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Search Results: 1 - 10 of 340 matches for " Abdussalam Adina-Zada "
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Ligand Recognition by the TPR Domain of the Import Factor Toc64 from Arabidopsis thaliana
Rashmi Panigrahi, Abdussalam Adina-Zada, James Whelan, Alice Vrielink
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083461
Abstract: The specific targeting of protein to organelles is achieved by targeting signals being recognised by their cognate receptors. Cytosolic chaperones, bound to precursor proteins, are recognized by specific receptors of the import machinery enabling transport into the specific organelle. The aim of this study was to gain greater insight into the mode of recognition of the C-termini of Hsp70 and Hsp90 chaperones by the Tetratricopeptide Repeat (TPR) domain of the chloroplast import receptor Toc64 from Arabidopsis thaliana (At). The monomeric TPR domain binds with 1:1 stoichiometry in similar micromolar affinity to both Hsp70 and Hsp90 as determined by isothermal titration calorimetry (ITC). Mutations of the terminal EEVD motif caused a profound decrease in affinity. Additionally, this study considered the contributions of residues upstream as alanine scanning experiments of these residues showed reduced binding affinity. Molecular dynamics simulations of the TPR domain helices upon peptide binding predicted that two helices within the TPR domain move backwards, exposing the cradle surface for interaction with the peptide. Our findings from ITC and molecular dynamics studies suggest that AtToc64_TPR does not discriminate between C-termini peptides of Hsp70 and Hsp90.
Diagnosis and Multimodality Management of Cushing’s Disease: A Practical Review
Gabriel Zada
International Journal of Endocrinology , 2013, DOI: 10.1155/2013/893781
A characterization of dichotomy in terms of boundedness of solutions for some Cauchy problems
Akbar Zada
Electronic Journal of Differential Equations , 2008,
Abstract: We prove that a quadratic matrix of order $n$ having complex entries is dichotomic (i.e. its spectrum does not intersect the imaginary axis) if and only if there exists a projection $P$ on $ mathbb{C}^n$ such that $Pe^{tA}=e^{tA}P$ for all $tge 0$ and for each real number $mu$ and each vector $b in mathbb{C}^n$ the solutions of the following two Cauchy problems are bounded: $$displaylines{ dot x(t) = A x(t) + e^{i mu t}Pb,quad tgeq 0, cr x(0) = 0 }$$ and $$displaylines{ dot{y}(t)= -Ay(t) + e^{imu t}(I-P)b, quad tgeq 0, cr y(0) = 0,. }$$
A Full 24-Parameter MSSM Exploration
AbdusSalam, Shehu S.
High Energy Physics - Phenomenology , 2008, DOI: 10.1063/1.3051939
Abstract: Up until now a complete scan in all phenomenologically relevant directions of the MSSM at the TeV scale for performing global fit has not been done. Given the imminent start of operation of the LHC, this is a major gap on our quest to discovering and understanding the physical implications of low energy supersymmetry. The main reason for this is the large number of parameters involved that makes it computationally extremely expensive using the traditional methods. In this talk I demonstrate that with advanced sampling techniques the problem is solvable. The results from the explored 24-parameter TeV scale MSSM (phenoMSSM) are remarkably distinct from previous studies and are independent of models for supersymmetry breaking and mediation mechanisms. Hence they are a more robust guide to searches for supersymmetry and dark matter.
Collective spontaneous emission from pairs of quantum dots: long-range vs. short-range couplings
Wildan Abdussalam,Pawe? Machnikowski
Physics , 2011,
Abstract: We study the spontaneous emission from a coherently delocalized exciton state in a double quantum dot as a function of the distance between the dots, focusing on the similarities and differences between the cases of radiative (long-range, dipole) and tunnel coupling between the excitons in the dots. We show that there may be no qualitative difference between the collective emission induced by these two coupling types in spite of their essentially different physical properties.
