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Search Results: 1 - 10 of 18551 matches for " Alberto Polimeni "
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Non-Coding RNAs: The “Dark Matter” of Cardiovascular Pathophysiology
Claudio Iaconetti,Clarice Gareri,Alberto Polimeni,Ciro Indolfi
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms141019987
Abstract: Large-scale analyses of mammalian transcriptomes have identified a significant number of different RNA molecules that are not translated into protein. In fact, the use of new sequencing technologies has identified that most of the genome is transcribed, producing a heterogeneous population of RNAs which do not encode for proteins (ncRNAs). Emerging data suggest that these transcripts influence the development of cardiovascular disease. The best characterized non-coding RNA family is represented by short highly conserved RNA molecules, termed microRNAs (miRNAs), which mediate a process of mRNA silencing through transcript degradation or translational repression. These microRNAs (miRNAs) are expressed in cardiovascular tissues and play key roles in many cardiovascular pathologies, such as coronary artery disease (CAD) and heart failure (HF). Potential links between other ncRNAs, like long non-coding RNA, and cardiovascular disease are intriguing but the functions of these transcripts are largely unknown. Thus, the functional characterization of ncRNAs is essential to improve the overall understanding of cellular processes involved in cardiovascular diseases in order to define new therapeutic strategies. This review outlines the current knowledge of the different ncRNA classes and summarizes their role in cardiovascular development and disease.
Le città del Jabal Nafusah Libico: strutture insediative e spazi abitativi. The Cities of the Libyan Nafusah Mountain: Type of Dwellings and Urban Settlements.
Beniamino Polimeni
DISEGNARECON , 2010,
Abstract: L’interesse verso la zona del Jabal Nafusah, nella Libia nord occidentale, nasce dalla volontà di studiare un sistema di insediamenti e di trasformazioni del paesaggio che per caratteristiche ed esiti formali rappresentano un unicum all’interno del Maghreb. Il lavoro presentato, diviso in quattro sezioni, si propone come un possibile metodo di lettura delle forme urbane e delle architetture che le hanno generate, attraverso lo studio delle tre città berbere di Nalut, Cabao, Ulad Mahmud. Tre casi di studio significativi analizzati mediante gli strumenti del disegno e dell’analisi grafica con lo scopo di comprenderne l’organizzazione logica delle configurazioni e verificarne la continuità territoriale. L’obiettivo è quello di creare una sequenza storico/analitica che partendo dagli oggetti architettonici più minuti, i più vicini alla scala umana per struttura e dimensione, proceda fino all’estensione urbana e territoriale. Un metodo di analisi induttivo che seppur limitato ad una porzione circoscritta dà vita ad un valido processo di interpretazione formale. Interest in the Jabal Nafusah Mountain, in the north-eastern part of Libya, arises from the desire to study a system of settlements and landscape transformations which are unique to the Maghreb territory characteristics. The goal of this research is to propose a reading method for the urban structure and architectural forms, by the analysis of three models of settlement: Nalut, Cabao, Ulad Mahamud. These three significant study cases are analyzed by graphic and historical instruments with the purpose of under standing and verifying configuration and territorial continuity. The aim is to create an analytic sequence which starts from the territory with minimal architectural objects and extends to those nearest to the human scale of structure and dimensions, allowing us to understand the relations among the landscape, the history and the city formation.
The Potential Economic Rent In The United States From Co 2 Abatement Policies
John M. POLIMENI,Wyatt HARPER
Review of Economic and Business Studies (REBS) , 2010,
Abstract: Increasingly, climate change has come to the fore as an environmental issue with nearly universal agreement that the current trend is unsustainable and must be addressed. Of particular concern is the amount of carbon dioxide (CO2) emitted into the atmosphere, the primary contributor to climate change through the combustion of fossil fuels. In the United States alone, CO2 emissions account for approximately 85% of all U.S. greenhouse gas emissions, most of which come from fossil fuels (EPA, 2008). Reducing the risk of the damage caused by climate change requires the world to substantially reduce CO2 production. In the past five to ten years several proposals to address climate change have been suggested; most prominently cap-and-trade and carbon taxes. These market-based approaches differ from the traditional command-and-control policies, such as Corporate Average Fuel Efficiency (CAFé) standards which mandate minimum fleet mileage standards for vehicles sold in the United States, by providing firms a cost-effective and flexible form of environmental regulation. Other benefits also exist, such as technological innovation to reduce greenhouse gas emissions and potential revenue sources for governments; the more a firm emits CO2, the more they pay, either in taxes or through purchased emission permits.
