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Search Results: 1 - 10 of 8571 matches for " Abu Saleh Mohammed Arifuzzaman "
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Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial
Rubhana Raqib, Protim Sarker, Akhirunnesa Mily, Nur Haque Alam, Abu Saleh Mohammed Arifuzzaman, Rokeya Sultana Rekha, Jan Andersson, Gudmundur H Gudmundsson, Alejandro Cravioto, Birgitta Agerberth
BMC Infectious Diseases , 2012, DOI: 10.1186/1471-2334-12-111
Abstract: A randomized, double-blind, placebo-controlled, parallel-group designed clinical trial was conducted. Eighty adult patients with shigellosis were randomized to either the Intervention group (butyrate, n?=?40) or the Placebo group (normal saline, n?=?40). The Intervention group was given an enema containing sodium butyrate (80?mM), twice daily for 3?days, while the Placebo group received the same dose of normal saline. The primary endpoint of the trial was to assess the efficacy of butyrate in improving clinical, endoscopic and histological features of shigellosis. The secondary endpoint was to study the effect of butyrate on the induction of antimicrobial peptides in the rectum. Clinical outcomes were assessed and concentrations of antimicrobial peptides (LL-37, human beta defensin1 [HBD-1] and human beta defensin 3 [HBD-3]) and pro-inflammatory cytokines (interleukin-1β [IL-1β] and interleukin-8 [IL-8]) were measured in the stool. Sigmoidoscopic and histopathological analyses, and immunostaining of LL-37 in the rectal mucosa were performed in a subgroup of patients.Compared with placebo, butyrate therapy led to the early reduction of macrophages, pus cells, IL-8 and IL-1β in the stool and improvement in rectal histopathology. Butyrate treatment induced LL-37 expression in the rectal epithelia. Stool concentration of LL-37 remained significantly higher in the Intervention group on days 4 and 7.Adjunct therapy with butyrate during shigellosis led to early reduction of inflammation and enhanced LL-37 expression in the rectal epithelia with prolonged release of LL-37 in the stool.ClinicalTrials.gov, NCT00800930.
Phenolic Contents and Antioxidant Activity of Various Date Palm (Phoenix dactylifera L.) Fruits from Saudi Arabia  [PDF]
Ebtesam Abdullah Saleh, Manal Said Tawfik, Hamza Mohammed Abu-Tarboush
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.210152
Abstract: The present study aimed to estimate the individual and total phenols and antioxidant activity of the aqueous and alcoholic extracts of three premium quality date varieties (Khalas, Sukkari and Ajwa) from Saudi Arabia. In general, water extract has shown significantly higher contents of total phenols than alcoholic, especially in Ajwa (455.88 and 245.66 mg/100 g respectively). However, phenolic profile indicated that Sukkari contained the highest rutin concentration (8.10 mg/kg), whereas, catechin was approximately the same in Sukkari and Ajwa (7.50 and 7.30 mg/kg respectively). Khalas was the highest variety content of caffeic acid (7.40 mg/kg). A significant difference has indicated among extracts and varieties in suppressing lipid peroxidation. Sukkari and Ajwa have reduced the oxidation with 50% at lower concentration in water extract than alcoholic (0.63, 0.70 and 1.60, 1.43 mg/ml respectively). Furthermore, high positive linear correlation was found between total phenols in water (r = 0.96) and alcohol (r = 0.85) extracts and inhibition of lipid oxidation activity. The compounds responsible for the activity were catechin (r = 0.96), and rutin (r = 0.74) in water extract, whereas this correlation decreased in alcoholic extract (r = 0.66) for catechin and very weak (r = 0.38) for rutin. No correlation was found between caffeic acid and lipid peroxidation in both extracts. Similar significant results were obtained with DPPH test, except with Sukari, which has shown no difference between aqueous and alcoholic extracts (4.30, 4.10 mg/ml respectively).
Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone  [PDF]
Mohammed Saleh Tawfek Makki, Reda Mohammady Abdel Rahman, Ola Ahmad Abu Ali
International Journal of Organic Chemistry (IJOC) , 2015, DOI: 10.4236/ijoc.2015.53017
Abstract: Some new fluorinated 3-N-acyl/3-N-alkylaminophenyl-1,2,4-triazino[3,4-b][1,3,4]thiadiazolones (2-12) have been obtained from treatment of 2-(4'-fluorophenyl)-6-(2'-amino-5'-fluorophenyl)-1,2,4-triazino[3,4-b][1,3,4]thiadiazol-4-one(1) with active functional oxygen, sulfur and halogen compounds in different conditions. Former structures of the products have been characterized from elemental and spectral data (UV, IR, NMR and Mass). The new products were evaluated as potential anthelmintic drugs.
