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Search Results: 1 - 10 of 187 matches for " Aletta Poll "
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Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women
William D Foulkes, Parviz Ghadirian, Mohammed Akbari, Nancy Hamel, Sylvie Giroux, Nelly Sabbaghian, Andrew Darnel, Robert Royer, Aletta Poll, Eve Fafard, André Robidoux, Ginette Martin, Tarek A Bismar, Marc Tischkowitz, Francois Rousseau, Steven A Narod
Breast Cancer Research , 2007, DOI: 10.1186/bcr1828
Abstract: We screened all coding exons of PALB2 in a sample of 50 French-Canadian women diagnosed with either early-onset breast cancer or familial breast cancer at a single Montreal hospital. The genetic variants identified in this sample were then studied in 356 additional women with breast cancer diagnosed before age 50 and in 6,448 newborn controls.We identified a single protein-truncating mutation in PALB2 (c.2323 C>T, resulting in Q775X) in 1 of the 50 high-risk women. This variant was present in 2 of 356 breast cancer cases and in none of 6,440 newborn French-Canadian controls (P = 0.003). We also identified two novel new non-synonymous single nucleotide polymorphisms in exon 4 of PALB2 (c.5038 A>G [I76V] and c.5156 G>T [G115V]). G115V was found in 1 of 356 cases and in 15 of 6,442 controls (P = 0.6). The I76V variant was not identified in either the extended case series or the controls.We have identified a novel truncating mutation in PALB2. The mutation was found in approximately 0.5% of unselected French-Canadian women with early-onset breast cancer and appears to have a single origin. Although mutations are infrequent, PALB2 can be added to the list of breast cancer susceptibility genes for which founder mutations have been identified in the French-Canadian population.Approximately 3% to 5% of breast cancer is estimated to be due to a dominantly inherited gene, and two breast cancer genes, BRCA1 and BRCA2, account for approximately 85% of families with four or more cases of breast and ovarian cancer [1]. Soon after these genes were discovered, it became apparent that specific founder mutations in these genes were present in different ethnic groups [2,3], including individuals of French-Canadian descent [4]. Five founder mutations account for 75% to 85% of all BRCA1/2 mutations in the French-Canadian population of Quebec [5,6]. However, for approximately one half of strongly hereditary breast cancer families, no BRCA1/2 mutation has been identified and other genes a
Australian and South African perspectives on the implementation of flexible work practices (Fwp): an exploratory study
Aletta Odendaal,Gert Roodt
South African Journal of Industrial Psychology , 2002, DOI: 10.4102/sajip.v28i3.57
Abstract: The purpose of this study was to identify examples of good and innovative practices of Flexible Work Practices to benchmark against and then to use the information to develop strategies of implementation that will assist South African organisations to emulate their success. One hundred-and-twenty (120) individuals, representing different stakeholder groups were requested to complete a questionnaire, based on an Australian study. Comparative findings of both countries strongly confirmed variables that are positively associated with the adoption and successful implementation of Flexible Work Practices (FWP). Opsomming Die doel van hierdie studie was om voorbeelde van goeie en innoverende gebruike van Buigsame Werkspraktyke te identifiseer ten einde daarteen te kan vergelyk, en dan om hierdie inligting te gebruik ten einde implementeringstrategie te ontwikkel wat Suid Afrikaanse maatskappye kan gebruik om sukses na te volg. Honderd en twintig (120) individue, wat verskillende belangegroepe verteenwoordig, is genader om ‘n vraelys, gebaseer op ‘n Australiese studie, te voltooi. Vergelykende bevindinge van beide lande bevestig veranderlikes wat positief geassosieer word met die aanvaarding en suksesvolle implementering van Buigsame Werkspraktyke (BWP).
