterized by rapid response to aggression, regardless of previous stimulus, being the organism first line of defense. its mechanisms include physical, chemical and biological barriers, cellular components, as well as soluble molecules. the organism first line of defense against tissue damage involves several steps closely integrated and constituted by different components of this system. the aim of this review is to restore the foundations of this response, which has high complexity and consists of several components that converge to articulate the development of adaptive immune response. we selected some of the following steps to review: perception and molecular recognition of aggressive agents; activation of intracellular pathways, which result in vascular and tissue changes; production of a myriad of mediators with local and systemic effects on cell activation and proliferation, synthesis of new products involved in the chemoattraction and migration of cells specialized in destruction and removal of offending agent; and finally, tissue recovery with restoration of functional tissue or organ
Agente antifator de necrose tumoral alfa no tratamento da artrite reumatóide na prática clínica diária Anti-tumor necrosis factor alpha agent in the treatment of rheumatoid arthritis in the clinical practice
Cristiane Kayser,Alexandre Wagner Silva de Souza
Revista Brasileira de Reumatologia , 2007, DOI: 10.1590/s0482-50042007000300011
Abstract:
Tratamento com infliximabe da doen?a de Beh?et ativa
Souza, Alexandre Wagner Silva de;Pileggi, Paula;Hachbarth, Elisa Terezinha;
Revista Brasileira de Reumatologia , 2005, DOI: 10.1590/S0482-50042005000200009
Abstract: the authors describe the case of a 41 years old woman with the diagnosis of beh?et's syndrome since april 2000, when she presented mucocutaneous, articular and ocular manifestations. the disease remained active despite of the treatment with colchicine, corticosteroid and methotrexate, during the three years following diagnosis. in april 2003, the patient still needed high doses of corticosteroid and methotrexate. nevertheless, the disease remained active. treatment with infliximab was then started with intravenous 3 mg/kg and, one week later, all the manifestations of this patient were in complete remission.
Molecular cloning and sequence analysis of growth hormone cDNA of Neotropical freshwater fish Pacu (Piaractus mesopotamicus)
Pinheiro, Janeth Silva;Wolff, José Luiz Caldas;Araújo, Ronaldo de Carvalho;Hilsdorf, Alexandre Wagner Silva;
Genetics and Molecular Biology , 2008, DOI: 10.1590/S1415-47572008000200037
Abstract: rt-pcr was used for amplifying piaractus mesopotamicus growth hormone (gh) cdna obtained from mrna extracted from pituitary cells. the amplified fragment was cloned and the complete cdna sequence was determined. the cloned cdna encompassed a sequence of 543 nucleotides that encoded a polypeptide of 178 amino acids corresponding to mature p. mesopotamicus gh. comparison with other gh sequences showed a gap of 10 amino acids localized in the n terminus of the putative polypeptide of p. mesopotamicus. this same gap was also observed in other members of the family. neighbor-joining tree analysis with gh sequences from fishes belonging to different taxonomic groups placed the p. mesopotamicus gh within the otophysi group. to our knowledge, this is the first gh sequence of a neotropical characiform fish deposited in genbank.
Variabilidade genética de duas variedades de tilápia nilótica por meio de marcadores microssatélites
Moreira, Angela Aparecida;Hilsdorf, Alexandre Wagner Silva;Silva, Juliana Viana da;Souza, Vania Ribeiro de;
Pesquisa Agropecuária Brasileira , 2007, DOI: 10.1590/S0100-204X2007000400010
Abstract: the objective of this work was to evaluate the genetic variability of two nile tilapia strains (oreochromis niloticus), chitralada and red stirling, as well as its offsprings submitted to genetic enhancement programs, in intensive systems farming by microsatellites markers. thirty individuals of each parental strain, 30 crossbred (ch) individuals from chitralada and red stirling strains, and 30 individuals from red stirling progeny (rr) were used. five microsatellites loci were utilized: unh104, unh108, unh118, unh222 e unh231. low values of inbreeding were observed with a negative fis in both strains and their crossings. genetic differences between the two strains were detected through fst = 0.131 and rst = 0.130. the parental strains chitralada and red stirling presented 24.4% of genetic distance, which produced 23.5% of hybrid vigor in the ch stock.
