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Search Results: 1 - 10 of 340661 matches for " Adriana S. Tan "
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Clinical Relevance and Discriminatory Value of Elevated Liver Aminotransferase Levels for Dengue Severity
Linda K. Lee ,Victor C. Gan,Vernon J. Lee,Adriana S. Tan,Yee Sin Leo,David C. Lye
PLOS Neglected Tropical Diseases , 2012, DOI: 10.1371/journal.pntd.0001676
Abstract: Background Elevation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) is prominent in acute dengue illness. The World Health Organization (WHO) 2009 dengue guidelines defined AST or ALT≥1000 units/liter (U/L) as a criterion for severe dengue. We aimed to assess the clinical relevance and discriminatory value of AST or ALT for dengue hemorrhagic fever (DHF) and severe dengue. Methodology/Principal Findings We retrospectively studied and classified polymerase chain reaction positive dengue patients from 2006 to 2008 treated at Tan Tock Seng Hospital, Singapore according to WHO 1997 and 2009 criteria for dengue severity. Of 690 dengue patients, 31% had DHF and 24% severe dengue. Elevated AST and ALT occurred in 86% and 46%, respectively. Seven had AST or ALT≥1000 U/L. None had acute liver failure but one patient died. Median AST and ALT values were significantly higher with increasing dengue severity by both WHO 1997 and 2009 criteria. However, they were poorly discriminatory between non-severe and severe dengue (e.g., AST area under the receiver operating characteristic [ROC] curve = 0.62; 95% confidence interval [CI]: 0.57–0.67) and between dengue fever (DF) and DHF (AST area under the ROC curve = 0.56; 95% CI: 0.52–0.61). There was significant overlap in AST and ALT values among patients with dengue with or without warning signs and severe dengue, and between those with DF and DHF. Conclusions Although aminotransferase levels increased in conjunction with dengue severity, AST or ALT values did not discriminate between DF and DHF or non-severe and severe dengue.
Implications of Discordance in World Health Organization 1997 and 2009 Dengue Classifications in Adult Dengue
Victor C. Gan, David C. Lye, Tun L. Thein, Frederico Dimatatac, Adriana S. Tan, Yee-Sin Leo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060946
Abstract: Background Revised dengue guidelines were published by the World Health Organization (WHO) in 2009 addressing severe dengue cases not classified by dengue hemorrhagic fever (DHF) and shock syndrome (DSS). Methods and Principal Findings We conducted a retrospective cohort study to compare WHO 2009 and 1997 classifications using 1278 adult dengue cases confirmed by polymerase chain reaction assay from Singapore epidemics in 2004 and 2007 (predominantly serotype 1 and 2 respectively).DHF occurred in 14.3%, DSS 2.7% and severe dengue 16.0%. The two WHO dengue classifications were discordant in defining severe disease (p<0.001). Five DSS patients (15%) were classified as non-severe dengue without warning signs. Of severe dengue patients, 107 did not fulfil DHF criteria. Of these, 14.9% had self-resolving isolated elevated aminotransferases, 18.7% gastrointestinal bleeding without hemodynamic compromise and 56.1% plasma leakage with isolated tachycardia. We compared both guidelines against requirement for intensive care including the single death in this series: all six had severe dengue; only four had DHF as two lacked bleeding manifestations but had plasma leakage. Increasing length of hospitalization was noted among severe cases with both classifications but the trend was only statistically significant for WHO 2009. Length of hospitalization was significantly longer for severe plasma leakage compared with severe bleeding or organ impairment. Requirement for hospitalization increased using WHO 2009 from 17.0% to 51.3%. Conclusions While the WHO 2009 dengue classification is clinically useful, we propose retaining criteria for plasma leakage and hemodynamic compromise from WHO 1997, and refining definitions of severe bleeding and organ impairment to improve clinical relevance having found that differences in these accounted for the discordance between classifications. Findings from our retrospective study may be limited by the study site - a tertiary referral center in a hyperendemic country - and should be evaluated in a wider range of geographic settings.
