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Search Results: 1 - 10 of 24047 matches for " Ae-Ran Kim "
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Low Amount of Salinomycin Greatly Increases Akt Activation, but Reduces Activated p70S6K Levels
Ju-Hwa Kim,Ae-Ran Choi,Yong Kee Kim,Hyung Sik Kim,Sungpil Yoon
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140917304
Abstract: The present study identified a novel salinomycin (Sal)-sensitization mechanism in cancer cells. We analyzed the signal proteins Akt, Jnk, p38, Jak, and Erk1/2 in cancer cell lines that had arrested growth following low amounts of Sal treatment. We also tested the signal molecules PI3K, PDK1, GSK3β, p70S6K, mTOR, and PTEN to analyze the PI3K/Akt/mTOR pathway. The results showed that Sal sensitization positively correlates with large reductions in p70S6K activation. Interestingly, Akt was the only signal protein to be significantly activated by Sal treatment. The Akt activation appeared to require the PI3K pathway as its activation was abolished by the PI3K inhibitors LY294002 and wortmannin. The Akt activation by Sal was conserved in the other cell lines analyzed, which originated from other organs. Both Akt activation and C-PARP production were proportionally increased with increased doses of Sal. In addition, the increased levels of pAkt were not reduced over the time course of the experiment. Co-treatment with Akt inhibitors sensitized the Sal-treated cancer cells. The results thereby suggest that Akt activation is increased in cells that survive Sal treatment and resist the cytotoxic effect of Sal. Taken together; these results indicate that Akt activation may promote the resistance of cancer cells to Sal.
Acupuncture Treatment of a Patient with Persistent Allergic Rhinitis Complicated by Rhinosinusitis and Asthma
Ae-Ran Kim,Jun-Yong Choi,Jong-In Kim,So-Young Jung,Sun-Mi Choi
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep240
Abstract: A pathophysiologic relationship between allergic rhinitis and rhinosinusitis and asthma has long been suggested. However, few clinical studies of acupuncture have been conducted on these comorbid conditions. A 48-year-old male suffering from persistent allergic rhinitis with comorbid chronic rhinosinusitis and asthma since the age of 18 years was studied. He complained of nasal obstruction, sneezing, cough, rhinorrhea and moderate dyspnea. He occasionally visited local ear-nose-throat clinics for his nasal symptoms, but gained only periodic symptom relief. The patient was treated with acupuncture, infrared radiation to the face and electro-acupuncture. Needles were inserted at bilateral LI20, GV23, LI4 and EX-1 sites with De-qi. Electro-acupuncture was performed simultaneously at both LI20 sites and additional traditional Korean acupuncture treatments were performed. Each session lasted for 10 min and the sessions were carried out twice a week for 5 weeks. The patient’s Mini-Rhinoconjunctivitis Quality-of-Life Questionnaire score decreased from 38, at the beginning of treatment, to 23, 3 weeks after the last treatment. The Total Nasal Symptom Score was reduced from six (baseline) to five, 3 weeks after the last treatment. There was significant clinical improvement in the forced expiratory volume in 1 s—from 3.01 to 3.50 l—with discontinuation of the inhaled corticosteroid, and no asthma-related complaints were reported. Further clinical studies investigating the effectiveness of acupuncture for the patients suffering from allergic rhinitis and/or rhinosinusitis with comorbid asthma are needed.
