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Search Results: 1 - 10 of 724 matches for " Albano Nicolai "
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Inflammatory Bowel Diseases: What Do We Still Need to Investigate?  [PDF]
Marina Taus, Debora Busni, Daniele Fumelli, Arianna Paci, Giulia Nicolai, Albano Nicolai
Open Journal of Gastroenterology (OJGas) , 2015, DOI: 10.4236/ojgas.2015.510024
Abstract: Inflammatory bowel disease (IBD) including Crohn (CD) and ulcerative colitis (UC), is intestinal disorders with an unknown specific etiology. Many factors are involved in the pathogenesis: genetic, environment, nutrition, immunity and intestinal dysbiosis. In the present work, we review the most important trigger mechanisms involved in IBD, with a particular regard to the role of microbiota and fecal mass transplantation as a new therapeutic approach, that even if it can be considered safe and effective, data are necessary regarding all procedures not yet standardized and timing of treatment.
Coeliac Disease: Gluten Free Diet and… What Else?  [PDF]
Marina Taus, Elsa Veronica Mignini, Daniele Fumelli, Debora Busni, Giulia Nicolai, Carla Carletti, Albano Nicolai
Open Journal of Gastroenterology (OJGas) , 2016, DOI: 10.4236/ojgas.2016.611035
Abstract: Coeliac Disease (CD) is a permanent gluten intolerance, whose pathogenesis involves multiple factors including genetics and environment. CD has different representations and non-specific symptoms such as diarrhea, bloating, pain, flatulence and constipation may sometimes be misleading. Once diagnosed of CD, patients must adhere to Gluten Free Diet, which consists in the lifelong avoidance of gluten containing foods and of those naturally gluten free but at risk of contamination. This dietary approach is considered the only therapy in order to avoid symptoms exacerbation and to reduce the digestive mucosa inflammation, which has been related to higher risks of lymphoproliferative malignancy and other immunological disorders. However, being on a Gluten Free Diet is not as resolving as it may seem since it has several criticalities. First of all, excluding gluten means limiting food variety so that coeliac patients may have unbalanced intake of several nutrients and develop clinical or subclinical deficiencies. This can be due to scarce attention to qualitative and quantitative composition of diets and poor information about gluten-containing foods, which only patient-tailored dietetic protocol and long-term follow-up can achieve. Secondly, Gluten Free Diet may not result in complete remission of mucosal damage or in resolution of symptoms. Unintentional contamination of gluten or poor adherence to diet are the main culprits of the incomplete mucosal healing but other triggers may be involved. Recent research has focused on the role of FODMAPs in changing gut microbiota and on the improvement of Irritable Bowel Syndrome (IBS) symptoms after their dietary avoidance or reduction. Since CD and IBS may share many clinical presentations, further studies are needed to evaluate if a subgroup of CD patients whose symptoms are not improved by Gluten Free Diet could benefit from a new therapeutic approach consisting in both gluten/wheat and FODMAPs avoidance.
Transient basilar artery occlusion monitored by transcranial color Doppler presenting with a spectacular shrinking deficit: a case report
Giuseppe Nicoletti, Gerardina Albano, Sandro Sanguigni, Salvatore Tardi, Giovanni Malferrari, Massimo Del Sette, Filomena Bruno, Aldo Nicolai
Journal of Medical Case Reports , 2010, DOI: 10.1186/1752-1947-4-13
Abstract: A 79-year-old woman affected by chronic atrial fibrillation and not treated with oral anticoagulants, cardioverted to sinus rhythm during a gastric endoscopy. She then showed a sudden-onset loss of consciousness, horizontal and vertical gaze palsy, tetraparesis and bilateral miosis and coma. Two hours later, the symptoms resolved quickly, leaving no residual neurologic deficits. Transcranial Doppler examination showed a dampened flow in the basilar artery in the emergency examination and a restored flow when the symptoms resolved.This is the first case of transient basilar occlusive disease diagnosed and monitored by transcranial Doppler. We believe that transcranial Doppler should be performed in all cases of unexplained acute loss of consciousness, in particular, if associated with signs of brainstem dysfunctions.Embolic occlusion of the basilar artery has been described as a dramatic event, with a severe and even fatal outcome if occlusion is permanent, and with a more benign course if the occlusion is transient [1]. Nevertheless, there are few cases where the clinical course has been correlated with basilar artery flow monitoring. In fact, the diagnosis of embolism in the basilar artery is often difficult; in some patients, symptoms resolve quickly, leaving no residual neurologic signs, and neuroradiologic findings may also be unremarkable.We describe the case of a 79-year-old woman with a typical clinical syndrome of basilar occlusion, in whom contrast-enhanced transcranial Doppler demonstrated the presence of a basilar occlusion that suddenly resolved, with parallel resolution of symptoms.A 79-year-old Caucasian Italian woman affected by chronic atrial fibrillation and not treated with oral anticoagulants, cardioverted to sinus rhythm during a gastric endoscopy; she then showed a sudden onset loss of consciousness. She was admitted to the emergency department, where pO2 saturation, arterial blood gases analysis, electrocardiogram and laboratory testing were al
Role of Adaptive Immunity in Alcoholic Liver Disease
Emanuele Albano
International Journal of Hepatology , 2012, DOI: 10.1155/2012/893026
Abstract: Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. Clinical and experimental data show the involvement of Th-1 and Th-17 T-lymphocytes in alcoholic hepatitis. Nonetheless, the mechanisms by which alcohol triggers adaptive immunity are still incompletely characterized. Patients with advanced ALD have circulating IgG and T-lymphocytes recognizing epitopes derived from protein modification by hydroxyethyl free radicals and end products of lipid-peroxidation. High titers of IgG against lipid peroxidation-derived antigens are associated with an increased hepatic production of proinflammatory cytokines/chemokines. Moreover, the same antigens favor the breaking of self-tolerance towards liver constituents. In particular, autoantibodies against cytochrome P4502E1 (CYP2E1) are evident in a subset of ALD patients. Altogether these results suggest that allo- and autoimmune reactions triggered by oxidative stress might contribute to hepatic inflammation during the progression of ALD.
