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Search Results: 1 - 10 of 209948 matches for " Adél Ambrus "
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A Single Centre Experience with Phenotype Dependent Perioperative Chemotherapy for Primary Breast Cancer  [PDF]
Tamás Kullmann, Kofi Agyemang-Prempeh, Adél Ambrus, Gabriella Herodek, Balázs Hillier, Károly Kocsis, Ilona Laszip, Mária Mák, Tamás Pintér, István Sip?cz
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.101002
Abstract: Background: Standard adjuvant or neo-adjuvant chemotherapy of primary breast cancers consists of docetaxel and the combination of anthracyclin-cyclophosphamide in two steps. According to international literature, the neo-adjuvant treatment of triple negative tumours by the combination of docetaxel-carboplatin allows a high rate of pathological complete remission and the adjuvant treatment of small, node negative HER2+ tumours by the combination of paclitaxel-trastuzumab allows a negligible recurrence rate together with a very good tolerance. Methods: Our aim was the retrospective analysis of the alternative chemotherapy regimens in our patient population. Results: The neo-adjuvant docetaxel-carboplatin allowed a 55% pathological complete remission rate among 20 patients. With the adjuvant paclitaxel-trastuzumab, we did not notice any recurrence among 5 patients at a median follow-up of 18 months. Conclusion: Our results correspond to the literature data. The spread of the protocols in the clinical practice is proposed.
Rigid cohomology over Laurent series field I: First definitions and basic properties
Christopher Lazda,Ambrusl
Mathematics , 2014,
Abstract: This is the first in a series of papers in which we construct and study a new $p$-adic cohomology theory for varieties over Laurent series fields $k(\!(t)\!)$ in characteristic $p$. This will be a version of rigid cohomology, taking values in the bounded Robba ring $\mathcal{E}_K^\dagger$, and in this paper, we give the basic definitions and constructions. The cohomology theory we define can be viewed as a relative version of Berthelot's rigid cohomology, and is constructed by compactifying $k(\!(t)\!)$-varieties as schemes over $k[\![ t]\!]$ rather than over $k(\!(t)\!)$. We reprove the foundational results necessary in our new context to show that the theory is well defined and functorial, and we also introduce a category of `twisted' coefficients. In latter papers we will show some basic structural properties of this theory, as well as discussing some arithmetic applications including the weight monodromy conjecture and independence of $\ell$ results for equicharacteristic local fields.
Rigid cohomology over Laurent series fields II: Finiteness and Poincaré duality for smooth curves
Christopher Lazda,Ambrusl
Mathematics , 2014,
Abstract: In this paper we prove that the $\mathcal{E}^\dagger_K$-valued cohomology, introduced in [9] is finite dimensional for smooth curves over Laurent series fields $k((t))$ in positive characteristic, and forms an $\mathcal{E}^\dagger_K$-lattice inside `classical' $\mathcal{E}_K$-valued rigid cohomology. We do so by proving a suitable version of the p-adic local monodromy theory over $\mathcal{E}^\dagger_K$, and then using an \'{e}tale pushforward for smooth curves to reduce to the case of $\mathbb{A}^1$. We then introduce $\mathcal{E}^\dagger_K$-valued cohomology with compact supports, and again prove that for smooth curves, this is finite dimensional and forms an $\mathcal{E}^\dagger_K$-lattice in $\mathcal{E}_K$-valued cohomology with compact supports. Finally, we prove Poincar\'{e} duality for smooth curves, but with restrictions on the coefficients.
