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Search Results: 1 - 10 of 22887 matches for " Alessandra Cristina;Abduch "
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Antiretroviral therapy during pregnancy and early neonatal life: consequences for HIV-exposed, uninfected children
El Beitune, Patrícia;Duarte, Geraldo;Quintana, Silvana Maria;Figueiró-Filho, Ernesto A.;Marcolin, Alessandra Cristina;Abduch, Renata;
Brazilian Journal of Infectious Diseases , 2004, DOI: 10.1590/S1413-86702004000200004
Abstract: women have emerged as the fastest growing human immunodeficiency virus (hiv) infected population worldwide, mainly because of the increasing occurrence of heterosexual transmission. most infected women are of reproductive age and one of the greatest concerns for both women and their physicians is that more than 1,600 infants become infected with hiv each day. almost all infections are a result of mother-to-child transmission of hiv. with the advent of combination antiretroviral therapies, transmission rates lower than 2% have been achieved in clinical studies. antiretroviral compounds differ from most other new pharmaceutical agents in that they have become widely prescribed in pregnancy in the absence of proof of safety. we reviewed antiretroviral agents used in pregnant women infected with human immunodeficiency virus, mother-to-child transmission, and their consequences for infants.
Bandagem reversível do tronco pulmonar: modelo experimental para preparo rápido do ventrículo pulmonar
ASSAD Renato S.,CARDARELLI Marcelo,ABDUCH Maria Cristina Donadio,AIELLO Vera Demarchi
Revista Brasileira de Cirurgia Cardiovascular , 1998,
Abstract: Um novo cateter-bal o foi desenvolvido com o objetivo de induzir o preparo rápido do ventrículo pulmonar. O cateter apresenta três vias, uma para o bal o e duas para medir press es, proximal e distal ao bal o [ventrículo direito (VD) e tronco pulmonar (TP)]. Os cora es de 6 cabritos jovens (peso médio: 5,3 kg) foram submetidos à sobrecarga sistólica imposta pelo cateter e avaliados morfologicamente e pelo ecocardiograma. A via de saída do VD (VSVD) foi exposta através de toracotomia esquerda. Foram realizadas biópsias do miocárdio para estudos de microscopia óptica e eletr nica. O cateter-bal o foi introduzido pela VSVD e posicionado no TP. Após a convalecen a pós-operatória, foi iniciado o treinamento do VD através da inje o de 0,5 ml de água no bal o. Posteriormente, volumes adicionais (0,5 ml) eram injetados no bal o a cada 2 dias, causando sobrecarga sistólica progressiva. A avalia o ecocardiográfica foi realizada com intervalos de 1 a 2 dias. Os animais foram sacrificados após 2 a 3 semanas de treinamento do VD, para avalia o morfológica do cora o. O diametro externo dos miócitos cardíacos, seccionados longitudinalmente, foi medido ao nível do núcleo, utilizando-se o sistema de análise de imagem (Quantimet-Leica). Sec es de 1μ de espessura do VD foram examinados sob microscopia eletr nica para determinar a densidade de volume das mitoc ndrias. O ecocardiograma revelou equaliza o das massas musculares dos ventrículos com intervalo de 6 a 10 dias de treinamento do VD. à microscopia óptica, foi observado aumento significativo do diametro dos miócitos (p<0,001) e dos núcleos (p<0,003), embora sob a microscopia eletr nica n o tenha havido varia o significativa da densidade média do volume de mitoc ndrias do VD (p=0,385). O cateter-bal o proposto neste trabalho permite a manipula o da luz do TP, possibilitando o preparo rápido e n o cirúrgico do ventrículo pulmonar e preservando a integridade anat mica das grandes artérias em pacientes com TGA.
Modelo experimental de bandagem ajustável do tronco pulmonar para preparo rápido do ventrículo
DIAS Carlos A.,ASSAD Renato S.,CANEO Luiz F.,ABDUCH Maria Cristina D.
