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The Comparison of the Levels of Leukotriene B4, TGF-β1, Collagen in Keloid Fibroblasts and Normal Skin Fibroblast  [PDF]
Yuli Kurniawati, Oki Suwarsa, Achadiyani Agung, Sudigdo Adi
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102801
Keloid pathogenesis occurs due to the longer duration of inflammation and the increase in the production of several factors such as TGF-β1 that causes the increase of fibroblast proliferation and collagen synthesis. The role of B4 Leukotriene (LTB4) in keloid pathogenesis particularly in the inflammation phase and tissue proliferation has not been clearly elucidated. The present study was to analyze the levels of LTB4, TGF-β1 and collagen in keloid fibroblast and normal skin fibroblast. Fibroblasts were cultured by applying explant method to the keloid and normal skin of the petient with the keloid. The measurement of the levels of LTB4, TGF-β1 and collagen was conducted by using Elisa method and triplicate was conducted subsequently. Statistic testing was performed through unpaired t test. The experiment was carried out in cell culture laboratory of The Faculty of Medicine Padjajaran University Bandung. The levels of LTB4, TGF-β1 are higher in keloid fibroblast, despite the fact that it does not show statistically significant difference. The level of collagen 1 is higher than that of collagen 3 in keloid fibroblast. Leukotriene B4 (LTB4) is one of the derivative of arachidonic acid that plays the role as lipid mediumtor of inflammation and fibroblast chemoattractant. The levels of LTB4, TGF-β1, collagen 1 and collagen 3 increase in keloid fibroblast. Such a result shows the role of LTB4 in the inflammation process that stretches in keloid pathogenesis.
Displacement of Morphological Characters of Barbodes gonionotus at Serpeng Cave Lake, Gunungkidul
Biodiversitas , 2001,
Abstract: Serpeng cave lake is located inside a cave that is isolated from any waters outside the cave, and the lake is located about 96 meters down under the ground surface. The isolated waters in the lake have also resulted in the isolation of the fishes from any other fish populations outside the cave. The objective of the study was to know how the displacement of morphological character occurred on a group of fish suspected belong to Barbodes gonionotus lived in Serpeng lake based on the observation of morphological characters of the fish. The Barbodes gonionotus from Kalisuci river and a well at Serpeng village was used as a comparison. The morphological characters observed were morphometric, meristic, color of scale, and number of vertebrae. The parameters of the water environment were also measured. The morphological characters from the three populations of fish were compared. The correlation coefficient of the morphologic data was measured, and grouping analysis was also applied for data. There was not any obvious differences observed between fishes from Kalisuci river and well at Serpeng village, on the other hand, the differences were obviously observed for the fish from the lake compared to the fishes from the river and well. The differences were evident from all characters observed. The grouping analysis indicated that the fish population suspected to be Barbodes gonionotus from the lake was separated from the same species of the river and well, while the distinct features were not observed between both fishes from the river and well. Based on the basic characters and observed morphological characters of Barbodes gonionotus suggest that the speciation of the fish to the subspecies taxonomic level has occurred.
Selection and potential aquaculture of “wader” fish of the Genus Rasbora
Biodiversitas , 2002,
Abstract: “Wader” fish is one of the local Indonesian wild fish that not cultured yet. This fish have amount of species, included Genus Rasbora. The aim of this research was to known the “wader” fish diversity of Genus Rasbora that potentially to aquaculture. The research conducted in 10 weeks to three species, namely R. lateristriata, R. aprotaenia, and R. argyrotaenia. The research was designed in two treatments, namely giving pellet and non-giving pellet. The growth data was measured every week. The result indicated that pellet could increase size and growth of the fish. R. argyrotaenia had bigger size and faster growth than R. lateristriata and R. aprotaenia. The optimum growth of R. argyrotaenia occured at third to sixth weeks, and it got maximum size at seventh week. So it was suitable to aquaculture.
Reproduction pattern of “gading starling” (Turdus sp.) at Mount Lawu, Central Java
Biodiversitas , 2005,
Abstract: The aim of the research was to know reproduction pattern of “gading starling” (Turdus sp.) in natural habitat, namely Mount Lawu. This research was expected to give accurate information that can be used as base of conservation effort. Research had been done alongside of Cemoro Sewu tracking line. Data was collected at 2600, 2800, 3000, 3100, and 3200 m. asl., in March, April, May, and October 2004. Nesting observation was concerning with nest place at tree, height of ground surface, apart from tracking line, nest materials, size and shape of nest. Egg observation was concerning with the amount of egg per nest, time lay eggs, and amount of infant. Environmental data was concerning with air temperature and humidity. The result indicated that nest location had similar type, i.e. located among ramification encircled by some small stick and shaded by leaves. Height of nest about 0.2-7 m above ground surface. About 90% nest was laid in radius less than 40 m of tracking line. Nest materials predominated by grasses mixtured with dry leaf and small stick. Shape of nest was bowl-like with external diameter 16-19 cm and internal diameter 8-12 cm, and deepness of nest 5-7 cm. Breeding season was around March-April. Shape of egg was oval with mean of length 2.4 cm and diameter 1.5 cm. Egg color was pale blue with small pock of pale brown. Mean of egg amount 2-3 items per nest. Mean of efficacy hatch 1-2 individual per nest, but infant which living on generally only 1 individual. During research noted that lowest temperature 80oC, highest temperature 20oC, and mean of air humidity 70-90%. This research concluded that “gading starling” had typical reproduction behavior, especially in selecting nest location and nest materials.
