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Search Results: 1 - 10 of 27 matches for " Aboubaker Elhessni "
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Synthesis and Influence of Two Quinoxalinone Derivatives on Anxiety- and Depressive-Like Responses in Wistar Rat  [PDF]
Redouan Nakache, Brahim Lakhrissi, Fatima Zahra El Mrabet, Aboubaker Elhessni, Ali Ouichou, Bouchra Benazzouz, Abdelhalem Mesfioui
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.34039
Abstract: Two new quinoxalinone derivatives have been synthesized adopting the HONG method, and investigated for some neuropharmacological effects (anxiety- and depressive-like responses) in rats. The present experiment sought to determine whether treatment with these compounds produces changes in affective responses. We found that the chronic injection of 6-nitro-2(1H)-quinoxalinone (NQu) showed obvious anxiolytic- and antidepressant-like effects, respectively, measured in the behavioral tests of Elevated Plus Maze (EPM) and Forced Swim Test (FST). At the dose of 30 mg/kg, NQu showed a comparative anxiolytic-like effect in rats as diazepam (Dz) (1 mg/kg), and a comparative antidepressant effect as clomipramine (Clmp) (2 mg/kg; i.p). The 2(1H)-quinoxalinone (Qu) significantly reduced depressive-like responses as evaluated in FST, whereas no anxiolytic-like effect was found as measured by open field test (OF). Additionally, the locomotor activity levels were unaffected by treatment as measured by OF and EPM.
Base Doping Effects on the Efficiency of Vertical Parallel Junction Solar Cells  [PDF]
Almoustapha Samoura, Oumar Sakho, Omar Faye, Aboubaker Chedikh Beye
Open Journal of Applied Sciences (OJAppS) , 2017, DOI: 10.4236/ojapps.2017.76023
Abstract: In this work, we present a theoretical study of a vertical parallel junction silicon solar cell under monochromatic illumination. The internal quantum efficiency (IQE) and the photovoltaic conversion efficiency are calculated, taking into account the base doping density and illumination wave-length. The main purpose of this work is to show how conversion efficiency depends on internal quantum efficiency and the dependence of the later on the base doping density.
Flow Curves in the Centered Cylindrical Couette Geometry of a Polyethylene Oxide Solution  [PDF]
Ngargoto Ngarmoundou, Rilengar Godfroyd Ousman, Barka Mahamat, Aboubaker Chedikh Beye
Open Journal of Fluid Dynamics (OJFD) , 2017, DOI: 10.4236/ojfd.2017.74044
Abstract:
Polyethylene oxide solutions have a behavioral flexibility that provides researchers with the opportunity to use constitutive law models in a variety of ways for their MRI characterization. Our results obtained in numerical simulation carried out in 2D and 3D for speed profiles of a solution of PEO deployed by the simple method of the cylindrical Couette geometry considering the fluid Newtonian defect, allowed to identify the behavior of fluid complex (rheo-fluidifying threshold fluid). The relevance and the interest of the method are examined by analyzing these results generated by the numerical data obtained, since these profiles depend on the non-Newtonian properties of the fluid which one does not know a priori and which one seeks to measure by postulating first to the power law of Ostwald, then to the truncated power law.
Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline
A. Bruce Janati,Naif ALGhasab,Aboubaker Osman
Case Reports in Neurological Medicine , 2012, DOI: 10.1155/2012/183252
Abstract: A 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that the addition of amitriptyline to carbamazepine caused a decrease in the serum level of carbamazepine, resulting in NMS. We conclude that combination therapy with carbamazepine and amitriptyline should be avoided in patients who are predisposed to NMS. The purpose of this paper is to warn physicians against combination therapy with carbamazepine and tricyclic antidepressants which may be conducive to neuroleptic malignant syndrome in susceptible patients.
A QoS Framework for Heterogeneous Networking
Mahdi Aiash,Glenford Mapp,Aboubaker Lasebae
Lecture Notes in Engineering and Computer Science , 2011,
Abstract:
Security and QoS Integration for Protecting Service Providers in Heterogeneous Environments
Mahdi Aiash,Glenford Mapp,Aboubaker Lasebae
IAENG International Journal of Computer Science , 2011,
Abstract:
A Survey on Authentication and Key Agreement Protocols in Heterogeneous Networks
Mahdi Aiash,Glenford Mapp,Aboubaker Lasebae
International Journal of Network Security & Its Applications , 2012,
Abstract: Unlike current closed systems such as 2nd and 3rd generations where the core network is controlled by a sole network operator, multiple network operators will coexist and manage the core network in Next Generation Networks (NGNs). This open architecture and the collaboration between different network operators will support ubiquitous connectivity and thus enhances users’ experience. However, this brings to the fore certain security issues which must be addressed, the most important of which is the initial Authentication and Key Agreement (AKA) to identify and authorize mobile nodes on these various networks. This paper looks at how existing research efforts the HOKEY WG, Mobile Ethernet and 3GPP frameworks respond to this new environment and provide security mechanisms. The analysis shows that most of the research had realized the openness of the core network and tried to deal with it using different methods. These methods will be extensively analysed in order to highlight their strengths and weaknesses.
