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Search Results: 1 - 10 of 10518 matches for " Alexandre Senegas "
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A new ELISA kit which uses a combination of Plasmodium falciparum extract and recombinant Plasmodium vivax antigens as an alternative to IFAT for detection of malaria antibodies
Cecile Doderer, Aurelie Heschung, Phillippe Guntz, Jean-Pierre Cazenave, Yves Hansmann, Alexandre Senegas, Alexander W Pfaff, Tamer Abdelrahman, Ermanno Candolfi
Malaria Journal , 2007, DOI: 10.1186/1475-2875-6-19
Abstract: Two groups were used: 95 samples from malaria patients to assess the clinical sensitivity and 2,152 samples from blood donors, who had not been exposed to malaria, to assess the clinical specificity.The DiaMed ELISA test kit had a clinical sensitivity of 84.2% and a clinical specificity of 99.6% as compared with 70.5% and 99.6% respectively, using the IFAT method. The ELISA method was more sensitive than the IFAT method for P. vivax infections (75% vs. 25%). However, in 923 malaria risk donors the analytical sensitivity of the ELISA test was 40% and its specificity 98.3%, performances impaired by large numbers of equivocal results non-concordant between ELISA and IFAT. When the overall analytical performances of ELISA was compared to IFAT, the ELISA efficiency J index was 0.84 versus 0.71 for IFAT. Overall analytical sensitivity was 93.1% and the analytical specificity 96.7%. Overall agreement between the two methods reached 0.97 with a reliability k index of 0.64.The DiaMed ELISA test kit shows a good correlation with IFAT for analytical and clinical parameters. It may be an interesting method to replace the IFAT especially in blood banks, but further extensive investigations are needed to examine the analytical performance of the assay, especially in a blood bank setting.More than 2 billion people (40% of the world's population) live in areas where malaria is endemic. It was estimated that over 250 million people worldwide contracted malaria in 2002 [1]. Following infection with any of the four species of Plasmodium, specific antibodies are produced, in virtually all individuals, one or two weeks after initial infection and persist for three to six months after parasite clearance. These antibodies may persist for months or years in semi-immune patients in endemic countries where reinfection is frequent. However, in a non-immune patient, treated for a single infection, antibody levels fall more rapidly and may be undetectable by three to six months. Reinfection or
Editorial Special Issue on “Energetic Complementarity”  [PDF]
Alexandre Beluco
Energy and Power Engineering (EPE) , 2017, DOI: 10.4236/epe.2017.99033
Abstract: This editorial presents the motivations that were the focus of the papers that make up this Special Issue on energetic complementarity. The articles deal with the application of the concept of energetic complementarity in time under certain conditions and with the proposition of new means to evaluate complementarity in time between more than two renewable energy resources. An article further proposes a method for establishing energetic complementarity in space, a concept that is important and necessary for management and planning of energy resources but does not yet have tools that allow it to be quantified and handled appropriately. In addition, two letters to the editor discuss issues that still need to be matured for a better understanding and application of the concept of energetic complementarity, both in time and space.
Minamata Disease—Review  [PDF]
Alexandre Semionov
World Journal of Neuroscience (WJNS) , 2018, DOI: 10.4236/wjns.2018.82016
Abstract: Minamata disease is the name given to a neurological syndrome caused by or-ganic mercury intoxication. Most commonly it results from consumption of methylmercury contaminated seafood and in severe cases is classically mani-fested by concentric constriction of the visual fields, ataxia and sensory dis-turbance in the distal extremities. The radiographic and neuropathological find-ings parallel the clinical picture and typically consist of lesions selectively in-volving the visual cortex, cerebellum and postecentral gyri.
On Approximating the Gradient of the Value Function  [PDF]
Alexandre Dmitriev
Theoretical Economics Letters (TEL) , 2019, DOI: 10.4236/tel.2019.91011

The optimality conditions for macroeconomic problems with limited commitment often contain partial derivatives of the optimal value function, corresponding to the outside option. This paper contributes to the literature on recursive contracts by proposing an algorithm for approximating the gradient of the value function using simulation-based methods. Our method combines numerical solution and simulation of the model, Monte-Carlo integration and numerical differentiation. It does not suffer from the curse of dimensionality and is therefore convenient for models involving many state variables. The algorithm inherits the speed and accuracy limitations of the numerical solution method it relies on. Our accuracy analysis is limited to a few classical examples from macroeconomic literature.