La ficción : espacio simbólico de la ausencia en la novela argentina contemporánea
Graciela Aletta?de?Sylvas
Amerika : Mémoires, Identités, Territoires , 2010, DOI: 10.4000/amerika.1177
Abstract: La narrativa argentina ha producido novelas que narran los horrores de la dictadura militar que se gestó entre 1976 y 1983. En este trabajo hemos recortado la temática de los desaparecidos y la apropiación de hijos.Resulta insoslayable relacionar los procedimientos del terrorismo de Estado llevado a cabo por la dictadura argentina con el holocausto nazi y subrayar el componente de perversión con que fueron ejecutados. La memoria se reconstruye en las tramas discursivas a través del lenguaje, y la literatura es una de las tres maneras simbólicas que permite abordar la cuestión del Mal.Las novelas elegidas se sostienen no sólo en la elección del tema, sino en el valor de su escritura : A veinte a os, Luz (1998) de E. Osorio ; Tumba de jaguares (2005) de A. Gorodischer ; El secreto y las voces (2002) de C. Gamerro ; Purgatorio (2008) de T. Eloy Martínez ; Dos veces junio (2002) de M. Kohan y Los Topos (2008) de F. Bruzzone. Apelan al realismo, al componente fantástico, a la estructura rizomática, a la polifonía y a la parodia ; todas subrayan el componente ficcional sin excluir el contexto. Nuestra lectura constituye una manera de exorcizar la ausencia y el olvido porque recurre a la memoria del pasado para construir el presente. Many Argentine authors have written novels about the military period that took place in that country between 1976 and 1983. In this work we have chosen the theme about disappeared people and kidnapped children. We compare this period with perverse proceedings committed during the Nazi Holocaust. Literature can build the memory with its language. We have chosen : A veinte a os, Luz (1998) by E. Osorio, Tumba de Jaguares (2005) by A. Gorodischer, Purgatorio (2008) by T. Eloy Martínez, El secreto y las voces (2002) by C. Gamerro, Dos veces junio (2002) by M. Kohan, y Los Topos (2008) by F. Bruzzone. These pieces of literature build their memory of dictatorship with its own language and they use different approaches to express their fictions, like realism, the fantasy, polyphonies, and parody. Our reading is a way to remember the absence and the oblivion by the memory of the past looking forward to the future.
Moral perfectionism and democratic responsiveness: reading Cavell with Foucault
Aletta J. Norval
Ethics & Global Politics , 2011, DOI: 10.3402/egp.v4i4.14448
Abstract: Starting from existing interpretations of Cavell's account of moral perfectionism, this article seeks to elaborate an account of democratic responsiveness that foregrounds notions of ‘turning’ and ‘manifesting for another’. In contrast to readings of Cavell that privilege reason-giving, the article draws on the writings of Cavell as well as on Foucault's work on parrēsia to elaborate a grammar of responsiveness that is attentive to a wider range of practices, forms of embodiment and modes of subjectivity. The article suggests that a focus on the notions of ‘turning’ and ‘manifesting for another’ is crucial if we are to account for the processes through which political imagination is opened up so as to bring about novel ways of being and acting. The arguments are illustrated with reference to recent events in the Arab Spring as well as to the politics of redress in a post-transitional social movement, Khulumani.
Impact/outcome measures for libraries
Roswitha Poll
Liber Quarterly : The Journal of European Research Libraries , 2003,
Abstract: Libraries today document their performance for the most part only in data of input and output (e.g. size of the collection, number of issues, of reference answers etc.). If they do more, they evaluate the quality and user-orientation of their services by applying performance indicators or user satisfaction surveys. Data of high use or high user satisfaction seem to indicate that users benefit from the library's services. But in demonstrating the library's value to the financing authorities or the public it would be much more effective if libraries could show a direct impact/outcome of their services on their users. Such outcome might be either a monetary value attributed to one case of use, or the impact on the users' skills and knowledge, their information literacy. Quite a number of projects in different countries have tested methods to catch this 'outcome'. They have tried to assess the value assigned by the population to certain library services, to find a connection between success in studies or research and library use, to assess the library's impact on students' information literacy, to explore the information behaviour of groups in order to specify the library's role in information research and information delivery. The paper describes the different starting points for assessing outcome of library services.
Digitisation in European Libraries: Results of the NUMERIC Project
Roswitha Poll
Liber Quarterly : The Journal of European Research Libraries , 2010,
Abstract: NUMERIC, a project of the European Commission, started out to define units of measurement and methods for assessing the current state of digitisation in Europe’s cultural institutions (archives, libraries and museums). The aim was to show on the one side the financial input into digitisation and on the other side the progress achieved in digitising the national heritage. The article describes methods and results of the project, with special consideration to libraries.
Performance Indicators for the Digital Library
Roswitha Poll
Liber Quarterly : The Journal of European Research Libraries , 2001,
Abstract: The purpose of performance indicators is to assess the quality and effectiveness of services provided by a library ... and to assess the efficiency of resources allocated by the library to such services.” In the last decades, libraries have developed sets of performance indicators for evaluating the quality of their services. Such indicators have been presented in handbooks and in an international standard. They were for the most part restricted to the traditional library services (collection, lending and ILL services, reading rooms, reference desk). For the fast developing electronic library services new and special indicators are needed in order to assess the effectiveness of services and to justify expenditure and resource allocation to that sector. In several projects on a national and international scale, such indicators have been developed and tested.
