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Search Results: 1 - 10 of 63738 matches for " Adriana da Rocha; "
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Contamina??o provocada por um depósito de lixo no aqüífero Alter do Ch?o em Manaus - AM
Rocha, Luiz Cláudio Ribeiro da;Horbe, Adriana Maria Coimbra;
Acta Amazonica , 2006, DOI: 10.1590/S0044-59672006000300003
Abstract: the present paper deals with the chemical composition of water from deep and shallow wells and water- holes near a garbage dump in the city of manau. ph, eh, turbidity, nitrate, nitrite, ammonia and the elements cl, f, si, k, na, ca, mg, al, as, mn, p, sb, ba, cr, fe, se, sn, cd, cu, pb and zn were analysed at the end of the rainy season and in the dry period in 18 wells. in almost all wells the water is no longer suitable for human consumption due the high contents of al, fe, as, cd, pb, sb and se, nitrogen compounds and local contaminations by mn and zn. the contamination plume, which expands at the end of the rainy season, extends to the east and southeast of the garbage dump on account of the natural directions of the aquifer flow and the potenciometric low level generated by the stream flow cutting through the area.
A??es neuroprotetoras da vitamina C no corpo estriado de ratos após convuls?es induzidas pela pilocarpina
Freitas, Rivelilson Mendes de;Tomé, Adriana da Rocha;
Revista de Psiquiatria Clínica , 2010, DOI: 10.1590/S0101-60832010000300002
Abstract: background: seizures may produce neuronal damage in several areas and especially in limbic structures. objectives: this study aimed to evaluate the neuroprotective effects of vitamin c in the histopathological changes observed in rat striatum after seizures. material and methods: healthy wistar rats were divided into four groups. the first group was treated with 0.9% saline (control group) and the second one with pilocarpine (400 mg/kg, p400 group). third and fourth groups were treated with vitamin c (250 mg/kg), 30 minutes before receiving p400 (p400 + vit c group) or 0.9% saline (vit c group), respectively. after the treatments, all groups were observed for 24 hours, sacrificed and dissected out to remove their brains for histopathological analysis. results: the group p400 presented seizures that progressed to status epilepticus in 75% of the animals. pretreatment with vitamin c produced a 35% reduction in this index. p400 and p400 + vit c groups revealed 80% and 20% of animals with brain injury, respectively. in p400 group, lesion severity of the striatum was 50%. in turn, in striatal region of animals treated with p400 + vit c group, we detected a reduction of 40% in the severity degree. discussion: pilocarpine-induced seizures are installed by the cholinergic system and propagated by free radicals and by glutamatergic system, leading to brain damage. the antioxidant drugs may have therapeutic potential for epileptic patients to protect against brain injure through removing free radicals produced, suggesting that vitamin c may influence epileptogenesis and promote neuroprotective actions during seizures.
O currículo em educa o de jovens e adultos em Maceió na perspectiva de rede temática
Adriana Rocely Viana da Rocha,Marinaide Lima de Queiroz Freitas
Revista Brasileira de Educa??o de Jovens e Adultos , 2013,
Abstract: Nestes escritos, enfatizamos a experiência de uma proposta curricular na perspectiva de rede temática no II segmento da Educa o de Jovens e Adultos, em Maceió, em escolas públicas municipais. é uma investiga o de base qualitativa, que se utilizou da entrevista e de grupo focal, que permitiram, por meio das vozes e dos olhares dos sujeitos envolvidos, a análise dos avan os e limites dessa experiência curricular. Os avan os evidenciados ficaram no plano político-pedagógico, principalmente em fun o do comprometimento dos atores envolvidos. Os limites ficaram por conta dos condicionantes institucionais, que para serem superados, requer que os gestores públicos assumam, de fato, uma política educacional voltada para as camadas populares na rede pública municipal de educa o de Maceió
Express?o imuno-histoquímica das metaloproteinases 2 e 9 n?o está associada à progress?o do carcinoma de células escamosas de es?fago
Felin, Izabella Paz Danezi;Grivicich, Ivana;Felin, Carlos Roberto;Fedrigo, Carlos Alexandre;Rocha, Adriana Brondani da;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2009, DOI: 10.1590/S1676-24442009000400009
Abstract: introduction: esophageal squamous cell carcinoma is an aggressive malignant neoplasia with poor prognosis. the expression of matrix metalloproteinases (mmps), mainly 2 and 9, has been used for the prognostic evaluation of cancer in association with tumor invasion, size and tumoral growth analysis. objective: the aim of the present study was to investigate the immunohistochemical expression of mmp-2 and mmp-9 and evaluate if there is an association between their expression and tumor staging, vascular invasion, local invasion (pt) and tumoral differentiation in esophageal squamous cell carcinoma. material and methods: we conducted a retrospective study using 31 paraffin-embedded specimens of esophageal squamous cell carcinoma obtained by esophagectomies performed at santa maria university hospital, rio grande do sul state, brazil between 1998 and 2003. the histological sections were immunohistochemically studied using a non-biotinylated novolink system for mmp-2 and mmp-9 detection. results: mmp-2 immunohistochemical expression was detected only in 5 cases and did not demonstrate correlation with the variables analyzed. furthermore, mmp-9 immunohistochemical expression was not significantly associated with the other variables. conclusion: mmp-2 and mmp-9 immunohistochemical expression does not seem to be influenced by the variables reported in this study. thus further investigations are required to a better understanding of their association with the prognostic factors of esophageal squamous cell carcinoma.
