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Search Results: 1 - 10 of 119917 matches for " Adriana Aigotti Brand?o "
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Fine needle aspiration cytology in the diagnosis of multiple myeloma  [PDF]
Luiz Antonio Guimar?es Cabral, Andrea Silveira Penteado, Adriana Aigotti Haberbeck Brando, Janete Dias Almeida
Health (Health) , 2012, DOI: 10.4236/health.2012.48075
Abstract: Multiple Myeloma (MM) is a disseminated plasma cell tumor caused by the proliferation of a single plasma cell clone which results from the production of monoclonal immunoglobulin, most commonly class G (IgG). MM is a cancer of the elderly, with a mean age at diagnosis of 68 years. A 79-year-old white patient sought the outpatient clinic of the Discipline of Stomatology, S?o José dos Campos Dental School, UNESP, because of a fracture associated with an osteolytic lesion in the right ascending ramus of the mandible. In view of the clinical-radiographic findings, exploratory fine needle aspiration (FNA) of the lesion was performed and the sanguinolent material obtained was submitted to the preparations of smears for cytology analysis. The diagnosis of MM was based on laboratory and radiographic findings. FNA cytology analysis of the lesion permitted a diagnostic hypothesis of MM.
Detec o de anticorpo anticora o em camundongos Balb/c imunizados com Streptococcus mutans
LE?O Mariella Vieira Pereira,BRANDO Adriana Aigotti Haberbeck,MORAES Elisabete,SHIMIZU Mário Tsunezi
Pesquisa Odontológica Brasileira , 2000,
Abstract: Anticorpos para antígenos cardíacos foram analisados por ELISA em 14 soros de camundongos Balb/c hiperimunizados com Streptococcus mutans, inativado pelo formaldeído. Os níveis de anticorpos da classe IgG anticora o e antimiosina elevaram-se significativamente nos animais imunizados quando comparados com os controles, especialmente no grupo A, imunizado e reestimulado com antígenos solúveis de S. mutans. Neste grupo, os resultados do "Western Blot" mostraram reatividade com miosina cardíaca e uma banda de 35 kDa. A análise histológica dos cora es dos animais do grupo B, imunizado e reestimulado com antígenos de superfície do microrganismo, demonstrou a presen a de degenera o celular, tipo hidrópica e hialina e focos inflamatórios constituídos de linfócitos e macrófagos no miocárdio e pericárdio. Os resultados deste trabalho refor am a hipótese da existência de mimetismo antigênico entre tecido cardíaco e S. mutans e chamam a aten o para o risco de desenvolvimento de anticorpos reativos com antígenos próprios induzidos por vacina anticárie com componentes estreptocócicos.
Peripheral calcifying cystic odontogenic tumour of the maxillary gingiva
Ana Lima, Dárcio Kitakawa, Janete Almeida, Adriana Aigotti Brando, Ana Anbinder
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-455
Abstract: Authors report a rare case of a peripheral calcifying cystic odontogenic tumor of the maxillary gingiva. A 39-year-old male patient presented with a fibrous mass on the attached buccal gingiva of the upper left cuspid teeth. It was 0.7-cm-diameter, painless and it was clinically diagnosed as a peripheral ossifying fibroma. After an excisional biopsy, the diagnosis was peripheric calcifying cystic odontogenic tumor. The patient was monitored for five years following the excision, and no recurrence was detected.All biopsy material must be sent for histological examination. If the histological examination of gingival lesions with innocuous appearance is not performed, the frequency of peripheral calcifying cystic odontogenic tumor and other peripheral odontogenic tumors may be underestimated.A calcifying cystic odontogenic tumor (CCOT) is an extremely rare benign cystic neoplasm that is characterized by an ameloblastoma-like epithelium and ghost cells that have the potential to undergo calcification [1]. Originally, CCOTs were referred to as calcifying odontogenic cysts (COC). The structure was first described by Gorlin in 1962 as a distinct entity and was therefore called Gorlin cyst [2]. COC was considered as a developmental