Conversion of L-Tryptophan into Melatonin Is the Possible Action Pathway Involved in the Effect of L-Tryptophan on Antidepressant-Related Behavior in Female Rats: Analysis of the Influence of Treatment Duration  [PDF]
Sihame Ouakki, Fatima Zahra El Mrabet, Aboubaker El Hessni, Abdelhalem Mesfioui, Paul Pévet, Ali Ouichou
Journal of Behavioral and Brain Science (JBBS) , 2013, DOI: 10.4236/jbbs.2013.34036
Abstract: The aim of this study was to determine the effect of pharmacological doses of melatonin (MEL) and L-tryptophan (L-TRP) on depression-like behavior in female rats submitted to the forced swimming test (FST) after 2, 4, 6 or 8 weeks of treatment. This will allow exploring the different mechanisms of L-TRP actions particularly that due to its conversion into MEL. For this purpose, four groups of 24 rats each were constituted; (Group 1: Control): received saline solution NaCl (0.9%), (Group 2: MEL4): received 4 mg/Kg of MEL, (Group 3: L-TRP4): received 4 mg/Kg of L-TRP and (Group 4: L-TRP20): received 20 mg/Kg of L-TRP. Animals of each group were distributed on 4 subgroups of 6 rats submitted to different time treatments. The duration of immobility (TIM) and struggling period (TST) of rats in FST were measured after 2, 4, 6 and 8 weeks of drug treatment and the effects of MEL and L-TRP were compared. Chronical administration of different doses of MEL or L-TRP failed to induce any anti-depressant activity in rats subjected to FST after 2 weeks of treatment. However, after 4 weeks, daily administration of MEL at 4 mg/Kg significantly reduced the immobility period and enhanced struggling time. After 6 weeks, MEL at 4 mg/Kg and L-TRP at 20 mg/Kg were both effective in reducing immobility and increasing struggling movement, their effects being statistically comparable. All treatments were able to significantly reduce immobility time and increase struggling duration after 8 weeks, but L-TRP at 4 mg/Kg was less
Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline
A. Bruce Janati,Naif ALGhasab,Aboubaker Osman
Case Reports in Neurological Medicine , 2012, DOI: 10.1155/2012/183252
Abstract: A 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that the addition of amitriptyline to carbamazepine caused a decrease in the serum level of carbamazepine, resulting in NMS. We conclude that combination therapy with carbamazepine and amitriptyline should be avoided in patients who are predisposed to NMS. The purpose of this paper is to warn physicians against combination therapy with carbamazepine and tricyclic antidepressants which may be conducive to neuroleptic malignant syndrome in susceptible patients. 1. Introduction Neuroleptic malignant syndrome (NMS) was first reported by French psychiatrists in 1960 [1]. NMS is an uncommon but potentially fatal idiosyncratic reaction to neuroleptics characterized by muscular rigidity, fever, autonomic dysfunction, and altered consciousness. Pertinent laboratory findings include leukocytosis and an elevated serum creatine phosphokinase (CPK) level [1]. Although potent neuroleptics (e.g., haloperidol and fluphenazine) are more frequently associated with NMS, all antipsychotic agents, typical or atypical, may precipitate the syndrome. NMS has also been associated with nonneuroleptic agents that block central dopamine pathways (e.g., metoclopramide, amoxapine, and lithium) [2, 3]. NMS can present a clinical challenge where early diagnosis and intervention are essential to avoid a fatal outcome [4]. A molecular basis for NMS has not been established, however, studies suggest that genetic factors may play a part in the pathogenesis of NMS [5]. Involvement of serotonin pathways in NMS has been suggested, but disputed by the notion that polymorphisms in the 5-HT1A and 5-HT2A receptor genes do not determine susceptibility to NMS [6]. In this paper, we report, for the first time, the occurrence of NMS in a patient who received a combination of carbamazepine and amitriptyline. 2. Case Report A 32-year-old Saudi female with a history of mental retardation and secondarily generalized convulsive seizures since childhood was admitted to King Khalid Hospital on December 19, 2011 because of altered mental status, poor feeding, and fever. For years, she had been treated with carbamazepine (CBZ) 200?mg TID with successful seizure control. Also, she had been followed by psychiatry for an unknown psychiatric illness, and was placed on amitriptyline 50?mg daily two months prior to admission. General physical examination showed a
Obese Nulliparous Women and the Risk for Maternal and Fetal Complications  [PDF]
Hussein Attia Sharara, Laman Naji Abdul Rhaman, Firdous Ummunnisa, Naseera Aboubaker, Maisa Mohammed Abdullah, Nissar Shaikh
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.45039
Abstract:

Obesity is becoming a global health care problem and an increasing number of obese female patients are getting pregnant. Aim of our study was to know the prevalence of obesity in nulliparous women and its impact on pregnancy as well as fetus. Patients and Methods: All nulliparous women with single pregnancy and gestational age of 37 weeks and above were included in the study. Primigradvida with multiple pregnancies, fetal abnormalities, and gestational age less than 37 weeks were excluded. Patients were divided into normal, overweight and obese group according to their prepragnancy body mass index (BMI). Results: Total 2243 nulliparous women were included in the study, majority (56.8%) of patients were in the normal BMI group and only 24.8% were obese. But a significantly higher number of obese nulliparous women were in the age group of 18 to 29 years (P < 0.05). Comorbidities were significantly higher in obese primigravida. The incidence of gestational diabetes and pregnancy induced hypertension was significantly higher (P < 0.05) in obese nulliparous women. Overweight and

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