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Search Results: 1 - 10 of 785 matches for " Akio Tsuboi "
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Regressive Changes of the Myocardial Sleeves in Elderly Victims of Sudden Bathtub Death  [PDF]
Fumiko Satoh, Yoshihisa Seto, Akio Tsuboi, Motoki Osawa
Forensic Medicine and Anatomy Research (FMAR) , 2015, DOI: 10.4236/fmar.2015.32011
Abstract: In Japan, most sudden deaths occurring during bathing happen in the winter, and predominantly to elderly people. One can infer a relation to physical conditions that are specific to aging. Atrial fibrillation, an arrhythmia, increases with age. This study examined histological changes in the pulmonary vein myocardial sleeves of sudden bathtub death victims and compared them with those of control individuals. We investigated 35 sudden deaths that occurred during bathing and 34 accidental deaths or deaths caused by diseases unrelated to cardiopathies. Pulmonary veins were excised cross-sectionally from the hilar side to the venoatrial junction. Then they were stained with hematoxylin and eosin, resorcin-fuchsin van Gieson, and Congo-red stains. Amyloid deposits in the pulmonary vein myocardial sleeves, as well as the range and severity of scarring, were graded microscopically on a scale of 0-3. In the sudden bathtub death victims, severe scarring was found in the myocardial sleeves of the four pulmonary veins (mean score, 2.0), which was significantly different (p < 0.05) from the control subjects (mean score, 1.4). Cardiomegaly was found in 28 out of the autopsied individuals. In subjects with cardiomegaly, the mean value of pulmonary vein myocardial sleeve scarring was 2.1. In subjects without cardiomegaly, the mean value was 1.8. Comparison revealed that cardiomegaly was associated significantly with scarring progression and degeneration of the myocardial sleeves. Scarring of the pulmonary vein myocardial sleeves was more advanced in victims of sudden bathtub death than in controls without heart disease. Elderly people with scarring of the pulmonary vein myocardial sleeves are likely to develop degenerative variations in their intra-atrial excitation conduction. These results demonstrate that taking hot baths might induce supraventricular arrhythmias such as atrial fibrillation.
Thermally Induced Nanocrystal Array of Poly(N-Vinylcarbazole) on Si-Wafer Substrate  [PDF]
Kazushi Yamada, Yasuyuki Tsuboi
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.55032
Abstract:

Recently, nanostructures such as nanocrystals and nanoaggregates have attracted much attention in many quarters of materials, electronics, and biology to create higher-value-added functional nanoscale materials and films. In this research, the fabrication of nanoaggregates on ultrathin photoconductive films of poly(N-vinylcarbazole) (PVCz) by applying thermal treatment is demonstrated. The structure and size are discussed on the basis of the results of atomic force microscope images. As a result, after thermal treatment of these films above the glass transition temperature (Tg) of PVCz, different types of surface morphological changes were induced showing a dependence on the tacticity of PVCz. Radically polymerized PVCz(r) ultrathin film showed small aggregates with heights of ~8 nm on the film surface after thermal treatment, while cationically polymerized PVCz(c), which has higher isotactic diad fractions than PVCz(r), indicated similar aggregates on the film surface, although the number of aggregates was smaller than PVCz(r). It is considered that these different phenomena depend on the tacticity of PVCz and the interaction between PVCz molecules and the substrate surface.

DNS Analysis on the Indirect Relationship between the Local Burning Velocity and the Flame Displacement Speed of Turbulent Premixed Flames  [PDF]
Kazuya Tsuboi, Eiji Tomita
Open Journal of Fluid Dynamics (OJFD) , 2014, DOI: 10.4236/ojfd.2014.43022
Abstract: The local burning velocity and the flame displacement speed are the dominant properties in the mechanism of turbulent premixed combustion. The flame displacement speed and the local burning velocity have been investigated separately, because the flame displacement speed can be used for the discussion of flame-turbulence interactions and the local burning velocity can be used for the discussion of the inner structure of turbulent premixed flames. In this study, to establish the basis for the discussion on the effects of turbulence on the inner structure of turbulent premixed flames, the indirect relationship between the flame displacement speed and the local burning velocity was investigated by the flame stretch, the flame curvature, and the tangential strain rate using DNS database with different density ratios. It was found that for the local tangential strain rate and the local flame curvature, the local burning velocity and the flame displacement speed had the opposite correlations in each density ratio case. Therefore, it is considered that the local burning velocity and the flame displacement speed have a negative correlation.
Transmedullary Decompression for Humeral Diaphysis Solitary Bone Cysts  [PDF]
Akio Sakamoto
Open Journal of Orthopedics (OJO) , 2013, DOI: 10.4236/ojo.2013.32015
Abstract:

Solitary bone cysts are benign, fluid-filled cavities that most often occur in childhood. Several minimally invasive decompression methods have been proposed; however, performing a surgical procedure through the thinned overlying cortex raises the risk of pathological fracture and neurovascular damage, especially in lesions located in the bone diaphysis. We describe a new technique that circumvents these problems: tunneling through the normal cortex and medullary space with a flexible reamer, placing a retrograde medullary nail for cyst decompression.

