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Search Results: 1 - 10 of 21141 matches for " Alexandre Bella Cruz "
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Chemical composition and antimicrobial activity of Hedyosmum brasiliense Miq., Chloranthaceae, essential oil
Kirchner, Karoline;Wisniewski Jr, Alberto;Cruz, Alexandre Bella;Biavatti, Maique W.;Netz, Daisy J. A.;
Revista Brasileira de Farmacognosia , 2010, DOI: 10.1590/S0102-695X2010005000005
Abstract: hedyosmum brasiliense miq., chloranthaceae, is an endemic species of brazil, locally known as "cidr?o". although h. brasiliense is popularly used as sedative, chemical constituents of this species remains uncharacterized. this work presents the essential oil composition, obtained by distillation of the fresh leaves and from a stored sample for three months, analysed by gc-fid and gc-ms. the inhibitory effects of essential oil were tested by the agar dilution method against six bacterial species (bacillus subtilis, escherichia coli, proteus mirabilis, pseudomonas aeruginosa, staphylococcus aureus and s. saprophyticus). in addition, six fungal species (candida albicans, c. parapsilosis, microsporum canis, m. gypseum, trichophyton rubrum and t. mentagrophytes) were included. among the determined constituents, α-terpineol (10.2%), curzerene (8.9%), pinocarvone (8.4%) and β-thujene (7.1%) were found as the main components. the essential oil has only low activity against gram-negative microorganisms. however, is remarkable active against gram-positive bacteria and fungi with mic values ranging from 0.125 to 2.5% (v/v).
Chemical composition and antimicrobial activity of Hedyosmum brasiliense Miq., Chloranthaceae, essential oil
Karoline Kirchner,Alberto Wisniewski Jr,Alexandre Bella Cruz,Maique W. Biavatti
Revista Brasileira de Farmacognosia , 2010,
Abstract: Hedyosmum brasiliense Miq., Chloranthaceae, is an endemic species of Brazil, locally known as "cidr o". Although H. brasiliense is popularly used as sedative, chemical constituents of this species remains uncharacterized. This work presents the essential oil composition, obtained by distillation of the fresh leaves and from a stored sample for three months, analysed by GC-FID and GC-MS. The inhibitory effects of essential oil were tested by the agar dilution method against six bacterial species (Bacillus subtilis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus and S. saprophyticus). In addition, six fungal species (Candida albicans, C. parapsilosis, Microsporum canis, M. gypseum, Trichophyton rubrum and T. mentagrophytes) were included. Among the determined constituents, α-terpineol (10.2%), curzerene (8.9%), pinocarvone (8.4%) and β-thujene (7.1%) were found as the main components. The essential oil has only low activity against Gram-negative microorganisms. However, is remarkable active against Gram-positive bacteria and fungi with MIC values ranging from 0.125 to 2.5% (v/v). óleo essencial de Hedyosmum brasiliense Miq., Chloranthaceae: composi o e atividade antimicrobiana. Hedyosmum brasiliense Miq. Chloranthaceae, é uma espécie endêmica no Brasil, conhecida como "cidr o". Embora H. brasiliense seja utilizada como calmante na medicina popular, n o foi ainda caracterizada quanto aos constituintes químicos. Este trabalho apresenta a composi o do óleo essencial, obtido pela destila o de folhas frescas e de amostra de óleo essencial armazenada por três meses, analisadas por GC-FID e CG-MS. Os efeitos inibitórios do óleo essencial foram testados pelo método da dilui o em agar, contra seis espécies de bactérias (Bacillus subtilis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus e S. saprophyticus). Adicionalmente, seis espécies de fungos (Candida albicans, C. parapsilosis, Microsporum canis, M. gypseum, Trichophyton rubrum e T. mentagrophytes) foram incluídas. Dentre os principais constituintes, α-terpineol (10,2%), curzereno (8,9%), pinocarvona (8,4%) e β-tujeno (7,1%) foram os encontrados em maior quantidade. O σleo essencial apresentou baixa atividade contra microorganismos Gram-negativos. Entretanto, a atividade é extraordinária contra bactérias Gram-positivas e fungos, com valores de MIC entre 0,125 a 2,5% (v/v).