Duplex Al-based thermal spray coatings for corrosion protection in high temperature refinery applications
Rocha, Adriana da Cunha;Rizzo, Fernando;Zeng, Chaoliu;Paes, Marcelo Piza;
Materials Research , 2004, DOI: 10.1590/S1516-14392004000100025
Abstract: the application of thermal spray coatings has been effective in preventing corrosion of steel and iron products. it has been used in a wide range of applications spreading from the petroleum to the food industry. in this work, the performance and effectiveness of a two-layered aluminum-based thermal spray coating applied to an astm a387 g11 steel was evaluated. the coating structure was comprised of an inner al-fe-cr layer and an outer layer of aluminum. coated samples were tested in the reactor zone of a fluid catalytic cracking unit (fccu) of a petrochemical plant for 2.5 years. the reactor zone temperature was about 793 k (520 °c) and the environment was a mixed gas containing sulfur, oxygen and carbon. laboratory-scale tests were also conducted on the coated samples in order to gain a better understanding of the corrosive effect of the gaseous species present in the fccu atmosphere. porosity present in the thermal spray coatings allowed the penetration of the atmosphere corrodents, which instigated intergranular corrosion of the steel substrate. the presence of an inner al-fe-cr layer did not prevent coating spallation, which further contributed to the internal corrosion process.
Inhibitory action of antioxidants (ascorbic acid or α-tocopherol) on seizures and brain damage induced by pilocarpine in rats
Tomé, Adriana da Rocha;Ferreira, Paulo Michel Pinheiro;Freitas, Rivelilson Mendes de;
Arquivos de Neuro-Psiquiatria , 2010, DOI: 10.1590/S0004-282X2010000300005
Abstract: temporal lobe epilepsy is the most common form of epilepsy in humans. oxidative stress is a mechanism of cell death induced by seizures. antioxidant compounds have neuroprotective effects due to their ability to inhibit free radical production. the objectives of this work were to comparatively study the inhibitory action of antioxidants (ascorbic acid or α-tocopherol) on behavioral changes and brain damage induced by high doses of pilocarpine, aiming to further clarify the mechanism of action of these antioxidant compounds. in order to determinate neuroprotective effects, we studied the effects of ascorbic acid (250 or 500 mg/kg, i.p.) and α-tocopherol (200 or 400 mg/kg, i.p.) on the behavior and brain lesions observed after seizures induced by pilocarpine (400 mg/kg, i.p., p400 model) in rats. ascorbic acid or α-tocopherol injections prior to pilocarpine suppressed behavioral seizure episodes. these findings suggested that free radicals can be produced during brain damage induced by seizures. in the p400 model, ascorbic acid and α-tocopherol significantly decreased cerebral damage percentage. antioxidant compounds can exert neuroprotective effects associated with inhibition of free radical production. these results highlighted the promising therapeutic potential of ascorbic acid and α-tocopherol in treatments for neurodegenerative diseases.
Express?o de p53, p16 E COX-2 em carcinoma escamoso de es?fago e associa??o histopatológica
Felin, Izabella Paz Danezi;Grivicich, Ivana;Felin, Carlos Roberto;Regner, Andrea;Rocha, Adriana Brondani da;
Arquivos de Gastroenterologia , 2008, DOI: 10.1590/S0004-28032008000400009
Abstract: background: the esophageal carcinoma represents about 2% of malignant tumors and is the third most common cause of gastrointestinal cancer. the correlation between immunohistochemistry markers, such as p53, p16 and cox-2 proteins and cancer esophageal prognosis has been suggested. aims: to investigate whether the expression of p53, p16 and cox-2 proteins are associated to tumor staging. methods: for this purpose we proceeded immunohistochemistry assays and tmn in 31 esophageal tumor and normal tissue samples. the p53 nuclear expression was considered positive when it appears in 10.00% or more cells. cox-2 expression was scored according to intensity in three scores (1+, 2+, 3+). results: on the tumor samples the results presented 48.38% positivity for p53, 16.12% for p16 and 100% with 1+, 2+ or 3+ scores for cox-2. however, when we investigated whether the expression of p53, p16 and cox-2 proteins are related to tumor staging, only cox-2 expression, score 3+, had shown statistical significant association. conclusion: therefore, in the present study we could see positive correlation between cox-2 protein and high grade tumor as well as advanced tumor staging in esophageal carcinoma.