Patient Perspectives of the Role of the Community Pharmacist in the Middle East: Jordan, United Arab Emirates and Iraq  [PDF]
Iman A. Basheti, Eyad A. Qunaibi, Salim A. Hamadi, Eman Abu-Gharbieh, Suhair Saleh, Salah AbuRuz, Mohammed Mohamoud, Nailya R. Bulatova
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.56069

Objectives: To explore patient’s perspectives of the role of the community pharmacist in view of other health care professionals (specialist physician, general practitioner, nurse and others (e.g. herbalist)) in Jordan, UAE and Iraq. The study also investigated patient’s willingness to pay for specialized pharmaceutical care services. Methods: This study followed a single phase cross sectional survey methodology, conducted in three Middle Eastern countries. Data were collected over a period of 6 months on two consecutive years (March to May 2009 and 2010). A questionnaire was designed and validated, then completed by patients walking into community pharmacies. The source of advice (specialist physician, general practitioner, pharmacist, nurse, or herbalist) regarding patient’s medication use and medical management were investigated. Key findings: Patients visiting community pharmacies in Jordan (n = 1000), UAE (n = 1000) and Iraq (n = 968) were recruited into the study (mean age 35.9 ± 13.1, 50.6% males). Significant difference between the three countries was shown, as more patients chose the pharmacist as their primary source of advice on medication use vs. the specialist physician in Jordan (50.8% vs. 37.3%) and Iraq (41.9% vs. 36.7%) compared to UAE (38.0% vs. 40.1%), P < 0.001, Chi-square test. Few agreed to receive paid pharmaceutical care services (Jordan 19.5%; UAE 24.7%; Iraq 2.3%). Conclusion: Current situation resulting in the lower socioeconomic status in Jordan and Iraq seems to lead to patients’ higher reliance on the pharmacist, as compared to the UAE. Majority of patients, regardless of the country of origin, are not willing to pay for specialized pharmaceutical care services. These findings are important for future social pharmacy research in the area.

The Level of Multiple Intelligences in Arabic Language Textbooks for Grades from (1 - 4) in Jordan in Light of Gardner’s Theory  [PDF]
Saleh Mohammad Abu Jado
Creative Education (CE) , 2015, DOI: 10.4236/ce.2015.614156
Abstract: This study aims to investigate the level of inclusion and balance of multiple intelligences in the Arabic Language textbooks in light of Gardner’s Theory using the analytical descriptive approach. Eight textbooks in grades (1 - 4) for the first and second semesters were taught in schools in the Jordanian educational system in 2013/2014. The selected textbooks were analyzed using Multiple Intelligences (MI) checklist devised by the researcher based on the framework of the Theory of Multiple Intelligences to examine them in relation to different intelligences as reflected through various activities, questions and tasks. The study sample consisted of all Arabic Language textbooks for the grades from 1 - 4. Results of the study showed that the verbal/linguistic intelligence in the textbooks in general scored the highest frequency amongst all types of intelligence; meanwhile the musical intelligence in the textbooks scored the lowest frequency among all types of intelligence. The study concluded with a recommendation to consider the necessity of employing all types of intelligence in designing Arabic language textbooks for young learners.
Antibiogram of Extended-Spectrum β-Lactamase (ESBL) Producing Escherichia coli  [PDF]
Jogendra Nath Sarker, Sarker Mohammed Ali Ahmed, Hafiza Sultana, Shaheda Anwar, Shirin Tarafder, Ahmed Abu Saleh
Open Journal of Medical Microbiology (OJMM) , 2019, DOI: 10.4236/ojmm.2019.92006
Abstract: Background: Extended-spectrum β-lactamases (ESBLs) are enzymes capable of hydrolyzing extended-spectrum cephalosporins, penicillins and monobactams but inactive against cephamycins and carbapenems. The ESBL-producing organisms are a breed of multidrug-resistant pathogens. Objectives: This study was aimed to determine the susceptibility pattern of ESBL-producing Escherichia coli to ciprofloxacin, amikacin and imipenem. Methods: A total of 75 ESBL-producing E. coli, were obtained from the tertiary care hospitals of Bangladesh and were studied for susceptibility pattern from October, 2010 to December, 2011. These isolates were identified by double disc synergy test (DDST) and were confirmed phenotypically as ESBL-producer by phenotypic confirmatory disc diffusion test (PCDDT). Minimum inhibitory concentrations (MICs) of ciprofloxacin, amikacin and imipenem among ESBL-producing E. coli were determined using agar dilution method. Results: Out of 75 DDST positive ESBL-producing E. coli, 71 (94.67%) were also positive by PCDDT. All ESBL-producing E. coli, were susceptible to imipenem. About 92.95% ESBL-producing E. coli were susceptible to amikacin but only 14.08% were susceptible to ciprofloxacin. Conclusion: In this study, ESBL-producing E. coli, showed high resistance to ciprofloxacin. Imipenem and amikacin were most effective against ESBL positive strains.