Revista Brasileira de Cirurgia Cardiovascular , 2000,
Abstract: OBJETIVO: Um dispositivo de bandagem do tronco pulmonar (TP) com ajuste percutaneo foi desenvolvido com o objetivo de induzir a hipertrofia rápida do ventrículo subpulmonar. MATERIAL E MéTODOS: Consiste de um manguito de silicone insuflável percutaneamente, através de um bot o de silicone auto-selante. Os cora es de 7 cabritos jovens (peso médio: 8,7 kg) foram submetidos à sobrecarga sistólica imposta pelo dispositivo e avaliados sob os aspectos hemodinamicos, ecocardiográficos e morfológicos. Foram extraídas biópsias basais do miocárdio do ventrículo direito (VD) para análise microscópica (perímetro e área do miócito). O dispositivo foi implantado no TP. As press es do VD, TP e aorta foram monitorizadas. Após convalescen a, foi iniciado o protocolo de insufla o do dispositivo de bandagem do TP. Foi injetada água destilada no bot o auto-selante (via percutanea), até que a press o sistólica do VD atingisse 70% da press o sistólica do VE. As avalia es ecocardiográfica e hemodinamica foram realizadas a cada 24 horas. A sobrecarga sistólica do VD foi mantida por um período de 96 horas, com insufla es progressivas no limite máximo tolerado, a cada 24 horas. Após esse período, os animais foram sacrificados para análise morfológica dos cora es. Outros 9 cabritos (peso médio: 7,7 kg) foram utilizados como grupo controle, para análise do peso do VD. RESULTADOS: Após 96 horas de sobrecarga sistólica do VD, foi observado um aumento do gradiente sistólico VD/TP de 10,1±4,3 mmHg para 60,0±11,0 mmHg e da press o sistólica no VD de 22,4±4,1 mmHg para 71,0±10,0 mmHg (p<0,0001). O ecocardiograma revelou aumento da espessura muscular do VD, de 4,4±0,5 mm para 7,3±1,7 mm (p=0,001). Quando comparado ao grupo controle, houve um ganho de peso de 74% do VD submetido à sobrecarga sistólica (p<0,0001). à microscopia óptica, foi observado aumento de 27% no perímetro e de 69% na área dos miócitos (p=0,0001). CONCLUS ES: O dispositivo proposto neste trabalho é efetivo e facilmente ajustável por via percutanea, possibilitando a hipertrofia do ventrículo subpulmonar em 96 horas de sobrecarga sistólica. A melhora na ajustabilidade da bandagem do TP poderá permitir melhores resultados da opera o de Jatene em dois estágios, nos pacientes com transposi o das grandes artérias.
Preparo do ventrículo subpulmonar através de dois diferentes modelos ajustáveis de bandagem do tronco pulmonar: estudo experimental
CANêO Luiz Fernando,DIAS Carlos A.,ASSAD Renato Sammy,ABDUCH Maria Cristina Donadio
Revista Brasileira de Cirurgia Cardiovascular , 2001,
Abstract: Dois modelos de dispositivos ajustáveis foram implantados em cabritos jovens, com o objetivo de avaliar suas capacidades de bandagem do tronco pulmonar (TP) e eficiência no treinamento do ventrículo subpulmonar. Foram utilizados 3 grupos de 7 animais, submetidos ao implante de cateter bal o (grupo I), implante de dispositivo de bandagem externa (grupo II) e para obten o dos pesos dos ventrículos direito (VD), esquerdo (VE) e septo interventricular em condi es normais (grupo controle). Os animais foram submetidos a ajustes progressivos dos dispositivos, a cada 24 horas, durante um período de 96 horas, avaliados através de monitoriza o hemodinamica e ecocardiograma seriado. A hipertrofia ventricular foi avaliada através de parametros morfológicos e de microscopia óptica. Todos os animais concluíram o período de treinamento proposto. O gradiente VD-TP, a raz o VD/VE e a press o sistólica do VD foram significativamente maiores no grupo II (p<0,05). Observou-se aumento significativo da espessura da parede do VD, ao ecocardiograma, nos grupos I e II ao longo dos momentos avaliados, n o havendo diferen a significativa entre eles. O peso indexado e o peso seco do VD foi significativamente maior nos grupos I e II que no grupo controle (p<0,05), n o havendo diferen a significativa entre os grupos I e II (p>0,05). O perímetro e a área dos miócitos mostraram um aumento significativo no final do treinamento, comparados à amostra retirada no momento do implante dos dispositivos. Observamos maior grau de estenose do TP com dispositivo de bandagem externa, porém ambos tiveram a capacidade e a eficiência de preparar o ventrículo subpulmonar.