Aberrant Cytoplasmic Accumulation of Connexin 43 in Human Testicular Seminoma
V. Mauro, D. Chevallier, J. Gilleron, N. Defamie, D. Carette, J.M. Gasc, F. Senegas-Balas, D. Segretain and G. Pointis
The Open Biomarkers Journal , 2008, DOI: 10.2174/1875318300801010020]
Abstract: In the present study Cx43 mRNA and protein were analyzed in germ cells of men with normal spermatogenesis and in human testicular seminoma. In normal testis Cx43 mRNAs were basally located within seminiferous tubules and expressed in the most basally located germ cells (spermatogonia, early spermatocytes, and pachytene spermatocytes) and in Sertoli cells. Immunofluorescence analysis showed that Cx43 signal was mainly located in the basal compartment of seminiferous tubules and was stage-dependent. Cx43 mRNAs were also detected in human testicular seminoma. Transcripts were present within seminoma cells identified by PLAP staining. However, Cx43 protein exhibited an intracytoplasmic accumulation, within an intracellular compartment distinct from the Golgi apparatus and was undetectable at the plasma membrane level, suggesting post-translational rather than transcriptional abnormalities. This aberrant intracytoplasmic accumulation of Cx43 is due neither to a dysfunction of the protein trafficking machinery nor to a specific alteration of its major protein partner, ZO-1, since the tight junction associated protein was detected at the plasma membrane level and did not colocalize with Cx43.
A Magnetically Levitated Precise Pointing Mechanism for Application to Optical Communication Terminals  [PDF]
Thomas Edward Donaldson Frame, Alexandre Alexandre Pechev
Optics and Photonics Journal (OPJ) , 2012, DOI: 10.4236/opj.2012.22012
Abstract: Increasing data bandwidth requirements from spacecraft systems is beginning to pressure existing microwave communications systems. Free-Space optical communications allows for larger bandwidths for lower relative power consumption, smaller size and weight when compared to the microwave equivalent. However optical communication does have a formidable challenge that needs to be overcome before the advantages of the technology can be fully utilized. In order for the communication to be successful the transmitter and receiver terminals need to be pointed with a high accuracy (generally in the order of ≤10 μradians) for the duration of communication. In this paper we present a new concept for the precise pointing of optical communications terminals (termed the Precise Pointing Mechanism). In this new concept we combine the separate pointing mechanisms of a conventional optical terminal into a single mechanism, reducing the complexity and cost of the optical bench. This is achieved by electromagnetically actuating the whole telescope assembly in 6 degrees-of-freedom with an angular resolution of less than ±3 μradians within a 10 (Az. El.) field of view and linear resolution of ±2 μm. This paper presents the new pointing mechanism and discusses the modelling, simulation and experimental work undertaken using the bespoke engineering model developed.
Bounds for Goal Achieving Probabilities of Mean-Variance Strategies with a No Bankruptcy Constraint  [PDF]
Alexandre Scott, Francois Watier
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.312A278

We establish, through solving semi-infinite programming problems, bounds on the probability of safely reaching a desired level of wealth on a finite horizon, when an investor starts with an optimal mean-variance financial investment strategy under a non-negative wealth restriction.

Vehicle to Grid Decentralized Dispatch Control Using Consensus Algorithm with Constraints  [PDF]
Alexandre Lucas, Sun Chang
Smart Grid and Renewable Energy (SGRE) , 2013, DOI: 10.4236/sgre.2013.46A002

With the transition to electric vehicle technologies, large scale support infrastructure is being deployed. The vehicleto-grid (V2G) concept is an opportunity to take advantage from both infrastructure and electric vehicle drive. However, coordinating large number of agents in a reasonable speed and lack of homogenous distribution of the service provided by vehicle users to the grid have been left unattended. We apply consensus theory to the V2G concept presenting a decentralized control solution to assure that all vehicles within a region, regardless of their technology, positioning or state of charge, can communicate with their neighbors and agree on how much energy each should individually exchange with the grid. Applying constraints to the system, we considered a 25,000 vehicle fleet connected to a grid during peak hours. Simulating power changes and vehicles entering and leaving the system, two groups of 5 vehicles were studied: the first group remained in the system during all peak hours, while the second group only an hour. Results showed that the two groups of vehicles despite connecting to the system at different times were able to reach consensus in t = 15 s, and reported a maximum error of ε < 0.01% if left in the system during all peak hours.

Hubble’s Constant and Flat Rotation Curves of Stars: Are Dark Matter and Energy Needed?  [PDF]
Alexandre Chaloum Elbeze
Journal of Modern Physics (JMP) , 2017, DOI: 10.4236/jmp.2017.81003
Abstract: Although dark energy and dark matter have not yet been detected, they are believed to comprise the majority of the universe. Observations of the flat rotation curve of galaxies may be explained by dark matter and dark energy. This article, using Newton’s laws and Einstein’s theory of gravitation, shows that it is possible to define a new term, called E0, variable in time and space, of which one of its limits is the Hubble constant H0. I show that E0?is strongly linked to an explanation of the flat rotation curve of galaxies. This strong correlation between Hubble’s constant H0?and E0 enables us to solve the mystery of the surplus of gravity that is stabilizing the universe.
Bases for a Methodology Assessing Time Complementarity in Space  [PDF]
Alfonso Risso, Alexandre Beluco
Energy and Power Engineering (EPE) , 2017, DOI: 10.4236/epe.2017.99037
Abstract: Energetic complementarity has been studied in recent years and can be an important tool for managers to decide on the design and operation of hybrid systems based on renewable energy resources. Complementarity is an ability presented by two or more energy resources to complement each other over time. Complementarity can be verified in one place or at different places. This second case can be termed as spatial complementarity and is more complex than the complementarity in the same place, requiring a specific approach for its quantification This paper discusses concepts related to energetic complementarity and presents the basis for a method to evaluate energetic time-complementarity across space, applying the concepts presented to the northern coast of the state of Rio Grande do Sul, the southernmost state of Brazil.
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