MicroRNA-1 Downregulation Increases Connexin 43 Displacement and Induces Ventricular Tachyarrhythmias in Rodent Hypertrophic Hearts
Antonio Curcio, Daniele Torella, Claudio Iaconetti, Eugenia Pasceri, Jolanda Sabatino, Sabato Sorrentino, Salvatore Giampà, Mariella Micieli, Alberto Polimeni, Beverley J. Henning, Angelo Leone, Daniele Catalucci, Georgina M. Ellison, Gianluigi Condorelli, Ciro Indolfi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070158
Abstract: Downregulation of the muscle-specific microRNA-1 (miR-1) mediates the induction of pathologic cardiac hypertrophy. Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular tachyarrhythmias (VT). However, it is still unknown whether miR-1 and Cx43 are interconnected in the pro-arrhythmic context of hypertrophy. Thus, in this study we investigated whether a reduction in the extent of cardiac hypertrophy could limit the pathological electrical remodeling of Cx43 and the onset of VT by modulating miR-1 levels. Wistar male rats underwent mechanical constriction of the ascending aorta to induce pathologic left ventricular hypertrophy (LVH) and afterwards were randomly assigned to receive 10mg/kg valsartan, VAL (LVH+VAL) delivered in the drinking water or placebo (LVH) for 12 weeks. Sham surgery was performed for control groups. Programmed ventricular stimulation reproducibly induced VT in LVH compared to LVH+VAL group. When compared to sham controls, rats from LVH group showed a significant decrease of miR-1 and an increase of Cx43 expression and its ERK1/2-dependent phosphorylation, which displaces Cx43 from the gap junction. Interestingly, VAL administration to rats with aortic banding significantly reduced cardiac hypertrophy and prevented miR-1 down-regulation and Cx43 up-regulation and phosphorylation. Gain- and loss-of-function experiments in neonatal cardiomyocytes (NCMs) in vitro confirmed that Cx43 is a direct target of miR-1. Accordingly, in vitro angiotensin II stimulation reduced miR-1 levels and increased Cx43 expression and phosphorylation compared to un-stimulated NCMs. Finally, in vivo miR-1 cardiac overexpression by an adenoviral vector intra-myocardial injection reduced Cx43 expression and phosphorylation in mice with isoproterenol-induced LVH. In conclusion, miR-1 regulates Cx43 expression and activity in hypertrophic cardiomyocytes in vitro and in vivo. Treatment of pressure overload-induced myocyte hypertrophy reduces the risk of life-threatening VT by normalizing miR-1 expression levels with the consequent stabilization of Cx43 expression and activity within the gap junction.
Use of Lozenges Containing Lactobacillus brevis CD2 in Recurrent Aphthous Stomatitis: A Double-Blind Placebo-Controlled Trial
Vito Trinchieri,Stefano Di Carlo,Maurizio Bossu',Antonella Polimeni
Ulcers , 2011, DOI: 10.1155/2011/439425
Abstract: Recurrent aphthous stomatitis is a common disorder of the oral cavity, affecting mainly young people. It is characterized by small ulcers which can be very painful and generally heal spontaneously within 7–14 days. There is currently no therapy that can provide rapid healing. This study evaluated the efficacy and rapidity of response of a lozenge containing Lactobacillus brevis CD2. 30 patients were randomized to take 4 lozenges a day of active product or placebo for 7 days. Signs and symptoms as well as laboratory parameters in the saliva were assessed at the start of the study and after 7 days of treatment. The study demonstrated the efficacy and the rapidity of response of the Lactobacillus brevis CD2 lozenges in resolving the clinical signs and symptoms of aphthous stomatitis, with a significantly rapid improvement of pain. This is the first study confirming the efficacy of a probiotic product in this pathology.