Detection of sexually transmitted infection and human papillomavirus in negative cytology by multiplex-PCR
Hyo-Sub Shim, Songmi Noh, Ae-Ran Park, Young-Nam Lee, Jong-Kee Kim, Hyun-Jae Chung, Keum-Soon Kang, Nam Cho
BMC Infectious Diseases , 2010, DOI: 10.1186/1471-2334-10-284
Abstract: We recruited 235 women of reproductive age who had negative cytology findings in a liquid-based cervical smear. STIs were identified by multiplex PCR, and HPV genotypes by multiplex PCR, hybrid capture 2, and DNA microaray; discordant results were analyzed by direct sequencing.Approximately 96.6% of patients with negative cytology results were positive for pathogens that cause STIs. The pathogens most frequently detected were Gardnerella vaginalis, Ureaplasma urealyticum. The incidence of HPV in negative cytology was 23.3%. Low-risk HPV infection was significantly correlated with Chalmaydia trachomatis, and high-risk HPV infection was significantly correlated with Group β streptococcus. The analytical sensitivities of the multiplex PCR and DNA microarray were higher than 80%, and the analytical specificity was nearly 100% for all tests.Multiplex PCR yielded results that most of patients with negative cytology were positive for pathogens that cause STIs, and were more similar to that of DNA microarray, than that of hybrid capture 2 in terms of analytical sensitivity and prediction value of HPV infection.Sexually transmitted diseases (STDs) are fairly common in people of reproductive age; more than 50% of new STD infections occur in adolescents. However, only 50% to 80% of reportable STDs that occur in the United States are actually reported [1]. Testing for STDs can result in negative cytology, that is, laboratory test results that revealed reactive cellular change (RCC) or atypical squamous cells of undetermined significance (ASCUS). RCC or ASCUS is routinely screened for, but they are not associated with neoplasms or preneoplastic stages known as squamous intraepithelial lesions (SILs). RCCs are cytological alterations related to inflammation or irritation but, whether subtle or marked, are typically not associated with human papillomavirus (HPV) infection. Common features of RCCs include the formation of small perinuclear halos, mild nuclear enlargement or nuclear
Evaluation of wet-cupping therapy for persistent non-specific low back pain: a randomised, waiting-list controlled, open-label, parallel-group pilot trial
Jong-In Kim, Tae-Hun Kim, Myeong Lee, Jung Kang, Kun Kim, Jun-Yong Choi, Kyung-Won Kang, Ae-Ran Kim, Mi-Suk Shin, So-Young Jung, Sun-mi Choi
Trials , 2011, DOI: 10.1186/1745-6215-12-146
Abstract: We recruited 32 participants (21 in the wet-cupping group and 11 in the waiting-list group) who had been having PNSLBP for at least 3 months. The participants were recruited at the clinical research centre of the Korea Institute of Oriental Medicine, Korea. Eligible participants were randomly allocated to wet-cupping and waiting-list groups. Following the practice of traditional Korean medicine, the treatment group was provided with wet-cupping treatment at two acupuncture points among the BL23, BL24 and BL25 6 times within 2 weeks. Usual care, including providing brochures for exercise, general advice for PNSLBP and acetaminophen, was allowed in both groups. Separate assessors participated in the outcome assessment. We used the 0 to100 numerical rating scale (NRS) for pain, the McGill Pain Questionnaire for pain intensity (PPI) and the Oswestry Disability Questionnaire (ODQ), and we assessed acetaminophen use and safety issues.The results showed that the NRS score for pain decreased (-16.0 [95% CI: -24.4 to -7.7] in the wet-cupping group and -9.1 [-18.1 to -0.1] in the waiting-list group), but there was no statistical difference between the groups (p = 0.52). However, the PPI scores showed significant differences between the two groups (-1.2 [-1.6 to -0.8] for the wet-cupping group and -0.2 [-0.8 to 0.4] for the waiting-list group, p < 0.01). In addition, less acetaminophen was used in the wet-cupping group during 4 weeks (p = 0.09). The ODQ score did not show significant differences between the two groups (-5.60 [-8.90 to -2.30] in the wet-cupping group and -1.8 [-5.8 to 2.2] in the waiting-list group, p = 0.14). There was no report of adverse events due to wet-cupping.This pilot study may provide preliminary data on the effectiveness and safety of wet-cupping treatments for PNSLBP. Future full-scale randomised controlled trials will be needed to provide firm evidence of the effectiveness of this intervention.ClinicalTrials.gov: (Identifier: NCT00925951)Date of tr
