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Search Results: 1 - 10 of 401282 matches for " Adolphe M. Kilembe "
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Prognostic Signification of Admission Hyperglycemia among Acute Stroke Patients in Intensive Care Units in Kinshasa, the Democratic Republic of the Congo  [PDF]
Josée K. Tshituta, Fran?ois B. Lepira, Fran?ois P. Kajingulu, Jean Robert R. Makulo, Ernest K. Sumaili, Pierre Z. Akilimali, Aliocha N. Nkodila, Freddy M. Mbuyi, Angèle I. Masewu, Stéphane Mutombo, Eric B. Amisi, Jean Pierre M. Ilunga, Wilfrid B. Mbombo, Patrick M. Mukuna, Adolphe M. Kilembe
World Journal of Cardiovascular Diseases (WJCD) , 2019, DOI: 10.4236/wjcd.2019.99060
Abstract:
BACKGROUND AND AIM: Although admission hyperglycemia has been reported to be associated with unfavorable outcomes in acute stroke, little is known about this association in sub-Saharan Africa. Therefore, the aim of the present study was to assess the prognostic significance of admission hyperglycemia in the acute phase of stroke in Congolese patients. METHODS: In a multicenter prospective cohort study, consecutive patients with acute stroke were examined in 5 Emergency Rooms or Intensive Care Units of Kinshasa between July 15th, 2017 and March 15th, 2018. The severity of stroke was assessed at admission using the Glasgow Coma Scale. Stress hyperglycemia was defined as random blood glucose levels at admission > 140 mg/dL in patients without known type 2 diabetes mellitus (T2DM). The endpoint was 10-day all-cause in-hospital mortality. Survival (time-to-death) curves were built using the Kaplan Meier methods. Cox proportional analysis was used to identify predictors of 10-day all-cause in-hospital mortality. The predictive performance of blood glucose level
Intertextuality in Theory and Practice
Adolphe Haberer
Literatura , 2007,
Abstract:
Docking of Human Heat Shock Protein 90 with Selenoderivatives of Geldanamycin  [PDF]
Jason T. Kilembe, Albert S. Lundemba, Dikima D. Bibelayi, Glodi M. Ndefi, Juliette Pradon, Zéphyrin G. Yav
Crystal Structure Theory and Applications (CSTA) , 2019, DOI: 10.4236/csta.2019.82002
Abstract: The interference of human heat shock protein 90 (HSP90) in many signalling networks associated with cancer progression makes it an important drug target. In the present work, we investigated the binding ability of 9 selenoderivatives of geldanamycin (GMDSe) at the N-terminal domain of HSP90 derived from Protein Data Bank (PDB code: 1YET) based on ligand-protein docking. All selenoderivatives interacted positively with HSP90, yet the binding strength decreased when replacing monovalent oxygen in position 1 (GMDSe1) or 9 (GMDSe9). Hydrogen-bonding and lipophilic interactions between selenoderivatives and amino acid residues in the inhibitor site of HSP90 were thermodynamically the main forces driving the binding stability. Molecular electrostatic potential surfaces of the selenoderivatives showed marked non polar areas, which were probably involved in the lipophilic interactions with the hydrophobic residues of amino acids. Interestingly, the amino acid residues forming the hydrogen bonds with GMD were also involved in the hydrogen-bonding interactions with the selenoderivatives. Moreover, HSP90 interacted with the GMDSe6 and GMDSe7 selenoderivatives stronger than with GMD, while maintaining lipophilic interactions and hydrogen bonds with amino acid residues like Asp93, which are catalytically crucial for therapeutic properties of HSP90 inhibitors. This finding should guide further studies of pharmacophore properties of GMD selenoderivatives in order to explore their therapeutic properties. It is noteworthy that selenium has been suggested to reduce the risk of various types of cancers.