Developing Dependability Requirements Engineering for Secure and Safe Information Systems with Knowledge Acquisition for Automated Specification  [PDF]
Mohammed Abu Lamddi
Journal of Software Engineering and Applications (JSEA) , 2017, DOI: 10.4236/jsea.2017.102013
Abstract: Our dependability on software in every aspect of our lives has exceeded the level that was expected in the past. We have now reached a point where we are currently stuck with technology, and it made life much easier than before. The rapid increase of technology adoption in the different aspects of life has made technology affordable and has led to an even stronger adoption in the society. As technology advances, almost every kind of technology is now connected to the network like infrastructure, automobiles, airplanes, chemical factories, power stations, and many other systems that are business and mission critical. Because of our high dependency on technology in most, if not all, aspects of life, a system failure is considered to be very critical and might result in harming the surrounding environment or put human life at risk. We apply our conceptual framework to integration between security and safety by creating a SaS (Safety and Security) domain model. Furthermore, it demonstrates that it is possible to use goal-oriented KAOS (Knowledge Acquisition in automated Specification) language in threat and hazard analysis to cover both safety and security domains making their outputs, or artifacts, well-structured and comprehensive, which results in dependability due to the comprehensiveness of the analysis. The conceptual framework can thereby act as an interface for active interactions in risk and hazard management in terms of universal coverage, finding solutions for differences and contradictions which can be overcome by integrating the safety and security domains and using a unified system analysis technique (KAOS) that will result in analysis centrality. For validation we chose the Systems-Theoretic Accident Model and Processes (STAMP) approach and its modelling language, namely System-Theoretic Process Analysis for safety (STPA), on the safety side and System-Theoretic Process Analysis for Security (STPA-sec) on the security side in order to be the base of the experiment in comparison to what was done in SaS. The concepts of SaS domain model were applied on STAMP approach using the same example @RemoteSurgery.
Competency Improvement Needs of Farmers in Soil Erosion Prevention and Control for Enhancing Crop Production: Case Study of Kogi State, Nigeria  [PDF]
F. M. Onu, Abu Mohammed
Agricultural Sciences (AS) , 2014, DOI: 10.4236/as.2014.511103
Abstract: This study investigated the competency improvement needs of farmers in soil erosion prevention and control for enhancing crop production in Kogi state of Nigeria and was carried out between January and June, 2014. The study adopted descriptive survey research design and was guided by two research questions. The study found out that farmers needed improvement on 37 cultural practices as follows: 10 competencies in mulching, 12 in cover cropping, 8 in strip cropping, 7 in contour farming and 45 mechanical field practice as follows: 10 competencies in contour bonding, 11 in terracing, 12 in channeling and 11 in tunneling for success in soil erosion prevention and control. The study recommended the organization of rural based programmes for the training of farmers in the practice identified to enhance their competencies in soil erosion prevention and control for increased crop production.
Delta Excitation in the Compressed Finite Nucleus 90Zr  [PDF]
Mohammed Hassen Eid Abu-Sei’leek
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.43064
Abstract: Constrained spherical Hartree-Fock (CSHF) calculations under radial compression are presented for 90Zr in a model space consisting of nine major oscillator shells. An effective baryon-baryon interaction which includes the Δ resonances is used. The nucleon-nucleon (N-N) interaction is Reid Soft Core (RSC) potential. The sensitivity of the results to the choice model space is examined. It is found that the nuclear system becomes more compressible when the model space is increased. The radial density and the number of Δs are decreased by increasing model space. The results suggest that the behavior of single particle energies is independent of the model space.
Ground State Properties of Closed Shell 4He Nucleus under Compression  [PDF]
Mohammed Hassen Eid Abu-Sei’leek
Journal of Applied Mathematics and Physics (JAMP) , 2018, DOI: 10.4236/jamp.2018.63042
Abstract: This paper addresses the effects of nuclear properties at different potentials. Reid Soft Core (RSC) and Nijmegen potentials were used to study the nuclear system of 4He nucleus. It has been examined with and without large compression. Moreover, the constrained spherical Hartree-Fock (CSHF) approximations are used as a major tool of analysis. The dependence of the ground state properties was investigated to the degree of compression. It was noticed that it is possible to compress the nucleus to a smaller volume and the nucleus becomes more bounded using RSC than Nijmegen potential. It was also shown that the spectrum of single particle levels increases more rapidly for Nijmegen than RSC potential under compression. Finally, the radial density distribution remains constant, except in the interior region, while it is larger with RSC than Nijmegen potential. At large compression, the radial density distribution becomes larger than that in the interior region when RSC potential is used.
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