Acupuncture for dry eye: a multicentre randomised controlled trial with active comparison intervention (artificial tear drop) using a mixed method approach protocol
Tae-Hun Kim, Jung Kang, Kun Kim, Kyung-Won Kang, Mi-Suk Shin, So-Young Jung, Ae-Ran Kim, Hee-Jung Jung, Seung-Deok Lee, Jin-Bong Choi, Sun-Mi Choi
Trials , 2010, DOI: 10.1186/1745-6215-11-107
Abstract: One hundred fifty participants with dry eye will be recruited into three independent hospitals from different areas: Korea Institute of Oriental Medicine, DongGuk University Ilsan Oriental Hospital and Dongshin University Gwangju Oriental Hospital. The number of participants required was calculated from the data of a previous, relevant study. These patients will be randomly allocated into acupuncture treatment or artificial tear groups. Either 17 acupuncture points (bilateral BL2, GB14, TE 23, Ex1, ST1, GB20, LI4, LI11 and single GV23) will be used 3 times a week or disposable artificial tear drops (Refresh Plus?, ALLERGAN) will be provided for use at least once a day for 4 weeks. The ocular surface disease index (OSDI), tear film break-up time (TFBUT), Schirmer I test, visual analogue scale (VAS) for self-assessment of ocular discomfort, general assessment (by both acupuncture practitioners and participants) and quality of life (QOL) through the Measure Yourself Medical Outcome Profile-2 (MYMOP-2) will be assessed for approximately 3-months for each study participant. In addition, qualitative study and cost-effectiveness of acupuncture treatment will be conducted.ClinicalTrials.gov (Identifier: NCT01105221).Dry eye is not a life-threatening disease, but it is one of the most common and irritating conditions in ophthalmology. Because of recent data on both the pathological mechanism and aetiology, the definition of dry eye has been changed from simple ocular discomfort (related to the deficiency or hyper-evaporation of tears) to a multifactorial disease (with ocular discomfort and visual disturbances, which are related to tear-film instability and both the hyper-osmolarity and chronic inflammation of the ocular surface) [1]. The overall prevalence has been reported to be between 5 and 35 percent in different populations [2]. The incidence is now increasing more rapidly than other ophthalmologic diseases such as cataracts, retinal disease and glaucoma [3]. This may b
Acupuncture for dry eye: a randomised controlled trial protocol
Tae-Hun Kim, Jong-In Kim, Mi-Suk Shin, Myeong Lee, Jun-Yong Choi, So-Yong Jung, Ae-Ran Kim, Jae-Uk Seol, Sun-Mi Choi
Trials , 2009, DOI: 10.1186/1745-6215-10-112
Abstract: A randomised, patient-assessor blinded, sham (non-acupuncture point, shallow acupuncture) controlled study was established. Participants allocated to verum acupuncture and sham acupuncture groups will be treated three times weekly for three weeks for a total of nine sessions per participant. Seventeen points (GV23; bilateral BL2, GB4, TE23, Ex1 (Taiyang), ST1 and GB20; and left SP3, LU9, LU10 and HT8 for men, right for women) have been selected for the verum acupuncture; for the sham acupuncture, points have been selected that do not coincide with a classical acupuncture point and that are located close to the verum points, except in the case of the rim of the eye. Ocular surface disease index, tear film breakup time, the Schirmer I test, medication quantification scale and general assessment of improvement will be used as outcome variables for evaluating the effectiveness of acupuncture. Safety will also be assessed at every visit. Primary and secondary outcomes will be assessed four weeks after screening. All statistical analyses will be performed using analysis of covariance.The results of this trial will be used as a basis for clarifying the efficacy of acupuncture for dry eye.ClinicalTrials.gov NCT00969280.Dry eye is one of the most frequently occurring opthalmological health problems worldwide. The prevalence of dry eye is estimated to be in the range of 5% to 35% and its incidence has recently been increasing [1]. According to a recent survey, over 20% of outpatients in ophthalmologic clinics in Korea were diagnosed with dry eye [2]. The burden of dry eye involves not only problems with common activities such as reading, carrying out professional work, using the computer, watching television, and driving [3], but also widespread limitations in the activities of daily life, bodily pain, discomfort and lower energy and vitality [4].Currently, the use of artificial tears and lifestyle modifications are the most common choices in management of patients with mild