Superradiance and enhanced luminescence from ensembles of a few self-assembled quantum dots
Wildan Abdussalam,Pawe? Machnikowski
Physics , 2014, DOI: 10.1103/PhysRevB.90.125307
Abstract: We study the evolution of photoluminescence (PL) from homogeneous and inhomogeneous ensembles of a few coupled QDs. We discuss the relation between signals from a given QD ensemble under strong and weak excitation (full inversion and linear response regimes): A system homogeneous enough to manifest superradiant emission when strongly inverted shows a non-exponential decay of the PL signal under spatially coherent weak excitation. In an inhomogeneous ensemble the PL decay is always nearly exponential with a qualitatively different form of the time dependence in the two excitation regimes and with a higher rate under weak excitation.
Collective spontaneous emission from a system of quantum dots
Wildan Abdussalam,Pawe? Machnikowski
Physics , 2012,
Abstract: We study the spontaneous emission from a regular lateral array or a randomly distributed ensemble of quantum dots under strong excitation (full inversion) conditions. We focus on the similarities and differences between the cases of random and regular arrangement of the dots and show that there is very little difference between the evolution of luminescence in these two cases, both for identical dots and for a realistically inhomogeneously broadened ensemble. This means that the enhanced emission or superradiance effect is not due to accidental clustering of pairs of dots. Moreover, we point out that observation of an enhanced emission under weak excitation does not prove that true superradiance will develop in a fully inverted system.
Clinical Outcome after Laminectomy without Fusion for Cervical Spondylotic Myelopathy  [PDF]
Kerstin Woernle, Serge Marbacher, Abdussalam Khamis, Hans Landolt, Javier Fandino
Open Journal of Modern Neurosurgery (OJMN) , 2015, DOI: 10.4236/ojmn.2015.52007
Abstract: Dorsal decompression in patients, presenting with cervical spondylotic myelopathy with no signs of instability, is a standard surgical option. Laminectomy or laminoplasty is applied to reduce the pressure on the myelon. The aim of this study was to evaluate the clinical outcome in a consecutive series of patients. This retrospective study included a total of 65 patients who underwent laminectomy or laminoplasty at a single or more levels, without fusion for cervical spondylotic myelopathy, during an 8-year period (2000-2007). The clinical data evaluation included pre- and postoperative patient history and neurological and surgical variables. The radiological assessment included MRI, CT, and plain anterior-posterior, lateral, and lateral flexion-extension X-rays. The mean follow-up time was 15 months. Improvement of gait disturbance was documented in 74% of the patients concerned. Radicular pain in the upper limbs (UL) and lower limbs (LL) improved in 87% and 50% of the patients, respectively. Sensory deficits improved in the UL and LL in 76% and 54%, respectively. Motor deficits improved in the UL and LL in 70% and 56% of the patients, respectively. Clinical deterioration after surgery was documented in one patient. Based on our results, laminectomy without fusion can be advocated as a safe and effective surgical strategy to treat cervical spondylotic myelopathy in patients without preoperative instability. In these patients, the occurrence of post-procedural clinical deterioration and instability was low, and overall improvement of neurological deficits and amelioration of radicular pain can be expected in a significant number of patients.
Some Absolutely Continuous Representations of Function Algebras
Adina Juratoni
Surveys in Mathematics and its Applications , 2006,
Abstract: In this paper we study some absolutely continuous representations of function algebras, which are weak ρ-spectral in the sense of [5] and [6], for a scalar ρ > 0. Precisely we investigate certain conditions for the existence of a spectral ρ-dilation of such representation. Among others we obtain different results which generalize the corresponding theorems of D. Gaspar
A. Gide’s ‘Paludes’ – between Talent and Work
Studii de Stiinta si Cultura , 2012,
Abstract: The aim of this paper is to prove that André Gide’s apparent “book about nothing”, ‘Paludes’, represents, in fact, an important step in the evolution of modern literature and its significance lies not in its simple subject and lack of action, but in the original writing technique that the author chooses for his “sotie”, in which the form is more important than the content and the characters. This paper contains instances taken from the book, and the author’s own explanations, as well as various critical references that are meant to support the arguments that we want to underline, namely that this satire presents a narrator in the process of creating a storywithin-a-story, using what is called the “mise en abyme”-technique that Gide will also apply in his only novel, ‘The Counterfeiters’. The ambiguity of ‘Paludes’ is intentional, the readers being invited to discover what is left unsaid and to contribute to the composition of the book.
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