Tratamento da arterite de Takayasu
Souza, Alexandre Wagner Silva de;Neves, Raissa Maria Sampaio;Oliveira, Kathia Regina;Sato, Emília Inoue;
Revista Brasileira de Reumatologia , 2006, DOI: 10.1590/S0482-50042006000700002
Abstract: takayasus?s arteritis is a chronic granulomatous vasculitis involving the aorta and its main branches. monitoring disease activity and the choice for the best therapy has been major challenger faced by all physicians who treat these patients. corticosteroids and immunosuppressive therapy have been used in daily medical practice, but results have not always been encouraging. although there are no controlled studies evaluating the treatment of takayasu?s arteritis, observational studies have described the response to the use of corticosteroids, methotrexate, azathioprine and cyclophosphamide. the emerging of biological therapy has brought new perspective for takayasu?s patients who are refractory to conventional therapy.
Atherosclerotic plaque in carotid arteries in systemic lupus erythematosus: frequency and associated risk factors
Souza, Alexandre Wagner Silva de;Hatta, Francisca Satomi;Miranda Jr., Fausto;Sato, Emília Inoue;
Sao Paulo Medical Journal , 2005, DOI: 10.1590/S1516-31802005000300010
Abstract: context and objective: atherosclerotic disease is an important cause of morbidity and mortality in systemic lupus erythematosus (sle) patients. no previous study has estimated carotid disease prevalence in such patients in brazil. the aim was to evaluate the prevalence of atherosclerotic plaque in carotid arteries, in sle patients and controls, and to verify possible associations between risk factors and carotid plaque. design and setting: cross-sectional study, at universidade federal de s?o paulo - escola paulista de medicina. methods: carotid plaque prevalence was assessed by b-mode ultrasound in 82 female sle patients of mean age 34.0 years and 62 controls of mean age 35.7 years. plaque was defined as a distinct area of hyperechogenicity and/or focal protrusion of the vessel wall into the lumen. risk factors for coronary disease and sle-related variables were determined. results: 50% of patients and 29% of controls presented carotid plaque. older age, longer disease duration, higher systemic lupus international collaborating clinics (slicc) score, higher levels of low-density lipoprotein and greater diabetes, obesity, premature ovarian failure and family history of coronary artery disease were found in patients with carotid plaque than in those without plaque. patients with plaque were younger than controls with plaque. sle diagnosis, obesity, older age, higher slicc score and longer disease duration were independent risk factors for carotid plaque. conclusion: young patients with sle present higher prevalence of carotid plaque than controls. sle diagnosis was a significant risk factor for carotid atherosclerosis.
UMA ARQUITETURA PARA DISTRIBUI O DE AMBIENTES VIRTUAIS DE REALIDADE AUMENTADA APLICADA à EDUCA O
Wender Ant?nio da Silva,Marcos Wagner de Souza Ribeiro,Edgard Lamounier Júnior,Alexandre Cardoso
Revista Brasileira de Informática na Educa??o , 2009,
Abstract: O processo de ensino-aprendizagem, baseados em aulas expositivo-dialogadas, tendo como principal recurso didático o quadro negro e o giz, n o traz atualmente atratividade condizente e coerente com o meio ao qual os alunos da educa o básica est o inseridos, repleto de tecnologias e inova es. O computador teve e tem um papel decisivo na mudan a desse cenário. Sua implanta o na educa o levou três gera es, e a quarta gera o come a a surgir com a Realidade Virtual (RV). A forma de aprendizagem depende de cada pessoa, umas aprendem visualmente, outras verbalmente, algumas exploram e outras deduzem. Um exemplo de objeto de aprendizagem que necessita que o aluno fa a uma abstra o ou crie mentalmente um modelo para compreens o do mesmo é a fisiologia vegetal. Esta área do conhecimento aborda a anatomia das plantas, a qual n o deveria mais ser ensinada apenas com o uso dos instrumentos tradicionais de ensino, pois apresenta dinamicidade e complexidade que somente podem ser visualizadas por meio de simula es. Nesse contexto a Realidade Aumentada (RA) se apresenta como ferramenta para visualiza o, intera o e envolvimento com objetos de aprendizagem. Para tanto é objetivo deste trabalho apresentar uma arquitetura para distribui o de ambientes virtuais de RA como ferramenta de apoio a projetos de ensino. Foi criada uma interface cognitiva de RA que possibilita a intera o do usuário com o ambiente virtual por meio de menus de intera o e também por meio de marcadores reais. Com a implementa o, as intera es feitas em um ambiente s o replicadas para os outros ambientes, gerando um sistema fortemente aplicável à educa o, pois proporciona múltiplas visualiza es dos objetos virtuais sobre os objetos reais. Entende-se que ao se distribuir as intera es realizadas, os usuários conseguem fazer colabora o em um ambiente de RA, possibilitando um maior nível de entendimento do conteúdo.
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