Fazendo sentido do som
Eleonora Albano
Ilha do Desterro , 2008,
Abstract: é um lugar comum na Linguistica deste século dizer-se que s o fonológicas apenas aquelas diferen as de som que ervem para distinguir significa es (Jakobson 1976:12[1932], Troubetzkoy1957119391: 1-15, Chomsky & Halle 1968:3-14). 0 que poucos linguistas reconhecem é que essa afirma o pode ser virada pelo avesso se interpretada à luz da Semántica e da Pragmática contemporaneas. Para simplificar, tomemos como ponto-de-partida a distin o feita por Lyons entre significado descritivo e n o descritivo (1977, vol. 1:50-56). Se esse último contribui para diferenciar entre os enunciados possíveis, ent o há mais trilhas entre o som e a "coisa" do que sonha a nossa v Fonologia. Pois um signatum elástico, variável, que vai além de um estado de coisas determinado num mundo objetivo, para incluir o social e até subjetivo, como querem, por exemplo, Austin (1962), Searle(1969) ou Ducrot (1973), sup e também um signans elástico, variável, que possa, ao menos, apontar para os contornos - vagos - de um tal real. Em outras palavras, assumir a existência de uma lista aberta de diferen as de sentido implica abrir m o de uma lista fechada de diferen as pertinentes de som.
The Need and the Present Situation of Educational Sciences. Conference given at the Lisbon Science Academy, on 27th July 2006
Albano Estrela
Sísifo : Educational Sciences Journal , 2006,
Abstract:
The brain drain: winners and losers. Socio-economic effects of highly skilled migrations on both sending and host countries
Alessandro Albano
Sfera Politicii , 2012,
Abstract: The aim of this paper is to provide an overview of the most important theories on brain drain” socio-economic effects both on sending and host countries. Therefore, all the main results of the analysis of three generations of Authors will be examined. So, this study will allow to understand which countries should have benefits from highly skilled migrations.
Carleman estimates for the Euler-Bernoulli plate operator
Paolo Albano
Electronic Journal of Differential Equations , 2000,
Abstract: We present some a-priori estimates of Carleman type for the Euler-Bernoulli plate operator. As an application, we consider a problem of boundary observability for the Euler-Bernoulli plate coupled with the heat equation.
Role of Adaptive Immunity in Alcoholic Liver Disease
Emanuele Albano
International Journal of Hepatology , 2012, DOI: 10.1155/2012/893026
Abstract: Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. Clinical and experimental data show the involvement of Th-1 and Th-17 T-lymphocytes in alcoholic hepatitis. Nonetheless, the mechanisms by which alcohol triggers adaptive immunity are still incompletely characterized. Patients with advanced ALD have circulating IgG and T-lymphocytes recognizing epitopes derived from protein modification by hydroxyethyl free radicals and end products of lipid-peroxidation. High titers of IgG against lipid peroxidation-derived antigens are associated with an increased hepatic production of proinflammatory cytokines/chemokines. Moreover, the same antigens favor the breaking of self-tolerance towards liver constituents. In particular, autoantibodies against cytochrome P4502E1 (CYP2E1) are evident in a subset of ALD patients. Altogether these results suggest that allo- and autoimmune reactions triggered by oxidative stress might contribute to hepatic inflammation during the progression of ALD. 1. Introduction According to the World Health Organization, alcohol-related diseases are the third cause of death and disability in most well-developed countries and a leading cause of disease in the developing countries in Eastern Europe, Central and South America, and East Asia [1]. Although several organs are injured by ethanol, alcoholic liver disease (ALD) is the most common medical consequence of excessive alcohol intake accounting for about 70% of the recorded mortality [2]. Thus, understanding the mechanisms responsible for alcohol liver injury has a relevant clinical and social impact. Current view indicates that multiple factors including oxidative stress, endoplasmic reticulum stress, metabolic alterations, and interferences with the transduction of intracellular signals are involved in ALD pathogenesis [3]. Furthermore, emerging evidence suggests that chronic inflammation represents the driving force in the evolution of alcohol liver injury. In this context, a large number of studies have investigate the role of innate immunity in ALD ([4–8] for recent review), while the contribution of adaptive immunity to alcohol-induced hepatic inflammation has received much less attention. This paper will give an overview of the possible implications of adaptive immunity in the inflammatory processes associated with ALD. Early studies have shown that liver inflammatory infiltrates in alcoholic hepatitis and active alcoholic
"Less Calcium – Fewer Oral Doses" A New Approach to Milk Fever Prevention"
Agger Nicolai
Acta Veterinaria Scandinavica , 2003, DOI: 10.1186/1751-0147-44-s1-p68
Abstract:
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