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Search Results: 1 - 10 of 778 matches for " Akiko Miyagawa "
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The Relationship between Living Environment and Oral Function in Elderly Japanese  [PDF]
Naoko Morisaki, Hiroe Uchida, Akiko Miyagawa
Advances in Applied Sociology (AASoci) , 2019, DOI: 10.4236/aasoci.2019.92006
Abstract: This study aims to clarify the current state of oral function among elderly people and to analyze the relation with basic attributes. The subjects of the survey were dependent elderly people receiving nursing care in Japan. We examined the subjects’ age, sex, level of care required, living environment (home or facility), and oral functions. Tongue pressure and oral diadochokinesis (OD) were used to evaluate oral function. The relationship between the basic attributes of the elderly subjects and the oral function evaluation value was analyzed by multiple regression analysis. The average value of tongue pressure was 24.70 ± 10.20 Pa. The average value of OD was 4.7 ± 1.4 for /pa/, 4.6 ± 1.3 for /ta/, and 4.3 ± 1.3 for /ka/. Tongue pressure was found to be significantly related to the degree of care required (p < 0.01). The OD recognized syllables of /pa/, /ta/, /ka/ were significantly related to the degree of need for care and living environment (p < 0.05). The living environment is thought to affect oral function.
Distribution of Deviation Distance to Alternative Fuel Stations  [PDF]
Masashi Miyagawa
American Journal of Operations Research (AJOR) , 2013, DOI: 10.4236/ajor.2013.33033
Abstract: This paper derives the distribution of the deviation distance to visit an alternative fuel station. Distance is measured as the Euclidean distance on a continuous plane. The distribution explicitly considers the vehicle range and whether the round trip between origin and destination can be made. Three cases are examined: fuel is available at both origin and destination, fuel is available at either origin or destination, and fuel is available at neither origin nor destination. The analytical expressions for the distribution demonstrate how the vehicle range, the shortest distance, and the refueling availability at origin and destination affect the deviation distance. The distribution will thus be useful to estimate the number of vehicles refueled at a station.

Effects of Oral L-Carnitine Administration in Narcolepsy Patients: A Randomized, Double-Blind, Cross-Over and Placebo-Controlled Trial
Taku Miyagawa, Hiromi Kawamura, Mariko Obuchi, Asuka Ikesaki, Akiko Ozaki, Katsushi Tokunaga, Yuichi Inoue, Makoto Honda
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053707
Abstract: Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and rapid eye movement (REM) sleep abnormalities. A genome-wide association study (GWAS) identified a novel narcolepsy-related single nucleotide polymorphism (SNP), which is located adjacent to the carnitine palmitoyltransferase 1B (CPT1B) gene encoding an enzyme involved in β-oxidation of long-chain fatty acids. The mRNA expression levels of CPT1B were associated with this SNP. In addition, we recently reported that acylcarnitine levels were abnormally low in narcolepsy patients. To assess the efficacy of oral l-carnitine for the treatment of narcolepsy, we performed a clinical trial administering l-carnitine (510 mg/day) to patients with the disease. The study design was a randomized, double-blind, cross-over and placebo-controlled trial. Thirty narcolepsy patients were enrolled in our study. Two patients were withdrawn and 28 patients were included in the statistical analysis (15 males and 13 females, all with HLA-DQB1*06:02). l-carnitine treatment significantly improved the total time for dozing off during the daytime, calculated from the sleep logs, compared with that of placebo-treated periods. l-carnitine efficiently increased serum acylcarnitine levels, and reduced serum triglycerides concentration. Differences in the Japanese version of the Epworth Sleepiness Scale (ESS) and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) vitality and mental health subscales did not reach statistical significance between l-carnitine and placebo. This study suggests that oral l-carnitine can be effective in reducing excessive daytime sleepiness in narcolepsy patients. Trial Registration University hospital Medical Information Network (UMIN) UMIN000003760
Electronic states and molecular dynamics of single-component molecular conductors [M(tmdt)$_2$] (M=Ni, Pt) studied by $^{13}$C and $^1$H NMR
Rina Takagi,Kazuya Miyagawa,Masahide Yoshimura,Hiro Gangi,Kazushi Kanoda,Biao Zhou,Yuki Idobata,Akiko Kobayashi
Physics , 2015,
Abstract: The molecular conductors [M(tmdt)$_2$] (M=Ni, Pt) consisting of single molecular species are investigated with $^{13}$C NMR and $^1$H NMR. The temperature dependences of $^{13}$C NMR shift and relaxation rate provide microscopic evidences for the metallic nature with appreciable electron correlations. Both compounds exhibit an anomalous frequency-dependent enhancement in $^1$H nuclear spin-lattice relaxation rate in a wide temperature range. These observations signify the presence of extraordinary molecular motions with low energy excitations.
NMR Evidence for Antiferromagnetic Transition in the Single-Component Molecular System, [Cu(tmdt)$_{2}$]
Rina Takagi,Kazuya Miyagawa,Kazushi Kanoda,Biao Zhou,Akiko Kobayashi,Hayao Kobayashi
Physics , 2012, DOI: 10.1103/PhysRevB.85.184424
Abstract: The magnetic state of the single-component molecular compound, [Cu(tmdt)$_{2}$], is investigated by means of $^{1}$H-NMR. An abrupt spectral broadening below 13 K and a sharp peak in nuclear spin-lattice relaxation rate, $T_{1}^{-1}$, at 13 K are observed as clear manifestations of a second-order antiferromagnetic transition, which is consistent with the previously reported magnetic susceptibility and EPR measurement. The ordered moment is estimated at $0.22-0.45$ ${\mu}_{\rm B}$/molecule. The temperature-dependence of $T_{1}^{-1}$ above the transition temperature indicates one-dimensional spin dynamics and supports that the spins are on the central part of the molecule differently from other isostructural compounds.
From bench to bedside, work in cell-based myocardial regeneration therapy  [PDF]
Shigeru Miyagawa, Yoshiki Sawa
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.72012