A trial for the use of qigong in the treatment of pre and mild essential hypertension: a study protocol for a randomized controlled trial
Ji-Eun Park, Yan Liu, Taeseob Park, Sanghoon Hong, Jung-Eun Kim, Tae-Hun Kim, Ae-Ran Kim, So-Young Jung, Hyoju Park, Sun-Mi Choi
Trials , 2011, DOI: 10.1186/1745-6215-12-244
Abstract: Our objectives are the following: 1) To evaluate the effects of qigong on blood pressure, health status and hormone levels for pre- or mild hypertension. 2) To test the methodological appropriateness of this clinical trial and calculate a sample size for future randomized trials.Forty subjects with pre- or mild hypertension will be randomized to either the qigong exercise group or the non-treated group. Participants in the qigong group will conduct qigong exercises 5 times per week for 8 weeks, and participants in the non-treated group will maintain their current lifestyle, including diet and exercise. The use of antihypertensive medication is not permitted. The primary endpoint is a change in patient blood pressure. Secondary endpoints are patient health status (as measured by the SF-36 and the MYMOP2 questionnaires) and changes in hormone levels, including norepinephrine, epinephrine, and cortisol.This study will be the first randomized trial to investigate the effectiveness of qigong exercises for the treatment of pre- and mild hypertension. The results of this study will help to establish the optimal approach for the care of adults with pre- or mild hypertension.Clinical Research Information Service KCT0000140Hypertension is a risk factor for future cardiovascular events, including heart attack, heart failure, and stroke, which are the most frequent causes of death in developed countries [1,2]. Hypertension affects approximately one billion individuals worldwide, and the prevalence of hypertension tends to increase with age [3]. In Korea, hypertension affects more than 30% of people over the age of 30 and up to 65% of people over 65 [4].Current interventions for hypertension include sodium restriction, pharmacological management, and lifestyle modifications, such as stress management and exercise. However, in clinical practice, hypertension can be difficult to control, due to poor adherence to prescribed interventions [5]. Lifestyle interventions are difficult t
Acupuncture for the Treatment of Dry Eye: A Multicenter Randomised Controlled Trial with Active Comparison Intervention (Artificial Teardrops)
Tae-Hun Kim, Jung Won Kang, Kun Hyung Kim, Kyung-Won Kang, Mi-Suk Shin, So-Young Jung, Ae-Ran Kim, Hee-Jung Jung, Jin-Bong Choi, Kwon Eui Hong, Seung-Deok Lee, Sun-Mi Choi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036638
Abstract: Purpose To evaluate the effects of acupuncture compared to a control group using artificial tears. Methods Setting & design: multicenter randomised controlled trial (three local research hospitals of South Korea). Study Population: 150 patients with moderate to severe dry eye. Intervention: Participants were randomly allocated into four weeks of acupuncture treatment (bilateral BL2, GB14, TE 23, Ex1, ST1, GB20, LI4, LI11 and single GV23) or to the artificial tears group (sodium carboxymethylcellulose). Main Outcome Measure(s): The ocular surface disease index (OSDI), tear film break-up time (TFBUT), Schirmer Ι test, visual analogue scale (VAS) for self-assessment of ocular discomfort, general assessment (by both acupuncture practitioners and participants) and quality of life (QOL) through the Measure Yourself Medical Outcome Profile-2 (MYMOP-2). Results There was no statistically significant difference between two groups for the improvement of dry eye symptoms as measured by OSDI (MD ?16.11, 95% CI [?20.91, ?11.32] with acupuncture and ?15.37, 95% CI [?19.57, ?11.16] with artificial tears; P = 0.419), VAS (acupuncture: ?23.84 [?29.59, ?18.09]; artificial tears: ?22.2 [?27.24, ?17.16], P = 0.530) or quality of life (acupuncture: ?1.32 [?1.65, ?0.99]; artificial tears: ?0.96 [?1.32, ?0.6], P = 0.42) immediately after treatment. However, compared with artificial tears group, the OSDI (acupuncture: ?16.15 [?21.38, ?10.92]; artificial tears: ?10.76 [?15.25, ?6.27], P = 0.030) and VAS (acupuncture: ?23.88 [?30.9, ?16.86]; artificial tears: ?14.71 [?20.86, ?8.55], P = 0.018) were significantly improved in the acupuncture group at 8 weeks after the end of acupuncture treatment. TFBUT measurements increased significantly in the acupuncture group after treatment. Conclusions Acupuncture may have benefits on the mid-term outcomes related to dry eye syndrome compared with artificial tears. Trial registration ClinicalTrials.gov NCT01105221.