odontogenic cyst in the jaw. In their first report, Gorlin et al. [2] considered this lesion to be a possible analogue of the cutaneous calcifying epithelioma of Malherbe (the pilomatrixoma). COC accounted for approximately 1% of jaw cysts. In 1981, Praetorius et al. [3] studied and reevaluated 16 cases of COC and proposed that the group actually contained two entities, a cyst and a neoplasm. Since then, neoplastic potential has been investigated.In 2005, the World Health Organization (WHO) designated Gorlin’s cyst as a tumor and described it as belonging to a group of related neoplasms, including the benign cystic-type (CCOT), the benign solid-type dentinogenic ghost cell tumor, and the malignant ghost cell odontogenic carcinoma [1]. The dentino
Influence of different durations of estrogen deficiency on alveolar bone loss in rats
Amadei, Susana Ungaro;Souza, Daniela Martins de;Brando, Adriana Aigotti Haberbeck;Rocha, Rosilene Fernandes da;
Brazilian Oral Research , 2011, DOI: 10.1590/S1806-83242011000600011
Abstract: the purpose of this study was to morphometrically evaluate the influence of different durations of ovariectomy-induced estrogen deficiency on alveolar bone loss associated with ligature-induced bone loss in rats. sixty female wistar rats were randomly assigned to ovariectomy (ovx test group) or sham operation (sham control group). the ovx and sham groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days). in all groups, for the last 30 days of the experimental period, cotton ligatures were placed around the cervix of the right upper second molar; the contralateral tooth was left unligated to serve as a control. the maxillary bones were removed, and the alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at the buccal site of the right upper second molar. a comparison between the ligated and unligated groups verified the presence of ligature-induced alveolar bone loss (p < 0.05). no significant differences were observed among the unligated groups (p > 0.05). a significant increase in bone loss was observed when ligation occurred 90 days after ovariectomy compared with the sham group (p < 0.05). these results demonstrate that long-term estrogen deficiency affects ligature-induced alveolar bone loss.
Comparative therapeutic use of Risedronate and Calcarea phosphorica - allopathy versus homeopathy - in bone repair in castrated rats
Werkman, Cristina;Segnini Senra, Giselle;Rocha, Rosilene Fernandes da;Brando, Adriana Aigotti Haberbeck;
Brazilian Oral Research , 2006, DOI: 10.1590/S1806-83242006000300003
Abstract: osteoporosis, a disease characterized by progressive bone loss, has been the target of several studies in the past few years. it results in a much higher risk for fractures and might cause slower bone lesion healing. the aim of this work was to study the effects of risedronate (allopathic medicine) and calcarea phosphorica 6ch (homeopathic medicine) on the repair of bone lesions in male rats with osteoporosis induced by castration. eighty-four three-month-old rats were used divided into four groups of twenty-one animals each. three groups where castrated and one group was submitted to sham surgery. one month later, cortical lesions were made in all animals' tibiae and, after one day, the different experimental treatments began according to the following groups: cr - castrated/risedronate (1 mg/kg/day); ccp - castrated/calcarea phosphorica 6ch (3 drops/day); cp - castrated/placebo and sp - sham/placebo. the animals were sacrificed at seven, fourteen and twenty-eight days after the beginning of the treatments and had their tibiae removed. digital radiographs of the tibiae were taken and analyzed in order to evaluate the optical density of the defect area. then, they were decalcified and processed for histological and histomorphometrical analysis. the data were submitted to anova, and to the tukey and dunnett tests (5%). the allopathic and homeopathic treatments led to different bone formation as regards remodeling and maturation aspects. further research is necessary to access the resistance and quality of the newly formed bone.