In clinical cellular cardiomyoplasty, bone marrow cells and myoblasts are introduced mainly to ischemic cardiomyopathy tissue via several cell delivery systems, such as needle injection or catheter. These clinical studies have demonstrated the safety and feasibility of this technique, but its effectiveness for treating heart failure, especially in the long term, is still under discussion. Neither of these cell types can differentiate into cardiomyocytes; rather, they improve the failing heart mainly by the paracrine effects of some cytokines, such as Hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF). Thus, many researchers have a great interest in stem cells, which exist in bone marrow, circulating blood, atrium, and adipose tissue, and can differentiate into cardiomyocytes. Although several stem cells with the potential to differentiate into various cell types have been reported, few can differentiate into cardiomyocytes. Moreover, beating cells that can demonstrate synchronized contraction with native cardiomyocytes are critical for the complete repair of severe heart failure. Therefore, stem cells with a high differentiation capacity should be explored for the goal of completely repairing severely damaged myocardium. In this review, we summarize the clinical protocols and basic experiments for cellular cardiomyoplasty using bone marrow cells, myoblasts, and other stem cells.

Analytic properties of generalized Mordell-Tornheim type of multiple zeta-functions and L-functions
Takashi Miyagawa
Mathematics , 2015,
Abstract: Analytic properties of three types of multiple zeta functions, that is, the Euler-Zagier type, the Mordell-Tornheim type and the Apostol-Vu type have been studied by a lot of authors. In particular, in the study of multiple zeta functions of the Apostol-Vu type, a generalized multiple zeta function, including both the Euler-Zagier type and the Apostol-Vu type, was introduced.In this paper, similarly we consider generalized multiple zeta-functions and $ L $-functions, which include both the Euler-Zagier type and the Mordell-Tornheim type as special cases.We prove the meromorphic continuation to the multi-dimensional complex space, and give the results on possible singularities.
Experimental Therapeutic Trial of an Antibody against the Cell Adhesion Molecule Gicerin for Lymphomas Using a Murine Cell Line  [PDF]
Yasuhiro Tsukamoto, Yukiko Miyagawa, Osamu Maeda
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.910066
Abstract: Chemotherapy, occasionally combined with radiotherapy, is a major method for treating lymphoma but frequently produces side-effects in patients. Thus, novel therapeutics should be developed as an alternative the chemotherapy in lymphoma patients. Although the cell adhesion molecule gicerins are almost entirely absent in most mature tissues, except for muscle and endothelial cells, various neoplastic cells strongly express gicerin in their cell membranes. This suggests the potential function of gicerin in the progression of tumors, including tumor growth, invasion and metastasis to distant organs from primary sites. In the present study, we assessed therapeutic effects of anti-gicerin antibodies on the murine lymphoma cell line YAC1. Gicerin was found to be expressed in the cell membrane of YAC1 cells and promoted the cell adhesion activity of the YAC1 cells on HUVECs, an endothelial cell line. In addition, YAC1 cells were implanted sub-cutaneously in mice in order to examine the therapeutic effects of anti-gicerin antibodies on lymphoma progression
Advances in therapeutics for liver metastasis from colorectal cancer
Akira Kobayashi,Shinichi Miyagawa
World Journal of Gastrointestinal Oncology , 2010,
Abstract: The evolution of chemotherapeutic regimens that include targeted molecular agents has resulted in a breakthrough in the management of advanced colorectal liver metastasis (CLM), improving the progression-free survival after liver resection, and rendering initially unresectable liver tumors resectable, with reported resection rates ranging from 13% to 51%. In addition, the criteria used for selecting patients for hepatectomy have been expanding because of advances in surgical techniques and improvements in chemotherapy. However, the increasing use of chemotherapy has raised concern about potential hepatotoxicities such as steatosis, chemotherapy-associated steatohepatitis, and sinusoidal obstruction syndrome, and their deleterious effects on postoperative outcome. The present review focuses on the advantages and disadvantages of chemotherapy, strategies for the prevention and diagnosis of chemotherapy-associated liver injury, and the adoption of more aggressive surgical approaches, which have changed the traditional paradigm for CLM.
$S$-matrix poles near the $ΛN$ and $ΣN$ Thresholds in the Coupled \\$ΛN-ΣN$ System
K. Miyagawa,H. Yamamura
Physics , 1999, DOI: 10.1103/PhysRevC.60.024003
Abstract: We search $t$-matrix poles for $\Lambda N-\Sigma N$ coupling interactions using two soft core models of the Nijmegen group which bind the hypertriton at the correct binding energy, and hard core models which are still influential in hypernuclear physics. To treat the hard core potentials, a useful method for calculating the off-shell $t$-matrix is proposed. We find poles close to the $\Sigma N$ threshold in the second or third quadrant of the complex plane of the $\Sigma N$ relative momentum. The relation between the poles and the shape of the $\Lambda N$ elastic total cross section is discussed based on a so-called uniformization by which two-channel $t$-matrices become single-valued on a complex valuable. We also find poles near the $\Lambda N$ threshold. These are correlated to the $S$-wave $\Lambda N$ scattering lengths, the values of which have yet to be determined.
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