Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 203 )

2018 ( 347 )

2017 ( 319 )

2016 ( 475 )

Custom range...

Search Results: 1 - 10 of 303126 matches for " Adele J Vincent "
All listed articles are free for downloading (OA Articles)
Page 1 /303126
Display every page Item
TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons
Robert J Gasperini, Xu Hou, Helena Parkington, Harry Coleman, David W Klaver, Adele J Vincent, Lisa C Foa, David H Small
Molecular Neurodegeneration , 2011, DOI: 10.1186/1750-1326-6-19
Abstract: Levels of intracellular cytosolic calcium were monitored in dorsal root ganglion (DRG) neurons isolated from embryonic rats using the calcium-sensitive fluorescent indicator Fluo4. An amyloidogenic mutant form of TTR, L55P, induced calcium influx into the growth cones of DRG neurons, whereas wild-type TTR had no significant effect. Atomic force microscopy and dynamic light scattering studies confirmed that the L55P TTR contained oligomeric species of TTR. The effect of L55P TTR was decreased by blockers of voltage-gated calcium channels (VGCC), as well as by blockers of Nav1.8 voltage-gated sodium channels and transient receptor potential M8 (TRPM8) channels. siRNA knockdown of TRPM8 channels using three different TRPM8 siRNAs strongly inhibited calcium influx in DRG growth cones.These data suggest that activation of TRPM8 channels triggers the activation of Nav1.8 channels which leads to calcium influx through VGCC. We suggest that TTR-induced calcium influx into DRG neurons may contribute to the pathophysiology of FAP. Furthermore, we speculate that similar mechanisms may mediate the toxic effects of other amyloidogenic proteins such as the β-amyloid protein of Alzheimer's disease.Protein misfolding is a common feature of many neurodegenerative diseases. In some of these diseases, such as the synucleinopathies and the tauopathies, cytoplasmic proteins aggregate to form intracellular deposits. However, in the amyloidoses, which include Alzheimer's disease (AD), prion diseases and the British and Danish familial dementias, proteinaceous aggregates are observed extracellularly [1-4]. There is increasing evidence that the mechanism of neurotoxicity in these amyloidoses is similar and that it is the conformation of the aggregated protein, rather than its specific amino acid sequence which results in altered membrane permeability to calcium [5]. Therefore, studies on the mechanism of neurotoxicity in one disease may provide insights into the mechanisms involved in other
The Rise and Fall of the Two Party-System: The Nigerian Example
Bamgbose, J. Adele
Pakistan Journal of Social Sciences , 2012,
Abstract: The aim of this study is to examine the origins of the two party system consisting of the defunct Social Democratic Party (SDP) and National Republican Convention (NRC) brought into existence through, the military administrative fiat of Rtd. General Babangida. The study points out that the annulment of the June 12 presidential election of 1993, the post election crises and Abacha s palace coup were the 3 principal factors that stifled and removed the two party system from Nigeria s political history thereby paving way for the present multi-party state structure.
Irish Cepaea nemoralis Land Snails Have a Cryptic Franco-Iberian Origin That Is Most Easily Explained by the Movements of Mesolithic Humans
Adele J. Grindon, Angus Davison
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065792
Abstract: The origins of flora and fauna that are only found in Ireland and Iberia, but which are absent from intervening countries, is one of the enduring questions of biogeography. As Southern French, Iberian and Irish populations of the land snail Cepaea nemoralis sometimes have a similar shell character, we used mitochondrial phylogenies to begin to understand if there is a shared “Lusitanian” history. Although much of Europe contains snails with A and D lineages, by far the majority of Irish individuals have a lineage, C, that in mainland Europe was only found in a restricted region of the Eastern Pyrenees. A past extinction of lineage C in the rest of Europe cannot be ruled out, but as there is a more than 8000 year continuous record of Cepaea fossils in Ireland, the species has long been a food source in the Pyrenees, and the Garonne river that flanks the Pyrenees is an ancient human route to the Atlantic, then we suggest that the unusual distribution of the C lineage is most easily explained by the movements of Mesolithic humans. If other Irish species have a similarly cryptic Lusitanian element, then this raises the possibility of a more widespread and significant pattern.
Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite
Adele M Lehane, Kevin J Saliba
BMC Research Notes , 2008, DOI: 10.1186/1756-0500-1-26
Abstract: A chloroquine-sensitive (3D7) and a chloroquine-resistant (7G8) strain of P. falciparum were tested for in vitro susceptibility to a range of individual dietary flavonoids and flavonoid combinations. Parasite susceptibility was measured in 96-well plates over 96 h using a previously described [3H]hypoxanthine incorporation assay. Of the eleven flavonoids tested, eight showed antiplasmodial activity against the 3D7 strain (with IC50 values between 11 and 66 μM), and all showed activity against the 7G8 strain (with IC50 values between 12 and 76 μM). The most active compound against both strains was luteolin, with IC50 values of 11 ± 1 μM and 12 ± 1 μM for 3D7 and 7G8, respectively. Luteolin was found to prevent the progression of parasite growth beyond the young trophozoite stage, and did not affect parasite susceptibility to the antimalarial drugs chloroquine or artemisinin. Combining low concentrations of flavonoids was found to produce an apparent additive antiplasmodial effect.Certain common dietary flavonoids inhibit the intraerythrocytic growth of the 3D7 and 7G8 strains of P. falciparum. Flavonoid combinations warrant further investigation as antiplasmodial agents.Flavonoids are ubiquitous plant phenolic compounds that consist of two aromatic rings linked by a three-carbon bridge (see Table 1 for structure). More than 6000 flavonoids have been identified to date, and their essential functions in plants include regulating growth and providing protection against pathogens (reviewed in [1]). They are currently attracting significant medical interest because of their antioxidant, antitumor, antiinflammatory, antimicrobial and antiviral activities. Flavonoids are present in fruits, vegetables, wine, tea and coffee. Estimates of the daily intake of flavonoids in developed countries are as high as 1–2 g [1].A number of reports have demonstrated growth inhibitory effects of flavonoids, particularly of the flavonol quercetin and of the flavone luteolin, on the protozoan
Creativity in Science: Tensions between Perception and Practice  [PDF]
Adele L. Schmidt
Creative Education (CE) , 2011, DOI: 10.4236/ce.2011.25063
Abstract: Many countries are reviewing science education programmes and implementing new pedagogical paradigms aimed at reversing a trend of declining enrolments. A key factor in this decline is a public perception that science is not a creative endeavour. Attempts to reframe public perception tend to focus on primary and secondary schooling, but do little to address ongoing declines in quality and originality of intellectual output beyond the highschool environment. To overcome systemic devaluation of science requires appreciation of the complex, dynamic, and often stochastic, interplay of sociocultural, psychological and cognitive factors that drive human creativity. Viewing creativity from this perspective reveals tensions between perception and practice that limit opportunities for students, science educators and scientists. Resolving the tension requires integration of developmental, psychometric and sociocultural discourses of creativity in ways that generate opportunities for individuals at all levels of education and practice to: 1) acquire a high level of domain-specific knowledge; 2) practise application of that knowledge in developing solutions to problems across a gradient of difficulty and; 3) be challenged to integrate their knowledge of science with their knowledge of other fields to pursue and solve problems with personal relevance.
Port and Shipping Express Management: The Challenges Faced by West and Central Africa in This Century  [PDF]
Regine Adele Ngono Fouda
Open Journal of Applied Sciences (OJAppS) , 2012, DOI: 10.4236/ojapps.2012.24043
Abstract: Shipping industry has become more capital intensive, technically more demanding and subject to major global regulatory reforms. As a consequence, the number of African shipping lines has been severely reduced. International trade of the WCA countries remains weak, limited to 30% of their Gross Domestic Product (GDP). The goal of this paper is to provide a comprehensive overview of the port and shipping convey management in the WCA region, and of course to describe what has been achieved since then and what still have to be done to better its infrastructures and port community.
Supply Chain Integration, a Chain of Efficient Utilization of Information Technology: Its Benefits & Challenges  [PDF]
Regine Adele Ngono Fouda
Open Journal of Applied Sciences (OJAppS) , 2012, DOI: 10.4236/ojapps.2012.24044