Do skeletal cephalometric characteristics correlate with condylar volume, surface and shape? A 3D analysis
Matteo Saccucci, Antonella Polimeni, Felice Festa, Simona Tecco
Head & Face Medicine , 2012, DOI: 10.1186/1746-160x-8-15
Abstract: For 94 patients (46 females and 48 males; mean age 24.3?±?6.5?years), resultant rendering reconstructions of the left and right temporal mandibular joints (TMJs) were obtained.Subjects were then classified on the base of ANB angle the GoGn-SN angle in three classes (I, II, III) . The data of the different classes were compared.No significant difference was observed in the whole sample between the right and the left sides in condylar volume.The analysis of mean volume among low, normal and high mandibular plane angles revealed a significantly higher volume and surface in low angle subjects (p?<?0.01) compared to the other groups.Class III subjects also tended to show a higher condylar volume and surface than class I and class II subjects, although the difference was not significant.Higher condylar volume was a common characteristic of low angle subjects compared to normal and high mandibular plane angle subjects. Skeletal class also appears to be associated to condylar volume and surface.The shape and volume of the condyle in young adults is considered to play an important role in the stability of long-term orthodontic and orthognathic therapies [1]‐ [7].Since the mandibular condyle undergoes a remodelling process as it responds to continuous stimuli from childhood to adulthood, it is the primary centre of growth in the mandible, where its final dimension of shape and volume could be linked to the relation between the maxillary and mandibular bases.Being a part of the TMJ structure, the condyle shows a continuous adaptability to functional stimuli. During adulthood, the condyle is often subjected to an ongoing remodelling processes, such as flattening, erosion, sclerosis, osteophytes, and resorption, which could affect its volume and shape [3].Such changes in the condyle are more associated with a number of clinical conditions: (i) arthritis, which can affect the condylar volume; (ii) the asymmetry, as recently assessed in humans [8]; (iii) anterior disc displacement
Postural loads during walking after an imbalance of occlusion created with unilateral cotton rolls
Simona Tecco, Antonella Polimeni, Matteo Saccucci, Felice Festa
BMC Research Notes , 2010, DOI: 10.1186/1756-0500-3-141
Abstract: In a sample of thirty Caucasian adult females (mean age 28.5 ± 4.5), asymptomatic for TMDs, when a cotton roll was positioned on the left or the right sides of dental arches, so causing a lateral shift of the mandible, the percentage of loading and the loading surface of the ipsi-lateral foot, left or right, were found to be significantly lower than in habitual occlusion (p < 0.05). Males were not included because of their different postural attitude respect to females. Further studies in a sample of males will be presented.This study showed that in health subjects without TMD's symptoms, an experimentally induced imbalance of the occlusion, obtained through an unilateral cotton roll, is associated to detectable alterations in the distribution of loading on feet surface, during walking.This study adds new data on a previous investigation, recently published, [1] in which it was showed, in a group of Caucasian adult females with TMD's symptoms, that the the interposition of two cotton rolls between dental arches causes an increase of the percentage of loading on feet during locomotion, that can not be observed in subjects without TMD's symptoms. However, this previous study does not clarify whether these types of correlations are proper of TMDs patients, or are detectable also in subjects without TMD's symptoms, that could have importance for a correct diagnosis of postural disorders.Now, we are able to add new data to these previous findings, about the changes in the loading on feet, during walking, in health subjects without TMD's symptoms.In this study, an imbalance of the occlusion was experimentally induced in agroup of health subjects without TMD's symptoms, through an unilateral cotton rollinterposed between the upper and the lower teeth, thus generating an asymmetric imbalance of the occlusion. The postural loading on feet during walking was then investigated.This protocol was performed after the first study [1] from the same authors, in which some correlatio
Fuzzy Characterization of Flawed Metallic Plates with Eddy Current Tests
Matteo Cacciola;Francesco Carlo Morabito;Daniela Polimeni;Mario Versaci
PIER , 2007, DOI: 10.2528/PIER07031301
Abstract: Eddy Current Techniques (ECT) for Non-Destructive Testing and Evaluation (NDT/NDE) of conducting materials is one of the most application-oriented field of research within electromagnetism. In this work, a novel approach is proposed in order to characterize defects on metallic plates in terms of their depth and shape, starting from a set of experimental measurements. The problem is solved by means of a hybrid classification system based on Computation with Words (CWs) and Fuzzy Entropy (FE). They extract information about the specimen under test from the measurements. Main advantages of proposed approach are the introduction of CWs as well as the usage of the FE based minimization module, in order to improve flaw characterization by a low computational complexity system.
