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Search Results: 1 - 10 of 3867 matches for " Alessandra Auriemma "
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Bone Marrow Micrometastases in Breast Cancer Patients: A Long-Term Follow-up Study
Annamaria Molino,Monica Giovannini,Rocco Micciolo,Alessandra Auriemma
Clinical Medicine : Oncology , 2008,
Abstract: In 125 early breast cancer patients who underwent multiple bone marrow aspirates, there was no significant difference in terms of disease-free and overall survival after a median follow-up of 163 months between the patients with or without micrometastasis at the time of primary surgery. However, when the time-dependent evolution of the bone marrow aspirates was taken into account, some evidence for a longer disease-free and overall survival was found for the patients with negative bone marrow.
High energy neutrinos
Giulio Auriemma
Physics , 2002,
Abstract: In this paper we compare the results of the MACRO detector at Gran Sasso, that is the largest neutrino telescope operated before the year 2k, with theoretical predictions of the neutrino emission from some promising targets, such as blazars and GRB's. In particular we propose a new statistical method, justified by the maximum entropy principle, for assessing a model independent upper limit to the differential flux of neutrinos inferred from the measured up-ward going muon flux. This comparison confirms that the acceptance of a detector of up-ward going muons should be of the order of $1 \mathrm{km}^2$, in order to challenge the present theoretical estimates of possible neutrino production in both galactic and extra-galactic objects.
On the detectability of gravitational waves background produced by gamma ray bursts
Giulio Auriemma
Physics , 2001, DOI: 10.1088/0954-3899/27/11/101
Abstract: In this paper we discuss a new strategy for the detection of gravitational radiation likely emitted by cosmological gamma ray burst. Robust and conservative estimates lead to the conclusion that the uncorrelated superimposition of bursts of gravitational waves can be detected by interferometric detectors like VIRGO or LIGO. The expected signal is predicted to carry two very distinctive signatures: the cosmological dipole anisotropy and a characteristic time scale in the auto correlation spectrum, which might be exploited, perhaps with ad hoc modifications and/or upgrading of the planned experiments, to confirm the non-instrumental origin of the signal.
Neutrinos and gravitational waves from cosmological gamma-ray bursts
Giulio Auriemma
Physics , 2003,
Abstract: Cosmological gamma ray bursts are very likely powerful sources of high energy neutrinos and gravitational waves. The aim of this paper is to review and update the current predictions about the intensity of emission in this two forms to be expected from GRB's. In particular a revised calculation of the neutrino emission by photohadronic interaction at the internal shock is obtained by numerical integration, including both the resonant and the hadronization channels. The detectability of gravitational waves from individual bursts could be difficult for presently planned detectors if the GRB's are beamed, but it is possible, as we have proposed in a paper two years ago, that the incoherent superimposition of small amplitude pulse trains of GW's impinging on the detector, could be detected as an excess of noise in the full VIRGO detector, integrating over a time of the order of one year.
Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis
Elena Fiorio, Anna Mercanti, Marianna Terrasi, Rocco Micciolo, Andrea Remo, Alessandra Auriemma, Annamaria Molino, Veronica Parolin, Bruno Di Stefano, Franco Bonetti, Antonio Giordano, Gian Cetto, Eva Surmacz
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-305
Abstract: Expression of ObR, HER2, phospo-HER2 was assessed by immonoblotting. Physical interactions between ObR and HER2 were probed by immunoprecipitation and fluorescent immunostaining. Expression of leptin and ObR in breast cancer tissues was detected by immunohistochemistry (IHC). Associations among markers studied by IHC were evaluated using Fisher's exact test for count data.HER2 and ObR were coexpressed in all studied breast cancer cell lines. In MCF-7 cells, HER2 physically interacted with ObR and leptin treatment increased HER2 phosphorylation on Tyr 1248. In 59 breast cancers, the presence of leptin was correlated with ObR (the overall association was about 93%). This result was confirmed both in HER2-positive and in HER2-negative subgroups. The expression of leptin or ObR was numerically more frequent in larger (> 10 mm) tumors.Coexpression of HER2 and the leptin/ObR system might contribute to enhanced HER2 activity and reduced sensitivity to anti-HER2 treatments.Recent epidemiological and clinical data confirmed that obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive breast tumors and resistance to certain anti-breast cancer treatments [1-4]. The molecular mechanisms of this link are not clear, but several studies in animal and cellular models suggested that excess body weight could promote breast cancer through increased production of an adipocyte-derived hormone leptin [5-7]. The primary function of leptin is to regulate energy balance and food intake by acting in the brain, but the hormone also plays an important role in peripheral organs, modulating fertility, lactation, and immune response [8,9]. Leptin levels in humans correlate with adiposity and are usually higher in females than in males [8].Leptin action is mediated through the transmembrane leptin receptor ObR [10]. The human ObR can be expressed as at least four isoforms with different COOH-terminal cytoplasmic domains [11]. The full (long)
Biochemical and histological alterations of Mytilus galloprovincialis digestive gland
R Auriemma,S Battistella
Invertebrate Survival Journal , 2004,
Abstract: Electrophoretical and histological analysis were performed on Mytilus galloprovincialis digestivegland samples, in order to detect the presence of a previously identified protein ca 30 kDa MW,synthesized during Dinophysis spp. blooms, and assess a possible correlation between the occurrenceof this protein and okadaic acid (OA) exposure by ingestion. Mussels were sampled monthly from July2000 to November 2001 in the Gulf of Trieste (upper Adriatic Sea) and immediately processed. Parallelsamples were maintained in sea water plastic tanks and fed with marine invertebrate feed mixed withOA and derivatives at different concentration of toxins for each experimental group (25 mg, 50 mg, 100mg). In tank reared mussels fed with OA, degeneration of digestive cells and appearance of 24.6 kDaprotein were observed, while in wild mussels, neither histological alterations nor presence of a 24.6kDa protein, were detected. A correlation between the toxins concentration and time of appearancewas highlighted, to demonstrate this protein is synthesized in response to OA and derivativesexposure. About the identity of 24.6 kDa protein, it could be an enzyme involved in detoxificationreactions, probably Glyoxalase I.