Effects of the medicinal plants Curcuma zedoaria and Camellia sinensis on halitosis control
Vitor Hugo Farina,Ana Paula de Lima,Ivan Balducci,Adriana Aigotti Haberbeck Brando
Brazilian Oral Research , 2012,
Abstract: Volatile sulphur compounds (VSC) are the gases mainly responsible for halitosis (bad breath). The aim of this research was to evaluate the effects of medicinal plants on halitosis control. Two commonly used plants were tested: Curcuma zedoaria and Camellia sinensis (green tea). These plants were prepared as an aqueous solution and used as mouthwashes, compared with a standard mouthwash of 0.12% chlorhexidine gluconate and a placebo (water). The experiment was conducted with 30 volunteers from the School of Dentistry of S o Jose dos Campos, Univ. Estadual Paulista - UNESP, SP, Brazil. Each volunteer tested the four mouthwashes. The Cysteine Challenge Method, modified for this study, was used for initial breath standardization. Four breath assessments were conducted after volunteers rinsed orally with acetylcysteine: one before the test mouthwash was used; the second, one minute after its use; a third 90 minutes later; and the last 180 minutes later. The results showed that chlorhexidine gluconate lowered VSC production immediately, and that this effect lasted up to 3 hours, while the tested plants had immediate inhibitory effects but no residual inhibitory effects on VSC. We concluded that Curcuma zedoaria and Camellia sinensis, prepared as infusions and used as mouthwashes, did not have a residual neutralizing effect on VSC.
Detec??o de anticorpo anticora??o em camundongos Balb/c imunizados com Streptococcus mutans
LE?O, Mariella Vieira Pereira;BRANDO, Adriana Aigotti Haberbeck;MORAES, Elisabete;SHIMIZU, Mário Tsunezi;UNTERKIRCHER, Carmelinda Schimidt;
Pesquisa Odontológica Brasileira , 2000, DOI: 10.1590/S1517-74912000000400003
Abstract: heart-reactive antibodies were examined by elisa, in sera from 14 balb/c mice immunized with streptococcus mutans inactivated by treatment with formaldehyde. anti-heart and anti-myosin igg levels increased significantly in the sera from immunized mice, when compared with those of control sera, especially in the first group, inoculated with a new antigen preparation. this group displayed a notable reactivity with cardiac myosin and cardiac tissue proteins in western-blotting, mainly with a 35 kda peptide. the histological analysis of immunized animals? cardiac tissue demonstrated the existence of cell injury and eosinophilia attributable to cellular hyaline change. the pericardium and the myocardium showed inflammatory infiltrate formed by lymphocytes and macrophages. these findings suggest the existence of molecular mimicry between s. mutans and the cardiac tissue and emphasize the risk of development of an autoimmune myocarditis induced by caries vaccine containing streptococcal fractions.
Oral lichen planus versus epithelial dysplasia: difficulties in diagnosis
Sousa, Fernando Augusto Cervantes Garcia de;Paradella, Thaís Cachuté;Brando, Adriana Aigotti Haberbeck;Rosa, Luiz Eduardo Blumer;
Brazilian Journal of Otorhinolaryngology , 2009, DOI: 10.1590/S1808-86942009000500017
Abstract: histopathological diagnosis of oral lichen planus is not easy since some cases of epithelial dysplasia may present traits which are very similar to those from lichen planus. aim: to compare cell alterations which suggest malignancy present in oral lichen planus with those from epithelial dysplasia. material and methods: histological cross-sections of oral lichen planus and dysplasia, dyed by hematoxylin-eosin, were analyzed by means of light microscopy. results: variance analysis (alpha=5%) revealed a statistically significant difference between the average number of cell alterations in the lichen planus (5.83±1.61) and epithelial dysplasia (4.46±1.26). the chi-squared test did not show statistically significant differences between oral lichen planus and epithelial dysplasia in relation to the following cell alterations: increase in nucleus/cytoplasm ratio, nuclear hyperchromatism, irregular chromatin distribution and enlarged nuclei (p>0.05). conclusion: some cell alterations which suggest malignancy present in the oral lichen planus may also be found in epithelial dysplasia, impairing its diagnosis and, consequently, stressing the importance of following these patients in the long run.