A Unified Energy Approach for B-Spline Snake In Medical Image Segmentation
Agung Alfiansyah
Abstract: The parametric snake is one of the preferred approaches in feature extraction from images because of their simplicity and efficiency. However the method has also limitations. In this paper an explicit snake that represented using BSpline applied for image segmentation is considered. In this paper, we identify some of these problems and propose efficient solutions to get around them. The proposed method is inspired by classical snake from Kass with some adaption for parametric curve. The paper also proposes new definitions of energy terms in the model to bring the snake performance more robust and efficient for image segmentation. This energy term unify the edge based and region based energy derived from the image data. The main objective of developed work is to develop an automatic method to segment the anatomical organs from medical images which is very hard and tedious to be performed manually. After this segmentation, the anatomical object can be further measured and analyzed to diagnose the anomaly in that organ. The results have shown that the proposed method has been proven qualitatively successful in segmenting different types of medical images.
The most probable wave function of a single free moving particle
Agung Budiyono
Physics , 2009, DOI: 10.1103/PhysRevA.80.042110
Abstract: We develop the most probable wave functions for a single free quantum particle given its momentum and energy by imposing its quantum probability density to maximize Shannon information entropy. We show that there is a class of solutions in which the quantum probability density is self-trapped with finite-size spatial support, uniformly moving hence keeping its form unchanged.
Spatiotemporally-localized-stationary typical wave function satisfying Klein-Gordon equation with emergent mass
Agung Budiyono
Physics , 2005,
Abstract: Starting from relativistic mass-less Madelung fluid, we shall develop a class of typical wave functions by imposing it to maximize Shannon entropy given its finite average quantum potential. We show that there is a class of solutions in which the wave function is spatiotemporally localized with finite spacetime support, uniformly moving hence stationary. It turns out that the quantum amplitude satisfies Klein-Gordon equation with emergent mass term proportional to the square root of average quantum potential. We show that there is physical time uncertainty which decreases as the mass increases. We also rederive the classical energy-momentum relation provided the de Broglie-Einstein relation holds. In this case, the time uncertainty is proportional to the inverse of classical energy.
Perturbation Theory Based on Darboux Transformation on One-Dimensional Dirac Equation in Quantum Computation
Agung Trisetyarso
Physics , 2010, DOI: 10.1109/ICoICT.2013.6574591
Abstract: We present the recent works \cite{trisetyarso2011} on the application of Darboux transformation on one-dimensional Dirac equation related to the field of Quantum Information and Computation (QIC). The representation of physical system in one-dimensional equation and its transformation due to the Bagrov, Baldiotti, Gitman, and Shamshutdinova (BBGS)-Darboux transformation showing the possibility admitting the concept of relativity and the trade-off of concurrent condition of quantum and classical physics play into the area of QIC. The applications in cavity quantum electrodynamics and on the proposal of quantum transistor are presented.
On de Broglie's soliton wave function of many particles with finite masses, energies and momenta
Agung Budiyono
Physics , 2005,
Abstract: We consider a mass-less manifestly covariant {\it linear} Schr\"odinger equation. First, we show that it possesses a class of non-dispersive soliton solution with finite-size spatio-temporal support inside which the quantum amplitude satisfies the Klein-Gordon equation with finite {\it emergent} mass. We then proceed to interpret the soliton wave function as describing a particle with finite mass, energy and momentum. Inside the spatio-temporal support, the wave function shows spatio-temporal internal vibration with angular frequency and wave number that are determined by the energy-momentum of the particle as firstly conjectured by de Broglie. Imposing resonance of the internal vibration inside the spatio-temporal support leads to Planck-Einstein quantization of energy-momentum. The first resonance mode is shown to recover the classical energy-momentum relation developed in special relativity. We further show that the linearity of the Schr\"odinger equation allows one to construct many solitons solution through superposition, each describing a particle with various masses, energies and momenta.
Dirac four-potential tunings-based quantum transistor utilizing the Lorentz force
Agung Trisetyarso
Physics , 2010,
Abstract: We propose a mathematical model of \textit{quantum} transistor in which bandgap engineering corresponds to the tuning of Dirac potential in the complex four-vector form. The transistor consists of $n$-relativistic spin qubits moving in \textit{classical} external electromagnetic fields. It is shown that the tuning of the direction of the external electromagnetic fields generates perturbation on the potential temporally and spatially, determining the type of quantum logic gates. The theory underlying of this scheme is on the proposal of the intertwining operator for Darboux transfomations on one-dimensional Dirac equation amalgamating the \textit{vector-quantum gates duality} of Pauli matrices. Simultaneous transformation of qubit and energy can be accomplished by setting the $\{\textit{control, cyclic}\}$-operators attached on the coupling between one-qubit quantum gate: the chose of \textit{cyclic}-operator swaps the qubit and energy simultaneously, while \textit{control}-operator ensures the energy conservation.
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