Improving the Clinical Diagnosis of Influenza—a Comparative Analysis of New Influenza A (H1N1) Cases
Adrian K. Ong,Mark I. Chen,Li Lin,Adriana S. Tan,Ni Win Nwe,Timothy Barkham,Seow Yian Tay,Yee Sin Leo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008453
Abstract: The presentation of new influenza A(H1N1) is broad and evolving as it continues to affect different geographic locations and populations. To improve the accuracy of predicting influenza infection in an outpatient setting, we undertook a comparative analysis of H1N1(2009), seasonal influenza, and persons with acute respiratory illness (ARI) in an outpatient setting.
Efeito da hidroxiuréia e progesterona na regula o da transcri o do gene da gama globin
Duarte Adriana S. S.
Revista Brasileira de Hematologia e Hemoterapia , 2002,
Abstract:
Alfredo Jaar: "Soy un arquitecto que hace arte"
Valdés,Adriana;
ARQ (Santiago) , 2008, DOI: 10.4067/S0717-69962008000300002
Abstract: the work of alfredo jaar is situated on the limit between architecture and art. exposition halls in the landscape, temporary museums or city installations; all have the common denominator of bringing to light social problems that are not seen on the surface. they are investigations questioning that which we are incapable of perceiving or feeling.
ENRIQUE LIHN: SANTIAGO, PARíS, MANHATTAN
Valdés,Adriana;
Revista chilena de literatura , 2008, DOI: 10.4067/S0718-22952008000100004
Abstract: this text studies trauma and travel in enrique lihn's poetry, analyzing relationships between trauma, writing and the cultural experience the poet worked on, from a critical perspective, in three key places: santiago, paris and manhattan. in all three, a foreigner, a stranger, whose homeland is not to be found in aplace, but only in the act of writing itself ("días de mi escritura/ solar del extranjero"). a stranger in his city of origin, both in the earlier traumatic dimension of his formative years, and in the later writing in santiago during the military dictatorship. a stranger in paris, a city that does not recognize the fervent desire of those raised elsewhere, in the veneration of its culture. and a stranger in modern babel, manhattan, aplace in which the poet perceives the frantic anonimity of a civilization based on ephemeral images and spectacle.
Alfredo Jaar: "Soy un arquitecto que hace arte"
Adriana Valdés
ARQ , 2008,
Abstract: La obra de Alfredo Jaar se sitúa en el límite entre la arquitectura y el arte. Salas de exposición en el paisaje, museos temporales o instalaciones en la ciudad; todas tienen el denominador común de traer a presencia problemas sociales que no se ven a simple vista. Son cuestionamientos acerca de lo que no somos capaces de percibir o sentir. The work of Alfredo Jaar is situated on the limit between architecture and art. Exposition halls in the landscape, temporary museums or city installations; all have the common denominator of bringing to light social problems that are not seen on the surface. They are investigations questioning that which we are incapable of perceiving or feeling.
Susceptibilidad de Plutella xylostella a Heterorhabditis sp. SL0708 (Rhabditida: Heterorhabditidae) Susceptibility of Plutella xylostella to Heterorhabditis sp. SL0708 (Rhabditida: Heterorhabditidae)
ADRIANA SáENZ A.
