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Search Results: 1 - 10 of 261 matches for " Aisha Elsharkawy "
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Use of ultrasonic transient elastography (Fibroscan) in the assessment of hepatic focal lesion stiffness  [PDF]
Mohamed Yousef, Aisha Elsharkawy, Mohammad El Beshlawy, Gamal Esmat, Zakaria Salama
Open Journal of Gastroenterology (OJGas) , 2013, DOI: 10.4236/ojgas.2013.32018
Abstract:

Background and Aim: Hepatic focal lesions differ in their tissue composition and in the degree of stiffness, so our aim was to evaluate the role of Ultrasonic Transient Elastography (Fibroscan) in the measurement of hepatic focal lesions stiffness in order to differentiate hepatocellular carcinoma (HCC) focal lesions from other non HCC focal lesions. Methods: The study was conducted on 34 patients with hepatic focal lesion(s) in the right lobe located near the liver surface and more than or equal4 cmin diameter, detected by imaging studies and diagnosed by CT and histopathology. Stiffness over the focal lesions was measured by the fibroscan. Results: The median value of stiffness was 72.5 kPa over HCC focal lesions, 17.2 kPa over lymphoma focal lesions, 6.5 kPa over metastatic focal lesions and 10.5 kPa over the sarcoidosis focal lesion. Conclusions: Hepatocellular carcinoma focal lesions are much stiffer than lymphoma, metastasis or sarcoidosis focal lesions. Fibroscan may be a useful non-invasive method in the prediction of hepatocellular carcinoma in the future.

Use of the urinary trypsinogen-2 dipstick test in early diagnosis of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP)  [PDF]
Hasan El-Garem, Enas Hamdy, Sherif Hamdy, Mohammad El-Sayed, Aisha Elsharkawy, Azmi Mohammed Saleh
Open Journal of Gastroenterology (OJGas) , 2013, DOI: 10.4236/ojgas.2013.36049
Abstract: Background: Acute pancreatitis is one of the most serious complications of ERCP. Early diagnosis of post ERCP pancreatitis helps physicians to provide intensive care and possible medical treatment as early as possible. Trypsinogen-2 in urine is a good diagnostic and prognostic marker of acute pancreatitis. Objectives: To evaluate the diagnostic value of urinary trypsinogen-2 dipstick test for early diagnosis of post ERCP pancreatitis. Methods: A total of 37 patients with obstructive jaundice were tested with the urinary trypsinogen-2 dipstick test and serum levels of amylase and lipase before ERCP and 6 hours after ERCP. Results: Post ERCP pancreatitis was diagnosed in 6 (16%) of 37 patients. The sensitivity, specificity, positive predictive value and negative predictive value of urinary trypsinogen-2 dipstick test at 6 hours after ERCP were 100%, 97%, 86%, 100% respectively. At the cutoff level (130 U/L) for lipase, the positive predictive value and negative predictive value all were (100%), however, the positive predictive value and negative predictive value for amylase levels at cutoff (122 U/L) were 60%, 100% respectively. Serum lipase level was the best test for diagnosing post ERCP pancreatitis followed by the urinary trypsinogen-2 dipstick test. Conclusions: The urinary trypsinogen-2 dipstick test can be used as a rapid and easy test for early diagnosis of post ERCP pancreatitis with high sensitivity and specificity.