Evaluation of homeopathic treatments in early lactation in buffalo cows and neonatal mortality in buffalo calf  [PDF]
Fiorella Sarubbi, Rodolfo Baculo, Raffaele Palomba, Giuseppe Auriemma
Open Journal of Animal Sciences (OJAS) , 2012, DOI: 10.4236/ojas.2012.23027
Abstract: The trial was conducted on thirty buffalo cows subdivided in three groups. In the immediate pre-calving, 2.5 ml of Echinacea purpurea were orally administered to the first group (A) and, after calving, Nux vomica, Chelidonium and Lycopodium were administered at 7 days intervals. The second group (B) was only subjected to the post-calving treatment, while the third group (C) represented the control group. Immediately after calving two groups of calves were formed. The first group received 5 granules of Pyrogenium in the first days of life and then for 10 days the 0.5 ml of E. purpurea. The second group did not receive any remedy. Before the calving, in conventional farm twenty buffalo cows (D group) were vaccinated. Remedies administration did not affect milk protein content, milk lipid contents and the achievement of the lactation peak. Blood samples showed that total protein, albumin and globulin levels were lower in group A, compared to groups B and C. Cholesterol and urea were lower in the treated groups than in the control. We therefore conclude that the use of homeopathic remedies are a chance to improve animal welfare and their productive characteristics.
Effects of season calving and managements on lactating curves in two different farms (organic vs conventional) in buffalo cows  [PDF]
Fiorella Sarubbi, Franca Polimeno, Giuseppe Auriemma, Giuseppe Maglione, Rodolfo Baculo, Raffaele Palomba
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.31012

A total of 5852 records concerning daily milk yield, content of protein and fat, and somatic cell count was recorded in two farms (organic and conventional). Somatic cell count was log10- transformed before analysis because was not normally distributed. The mixed model methodology was used according to a repeated-measures scheme, as the restricted maximum likelihood method to estimate lactation curves at different season of calving and at different calving order. Calving order affected milk yield only in the first three calving order with the lowest production levels in the first six months of the year for both farm; no effect could be observed on fat and protein contents. The organic farm shows the minor milk production (7.77 vs8.10 kg/day/head organic and traditional respectively), but good qualitative characteristics of milk, and minor content of Somatic Cell Count. The milk production is major, in traditional farm, in summer respect the winter (10.4 vs6.34 kgof milk/day/ head). In biological farm no difference between seasons were observed. Peak milk yield occurs, for both farms, at around the 6th - 7th wk of lactation.

Repair of ascending aorta pseudoaneurysm without circulatory arrest in redo patient
Stefano Auriemma, Paolo Magagna, Ayman Sallam, Nicola Lamascese, Alessandro Fabbri
World Journal of Emergency Surgery , 2006, DOI: 10.1186/1749-7922-1-2
Abstract: Mediastinal pseudoaneurysms are rare but lifethreatening complications of thoracic aortic operations [1,2]. Predisponing factors are the dissection of the native aorta, infection, connettive tissue disorders, preoperative chronic hypertension, aortic calcification and blowout of the aortotomy site [1].A pseudoaneurysm of the ascending aorta could present itself as a pulsatile mass, angina due to graft compression, chest pain caused by local erosion, dysphagia or stridor [2].Redo operations for large pseudoaneurysm of the ascending aorta are a surgical challenge [3]. Sternal reentry by itself can precipitate fatal haemorrhage or cerebral air embolism.Our technique points out the use of right axillary artery cannulation and endoclamping perfusing aortic cannula to avoid hypothermic circulatory arrest [5].This allows us to prevent an impending rupture, to repair the defect and to preserve the brain and the other organs during the procedure.Our case treats of a 79-years-old man who has electively undergone aortic valve and ascending aorta replacement for degenerative aortic disease using a number 25 Edwards Lifesciences porcine stentless bioprosthesis (Edwards, California, USA). He was readmitted 4 months later with fever, intermittently painful and pulsatile swelling over the upper third of the sternum that appeared over a period of 15 days and had gradually increased in size to attain its present size of 6 × 4 cm (Fig. 1).A preoperative TEE showed a pseudoaneurysm with high flow velocity inside, developed between the prosthesis and the posterior surface of the sternum.Moderate hypothermic bypass was instituted with cannulation of right axillary artery for antegrade cerebral perfusion and femoral artery with Estech? cannula for aorta endoclamping and perfusion of lower body districts [5] (Fig. 2). The chest was opened through the previous scar reducing the CPB flows and obtaining digital control over the defect on the aorta. Subsequently a vent cannula has been placed
Experimental determination of the Townsend coefficient for Argon-CO2 gas mixtures at high fields
G. Auriemma,D. Fidanza,G. Pirozzi,C. Satriano
Physics , 2003, DOI: 10.1016/S0168-9002(03)02074-6
Abstract: The first Townsend coefficient for Ar-CO2 based gas mixtures has been measured over a wide range of reduced electric field. The experimental setup and the measurement technique are described here. A linear superposition model has also been successfully applied.
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