Abstract: Business renovation, effective utilization of information technology and the role of business process modeling are dealt in supply chain integration projects. The main idea is to show how the performance of supply chain can be improved with the integration of various tiers in the chain. Integration is preconditioned for efficient sharing and utilization of information between diverse companies in the chain.
The Genesis of the Quantum Theory of the Chemical Bond  [PDF]
Salvatore Esposito, Adele Naddeo
Advances in Historical Studies (AHS) , 2014, DOI: 10.4236/ahs.2014.35020
Abstract: An historical overview is given of the relevant steps that allowed the genesis of the quantum theory of the chemical bond, starting from the appearance of the new quantum mechanics and following later developments till approximately 1931. General ideas and some important details are discussed concerning molecular spectroscopy, as well as quantum computations for simple molecular systems performed within perturbative and variational approaches, for which the Born- Oppenheimer method provided a quantitative theory accounting for rotational, vibrational and electronic states. The novel concepts introduced by the Heitler-London theory, complemented by those underlying the method of the molecular orbitals, are critically analyzed along with some of their relevant applications. Further improvements in the understanding of the nature of the chemical bond are also considered, including the ideas of one-electron and three-electron bonds introduced by Pauling, as well as the generalizations of the Heitler-London theory firstly performed by Majorana, which allowed the presence of ionic structures into homopolar compounds and provided the theoretical proof of the stability of the helium molecular ion. The study of intermolecular interactions, as developed by London, is finally examined.
RTKN2 Induces NF-KappaB Dependent Resistance to Intrinsic Apoptosis in HEK Cells and Regulates BCL-2 Genes in Human CD4+ Lymphocytes
Fiona M Collier,Andrea Loving,Adele J Baker,Janet McLeod
Journal of Cell Death , 2009,
Abstract: The gene for Rhotekin 2 (RTKN2) was originally identified in a promyelocytic cell line resistant to oxysterol-induced apoptosis. It is differentially expressed in freshly isolated CD4+ T-cells compared with other hematopoietic cells and is down-regulated following activation of the T-cell receptor. However, very little is known about the function of RTKN2 other than its homology to Rho-GTPase effector, rhotekin, and the possibility that they may have similar roles. Here we show that stable expression of RTKN2 in HEK cells enhanced survival in response to intrinsic apoptotic agents; 25-hydroxy cholesterol and camptothecin, but not the extrinsic agent, TNFα. Inhibitors of NF-KappaB, but not MAPK, reversed the resistance and mitochondrial pro-apoptotic genes, Bax and Bim, were down regulated. In these cells, there was no evidence of RTKN2 binding to the GTPases, RhoA or Rac2. Consistent with the role of RTKN2 in HEK over-expressing cells, suppression of RTKN2 in primary human CD4+ T-cells reduced viability and increased sensitivity to 25-OHC. The expression of the pro-apoptotic genes, Bax and Bim were increased while BCL-2 was decreased. In both cell models RTKN2 played a role in the process of intrinsic apoptosis and this was dependent on either NF-KappaB signaling or expression of downstream BCL-2 genes. As RTKN2 is a highly expressed in CD4+ T-cells it may play a role as a key signaling switch for regulation of genes involved in T-cell survival.
Cu/CNF Nanocomposite Processed By Novel Salt Decomposition Method  [PDF]
C. Vincent, J. M. Heintz, J. F. Silvain, N. Chandra
Open Journal of Composite Materials (OJCM) , 2011, DOI: 10.4236/ojcm.2011.11001
Abstract: Thermal dissipation in power electronic devices can be improved through the elaboration of a new generation of layered heat sinks based on copper (Cu) -carbon nanofibers (CNF) composites. Though the high theoretical thermal conductivity of CNF (1200 W/m.K) no Cu-CNF composites with enhanced thermal properties are available. Indeed conventional compositing processes do not allow neither a good dispersion of the nano-reinforcements nor a control of the nanofiber-matrix interface which is not suitable for efficient heat transfers. In this paper, a process based on CNF coating with Cu followed by uniaxial hot pressing in described. It is shown that under proper experimental conditions the salt decomposition coating method is capable of achieving the desired high thermal conductivity values (> 400 W/m.K) thanks to a good dispersion of the CNF, low porosity content and the control of Cu-CNF interfaces.
Page 1 /303126
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.