Rigid cohomology over Laurent series fields III: Absolute coefficients and arithmetic applications
Christopher Lazda,Ambrusl
Mathematics , 2015,
Abstract: In this paper we investigate the arithmetic aspects of the theory of $\mathcal{E}_K^\dagger$-valued rigid cohomology introduced and studied in [11,12]. In particular we show that these cohomology groups have compatible connections and Frobenius structures, and therefore are naturally $(\varphi,\nabla)$-modules over $\mathcal{E}_K^\dagger$ whenever they are finite dimensional. We also introduce a category of `absolute' coefficients for the theory; the same results are true for cohomology groups with coefficients. We moreover prove a $p$-adic version of the weight monodromy conjecture for smooth (not necessarily proper) curves, and use a construction of Marmora to prove a version of $\ell$-independence for smooth curves over $k(\!(t)\!)$ that includes the case $\ell=p$. This states that after tensoring with $\mathcal{R}_K$, our $p$-adic cohomology groups agree with the $\ell$-adic Galois representations $H^i_{\mathrm{\'{e}t}}(X_{k(\!(t)\!)^\mathrm{sep}},\mathbb{Q}_\ell)$ for $\ell\neq p$.
Affinity Hemodialysis for Antiviral Therapy with Specific Application to HIV
Richard H. Tullis,David O. Scamurra,Julian L. Ambrus Jr.
Computational and Mathematical Methods in Medicine , 2002, DOI: 10.1080/1027366021000041395
Abstract: We propose an artificial lymph node to improve immune function in fighting viral diseases. The device is based on hemodialysis using a cartridge containing a solid phase affinity resin. Virus capture is mediated by a collection of broad specificity antibodies covalently coupled to agarose. Viral proteins, which can directly damage uninfected cells, are also efficiently removed. Immobilized antisense DNA provides a mechanism to remove infectious viral nucleic acids. Theoretical calculations suggest that the device could effectively remove virus, toxic viral proteins and infectious viral nucleic acids from the blood thereby limiting disease by preventing reinfection of new cells. In the absence of newly infected cells, previously infected cells are cleared by the immune system. For a typical immobilized antibody, calculations predict a pseudo-first order rate of capture (t1/2 ∼ 10 min) with viral load reduction ∼ 660-fold at equilibrium. Theoretical calculations of a diffusion limited process predict t1/2 ∼ 2.8 h. Measured transport rates for latex particles in a prototype device are significantly faster than the theoretical diffusion limit suggesting that transport is primarily convective and sufficient to allow rapid virus clearance. Since the device is highly selective it can be used in conjunction with drug therapy and other treatments.
Mitochondrial myopathy presenting as fibromyalgia: a case report
Mishal Abdullah, Sahana Vishwanath, Amro Elbalkhi, Julian L Ambrus
Journal of Medical Case Reports , 2012, DOI: 10.1186/1752-1947-6-55
Abstract: Our patient was a 41-year-old Caucasian woman with symptoms of fatigue, exercise intolerance, headache, and multiple trigger points. Treatment for fibromyalgia with a wide spectrum of medications including non-steroidal anti-inflammatory drugs, antidepressants, gabapentin and pregabalin had no impact on her symptoms. A six-minute walk study demonstrated an elevated lactic acid level (5 mmol/L; normal < 2 mmol/L). Biochemical and genetic studies from a muscle biopsy revealed a mitochondrial myopathy. Our patient was started on a compound of coenzyme Q10 (ubiquinone) 200 mg, creatine 1000 mg, carnitine 200 mg and folic acid 1 mg to be taken four times a day. She gradually showed significant improvement in her symptoms over a course of several months.This case demonstrates that adults diagnosed with fibromyalgia may have their symptom complex related to an adult onset mitochondrial myopathy. This is an important finding since treatment of mitochondrial myopathy resulted in resolution of symptoms.Fibromyalgia is a condition characterized by chronic widespread pain and fatigue which affects approximately 2% of the US population [1]. The diagnostic criteria include pain lasting for longer than three months on both sides of the body, involving the upper and lower halves of the body, and presence of at least 11 out of 18 specific tender points over the body [2].Over the years, several pathogenic mechanisms for the condition have been postulated but the exact pathogenesis still remains a mystery. Historically, disordered sleep [3], circadian rhythm abnormalities [4], and hormonal imbalance [5] have been looked upon as potential causes, but whether these factors are important in the pathogenesis, or merely arise secondary to bodily stress remains unclear. Alteration in pain modulatory neuropeptides [6] is another widely studied hypothesis, but several studies have shown variable results with no definitive conclusion. Finally, another more recent theory is the presence of unde