Entrepreneurs’ Views on the Effectiveness of the Adult Skills Development for Self-Employment in the National Literacy Programme of Namibia  [PDF]
Aletta Tuyenikelao Shikukumwa, Alex Tubawene Kanyimba, Rakel Kavena Shalyefu
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.46021
Abstract: The Adult Skills Development for Self-employment in the Ministry of Education, Arts and Culture is a partnership venture between the Directorate of Adult Education and the First National Bank of Namibia, which provides a Credit Guarantee Scheme as the common element of contract between these institutions. The aim of this paper is to report on the participating entrepreneurs’ views regarding the effectiveness of the Adult Skills Development for Self-employment in the National Literacy Programme in the Khomas Education Region of Namibia. The results show that the project held some benefits for these entrepreneurs in terms of profits generated as well as enabling them to meet living expenses. The training enabled them to record income and calculate expenditure on rent, telephone, water and electricity bills, savings, loan payments, salaries and other cost-related issues. However, knowledge pertaining to how to write a business proposal and conduct market research was still lacking as these issues were not addressed during the training provided. The challenges hampering the effectiveness of the self-employment project are the existence of red-tape; poor communication between the Ministry of Education and First National Bank of Namibia; the long route taken to process loans; screening procedures and delays caused by the bank. The possible support measures proposed to improve the effectiveness of the Adult Skills Development for Self-employment relate to the Ministry of Education, Arts and Culture, Ministry of Gender and Child Welfare and the possible involvement of other financial institutions. The recommendations to improve the project’s effectiveness involve the Ministry of Education, Arts and Culture, the Directorate of Adult Education and First National Bank of Namibia. These entities need to revisit some of their strategies taking into account the views outlined in this paper.
Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
Joanne Kotsopoulos, Jan Lubinski, Leonardo Salmena, Henry T Lynch, Charmaine Kim-Sing, William D Foulkes, Parviz Ghadirian, Susan L Neuhausen, Rochelle Demsky, Nadine Tung, Peter Ainsworth, Leigha Senter, Andrea Eisen, Charis Eng, Christian Singer, Ophira Ginsburg, Joanne Blum, Tomasz Huzarski, Aletta Poll, Ping Sun, Steven A Narod, the Hereditary Breast Cancer Clinical Study Group
Breast Cancer Research , 2012, DOI: 10.1186/bcr3138
Abstract: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer.Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43).These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.In the general population, reproductive factors, including late age at menarche, parity and breastfeeding, have been shown to protect against the development of breast cancer [1-3]. Various proposed mechanisms include reducing lifetime exposure to ovarian hormones, reducing the cumulative number of ovulatory cycles and differentiation of the breast lobules [4,5]. We and others have evaluated the impact of reproductive factors in the etiology of BRCA-associated breast cancer, although the results are conflicting and vary by BRCA1 or BRCA2 mutation [6-8]. With respect to breastfeeding and breast cancer risk in BRCA1 mutation carriers, two previous studies reported no relationship [9,10] and three studies reported a protectiv
USING THE INTERNET FOR DEMOCRACY: A STUDY OF SOUTH AFRICA, KENYA AND ZAMBIA
Aletta H. Janse van Rensburg
Global Media Journal : African Edition , 2012, DOI: 10.5789/6-1-84
Abstract: For the first time since democracy in the classical Greek sense became practically impossible, the Internet’s networking possibilities are creating opportunities for all citizens to be active engaging participants in democracy. Open communication channels to government and fellow citizens can now be a reality that allows people at all levels of society to form part of a vibrant public sphere by exchanging ideas, sharing experiences, spreading ideologies and news, and comparing agendas. For African countries dealing with unique and increasingly complicated political and socio-economic issues, the Internet provides a platform from which citizens can now address these issues themselves and, in doing so, contribute to a public sphere that strengthens the democratic fibre of their countries. This research posits that the Internet has significant potential to stimulate democratic culture through public discourse and citizen participation. The focus of this study is on finding evidence-based information about the current influence of information and communication technology (ICT) usage in South Africa, Kenya and Zambia as representatives of sub-Saharan Africa, and with specific focus on Internet usage through computers and mobile phones. The research also investigates the capacity and opportunity citizens have to successfully integrate ICTs into the accomplishment of self and mutually identified political goals in order to strengthen a broader democratic culture.
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