Revista Colombiana de Entomología , 2012,
Abstract: Plutella xylostella (Lepidoptera: Plutellidae) conocida como polilla dorso de diamante (DDM) es una de las plagas más importantes en cultivos de crucíferas en Colombia. La estrategia de control más utilizada ha sido el uso de insecticidas de síntesis química como piretroides, carbamatos, organofosforados y reguladores de crecimiento. Como una alternativa de control, se evalúa la susceptibilidad del tercer instar de DDM al nemátodo entomopatógeno Heterorhabditis sp. SL0708 en condiciones de laboratorio. Se probaron cinco dosis de juveniles infectivos (JI) (0, 100, 300, 600, 1200 JI/ml/5 larvas) y se evaluó cada 24 horas la sintomatología, mortalidad y recuperación de JI. Las larvas afectadas por Heterorhabditis sp. SL0708 presentaron cambios de coloración de verde a marrón claro, se mostraron poco móviles y con cuerpo flácido. Algunas larvas alcanzaron a mudar a pupa y se observó el desarrollo de adultos de primera generación. El porcentaje promedio de mortalidad fue de 95,6%, con un tiempo de mortalidad entre las 48 y 72 horas. La dosis que mostró diferencias significativas fue 100 JI. De las larvas infectadas por tratamiento se recuperó en promedio diariamente 2.743 JI en cinco días. Las larvas de P. xylostella fueron susceptibles a los JI de Heterorhabditis sp. SL0708, indicando que se debe continuar evaluando su capacidad patogénica en invernadero y campo. Plutella xylostella (Lepidoptera: Plutellidae) known as the diamondback moth (DBM) is the more important pestof cruciferous crops in Colombia. The most common control strategy has been the use of chemically synthesized insecticides such as pyrethroids, carbamates, organophosphates and growth regulators. As an alternative control, we evaluated the susceptibility of third instar DDM to Heterorhabditis sp. SL0708 under laboratory conditions. We tested five doses of infective juveniles IJ (0, 100, 300, 600.1200 IJ/ml/5 larvae) and every 24 hours we assessed symptoms of mortality and recovery IJ. Larvae affected by Heterorhabditis sp. SL0708 showed color changes from green to brown, little mobility and a flabby body. Some larvae reached the pupa instar and even reached first generation adults. The average mortality rate was 95.6%, with a time of death betWeen 48 and 72 hours. There were significant differences at a dose of 100 IJ. Around 2,743 IJ were recovered per larvae daily average along 5 days. The larvae of P. xylostella were susceptible to Heterorhabditis sp.SL0708 IJ, indicating that its pathogenicity should be evaluated in greenhouse and field conditions.
EN TORNO A TRíPTICO DE COBQUECURA DE ANDRéS GALLARDO
Adriana Valdés
Revista Chilena de Literatura , 2007,
Abstract:
ENRIQUE LIHN: SANTIAGO, PARíS, MANHATTAN
Adriana Valdés
Revista Chilena de Literatura , 2008,
Abstract: En este trabajo, se estudia el trauma y el viaje en la poesía de Enrique Lihn, analizando las relaciones entre lo traumático, la escritura y la experiencia cultural que el poeta trabajó, con una perspectiva crítica, en tres lugares clave: Santiago, París y Manhattan. En todos ellos, un extranjero que solo se asienta en el acto de escribir: "días de mi escritura/ solar del extranjero". Extranjero respecto de su ciudad de origen, tanto la primera dimensión traumática de los a os de formación, como en su escritura posterior en Santiago durante la dictadura militar. Extranjero en París, ciudad que no reconoce el deseo ferviente de quienes, en otras latitudes, han venerado su cultura. Y extranjero en la Babel moderna, en Manhattan, lugar en que el poeta trabaja el frenético anonimato de una civilización basada en las imágenes efímeras y en el espectáculo. This text studies trauma and travel in Enrique Lihn's poetry, analyzing relationships between trauma, writing and the cultural experience the poet worked on, from a critical perspective, in three key places: Santiago, Paris and Manhattan. In all three, a foreigner, a stranger, whose homeland is not to be found in aplace, but only in the act of writing itself ("días de mi escritura/ solar del extranjero"). A stranger in his city of origin, both in the earlier traumatic dimension of his formative years, and in the later writing in Santiago during the military dictatorship. A stranger in Paris, a city that does not recognize the fervent desire of those raised elsewhere, in the veneration of its culture. And a stranger in modern Babel, Manhattan, aplace in which the poet perceives the frantic anonimity of a civilization based on ephemeral images and spectacle.
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