Metabolic myopathy presenting with polyarteritis nodosa: a case report
Sahana Vishwanath, Mishal Abdullah, Amro Elbalkhi, Julian L Ambrus
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-262
Abstract: A 78-year-old African-American woman with a two-year history of progressive fatigue and exercise intolerance presented to our facility with new skin lesions and profound muscle weakness. Skin and muscle biopsies demonstrated a medium-sized artery vasculitis consistent with polyarteritis nodosa. Biochemical studies of the muscle revealed diminished cytochrome C oxidase activity (0.78 μmol/minute/g tissue; normal range 1.03 to 3.83 μmol/minute/g tissue), elevated acid maltase activity (23.39 μmol/minute/g tissue; normal range 1.74 to 9.98 μmol/minute/g tissue) and elevated neutral maltase activity (35.89 μmol/minute/g tissue; normal range 4.35 to 16.03 μmol/minute/g tissue). Treatment for polyarteritis nodosa with prednisone and cyclophosphamide resulted in minimal symptomatic improvement. Additional management with a diet low in complex carbohydrates and ubiquinone, creatine, carnitine, folic acid, α-lipoic acid and ribose resulted in dramatic clinical improvement.Our patient's initial symptoms of fatigue, exercise intolerance and progressive weakness were likely related to her complex metabolic myopathy involving both the mitochondrial respiratory chain and glycogen storage pathways. Management of our patient required treatment of both the polyarteritis nodosa as well as metabolic myopathy. Metabolic myopathies are common and should be considered in any patient with exercise intolerance. Metabolic myopathies may complicate the management of various disease states.Metabolic myopathies are common disorders that are however rarely recognized in adults. They include various mitochondrial myopathies, glycogen storage diseases and disorders of purine metabolism [1,2]. Common presentations in adults may include merely exercise intolerance and muscle weakness with or without pain [3]. Patients with metabolic myopathies clear infections slowly and therefore may be more susceptible to complications of chronic infections.Polyarteritis nodosa (PAN) is a systemic vasculitis invo
On the torsion of Drinfeld modules of rank two
Ambrus Pal
Mathematics , 2007,
Abstract: We study rational points and torsion points on Drinfeld modular curves defined over rational function fields. As a consequence we derive a conjecture of Schweizer describing completely the torsion of Drinfeld modules of rank two over $\Bbb F_2(T)$ implying Poonen's uniform boundedness conjecture in this particular case.
On the Eisenstein ideal of Drinfeld modular curves
Ambrus Pal
Mathematics , 2007,
Abstract: Let $\goth E(\goth p)$ denote the Eisenstein ideal in the Hecke algebra $\Bbb T(\goth p)$ of the Drinfeld modular curve $X_0(\goth p)$ parameterizing Drinfeld modules of rank two over $\Bbb F_q[T]$ of general characteristic with Hecke level $\goth p$-structure, where $\goth p\triangleleft\Bbb F_q[T]$ is a non-zero prime ideal. We prove that the characteristic $p$ of the field $\Bbb F_q$ does not divide the order of the quotient $\Bbb T(\goth p)/\goth E(\goth p)$ and the Eisenstein ideal $\goth E(\goth p)$ is locally principal.
On the kernel and the image of the rigid analytic regulator in positive characteristic
Ambrus Pal
Mathematics , 2009,
Abstract: We will formulate and prove a certain reciprocity law relating certain residues of the differential symbol dlog^2 from the K_2 of a Mumford curve to the rigid analytic regulator constructed by the author in a previous paper. We will use this result to deduce some consequences on the kernel and image of the rigid analytic regulator analogous to some old conjectures of Beilinson and Bloch on the complex analytic regulator. We also relate our construction to the symbol defined by Contou-Carrere and to Kato's residue homomorphism, and we show that Weil's reciprocity law directly implies the reciprocity law of Anderson and Romo.
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