New Sulfonamides Derived from Carvacrol: Compounds with High Antibacterial Activity against Resistant Staphylococcus aureus Strains  [PDF]
Aldo Sena de Oliveira, Luana Canzian Llanes, Inês Maria Costa Brighente, Ricardo José Nunes, Rosendo Augusto Yunes, Nilton Máximo Junior, Ana Milda Karsten Baumgart, Anays Noumeh Aust, Alexandre Bella Cruz
Journal of Biosciences and Medicines (JBM) , 2016, DOI: 10.4236/jbm.2016.47011
Abstract: Nine new sulfonamides derived from carvacrol were prepared through a reaction between 4-hydroxy-2-isopropyl-5-methyl benzene sulfonyl chloride with various amines in excellent yields (76% - 92%). The sulfonamides were characterized using spectrometric and spectroscopic methods. Among these compounds, three derivatives showed excellent results in antibacterial activity against resistant S. aureus strains, with MIC values ranging from 3.9 to 62.50 ppm. The sulfonamide derivative of 4-methylaniline (SULF-1) had the best performance for all tested strains of bacteria (MIC = 3.9 to 15.62 ppm). Furthermore, the sulfonamide derivative of 4-fluoro aniline (SULF-3), which also presented promising results, was found to have a synergistic effect when combined with tetracycline and partial synergistic effect when combined with ampicillin, exhibiting an FIC index between 0.50 and 0.75. The sulfonamide derivative of 4-methylaniline had a synergistic effect in combination with erythromycin exhibiting an FIC index of 0.37. Carvacrol in association with the antibiotics tested did not have a synergistic effect.
The influence of the essential oil of Melaleuca alternifolia on the healing of infected dental alveoli: a histological study in rats
Kreuger, Maria Regina Orofino;Ternes, Carlos Eduardo;Mello, Leonardo Lamim;Cruz, Alexandre Bella;Leite, Silvana Nair;Tames, David Rivero;
Revista Brasileira de Farmacognosia , 2007, DOI: 10.1590/S0102-695X2007000300008
Abstract: the plant melaleuca alternifolia is native to australia. the distillation of its leaves produces an essential oil, commonly known as oil of melaleuca, or tea tree oil, which present antimicrobial activity. this study investigates the action of this oil on the repair process of infected dental alveoli. 48 rats were used (rattus novergicus albinus, wistar). after tooth extraction and posterior infection of the dental alveoli with staphylococcus aureus, the animals were separated into three groups: group i: curettage and irrigation with physiologic saline solution; group ii: curettage and irrigation with physiologic saline solution and topical application of rifamycin diethylamide b 25 mg; and group iii: curettage and irrigation with physiologic saline solution and topical application of oil of melaleuca 20%. the animals were sacrificed 24 hours, 7, 14 and 21 days after the treatment with powder and the repair process of the dental alveoli was analyzed using an optical microscope. the results were submitted to qualitative and quantitative analysis and it was concluded that tea tree oil at 20% caused a delay in the repair process of infected dental alveoli in rats, as demonstrated by the presence of more necrosis area and less osteogenesis.
Composi??o química e avalia??o da atividade antimicrobiana do óleo essencial das folhas de Piper malacophyllum (C. Presl.) C. DC.
Santos, Thalita Gilda;Rebelo, Ricardo Andrade;Dalmarco, Eduardo Monguilhott;Guedes, Alessandro;Gasper, André Luís de;Cruz, Alexandre Bella;Schmit, Ana Paula;Cruz, Rosana Cé Bella;Steindel, Mário;Nunes, Rebeca K?rting;
Química Nova , 2012, DOI: 10.1590/S0100-40422012000300007
Abstract: this work reports the chemical composition as well as the antibacterial, antifungal and antiparasitic activities of the leaf essential oil from piper malacophyllum. the oil was extracted by hydrodistillation and analyzed by gc-fid, gc-ms and polarimetry. among the 28 compounds identified, (+)-camphor was the major constituent. the essential oil showed activity against most of the microorganisms tested, especially antifungal action, with a mic of 500 μg ml-1 against trichophyton mentagrophytes and cryptococcus neoformans. this is the first study reporting the composition and biological properties of leaf essential oil from p. malacophyllum.