Estudo comparativo das altera??es celulares no líquen plano e no carcinoma epidermóide bucal
Sousa, Fernando Augusto Cervantes Garcia de;Paradella, Thaís Cachuté;Brando, Adriana Aigotti Haberbeck;Rosa, Luiz Eduardo Blumer;
Revista Brasileira de Otorrinolaringologia , 2009, DOI: 10.1590/S0034-72992009000200014
Abstract: currently, much is discussed regarding the pre-malignant nature of mouth mucosa lichen planus. aim: the present study aims at analyzing the alterations found in the epithelial cells present in the oral cavity lichen planus, comparing them to those found in epidermoid carcinoma. materials and methods: histological cross-sections of oral lichen planus and epidermoid carcinoma, dyed by hematoxylineosin, were analyzed through light microscopy. result: the most frequently found alterations in oral lichen planus were: an increase in the nucleus/cytoplasm relation (93.33%), nucleus membrane thickness (86.67%) and bi-nucleus or multinucleous (86.67%). the student t test (alpha=5%) revealed a statistically significant difference between the average number of cell alterations in oral lichen planus (5.87±1.57) and in epidermoid carcinoma (7.60±1.81). as to the types of alterations, the chi-squared test also revealed statistically significant differences among the lesions assessed in relation to the following cell alterations: nuclear excess chromatism, atypical mitoses, cellular pleomorphism and abnormal cell differentiation (p<0.05). conclusion: despite the fact that in some cases, some pathologists may make mistakes in the histopathological diagnosis of oral lichen planus, the results obtained in this study show that the alterations present in oral lichen planus differ considerably from those seen in epidermoid carcinoma, thus showing how distinct these two diseases are.
Immunohistochemical features of multifocal melanoacanthoma in the hard palate: a case report
Luis Felipe das Chagas e Silva de Carvalho, Vitor Hugo Farina, Luiz Antonio Guimar?es Cabral, Adriana Aigotti Haberbeck Brando, Ricardo Della Coletta, Janete Dias Almeida
BMC Research Notes , 2013, DOI: 10.1186/1756-0500-6-30
Abstract: Based on the differential diagnosis of melanoma, a punch biopsy (4 mm in diameter) was performed. The material was fixed in 10% formalin, embedded in paraffin, and stained with hematoxylin-eosin or submitted to immunohistochemical analysis. Immunohistochemistry using antibodies against protein S-100, melan-A, HMB-45, MCM-2, MCM-5, Ki-67 and geminin was performed. Immunohistochemical analysis revealed strong cytoplasmic immunoreactivity of dendritic melanocytes for proteinS-100, HMB-45 and melan-A.Positive staining for proliferative markers (MCM-2, MCM-5, Ki-67) was only observed in basal and suprabasal epithelial cells, confirming the reactive etiology of the lesion. The diagnosis was oral Melanoacanthoma (MA).The patient has been followed up for 30 months and shows no clinical alterations. MA should be included in the differential diagnosis of pigmented lesions of the oral cavity.In an attempt to better define the melanoepithelioma types 1 and 2 described by Bloch (1937), Mishima & Pinkus (1960) were the first to use the term melanoacanthoma (MA) [1]. According to these authors, MA corresponds to Bloch’s melanoepithelioma type 1, a rare variant of pigmented seborrheic keratosis characterized by the proliferation of melanocytes and keratinocytes in the lower layers of the epithelium [2].The first report of oral MA was published by Schneider and coworkers (1981) [3]. Since then, MA has been described in the oral mucosa as a solitary lesion or, occasionally, as multiple lesions [2]. MA mainly affects dark skinned patients and grows rapidly, showing a plane or slightly raised appearance and a brown to black color. The differential diagnosis includes oral nevi, amalgam tattoos, and melanomas [4-8]. Histologically, MA is characterized by the proliferation of sparse melanocytes throughout the epithelium and epithelial spongiosis. An increase in the number of melanocytes in the basal layer and the presence of a chronic submucosal inflammatory infiltrate containing eosinoph
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