A Simple and Fast Separation Method of Fe Employing Extraction Resin for Isotope Ratio Determination by Multicollector ICP-MS  [PDF]
Akio Makishima
International Journal of Analytical Mass Spectrometry and Chromatography (IJAMSC) , 2013, DOI: 10.4236/ijamsc.2013.12012
Abstract:

A new, simple and fast separation method for Fe using an extraction chromatographic resin, Aliquat 336 (commercially available as TEVA resin) has been developed. A one milliliter column containing 0.33 mL TEVA resin on 0.67 mL CG-71C was used.Iron was adsorbed with 6mol·L-1 HCl + H2O2 on TEVA resin, and recovered with 2 mol·L-1HNO3. The recovery yield and total blank were 93.5 ± 6.5% and 6 ng, respectively. Theseparation method is simple, and takes < 2 hours. For evaluation of the Fe separation, Fe isotope ratios were measured by a double-spike method employing multicollector inductively coupled plasma source mass spectrometry (MC-ICP-MS) with repeatability of 0.06‰ (SD) for the standard solution and ~0.05‰ for the silicate samples. Therefore, the column chemistry developed in this study is a viable option for Fe isotope ratio measurement by MC-ICP-MS.

A Disease Mechanism Underlying Bleeding in Wiskott-Aldrich Syndrome
Shigeru Tsuboi
Clinical Medicine Insights: Blood Disorders , 2012,
Abstract: The Wiskott-Aldrich Syndrome (WAS) is an X chromosome-linked immunodeficiency disorder. The most common symptom in WAS is bleeding. Several clinical investigations indicate that low platelet counts and defective platelet aggregation are the major causes of bleeding in WAS patients. However, the molecular bases underlying these defects are unclear. This study focuses on the molecular mechanism of defective platelet aggregation of WAS patients. The gene responsible for WAS encodes WAS protein (WASP). The mutations or deletion of WASP causes various functional defects in hematopoietic cells. We previously showed that binding of WASP to calcium- and integrin-binding protein (CIB) is required for activation of platelet integrin, αIIbβ3. I here demonstrate that blocking WASP binding to CIB reduces binding of talin to the β3 cytoplasmic tail, resulting in impaired activation of αIIbβ3. Impaired αIIbβ3 activation causes defective platelet aggregation, resulting in bleeding. This finding suggests a potential disease mechanism underlying bleeding seen in WAS patients.
Reviewer acknowledgement 2012
Tsuboi Koji
BioPsychoSocial Medicine , 2013, DOI: 10.1186/1751-0759-7-3
Abstract: The editors of BioPsychoSocial Medicine would like to thank all our reviewers who have contributed to the journal in Volume 6 (2012).
A Disease Mechanism Underlying Bleeding in Wiskott-Aldrich Syndrome
Shigeru Tsuboi
Clinical Medicine : Blood Disorders , 2008,
Abstract: The Wiskott-Aldrich Syndrome (WAS) is an X chromosome-linked immunodeficiency disorder. The most common symptom in WAS is bleeding. Several clinical investigations indicate that low platelet counts and defective platelet aggregation are the major causes of bleeding in WAS patients. However, the molecular bases underlying these defects are unclear. This study focuses on the molecular mechanism of defective platelet aggregation of WAS patients. The gene responsible for WAS encodes WAS protein (WASP). The mutations or deletion of WASP causes various functional defects in hematopoietic cells. We previously showed that binding of WASP to calcium- and integrin-binding protein (CIB) is required for activation of platelet integrin, αIIbβ3. I here demonstrate that blocking WASP binding to CIB reduces binding of talin to the β3 cytoplasmic tail, resulting in impaired activation of αIIbβ3. Impaired αIIbβ3 activation causes defective platelet aggregation, resulting in bleeding. This finding suggests a potential disease mechanism underlying bleeding seen in WAS patients.
Analytic Bethe ansatz related to a one parameter family of finite dimensional representations of the Lie superalgebra sl(r+1|s+1)
Zengo Tsuboi
Physics , 2009, DOI: 10.1088/0305-4470/31/24/010
Abstract: As is well known, the type 1 Lie superalgebra sl(r+1|s+1) admits a one parameter family of finite dimensional irreducible representations. We have carried out an analytic Bethe ansatz related to this family of representations. We present formulae, which are deformations of previously proposed determinant formulae labeled by a Young superdiagram. These formulae will provide transfer matrix eigenvalues in dressed vacuum form related to the solutions of a graded Yang-Baxter equation, which depend not only on the spectral parameter but also on a non-additive continuous parameter. A class of transfer matrix functional relations among these formulae is briefly mentioned.
Analytic Bethe ansatz and functional equations for Lie superalgebra sl(r+1|s+1)
Zengo Tsuboi
Physics , 2009, DOI: 10.1088/0305-4470/30/22/031
Abstract: From the point of view of the Young superdiagrm method, an analytic Bethe ansatz is carried out for Lie superalgebra sl(r+1|s+1). For the transfer matrix eigenvalue formulae in dressed vacuum form, we present some expressions, which are quantum analogue of Jacobi-Trudi and Giambelli formulae for Lie superalgebra sl(r+1|s+1). We also propose transfer matrix functional relations, which are Hirota bilinear difference equation with some constraints.
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