Síntese e atividade antibacteriana de imidas cíclicas: 3,4-dicloromaleimidas e 3-cloro-4-substituída-maleimidas
Andricopulo, Adriano Defini;Yunes, Rosendo Augusto;Nunes, Ricardo José;Savi, Alessandro O. S.;Corrêa, Rogério;Cruz, Alexandre Bella;Cechinel Filho, Valdir;
Química Nova , 1998, DOI: 10.1590/S0100-40421998000500008
Abstract: in the present study, new n-aryl and n-alkylarylcyclic imides were synthesized and their antibacterial properties against escherichia coli and staphylococcus aureus were evaluated by using the diffusion method. all compounds were obtained in good yield (54 - 95%) and characterized by spectral data (1h-nmr, ms, ir) and elemental analysis (chn). the biological results indicated that some compounds exert significative antibacterial effects, confirming previous studies on biological activities of cyclic imides.
Avalia??o do potencial antimicrobiano de Plinia glomerata (Myrtaceae)
Serafin, Claudia;Nart, Viviane;Malheiros, ?ngela;Cruz, Alexandre Bella;Delle Monache, Franco;Gette, Maria de los Angeles;Zacchino, Susana;Cechinel Filho, Valdir;
Revista Brasileira de Farmacognosia , 2007, DOI: 10.1590/S0102-695X2007000400017
Abstract: plinia glomerata, commonly known as " yellow jaboticaba" or " cabelluda" occurs widely in south of brazil. this work evaluated the antimicrobial properties of the extracts, fractions and isolated compounds of this plant against pathogenic microorganisms, bacteria and fungi. the minimal inhibitory concentration (mic) was determined through the method of dilution in agar. the ethyl acetate (etoac) and aqueous fractions demonstrated the best activity against staphylococcus aureus. the aqueous fraction also exhibited good activity against escherichia coli. the pure substances 3,4,3?-trimethoxy-flavellagic-4?-o-glucose acid and 3,4,3?-trimethoxy-flavellagic acid were inactive up to 500 μg/ml. regarding results against fungi, ea and em extracts as well as aq fraction showed good activity only against dermatophytes. the results suggest that p. glomerata produces active principles with antimicrobial activity, suggesting that other substances from the plant are acting against the microorganisms or the existence of synergic effects.
Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats
Kreuger, Maria Regina Orofino;Farias, Bruna Gon?alves;Moreira, Janaína;Blind, Luise Zozula;Amoah, Solomon Kweku Sagoe;Leite, Andreia Siqueira;Biavatti, Maique Weber;van Hoof, Tom;D'Herde, Katharina;Cruz, Alexandre Bella;
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/S0102-695X2011005000192
Abstract: we investigated the healing process on excisional wounds infected with staphylococcus aureus in rats, treated with 50 μl of ethyl acetate iii from vernonia scorpioides (lam.) pers., asteraceae, rifamycin diethylamide b 25 mg, or saline. the lesions were measured daily and after seven days were surgically removed and histologically processed. the results indicate a favorable action of the eaiii, demonstrated by the increased wound contraction, smaller area of necrotic tissue, good development of granulation tissue, extensive extracellular matrix deposition and epithelial regeneration. this sub-fraction was phytochemically investigated in parallel studies, revealing the presence of sesquiterpene lactones (glaucolides and hirsutinolides) such as diacethylpiptocarphol and related hirsutinolides, flavonoids and cinnamic acid derivatives and also a new polyacetylene, which have been previously published. results support the effectiveness of v. scorpioides antimicrobial activity in infected wound healing in rats.
Tinea nigra nas formas geográficas em "cora??o" e "bico do papagaio"
Rossetto, André Luiz;Cruz, Rosana Cé Bella;
Anais Brasileiros de Dermatologia , 2011, DOI: 10.1590/S0365-05962011000200033
Abstract: through a photographic essay, we identified similarities between hyperchromic maculas of two cases of tinea nigra with images of a heart-shaped mangrove called "coeur de voh", located on the french island of new caledonia (oceania) and of a rock formation called "parrot beak" located on cabe?udas beach, itajaí, santa catarina state (brazil).
Spontaneous cure in a case of Tinea nigra
Rossetto, André Luiz;Cruz, Rosana Cé Bella;
Anais Brasileiros de Dermatologia , 2012, DOI: 10.1590/S0365-05962012000100029
Abstract: the authors report a case (in itajai, santa catarina state, brazil) of tinea nigra in a 4-year-old female child which spontaneously healed. we discuss the clinical and epidemiological aspects of the mycosis and this rare case of spontaneous healing.
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