Estudo Longitudinal de Variáveis Dopplervelocimétricas do Ducto Venoso Fetal em Gesta es Normais
Marcolin Alessandra Cristina
Revista Brasileira de Ginecologia e Obstetrícia , 2002,
Abstract:
A Renova o Carismática Católica no espa o laico: um estudo sobre o Grupo de Ora o Universitário (GOU)
Alessandra Cristina Rosa
Horizonte : Revista de Estudos de Teologia e Ciências da Religi?o , 2009, DOI: 10.5752/486
Abstract:
Análise da atividade da enzima conversora da angiotensina na hipertrofia aguda do ventrículo direito em modelo experimental de estenose endovascular ajustável do tronco pulmonar
RABELLO, Renato Rocha;ASSAD, Renato Samy;KRIEGER, José Eduardo;CARMONA, Renata;ABDUCH, Maria Cristina;OLIVEIRA, Sérgio Almeida de;
Revista Brasileira de Cirurgia Cardiovascular , 2001, DOI: 10.1590/S0102-76382001000400009
Abstract: introduction: the pulmonary trunk (pt) banding has been used to promote rapid left ventricular (lv) hypertrophy in patients with transposition of the great vessels (tgv) with intact septum, treated after the neonatal period. this procedure carries a high morbidity and mortality rates. genetic alterations of the cardiomyocytes resulting from acute hypertrophy have not been evaluated in models of variable systolic overload of the subpulmonary ventricle. in order to evaluate the activity of angiotensin converting enzyme (ace) in acute right ventricular (rv) hypertrophy, a balloon catheter was implanted in the pt of six young goats. material and methods: systolic overload was carried out throughout progressive balloon insufflations for a period of 96 hours. hypertrophy was followed by daily hemodynamic and echocardiographic evaluations. at the end of the 96 hours, the animals were killed to harvest the heart. the ventricles and septum were weighted separately. samples of each cardiac muscle were collected for ace analysis. eight goats (with similar age and weight) were used as control for weight and ace activity. results: at the end of the protocol, the following parameters were increased: rv/pt gradient (p=0.001), rv to lv ratio (p=0.005), thickness of the free wall of rv (p=0.002) and rv weight (p=0.002). the evaluation of ace activity showed an increase only in the hypertrophied rv muscle (p=0.002), indicating a high correlation with the increase in the rv to lv ratio (r=0.87). conclusion: the progressive systolic overload in the rv of goats induces ventricular hypertrophy. this hypertrophy is related to a significant increase in ace activity, an important molecular marker of this process.
Bandagem reversível do tronco pulmonar: modelo experimental para preparo rápido do ventrículo pulmonar
ASSAD, Renato S.;CARDARELLI, Marcelo;ABDUCH, Maria Cristina Donadio;AIELLO, Vera Demarchi;MAIZATO, Marina;JATENE, Adib D.;
Revista Brasileira de Cirurgia Cardiovascular , 1998, DOI: 10.1590/S0102-76381998000300010
Abstract: a balloon catheter was developed to induce rapid "pulmonary ventricle"(rv) hypertrophy. the hearts of six young goats (avg. wt: 5.3 kg) were submitted to increased afterload by the balloon catheter and assessed morphologically and by echocardiogram. through a left thoracothomy, right ventricular outflow tract (rvot) was exposed and baseline myocardial samples were harvested for electron and optical microscopic studies. the balloon catheter was then placed through the rvot, in the lumen of the pa. after the convalescence postoperative period, rv training was begun by inflating the balloon with 0.5 ml of water and progressively reimflating with additional volumes (0.5 ml) at intervals of two days, causing progressive afterload. serial echocardiographic assessments of the cardiac muscle mass were performed every one to two days. the animals were sacrificed after two to three weeks of rv training for morphologic evaluation of the heart. the external diameter of longitudinally sectioned myocytes was measured at the level of the nucleus, using an image analysis system (quantimet-leica). one micra thick sections from rv wall were examined at philips 301 electron microscope to determine the volume density for mitochondria. the echocardiogram showed equality of the ventricles' thickness with a short interval of six to ten days of rv training. there was a significant increase in the diameter of the myocyte (p<0.001) and the nucleus (p<0.003) of rv. there was no change between the mean volume density for the mitochondria of the rv myocardial samples before and after rv training (p=0.385). this catheter permits the manipulation of the pulmonary artery lumen, allowing for the nonsurgical rapid prepare of the pulmonary ventrícle. it preserves the anatomical integrity of the pericardial cavity and contents in patients with tga.