Coinfection with hepatitis C virus and schistosomiasis: Fibrosis and treatment response
Mahasen Abdel-Rahman,Mohammad El-Sayed,Maissa El Raziky,Aisha Elsharkawy
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i17.2691
Abstract: AIM: To assess whether schistosomiasis coinfection with chronic hepatitis C virus (HCV) influences hepatic fibrosis and pegylated-interferon/ribavirin (PEG-IFN/RIB) therapy response. METHODS: This study was designed as a retrospective analysis of 3596 chronic HCV patients enrolled in the Egyptian National Program for HCV treatment with PEG-IFN/RIB. All patients underwent liver biopsy and anti-schistosomal antibodies testing prior to HCV treatment. The serology results were used to categorize the patients into group A (positive schistosomal serology) or group B (negative schistosomal serology). Patients in group A were given oral antischistosomal treatment (praziquantel, single dose) at four weeks prior to PEG-IFN/RIB. All patients received a 48-wk course of PEG-IFN (PEG-IFNα2a or PEG-IFNα2b)/RIB therapy. Clinical and laboratory follow-up examinations were carried out for 24 wk after cessation of therapy (to week 72). Correlations of positive schistosomal serology with fibrosis and treatment response were assessed by multiple regression analysis. RESULTS: Schistosomal antibody was positive in 27.3% of patients (15.9% females and 84.1% males). The patients in group A were older (P = 0.008) and had a higher proportion of males (P = 0.002) than the patients in group B. There was no significant association between fibrosis stage and positive schistosomal serology (P = 0.703). Early virological response was achieved in significantly more patients in group B than in group A (89.4% vs 86.5%, P = 0.015). However, significantly more patients in group A experienced breakthrough at week 24 than patients in group B (36.3% vs 32.3%, P = 0.024). End of treatment response was achieved in more patients in group B than in group A (62.0% vs 59.1%) but the difference did not reach statistical significance (P = 0.108). Sustained virological response occurred in significantly more patients in group B than in group A (37.6% vs 27.7%, P = 0.000). Multivariate logistic regression analysis of patient data at treatment weeks 48 and 72 showed that positive schistosomal serology was associated with failure of response to treatment at week 48 (OR = 1.3, P = 0.02) and at week 72 (OR = 1.7, P < 0.01). CONCLUSION: Positive schistosomal serology has no effect on fibrosis staging but is significantly associated with failure of response to HCV treatment despite antischistosomal therapy.
Restricted Three-Body Problem in Cylindrical Coordinates System  [PDF]
Mohammed Sharaf, Aisha Alshaery
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.38134
Abstract: In this paper, the equations of motion for spatial restricted circular three body problem will be established using the cylindrical coordinates. Initial value procedure that can be used to compute both the cylindrical and Cartesian coordinates and velocities is also developed.
Effect of Cumulus Cells on the Efficiency of Vitrified-Thawed Immature Cattle Oocytes  [PDF]
Samia Mohamed Abd-El Rheem, Suzan Elsharkawy
Open Journal of Obstetrics and Gynecology (OJOG) , 2019, DOI: 10.4236/ojog.2019.95066
Abstract: The present work was designed to examine the effect of the presence or absence of cumulus cells on the efficiency of vitrification of immature cattle oocytes. In our experiment, we had two groups: group 1, immature cattle oocytes with cumulus cells and group 2, immature cattle oocytes without cumulus cells. The two groups underwent vitrification using 20% ethylene glycol and 20% DMSO, and then thawed, and in vitro matured in TCM-199 medium and examined after 22 hours for assessment of nuclear maturation. Higher survival rate (p < 0.05) after thawing was observed in group 1 (84.6%) than group 2 (57.8%). After in-vitro maturation, the rate of MII oocytes was significantly higher (p < 0.05) in group 1 (74.4%) than group 2 (47.7%). In conclusion, the cumulus cells are very important in increasing the survivability and developmental rate of vitrified-thawed immature cattle oocytes.
Anesthetic Management of Direct Laryngoscopy and Dilatation of Subglottic Stenosis in a Patient with Severe Myasthenia Gravis
Hesham A. Elsharkawy,Ursula Galway
Case Reports in Anesthesiology , 2012, DOI: 10.1155/2012/217561
Abstract: We describe the anesthetic management of a patient with severe myasthenia gravis and tracheal stenosis; the patient was scheduled for direct laryngoscopy and dilatation. The combination of myasthenia gravis and tracheal obstruction presents several difficulties for anesthetic management. The airway is shared; therefore, any complications are also shared by the anesthesiologist and bronchoscopists. The potential for respiratory compromise in patients undergoing the two procedures requires that anesthesiologists be familiar with the underlying disease state, as well as the interaction of anesthetic and nonanesthetic drugs in a case involving myasthenia gravis. We reviewed the literature and report our experience in this case. There is no strong evidence for choosing one approach to general anesthesia over another for bronchoscopy. Careful preoperative planning and experience in airway management and jet ventilation are crucial to prevent an adverse outcome and obtain favorable results.