Neuronal damage and memory deficits after seizures are reversed by ascorbic acid?
Tomé, Adriana da Rocha;Feitosa, Chistiane Mendes;Freitas, Rivelilson Mendes de;
Arquivos de Neuro-Psiquiatria , 2010, DOI: 10.1590/S0004-282X2010000400019
Abstract: the objective of the present study was to evaluate the neuroprotective effects of ascorbic acid (aa) in rats, against the neuronal damage and memory deficit caused by seizures. wistar rats were treated with 0.9% saline (i.p., control group), ascorbic acid (500 mg/kg, i.p., aa group), pilocarpine (400 mg/kg, i.p., pilocarpine group), and the association of ascorbic acid (500 mg/kg, i.p.) plus pilocarpine (400 mg/kg, i.p.), 30 min before of administration of ascorbic acid (aa plus pilocarpine group). after the treatments all groups were observed for 24 h. pilocarpine group presented seizures which progressed to status epilepticus in 75% of the animals. pretreatment with aa led to a reduction of 50% of this rate. results showed that pretreatment with aa did not alter reference memory when compared to a control group. in the working memory task, we observed a significant day's effect with important differences between control, pilocarpine and aa plus pilocarpine groups. pilocarpine and aa plus pilocarpine groups had 81 and 16% of animals with brain injury, respectively. in the hippocampus of pilocarpine animals, it was detected an injury of 60%. as for the animals tested with aa plus pilocarpine, the hippocampal region of the group had a reduction of 43% in hippocampal lesion. our findings suggest that seizures caused cognitive dysfunction and neuronal damage that might be related, at least in part, to the neurological problems presented by epileptic patients. aa can reverse cognitive dysfunction observed in rats with seizures as well as decrease neuronal injury in rat hippocampus.
Influence of different durations of estrogen deficiency on alveolar bone loss in rats
Amadei, Susana Ungaro;Souza, Daniela Martins de;Brand?o, Adriana Aigotti Haberbeck;Rocha, Rosilene Fernandes da;
Brazilian Oral Research , 2011, DOI: 10.1590/S1806-83242011000600011
Abstract: the purpose of this study was to morphometrically evaluate the influence of different durations of ovariectomy-induced estrogen deficiency on alveolar bone loss associated with ligature-induced bone loss in rats. sixty female wistar rats were randomly assigned to ovariectomy (ovx test group) or sham operation (sham control group). the ovx and sham groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days). in all groups, for the last 30 days of the experimental period, cotton ligatures were placed around the cervix of the right upper second molar; the contralateral tooth was left unligated to serve as a control. the maxillary bones were removed, and the alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at the buccal site of the right upper second molar. a comparison between the ligated and unligated groups verified the presence of ligature-induced alveolar bone loss (p < 0.05). no significant differences were observed among the unligated groups (p > 0.05). a significant increase in bone loss was observed when ligation occurred 90 days after ovariectomy compared with the sham group (p < 0.05). these results demonstrate that long-term estrogen deficiency affects ligature-induced alveolar bone loss.
Comparative therapeutic use of Risedronate and Calcarea phosphorica - allopathy versus homeopathy - in bone repair in castrated rats
Werkman, Cristina;Segnini Senra, Giselle;Rocha, Rosilene Fernandes da;Brand?o, Adriana Aigotti Haberbeck;
Brazilian Oral Research , 2006, DOI: 10.1590/S1806-83242006000300003
Abstract: osteoporosis, a disease characterized by progressive bone loss, has been the target of several studies in the past few years. it results in a much higher risk for fractures and might cause slower bone lesion healing. the aim of this work was to study the effects of risedronate (allopathic medicine) and calcarea phosphorica 6ch (homeopathic medicine) on the repair of bone lesions in male rats with osteoporosis induced by castration. eighty-four three-month-old rats were used divided into four groups of twenty-one animals each. three groups where castrated and one group was submitted to sham surgery. one month later, cortical lesions were made in all animals' tibiae and, after one day, the different experimental treatments began according to the following groups: cr - castrated/risedronate (1 mg/kg/day); ccp - castrated/calcarea phosphorica 6ch (3 drops/day); cp - castrated/placebo and sp - sham/placebo. the animals were sacrificed at seven, fourteen and twenty-eight days after the beginning of the treatments and had their tibiae removed. digital radiographs of the tibiae were taken and analyzed in order to evaluate the optical density of the defect area. then, they were decalcified and processed for histological and histomorphometrical analysis. the data were submitted to anova, and to the tukey and dunnett tests (5%). the allopathic and homeopathic treatments led to different bone formation as regards remodeling and maturation aspects. further research is necessary to access the resistance and quality of the newly formed bone.
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