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A Surgical Case of Bilateral Pulmonary Metastases from Thyroid Follicular Cancer  [PDF]
Motohisa Kuwahara, Masato Iwami, Masae Mano, Toshihiko Moroga, Akinori Iwasaki
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.610063
Abstract: An 80-year-old woman underwent a bilateral lung resection for metastases originating from follicular thyroid cancer. The resection was performed 30 years after right hemithyroidectomy to remove the follicular adenoma. Chest X-ray revealed a 30-mm mass shadow in the right lower lung filed. Chest computed tomography revealed a 32-mm mass shadow in right lung segment 10 (S10) and a 15-mm nodular shadow in left S10. Another partial lung resection of left S10 and a right lower lobectomy were performed 3 months later. Although rarely performed, resection of bilateral pulmonary metastases arising from follicular thyroid cancer was conducted for this patient.
Pulmonary metastasis from gastric cancer: A case report and review of literature  [PDF]
Motohisa Kuwahara, Mari Matsumoto, Kazuya Naritomi, Masae Mano, Daisuke Hamatake, Koji Inutsuka, Takayuki Shirakusa, Akinori Iwasaki
Advances in Lung Cancer (ALC) , 2013, DOI: 10.4236/alc.2013.23009

We present a case report of a 63-year-old male who underwent lung resections for metastases originating from gastric cancer 18-year after total gastrectomy with lymphadenectomy. The gastrectomy was performed in 1994; histological examination of the original tumor revealed stage II poorly differentiated adenocarcinoma [pT2 (MP), N0, M0]. Chest X-ray and computed tomography in 2012 showed a well-defined tumor, 9 mm in size, at the left S3 of the lung. Thoracoscopic partial resection was performed. The tumor was diagnosed as poorly differentiated carcinoma, most likely metastatic gastric adenocarcinoma. Although rarely performed, resection of pulmonary metastases from carcinoma of the stomach was done to improve the patient’s chances for long-term survival.

Chest Wall Hemangiopericytoma-Like Solitary Fibrous Tumor of the Pleura: Case Report with Computed Tomography Findings*  [PDF]
Motohisa Kuwahara, Hiroshi Nishimura, Masato Iwami, Kazuya Naritomi, Masae Mano, Koji Inutsuka, Keita Tokuishi, Akinori Iwasaki
Advances in Computed Tomography (ACT) , 2013, DOI: 10.4236/act.2013.24022

We present a case report of a 65-year-old woman who underwent resection of a chest wall tumor. In contrast with computed tomography, the tumor exhibited hypervascularity and was fed from the 9th intercostals artery. Histologically, the tumor was diagnosed as a cellular variant of solitary fibrous tumor of the pleura, with branching “staghorn” vessels and hypervascularity. The tumor thus resembled a chest wall hemangiopericytoma.

Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts
Takehito Kawakami, Tetsuro Sameshima, Hironobu Hojo, Kaori Koga, Yoshiaki Nakahara, Bryan P Toole, Junji Suzumiya, Yasunori Okada, Akinori Iwasaki, Kazuki Nabeshima
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-300
Abstract: The whole ECI peptides carrying sugar chains, a chitobiose unit or N-linked core pentasaccharide, were synthesized by the thioester method and added to fibroblasts to examine whether they stimulate MMP-2 production.ECI carrying a chitobiose unit, ECI-(GlcNAc) 2, but not ECI without a chitobiose unit or the chitobiose unit alone, dose-dependently stimulated MMP-2 production by fibroblasts. ECI with longer chitobiose units, ECI-[(Man)3(GlcNAc)2], also stimulated MMP-2 production, but the extent of its stimulation was lower than that of ECI-(GlcNAc)2.Our results indicate that ECI can mimic emmprin activity when substituted with chitobiose, the disaccharide with which N-glycosylation starts.Matrix metalloproteinases (MMPs) play an essential role in remodeling of extracellular matrices (ECMs) involved in various biological processes, such as inflammation, tissue regeneration and tumor invasion. Among the MMPs, gelatinase A (MMP-2) is the most abundant MMP and frequently correlates with malignant progression and invasive behavior of tumor cells [1]. In situ hybridization studies of human surgical specimens have shown that stromal fibroblasts are the predominant source of MMP-2 in the majority of carcinomas [2-4]. Malignant cells stimulate nearby fibroblasts to produce MMPs via soluble cytokines and growth factors or through cell surface interactions mediated by plasma membrane proteins, such as emmprin [5]. Emmprin, also known as basigin/CD147, is an integral plasma membrane glycoprotein of the Ig superfamily that contains two extracellular Ig domains [6]. Expression of emmprin is upregulated in human malignant tumors, such as breast, lung and bladder carcinomas, malignant melanomas, gliomas and lymphomas, compared with their normal counterparts [7-11]. In malignant tumors, emmprin acts as a modulator of tumor-stroma cross-talk, since it mediates not only MMP production but also tumor angiogenesis through the stimulation of vascular endothelial growth factor (VEGF) expres
The Effectiveness and Efficiency of Disease Management Programs for Patients with Chronic Diseases
Akinori Hisashige
Global Journal of Health Science , 2012, DOI: 10.5539/gjhs.v5n2p27
Abstract: Objective: Disease management (DM) approach is increasingly advocated as a means of improving effectiveness and efficiency of healthcare for chronic diseases. To evaluate the evidence on effectiveness and efficiency of DM, evidence synthesis was carried out. Methods: To locate eligible meta-analyses and systematic reviews, we searched Medline, EMBASE, the Cochrane Library, SCI-EXPANDED, SSCI, A&HCI, DARE, HTA and NHS EED from 1995 to 2010. Two reviewers independently extracted data and assessed a study quality. Results: Twenty-eight meta-analyses and systematic reviews were included for synthesizing evidence. The proportion of articles which observed improvement with a reasonable amount of evidence was the highest at process (69%), followed by health services (63%), QOL (57%), health outcomes (51%), satisfaction (50%), costs (38%) and so on. As to mortality, statistically significant results were observed only in coronary heart disease. Important components in DM, such as a multidisciplinary approach, were identified. Conclusion: The evidence synthesized shows considerable evidence in the effectiveness and efficiency of DM programs in process, health services, QOL and so on. The question is no longer whether DM programs work, but rather which type or component of DM programs works best and efficiently in the context of each healthcare system or country.
Mechanisms for the Modulation of Dopamine D1 Receptor Signaling in Striatal Neurons
Akinori Nishi
Frontiers in Neuroanatomy , 2011, DOI: 10.3389/fnana.2011.00043
Abstract: In the striatum, dopamine D1 receptors are preferentially expressed in striatonigral neurons, and increase the neuronal excitability, leading to the increase in GABAergic inhibitory output to substantia nigra pars reticulata. Such roles of D1 receptors are important for the control of motor functions. In addition, the roles of D1 receptors are implicated in reward, cognition, and drug addiction. Therefore, elucidation of mechanisms for the regulation of dopamine D1 receptor signaling is required to identify therapeutic targets for Parkinson’s disease and drug addiction. D1 receptors are coupled to Gs/olf/adenylyl cyclase/PKA signaling, leading to the phosphorylation of PKA substrates including DARPP-32. Phosphorylated form of DARPP-32 at Thr34 has been shown to inhibit protein phosphatase-1, and thereby controls the phosphorylation states and activity of many downstream physiological effectors. Roles of DARPP-32 and its phosphorylation at Thr34 and other sites in D1 receptor signaling are extensively studied. In addition, functional roles of the non-canonical D1 receptor signaling cascades that coupled to Gq/phospholipase C or Src family kinase become evident. We have recently shown that phosphodiesterases (PDEs), especially PDE10A, play a pivotal role in regulating the tone of D1 receptor signaling relatively to that of D2 receptor signaling. We review the current understanding of molecular mechanisms for the modulation of D1 receptor signaling in the striatum.
Ferromagnetic Pairing States on Two-Coupled Chains
Akinori Tanaka
Physics , 2008, DOI: 10.1088/1751-8113/41/36/365208
Abstract: We propose a concrete model which exhibits ferromagnetism and electron-pair condensation simultaneously. The model is defined on two chains and consists of the electron hopping term, the on-site Coulomb repulsion, and a ferromagnetic interaction which describes ferromagnetic coupling between two electrons, one on a bond in a chain and the other on a site in the other chain. It is rigorously shown that the model has fullypolarized ferromagnetic pairing ground states. The higher dimensional version of the model is also presented.
Liquid-Solid Phase Transition of the System with Two particles in a Rectangular Box
Akinori Awazu
Physics , 2000, DOI: 10.1103/PhysRevE.63.032102
Abstract: We study the statistical properties of two hard spheres in a two dimensional rectangular box. In this system, the relation like Van der Waals equation loop is obtained between the width of the box and the pressure working on side walls. The auto-correlation function of each particle's position is calculated numerically. By this calculation near the critical width, the time at which the correlation become zero gets longer according to the increase of the height of the box. Moreover, fast and slow relaxation processes like $\alpha$ and $\beta$ relaxations observed in supper cooled liquid are observed when the height of the box is sufficiently large. These relaxation processes are discussed with the probability distribution of relative position of two particles.
Segregation and Phase Inversion in a Simple Granular System
Akinori Awazu
Physics , 2003, DOI: 10.1143/JPSJ.72.1832
Abstract: The segregation and the phase inversion are investigated through a simple granular system which consists of only two inelastic hard spheres in a square box with an energy source. With the variation of the coefficient of restitution, the mass ratio between two spheres or the box size, we show that two types of segregated states and crossover between them are realized in such a small simple system.
A Model of Strongly Correlated Electrons with Condensed Resonating-Valence-Bond Ground States
Akinori Tanaka
Physics , 2003, DOI: 10.1088/0305-4470/37/5/007
Abstract: We propose a new exactly solvable model of strongly correlated electrons. The model is based on a $d$-$p$ model of the CuO$_2$ plane with infinitely large repulsive interactions on Cu-sites, and it contains additional correlated-hopping, pair-hopping and charge-charge interactions of electrons. For even numbers of electrons less than or equal to 2/3-filling, we construct the exact ground states of the model, all of which have the same energy and each of which is the unique ground state for a fixed electron number. It is shown that these ground states are the resonating-valence-bond states which are also regarded as condensed states in which all electrons are in a single two-electron state. We also show that the ground states exhibit off-diagonal long-range order.
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