Anesthetic Management of Direct Laryngoscopy and Dilatation of Subglottic Stenosis in a Patient with Severe Myasthenia Gravis
Hesham A. Elsharkawy,Ursula Galway
Case Reports in Anesthesiology , 2012, DOI: 10.1155/2012/217561
Abstract: We describe the anesthetic management of a patient with severe myasthenia gravis and tracheal stenosis; the patient was scheduled for direct laryngoscopy and dilatation. The combination of myasthenia gravis and tracheal obstruction presents several difficulties for anesthetic management. The airway is shared; therefore, any complications are also shared by the anesthesiologist and bronchoscopists. The potential for respiratory compromise in patients undergoing the two procedures requires that anesthesiologists be familiar with the underlying disease state, as well as the interaction of anesthetic and nonanesthetic drugs in a case involving myasthenia gravis. We reviewed the literature and report our experience in this case. There is no strong evidence for choosing one approach to general anesthesia over another for bronchoscopy. Careful preoperative planning and experience in airway management and jet ventilation are crucial to prevent an adverse outcome and obtain favorable results. 1. Introduction We present the anesthetic management of a patient with severe myasthenia gravis (MG) and tracheal stenosis she was scheduled for direct laryngoscopy and dilatation. Institutional review board (IRB) approval is not required by our institution for single case reports; therefore, written patient permission was not obtained. The combination of myasthenia gravis and tracheal stenosis presents several challenges for the anesthesiologist. Therefore, preoperative evaluation of the MG patient should include a review of the severity of the patient’s disease and the treatment regimen. The case should therefore be reviewed with the surgeon before formulating the anesthesia plan. Specific attention should be paid to voluntary and respiratory muscle strength. The patient’s ability to protect and maintain a patent airway postoperatively may be compromised if any bulbar involvement exists preoperatively. Respiratory muscle strength can be quantified by pulmonary function tests. Finally, it is critical to evaluate the severity of the subglottic stenosis and the difficulty of the intubation. 2. Case Presentation The patient was a 24-year-old female with a past medical history of myasthenia gravis (MG) and asthma. Her history included nine days of orotracheal intubation for myasthenia exacerbation. She needed five plasma phoresis exchanges and high doses of corticosteroids and azathioprine. Afterwards, the patient was discharged home in stable condition. At home, the MG was treated with oral pyridostigmine 60?mg, 3?times per day; prednisone 20?mg daily in the morning; oral
Clinical Outcome of Decompressive Craniectomy Operation for the Management of Acute Traumatic Brain Injury  [PDF]
Ahmed Elsharkawy, Ahmed M. Ali
Open Journal of Modern Neurosurgery (OJMN) , 2019, DOI: 10.4236/ojmn.2019.93027
Abstract: Objectives: To evaluate the efficacy of Decompressive Craniectomy (DC) on the postoperative clinical state of the patient to define a line of management of these cases. Take in considerations the surrounding circumstances of the patient till he reaches the ER in Egypt and the hospital resources. Methods: 200 patients suffering from acute traumatic brain injury causing DCL resulted from different pathologies causing increased ICP. In group A, patients with acute TBI were managed by surgical intervention in the form of Decompressive Craniectomy and in the control group B, patients were managed by medical treatment. The age range was from 8 to 65 with no history of associated medical disorders with exclusion criteria of non-traumatic causes of increased ICP. Results: Data collected showed: male to female ratio of 3:1. The most common mode of injury was falling from height. Mean time from injury to operative intervention was 4 hours. The leading initial symptoms were DCL. In group A the overall mortality was 60%, functional recovery rate was 30%, and left severely disabled or vegetative was 10%. 50% of the cases had associated injury. 20% suffered from post-operative complications. Conclusion: DC is the ideal solution for the management of acute TBI with persistent increased ICP when the other medical management fails, given an early intervention and taking into consideration other factors affecting surgical outcome.
Some Properties of the Class of Univalent Functions with Negative Coefficients  [PDF]
Aisha Ahmed Amer, Maslina Darus
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.312251
Abstract: The main object of this paper is to study some properties of certain subclass of analytic functions with negative coefficients defined by a linear operator in the open unit disc. These properties include the coefficient estimates, closure properties, distortion theorems and integral operators.
Deified Humans (Saints) in ancient Egypt
Aisha Abdalaal
Historical Kan Periodical , 2009,
Abstract: ( ) " ". - - - - " " D. Wildung " " " " .
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