Attitudes of US Obstetricians Toward a Combined Tetanus-Diphtheria-Acellular Pertussis Vaccine for Adults
Sarah J. Clark,Soukaina Adolphe,Matthew M. Davis,Anne E. Cowan,Katrina Kretsinger
Infectious Diseases in Obstetrics and Gynecology , 2006, DOI: 10.1155/idog/2006/87040
Abstract: Objective. To describe obstetricians' perspectives related to tetanus-diphtheria-acellular pertussis (Tdap) vaccination of mothers and other adults in close contact with infants. Methods. Mail survey of national random sample of 400 obstetricians . Results. Response rate was 54%. Most respondents would likely recommend Tdap for women during the postpartum hospital stay (78%) or during pregnancy (69%) if a national recommendation was issued. Expected barriers were knowing the date of patients' most recent Td booster (74%) and patient resistance (46%). Most felt that obstetricians have a role in promoting and administering Tdap vaccine to adults other than mothers likely to come in close contact with infants. Conclusion. Obstetricians are likely to agree with the recent provisional US recommendation to administer Tdap to postpartum mothers and other adults expected to come in close contact with infants. Obstetricians would also be likely to support a potential recommendation to administer Tdap during pregnancy. Barriers to adoption of new Tdap vaccine recommendations should be monitored.
Influence of Isolated PGPR Rhizobacteria in Central and Northern Benin on Maize Germination and Greenhouse Growth  [PDF]
Olaréwadjou Amogou, Gustave Dagbénonbakin, Nadège Adoukè Agbodjato, Pac?me Agossou Noumavo, Hafiz Adio Salami, Salako Valère, Aguegue Mèvognon Ricardos, Assogba Abado Sylvestre, Koda Fousseni Abdel Djihal, Adolphe Adjanohoun, Lamine Baba-Moussa
American Journal of Plant Sciences (AJPS) , 2018, DOI: 10.4236/ajps.2018.913201
Abstract: The objective of the study was to evaluate the effects of nine plant growth-promoting rhizobacteria (PGPR) alone or in combination on maize seed germination and seedling growth under laboratory and greenhouse conditions. The germination and growth tests were carried out in square petri dishes and pots. Maize seeds were inoculated with suspension of 108 CFU/ml of rhizobacteria. The experimental device was a random block of 16 treatments with four repetitions. Germination test results showed that seeds inoculated with PGPR including the control induced good germination in the range of 93.75% to 100%. The vigor index and root length of the seeds treated with Bacillus panthothenicus were significantly improved by 76.64% and 58.86%, respectively, while the maximal lengths of the seedlings were obtained with Pseudomonas cichorii with an increase of 118.95%. In greenhouse experience, data demonstrated that Serratia marcescens better improved the leaf area, height and underground biomass, respectively by 58.83%, 108.43%, and 59.16% as compared to the control. The highest fresh aerial biomass and air dry matter was obtained with plants treated only with Pseudomonas putida. These results show the potential to use such rhizobacteria as biofertilizers to improve maize productivity in Benin.
Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays
Naasha J Talati, Esteban Gonzalez-Diaz, Charles Mutemba, Joyanna Wendt, William Kilembe, Lawrence Mwananyanda, Elwyn Chomba, Susan Allen, Carlos del Rio, Henry M Blumberg
BMC Infectious Diseases , 2011, DOI: 10.1186/1471-2334-11-264
Abstract: A cross sectional study was conducted to assess the prevalence of and risk factors for a positive diagnostic test for LTBI, using tuberculin skin test (TST) and IGRAs among HIV-discordant couples in Zambia.A total of 596 subjects (298 couples) were enrolled. Median CD4 count among HIV positive persons was 388 cells/μl, (range 51-1330). HIV negative persons were more likely than their HIV positive partner, to have a positive diagnostic test for LTBI with TST (203 vs 128), QFT (171 vs 109) and TSPOT (156 vs. 109). On multivariate analysis, HIV negative status was an independent predictor for a positive QFT (OR = 2.22, 95% CI 1.42- 3.46) and TSPOT (OR = 1.79, 95% CI 1.16-2.77). Among HIV positive subjects a CD4 count ≥ 388 cells/μl was associated with a positive TST (OR = 1.76 95% CI 1.10-2.82) and QFT (OR = 1.71 95% CI 1.06-2.77) but not TSPOT (OR = 1.20 95% CI 0.74-1.94).Persons with HIV had significantly fewer positive diagnostic tests for LTBI with TST, QFT and TSPOT. Persons with a CD4 count < 388 cells/μl were less likely to have a positive TST or QFT, but not less likely to have a positive TSPOT. TSPOT may perform better than TST or QFT in HIV positive individuals.HIV and tuberculosis (TB) are the leading causes of death among adults due to an infectious disease worldwide. It is estimated that > 13 million people are co-infected with HIV and Mycobacterium tuberculosis [1]. The World Health Organization (WHO) estimates that there are approximately 9.3 million new cases of active TB and nearly 2 million deaths due to the disease worldwide each year [2,3]. Twenty-seven percent of TB cases and 31% of TB-related deaths occur in Africa, home to only 11% of the world's population [4].HIV infection is the most important risk factor for progression from latent tuberculosis infection (LTBI) to active TB [5,6]. In patients with HIV and LTBI, the annual risk of progression to active TB is approximately 10% per year [7-9] compared to a lifetime risk of 5-10% in immunocompete
Unintended Pregnancy among HIV Positive Couples Receiving Integrated HIV Counseling, Testing, and Family Planning Services in Zambia
Kristin M. Wall, Lisa Haddad, Bellington Vwalika, Naw Htee Khu, Ilene Brill, William Kilembe, Rob Stephenson, Elwyn Chomba, Cheswa Vwalika, Amanda Tichacek, Susan Allen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075353
Abstract: Objective We describe rates of unintended pregnancy among HIV positive couples in Lusaka, Zambia. We also identify factors associated with unintended pregnancy among oral contraceptive pill (OCP) using couples in this cohort. Design Data were analyzed from couples randomized in a factorial design to two family planning intervention videos. Methods Rates of unintended pregnancy were stratified by contraceptive method used at time of pregnancy. Predictors of time to unintended pregnancy among OCP users were determined via multivariate Cox modeling. Results The highest rates of unintended pregnancy were observed among couples requesting condoms only (26.4/100CY) or OCPs (20.7/100CY); these rates were not significantly different. OCP users accounted for 37% of the couple-years (CY) observed and 87% of unintended pregnancies. Rates of unintended pregnancy for injectable (0.7/100CY) and intrauterine device (1.6/100CY) users were significantly lower relative to condom only users. No pregnancies occurred among contraceptive implant users or after tubal ligation. Factors associated (p<0.05) with time to unintended pregnancy among OCP users in multivariate analysis included the man wanting more children, the woman being HIV negative versus having stage IV HIV disease, and the woman reporting: younger age, no previous OCP use, missed OCPs, or sex without a condom. Conclusions Long-acting reversible contraceptive methods were effective in the context of integrated couples HIV prevention and contraceptive services. Injectable methods were also effective in this context. Given the high user failure rate of OCPs, family planning efforts should promote longer-acting methods among OCP users wishing to avoid pregnancy. Where other methods are not available or acceptable, OCP adherence counseling is needed, especially among younger and new OCP users. Trial registration ClinicalTrials.gov NCT00067522
Degradation of Metalaxyl and Mefenoxam and Effects on the Microbiological Properties of Tropical and Temperate Soils
Adolphe Monkiedje,Michael Spiteller
International Journal of Environmental Research and Public Health , 2005, DOI: 10.3390/ijerph2005020011