Bandagem reversível do tronco pulmonar IV: análise da hipertrofia aguda do ventrículo direito em modelo experimental de sobrecarga intermitente
Valente, Acrisio Sales;Assad, Renato Samy;Abduch, Maria Cristina D.;Silva, Gustavo J. J.;Thomaz, Petronio G.;Miana, Leonardo A.;Krieger, José E.;Stolf, Noedir A. G.;
Revista Brasileira de Cirurgia Cardiovascular , 2008, DOI: 10.1590/S0102-76382008000100011
Abstract: objectives: adjustable pulmonary trunk (pt) banding device may induce a more physiologic ventricle retraining for the two-stage jatene operation. this experimental study evaluates the acute hypertrophy (96 hours) of the right ventricle (rv) submitted to an intermittent pressure overload. methods: five groups of seven young goats were distributed according to rv intermittent systolic overload duration (0, 24, 48, 72 and 96 hours). the zero-hour group served as a control group. echocardiographic and hemodynamic evaluations were performed daily. after completing the training program for each group, the animals were sacrificed for water content and cardiac masses evaluation. results: there was a significant increase in rv free wall thickness starting with the 48-hour group (p<0.05). however, a decreased rv ejection fraction, associated with an important rv dilation and a significant increase in the rv volume to mass ratio was observed at 24-hour training period, when compared to 96-hour period (p=0.003), with subsequent recovery throughout the protocol. a 104.7% increase in rv mass was observed in the 96-hour group, as compared to the control group, with no differences in water content between these two groups. the daily mean increase in rv mass during the study period was 21.6% ± 26.8%. the rate of rv mass acquisition for the overall study period of intermittent systolic overload was 0.084 g/h ± 0.035 g/h. conclusion: intermittent pt banding has allowed a significant rv mass acquisition in the 96-hour trained group. no myocardial water content changes were observed in this group, suggesting an increased myocardial protein synthesis.
Bandagem ajustável do tronco pulmonar: compara??o de dois métodos de hipertrofia aguda do ventrículo subpulmonar
Assad, Renato Samy;Rodriguez, Miguel Quintana;Abduch, Maria Cristina;Valente, Acrísio Sales;Andrade, José L.;Krieger, José Eduardo;Barbero-Marcial, Miguel;
Revista Brasileira de Cirurgia Cardiovascular , 2006, DOI: 10.1590/S0102-76382006000400012
Abstract: objective: this study compares ventricular hypertrophy induced by continuous versus intermittent systolic overload of the pulmonary ventricle (rv) of young goats. methods: three groups of seven goats were used (control, continuous, and intermittent). systolic overload was maintained for 96 hours in the continuous group, while the intermittent group suffered four 12-hour periods of systolic overload, alternating with 12-hour resting periods. echocardiographic and hemodynamic evaluations were performed every day. the animals were then killed for myocardial water content and weight evaluation. results: both study groups achieved significant increases in rv mass (p<0.05). however, significant increases of the septum mass were observed only in the intermittent group (p<0.05). a greater increase in the rv wall thickness was observed in the intermittent group (p<0.05). there was a significant difference in rv diastolic volume between the two groups (p= 0.01), with a greater rv dilation in the continuous group after 24 hours of continuous overload (p< 0.03). in both groups, the rv ejection fraction was maintained within the normal range throughout the protocol. a smaller rv perimeter was observed in the intermittent group after 96 hours of systolic overload (p<0.05). there was no significant difference in rv myocardial water content between the study groups and the control group. conclusions: adjustable pulmonary artery bandages permit rapid rv hypertrophy in both groups. nevertheless, it is more efficient in the intermittent group. this study suggests that preparation of the pulmonary ventricle with intermittent systolic overload might provide better results for the 2-stage arterial switch operation.
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