Acupuncture for persistent allergic rhinitis: a multi-centre, randomised, controlled trial protocol
Jong-In Kim, Myeong Soo Lee, So-Young Jung, Jun-Yong Choi, Sanghoon Lee, Jeong-Min Ko, Hong Zhao, Jiping Zhao, Ae-Ran Kim, Mi-Suk Shin, Kyung-Won Kang, Hee-Jung Jung, Tae-Hun Kim, Baoyan Liu, Sun-Mi Choi
Trials , 2009, DOI: 10.1186/1745-6215-10-54
Abstract: This study consists of a multi-centre (two centres in Korea and two centres in China), randomised, controlled trial with three parallel arms (active acupuncture, sham acupuncture, and waitlist group). The active acupuncture and sham acupuncture groups will receive real or sham acupuncture treatment, respectively, three times per week for a total of 12 sessions over four weeks. Post-treatment follow-up will be performed a month later to complement these 12 acupuncture sessions. Participants in the waitlist group will not receive real or sham acupuncture treatments during this period but will only be required to keep recording their symptoms in a daily diary. After four weeks, the same treatment given to the active acupuncture group will be provided to the waitlist group.This trial will provide evidence for the effectiveness of acupuncture as a treatment for persistent allergic rhinitis. The primary outcome between groups is a change in the self-reported total nasal symptom score (i.e., nasal obstruction, rhinorrhea, sneezing, and itching) from baseline at the fourth week. Secondary outcome measures include the Rhinitis Quality of Life Questionnaire score and total non-nasal symptom score (i.e., headache, itching, pain, eye-dropping). The quantity of conventional relief medication used during the follow-up period is another secondary outcome measure.Current Controlled Trials ISRCTN90807007Allergic rhinitis (AR) is a highly prevalent major chronic respiratory disease. It significantly impacts quality of life (QoL) and creates an economic burden. AR can be classified as intermittent or persistent allergic rhinitis (PER), as described by the recent 'Allergic Rhinitis and its Impact on Asthma (ARIA)' guidelines [1]. The conventional treatment of AR symptoms, such as nasal obstruction, rhinorrhea, sneezing, and itching, includes the use of intranasal corticosteroids, oral anti-histamines with or without decongestants, immunotherapy, and education [2]. Substantial numbers o
A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum
Hokyoung Son equal contributor,Young-Su Seo equal contributor,Kyunghun Min,Ae Ran Park,Jungkwan Lee,Jian-Ming Jin,Yang Lin,Peijian Cao,Sae-Yeon Hong,Eun-Kyung Kim,Seung-Ho Lee,Aram Cho,Seunghoon Lee,Myung-Gu Kim,Yongsoo Kim,Jung-Eun Kim,Jin-Cheol Kim,Gyung Ja Choi,Sung-Hwan Yun,Jae Yun Lim,Minkyun Kim,Yong-Hwan Lee,Yang-Do Choi,Yin-Won Lee
PLOS Pathogens , 2011, DOI: 10.1371/journal.ppat.1002310
Abstract: Fusarium graminearum is an important plant pathogen that causes head blight of major cereal crops. The fungus produces mycotoxins that are harmful to animal and human. In this study, a systematic analysis of 17 phenotypes of the mutants in 657 Fusarium graminearum genes encoding putative transcription factors (TFs) resulted in a database of over 11,000 phenotypes (phenome). This database provides comprehensive insights into how this cereal pathogen of global significance regulates traits important for growth, development, stress response, pathogenesis, and toxin production and how transcriptional regulations of these traits are interconnected. In-depth analysis of TFs involved in sexual development revealed that mutations causing defects in perithecia development frequently affect multiple other phenotypes, and the TFs associated with sexual development tend to be highly conserved in the fungal kingdom. Besides providing many new insights into understanding the function of F. graminearum TFs, this mutant library and phenome will be a valuable resource for characterizing the gene expression network in this fungus and serve as a reference for studying how different fungi have evolved to control various cellular processes at the transcriptional level.
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