Abstract: The degradation of various formulations of the racemic mixture and the enantiomers (including mefenoxam) of metalaxyl in typical soils from Germany and Cameroon in controlled incubation experiments was studied. The kinetics of the degradation or transformation was determined by means of reversed phase HPLC, while the enantiomeric ratios were measured by HPLC with a chiral Whelk O1 column. The dynamics of the quantitative changes in microbiological properties induced by the addition of these fungicides at their recommended field rates were determined in the soils during a 120-day incubation experiment. The degradation followed first-order kinetics (R2≥0.96). Higher metalaxyl acid metabolite concentrations were found in German than in Cameroonian soils. The enantiomers of the fungicide had different degradation rates in both soils, with half-lives ranging from 17 to 38 days. All forms of metalaxyl had lower degradation rates in the Cameroonian soil than in the German soil. The degradation of the R-enantiomer was much faster than the S-enantiomer in the German soil and slower than the S-enantiomer in the Cameroonian soil, suggesting that different microbial populations, which may be using different enzymes, have different degradation preferences. The type of soil significantly influenced the effect of these fungicides on the soil parameters studied. Incorporation of these fungicides resulted in a change in the ecophysiological status of the soil microbial community as expressed by microbial activities. The activity of phosphatases and ?-glucosidase, the mineralization and availability of N and most plant nutrients in soils were stimulated, whereas the activity of dehydrogenase and the availability of NO3-, were generally adversely affected. The soil NH4+, NO3-, and enzymes activities values in general did not correlate with the degradation of metalaxyl in both soils. However, the degradation of formulated and unformulated metalaxyl was positively correlated to the activity of acid phosphatase in the German soil (R2, 0.84 and 0.94 respectively) and in the Cameroonian soil (R2, 0.97 and 0.96 respectively).
La psicologia de l'adolescència. L'adolescència i l'escola aciva The Psychology of Adolescence: Adolescence and the Active School La psicología de la adolescencia. La adolescencia y la escuela activa
Adolphe Ferrière
Temps d'Educació , 2008,
Abstract: Text de la conferència pronunciada per Adolphe Ferrière el dia 5 de desembre de 1930 en la inauguració del Seminari de Pedagogia de la Universitat de Barcelona. El text, en versió catalana, ha estat tradu t i reconstru t per Joan Soler Mata. _____________________________________________ Texte de la conférence prononcée par le pédagogue suisse Adolphe Ferrière le 5 décembre 1930 pour l’inauguration du séminaire de pédagogie de l’Université de Barcelone. Le texte, en version catalane, a été traduit et reconstruit par Joan Soler Mata. La reconstruction a été faite avec trois sources documentaires : les notes manuscrites du même Ferrière ; un résumé, en version espagnole, de la conférence qui avec le même titre a donné pendant son voyage par l'Amérique latine, et un article étendu du même Ferrière. Text of a speech given by Adolphe Ferrière on 5 December 1930 to open the Seminary of Pedagogy, of the University of Barcelona. The Catalan version of the text has been translated and reconstructed by Joan Soler Mata. The reconstruction has required three documentary sources: the written by hand notes of the same Ferrière; a summary, in Spanish version, of the conference that with the same title it gave during his trip by Latin America, and an extensive article of the same Ferrière. Texto de la conferencia pronunciada por Adolphe Ferrière el día 5 de diciembre de 1930 en la inauguración del Seminario de Pedagogía de la Universidad de Barcelona. El texto, en versión catalana, ha sido traducido y reconstruido por Joan Soler Mata. La reconstrucción se ha hecho a partir de tres fuentes documentales: las notas manuscritas del mismo Ferrière; un resumen, en versión castellana, de la conferencia que con el mismo título dio durante su viaje por América Latina, y un extenso artículo del mismo Ferrière.
De la caractérisation matricielle des drapeaux complets d'extensions riemanniennes aux feuilletages riemanniens transversalement diagonaux sur une variété compacte connexe
Cyrille Dadi,Adolphe Codjia
Mathematics , 2014,
Abstract: In this paper we characterise with the matrix the complete flag of riemannian extension (see d\'efinition) on a riemannian compact manifold whose metric is bundlelike for any foliation F_{s} of this flag. This study show us that a foliation of a complete flag of riemannian extension on a riemannian compact manifold whose metric is bundlelike for any foliation of this flag is a transversely diagonal riemannian foliation (see d\'efinition).
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