Novel concepts on functional foods and nutrigenomics in healthy aging and chronic diseases: a review of fermented papaya preparation research progress
Francesco Marotta,Gulcin Sagdicoglu Celep,Anna Cabeca,Ascanio Polimeni
Functional Foods in Health and Disease , 2012,
Abstract: Functional foods are an emerging research field corresponding with genomical, epidemiological and clinical studies integrated with the food industry in accordance with the consumer demands. Consequently, the features of the functional foods are being discussed by various researchers and related institutions, and a common view has been pointed out about the availability and the nature of the components of functional foods. Recently, the outcomes of functional foods are being assessed by the help of all the available scientific tools. Genomic medicine is one of the most promising areas of research to reveal the benefits of functional foods and the bioactive ingredients. Nutrigenomics aims at studying the genetic and epigenetic interactions with a nutrient or the functional component in order to lead to a phenotype change and therefore to the cell metabolism, differentiation or even apoptosis. Papaya and its fermentation product arespecific products derived from the technologically advanced and controlled environmentalfriendly bio-fermentation process. Functional Foods in Health and Disease 2012, 2(5):120-136 It has been well known for a long time that the natural anti-oxidant properties of papaya, mainly depending on vitamins A and C in addition to certain amino acids, were consistent both in the fruit and derived from the papain enzyme which is no longer present in the fermented product. In this article, functional foods in genomic medicine are discussed in review of the fermented papaya preparation research progress. Clinical evidences about fermented papaya as a functional food are reported as supported by various research protocols and experimental models. The benefits of fermented papaya preparation are also discussed in nutrigenomic basis and it is reported to have an important antioxidant and transcriptomic potential which deserves further investigation. As a conclusion, fermented papaya preparation represents a Functional Food highly compliant with the novel features of the new nutrigenomic-driven action plan strategy aimed to reduce the incidences of diseases and successful integration within specific pharmacological treatments.
Use of Lozenges Containing Lactobacillus brevis CD2 in Recurrent Aphthous Stomatitis: A Double-Blind Placebo-Controlled Trial
Vito Trinchieri,Stefano Di Carlo,Maurizio Bossu',Antonella Polimeni
Ulcers , 2011, DOI: 10.1155/2011/439425
Abstract: Recurrent aphthous stomatitis is a common disorder of the oral cavity, affecting mainly young people. It is characterized by small ulcers which can be very painful and generally heal spontaneously within 7–14 days. There is currently no therapy that can provide rapid healing. This study evaluated the efficacy and rapidity of response of a lozenge containing Lactobacillus brevis CD2. 30 patients were randomized to take 4 lozenges a day of active product or placebo for 7 days. Signs and symptoms as well as laboratory parameters in the saliva were assessed at the start of the study and after 7 days of treatment. The study demonstrated the efficacy and the rapidity of response of the Lactobacillus brevis CD2 lozenges in resolving the clinical signs and symptoms of aphthous stomatitis, with a significantly rapid improvement of pain. This is the first study confirming the efficacy of a probiotic product in this pathology. 1. Introduction Recurrent aphthous stomatitis (RAS) is characterized by spontaneously self-limiting ulcerations of the mucosa of the oral cavity. The lesions can be single or multiple and generally affect the nonkeratinized mucosa of the cheeks, the soft palate, the fauces, the mouth floor, the tongue, and the gums. This pathology can be observed in 20–30% of the population and most commonly affects the higher social classes [1, 2]. The highest incidence is among young people between 10 and 20 years of age, the severity and frequency of ulcers decreasing with age [3–6]. Genetic predisposition is also involved; if both parents suffer from recurrent aphthous stomatitis, the probability of an early onset of such pathology is as high as 90%, but this probability falls to 10% if only one parent suffers from it [7]. Recurrent aphthous stomatitis can be divided into three categories according to the characteristics of the ulcer: major, minor, and herpetiform. The major form is characterized by painful ulcers (>10?mm) which erode the mucosa creating deep ulcers located on the palate, tonsils, pharynx, or tongue, which generally heal—often forming a scar—within 2 weeks, but can sometimes take months. The minor form is the most common and represents about 80% of all cases of recurrent aphthous stomatitis. Clinically, it presents painful, small (5–10?mm), well-defined ulcers, which are round or oval in shape; they usually affect the buccal or labial mucosa and heal in about 7–10 days. The herpetiform type is named after its likeness to Herpes Simplex Virus (HSV) ulcerations. Recurrences can generally be observed every 1–4 months, but some patients
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